Abstract：
:Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role of miR302 in the regulation of cell plasticity. Overexpression of miR302 effected silencing of the TGFβ type II receptor and facilitated plasticity in a manner distinct from pluripotency, characterized by increased expression of Snail. miR302 overexpressing mesangial cells also exhibited enhanced expression of EZH2 coincident with Snail upregulation. esiRNA silencing of each component suggest that Smad3 and EZH2 are part of a complex that regulates plasticity and that miR302 regulates EZH2 and Snail independently. Subsequent manipulation of miR302 overexpressing cells demonstrated the potential of using this approach for reprogramming as evidenced by de novo expression of the tight junction components ZO-1 and E-cadherin and the formation of ZO-1 containing tight junctions. Understanding the processes through which dynamic epigenetic silencing is controlled in adults cells will allow us to address the epigenetic state of acquired disease and whether original states, regenerative in nature, can be restored with therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
De Chiara L,Andrews D,Watson A,Oliviero G,Cagney G,Crean Jdoi
10.1038/srep42407subject
Has Abstractpub_date
2017-02-14 00:00:00pages
42407issn
2045-2322pii
srep42407journal_volume
7pub_type
杂志文章abstract：:To increase the energy storage density of lithium-ion batteries, silicon anodes have been explored due to their high capacity. One of the main challenges for silicon anodes are large volume variations during the lithiation processes. Recently, several high-performance schemes have been demonstrated with increased life...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51087-y
更新日期：2019-10-10 00:00:00
abstract：:Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in detail. The results indicated that there are two different species characteristics of Pb existing in sea food samples. About half of samples w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33294
更新日期：2016-09-14 00:00:00
abstract：:In a globalized world, plant invasions are common challenges for native ecosystems. Although a considerable number of invasive plants form arbuscular mycorrhizae, interactions between arbuscular mycorrhizal (AM) fungi and invasive and native plants are not well understood. In this study, we conducted a greenhouse expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77030-0
更新日期：2020-11-20 00:00:00
abstract：:Marine macroalgal forests are highly productive and iconic ecosystems, which are seriously threatened by number of factors such as habitat destruction, overgrazing, ocean warming, and pollution. The effect of chronic, but low levels of pollutants on the long-term survival of the canopy-forming algae is not well unders...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73990-5
更新日期：2020-10-20 00:00:00
abstract：:Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-34246-5
更新日期：2018-10-31 00:00:00
abstract：:Ultra-high resolution optical coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement the thicknesses. The purpose of this study was to validate the diagnostic power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT in the diagnosis...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep31550
更新日期：2016-08-11 00:00:00
abstract：:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09289
更新日期：2015-03-19 00:00:00
abstract：:In order to understand the physical properties of materials it is necessary to determine the 3D positions of all atoms. There has been significant progress towards this goal using electron tomography. However, this method requires a relatively high electron dose and often extended acquisition times which precludes the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10654-x
更新日期：2017-09-07 00:00:00
abstract：:Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae and is responsible for increased aortic stiffness and subsequent cardiovascular events. Current treatments for calcification, particularly in CK...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39639-8
更新日期：2019-02-22 00:00:00
abstract：:Oceanic submesoscale currents (SMCs) occur on an scale of 0.1-10 km horizontally and have a large influence on the oceanic variability and on ecosystems. At the mesoscale (10-250 km), oceanic thermal and current feedbacks are known to have a significant influence on the atmosphere and on oceanic dynamics. However, air...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31602-3
更新日期：2018-09-06 00:00:00
abstract：:Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16762-y
更新日期：2017-11-27 00:00:00
abstract：:With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rare...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02770-5
更新日期：2017-06-06 00:00:00
abstract：:Two-dimensional imaging of spontaneous ultra-weak photon emission was measured in the yeast cells, Arabidopsis plant and the human hand using highly sensitive charge coupled device (CCD) camera. For the first time, the detail analysis of measuring parameters such as accumulation time and binning is provided with the a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01211
更新日期：2013-01-01 00:00:00
abstract：:Solitons are of fundamental importance in photonics due to applications in optical data transmission and also as a tool for investigating novel phenomena ranging from light generation at new frequencies and wave-trapping to rogue waves. Solitons are also moving scatterers: they generate refractive index perturbations ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00932
更新日期：2012-01-01 00:00:00
abstract：:In this paper, we present a strategy to improve delivery of femtosecond laser pulses from a regenerative amplifier through a hollow core photonic crystal fiber for temporally focused wide-field two-photon endomicroscopy. For endomicroscope application, wide-field two-photon excitation has the advantage of requiring no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06626
更新日期：2014-10-15 00:00:00
abstract：:Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27927
更新日期：2016-06-13 00:00:00
abstract：:Computed Tomography derived Fractional Flow Reserve (CTFFR) is an emerging non-invasive imaging modality to assess functional significance of coronary stenosis. We performed a meta-analysis to compare the diagnostic performance of CTFFR to invasive Fractional Flow reserve (FFR). Electronic search was performed to iden...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-29910-9
更新日期：2018-08-01 00:00:00
abstract：:We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55616-7
更新日期：2019-12-23 00:00:00
abstract：:Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then anal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29855
更新日期：2016-07-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-77251-3
更新日期：2020-11-18 00:00:00
abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06501
更新日期：2014-10-13 00:00:00
abstract：:Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes with COL6A3 mRNA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77406-2
更新日期：2020-11-19 00:00:00
abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64678-x
更新日期：2020-05-08 00:00:00
abstract：:Copy Number Variants (CNVs) are a class of structural variations of DNA. Germline CNVs are known to confer disease susceptibility, but their role in breast cancer warrants further investigations. We hypothesized that breast cancer associated germline CNVs contribute to disease risk through gene dosage or other post-tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25801-1
更新日期：2018-05-14 00:00:00
abstract：:Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64753-3
更新日期：2020-05-12 00:00:00
abstract：:Silver (Ag) is one of the seven metals of antiquity and an important engineering material in the electronic, medical, and chemical industries because of its unique noble and catalytic properties. Ag thin films are extensively used in modern electronics primarily because of their oxidation-resistance. Here we report a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34769
更新日期：2016-10-05 00:00:00
abstract：:The striped venus (Chamelea gallina) is an important economic resource in the Mediterranean Basin; this species has exhibited a strong quantitative decline in the Adriatic Sea. The aim of this work was to provide a comprehensive view of the biological status of C. gallina to elucidate the bioecological characteristics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75984-9
更新日期：2020-11-05 00:00:00
abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73242-6
更新日期：2020-10-01 00:00:00
abstract：:Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08811-3
更新日期：2017-08-16 00:00:00
abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46060
更新日期：2017-04-24 00:00:00
