Abstract：
:Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. Here, we demonstrate that agglomerated single-walled carbon nanotubes (SWCNTs) are promising theranostic agent that enables photo-activated 'cold' destruction of the cancer cells keeping their environment alive. The absorption of picosecond pulses by SWCNT agglomerates results in the mechanical (due to photoacoustic effect) rather than photothermal cancer cell destruction, which was visualized by micro-Raman and ultrafast near-infrared CARS. The developed theoretical model allows us to distinguish photothermal, photoacoustic, and photothermoacoustic regimes of the cancer cell destruction, and also to optimize SWCNT-based theranostics recipe.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Golubewa L,Timoshchenko I,Romanov O,Karpicz R,Kulahava T,Rutkauskas D,Shuba M,Dementjev A,Svirko Y,Kuzhir Pdoi
10.1038/s41598-020-79238-6subject
Has Abstractpub_date
2020-12-17 00:00:00pages
22174issue
1issn
2045-2322pii
10.1038/s41598-020-79238-6journal_volume
10pub_type
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