An innovative magnetic state generator using machine learning techniques.

abstract：:SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, ...

journal_title：Scientific reports

authors： Kim M,Kwon YE,Song JO,Bae SJ,Seol JH

更新日期：2016-11-24 00:00:00

abstract：:When complementary resources are required for an optimal life cycle, most animals need to move between different habitats. However, the level of connectivity between resources can vary and, hence, influence individuals' behaviour. We show that landscape composition and configuration affect the connectivity between bre...

journal_title：Scientific reports

authors： Evens R,Beenaerts N,Neyens T,Witters N,Smeets K,Artois T

更新日期：2018-02-14 00:00:00

abstract：:During the Final Eneolithic the Corded Ware Complex (CWC) emerges, chiefly identified by its specific burial rites. This complex spanned most of central Europe and exhibits demographic and cultural associations to the Yamnaya culture. To study the genetic structure and kin relations in CWC communities, we sequenced th...

journal_title：Scientific reports

authors： Linderholm A,Kılınç GM,Szczepanek A,Włodarczak P,Jarosz P,Belka Z,Dopieralska J,Werens K,Górski J,Mazurek M,Hozer M,Rybicka M,Ostrowski M,Bagińska J,Koman W,Rodríguez-Varela R,Storå J,Götherström A,Krzewińska M

更新日期：2020-04-14 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in Cannabis, which is studied extensively for its medicinal value. A central gap in the science is the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profiles. Using a mass-spectrometry based metabolomic...

journal_title：Scientific reports

authors： Oza M,Becker W,Gummadidala PM,Dias T,Omebeyinje MH,Chen L,Mitra C,Jesmin R,Chakraborty P,Sajish M,Hofseth LJ,Banerjee K,Wang Q,Moeller PDR,Nagarkatti M,Nagarkatti P,Chanda A

更新日期：2019-07-19 00:00:00

abstract：:The innate immune system helps animals to navigate the microbial world. The response to microbes relies on the specific recognition of microbial-associated molecular patterns (MAMPs) by immune receptors. Sponges (phylum Porifera), as early-diverging animals, provide insights into conserved mechanisms for animal-microb...

journal_title：Scientific reports

authors： Pita L,Hoeppner MP,Ribes M,Hentschel U

更新日期：2018-10-31 00:00:00

abstract：:Surgical treatment of tendon lesions still yields unsatisfactory clinical outcomes. The use of bioresorbable scaffolds represents a way forward to improve tissue repair. Scaffolds for tendon reconstruction should have a structure mimicking that of the natural tendon, while providing adequate mechanical strength and st...

journal_title：Scientific reports

authors： Sensini A,Gualandi C,Zucchelli A,Boyle LA,Kao AP,Reilly GC,Tozzi G,Cristofolini L,Focarete ML

更新日期：2018-11-21 00:00:00

abstract：:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rho...

journal_title：Scientific reports

authors： Cano A,Pontes G,Sfara V,Anfossi D,Barrozo RB

更新日期：2017-11-14 00:00:00

abstract：:Vapor condensation is routinely used as an effective means of transferring heat or separating fluids. Dropwise condensation, where discrete droplets form on the condenser surface, offers a potential improvement in heat transfer of up to an order of magnitude compared to filmwise condensation, where a liquid film cover...

journal_title：Scientific reports

authors： Preston DJ,Lu Z,Song Y,Zhao Y,Wilke KL,Antao DS,Louis M,Wang EN

更新日期：2018-01-11 00:00:00

abstract：:Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation of glycolytic enzymes, such as hexokinase-2 (HK2)....

journal_title：Scientific reports

authors： Okano T,Saegusa J,Nishimura K,Takahashi S,Sendo S,Ueda Y,Morinobu A

更新日期：2017-02-10 00:00:00

abstract：:It is possible to accurately and economically predict change in protein-protein interaction energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available. This is of growing usefulness for design of high-affinity or otherwise modified binding proteins for therapeutic, diagnostic, industrial,...

journal_title：Scientific reports

authors： Dourado DF,Flores SC

更新日期：2016-05-13 00:00:00

abstract：:By means of extensive ab initio calculations, a new two-dimensional (2D) atomic material tin selenide monolayer (coined as tinselenidene) is predicted to be a semiconductor with an indirect gap (~1.45 eV) and a high hole mobility (of order 10000 cm(2)V(-1)S(-1)), and will bear an indirect-direct gap transition under a...

journal_title：Scientific reports

authors： Zhang LC,Qin G,Fang WZ,Cui HJ,Zheng QR,Yan QB,Su G

更新日期：2016-02-01 00:00:00

abstract：:While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM+ cell...

journal_title：Scientific reports

authors： Jenberie S,Thim HL,Sunyer JO,Skjødt K,Jensen I,Jørgensen JB

更新日期：2018-02-23 00:00:00

abstract：:Kluyveromyces marxianus, a non-conventional thermotolerant yeast, is potentially useful for production of ethanol and other products. This species has a strong tendency to randomly integrate transforming DNA fragments, making necessary the development of more precise methods for gene targeting. In this study, we first...

journal_title：Scientific reports

authors： Nambu-Nishida Y,Nishida K,Hasunuma T,Kondo A

更新日期：2017-08-21 00:00:00

abstract：:Carabids are considered beneficial arthropods in agroecosystems, where they prey on crop pests or consume weed seeds. Therefore, knowledge of the spatial distribution of carabids in agricultural landscapes is crucial to efficiently manage the ecosystem services that they provide. In the present study, we investigated ...

journal_title：Scientific reports

authors： Knapp M,Seidl M,Knappová J,Macek M,Saska P

更新日期：2019-06-20 00:00:00

abstract：:The origin of the enantio- and regioselectivity of ring-opening reaction of oxabicyclic alkenes catalyzed by rhodium/Josiphos has been examined using M06-2X density functional theory(DFT). DFT calculations predict a 98% ee for the enantioselectivity and only the 1,2-trans product as one regio- and diastereomer, in exc...

journal_title：Scientific reports

authors： Qi ZH,Zhang Y,Gao Y,Zhang Y,Wang XW,Wang Y

更新日期：2017-01-11 00:00:00

abstract：:During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

journal_title：Scientific reports

authors： Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

更新日期：2017-11-24 00:00:00

abstract：:Electrochemical capacitors (EC) have received tremendous interest due to their high potential to satisfy the urgent demand in many advanced applications. The development of new electrode materials is considered to be the most promising approach to enhance the EC performance substantially. Herein, we present a high-cap...

journal_title：Scientific reports

authors： Zhou J,Li N,Gao F,Zhao Y,Hou L,Xu Z

更新日期：2014-08-15 00:00:00

abstract：:Laryngeal squamous cell carcinoma is a major medical problem worldwide. Although our understanding of genetic changes and their consequences in laryngeal cancer has opened new therapeutic pathways over the years, the diagnostic as well as treatment options still need to be improved. In our previous study, we identifie...

journal_title：Scientific reports

authors： Kostrzewska-Poczekaj M,Bednarek K,Jarmuz-Szymczak M,Bodnar M,Filas V,Marszalek A,Bartochowska A,Grenman R,Kiwerska K,Szyfter K,Giefing M

更新日期：2020-01-08 00:00:00

abstract：:Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM2.5-induced inflammatory responses in mother rats, and PM2.5-induced inflammatory responses a...

journal_title：Scientific reports

authors： Tseng CY,Yu JY,Chuang YC,Lin CY,Wu CH,Liao CW,Yang FH,Chao MW

更新日期：2019-05-02 00:00:00

abstract：:Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosy...

journal_title：Scientific reports

authors： Sahib MR,Pervaiz ZH,Williams MA,Saleem M,DeBolt S

更新日期：2020-09-22 00:00:00

abstract：:Concerted evolution is often observed in multigene families such as the CEA gene family. As a result, sequence similarity of paralogous genes is significantly higher than expected from their evolutionary distance. Gene conversion, a "copy paste" DNA repair mechanism that transfers sequences from one gene to another an...

journal_title：Scientific reports

authors： Hänske J,Hammacher T,Grenkowitz F,Mansfeld M,Dau TH,Maksimov P,Friedrich C,Zimmermann W,Kammerer R

更新日期：2020-02-25 00:00:00

abstract：:Periodontal ligament stem cells (PDLSCs) are a major source of mesenchymal stem cells (MSCs) in adults and are effective for tissue engineering, like promoting angiogenesis and bone regeneration. CXCL12 has been reported to be involved in the recruitment and engraftment of MSCs in wound sites. However, whether CXCL12 ...

journal_title：Scientific reports

authors： Zhang L,Zhou Y,Sun X,Zhou J,Yang P

更新日期：2017-08-31 00:00:00

abstract：:Antimicrobial resistance is rapidly expanding, in a large part due to mobile genetic elements. We screened 94 fecal fluoroquinolone-resistant Escherichia coli isolates from Nigeria for six plasmid-mediated quinolone resistance (PMQR) genes. Sixteen isolates harbored at least one of the PMQR genes and four were positiv...

journal_title：Scientific reports

authors： Monárrez R,Braun M,Coburn-Flynn O,Botelho J,Odetoyin BW,Otero-Vera JI,Quartey NKE,Peixe L,Aboderin AO,Okeke IN

更新日期：2019-12-23 00:00:00

abstract：:Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been sh...

journal_title：Scientific reports

authors： Bax HJ,Bowen H,Dodev TS,Sutton BJ,Gould HJ

更新日期：2015-04-20 00:00:00

abstract：:Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. ...

journal_title：Scientific reports

authors： Golubewa L,Timoshchenko I,Romanov O,Karpicz R,Kulahava T,Rutkauskas D,Shuba M,Dementjev A,Svirko Y,Kuzhir P

更新日期：2020-12-17 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:The transition energies and formation energies of N, C, F, Cl, and S as substitutional dopants in Ag3PO4 are studied using first-principles calculations based on the hybrid Hartree-Fock density functional, which correctly reproduces the band gap and thus provides the accurate defect states. Our results show that NO an...

journal_title：Scientific reports

authors： Huang Y,Ma T,Chen QY,Cao C,He Y

更新日期：2015-08-03 00:00:00

abstract：:Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...

journal_title：Scientific reports

authors： Geissler CF,Schneider J,Frings C

更新日期：2021-01-12 00:00:00

abstract：:Captive breeding programs and aquaculture production have commenced worldwide for the globally distributed yellowtail kingfish (Seriola lalandi), and captive bred fingerlings are being shipped from the Southern Hemisphere to be farmed in the Northern Hemisphere. It was recently proposed that Pacific S. lalandi compris...

journal_title：Scientific reports

authors： Premachandra HKA,la Cruz FL,Takeuchi Y,Miller A,Fielder S,O'Connor W,Frère CH,Nguyen NH,Bar I,Knibb W

更新日期：2017-08-24 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00