A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis.

abstract：:Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors usin...

journal_title：Scientific reports

authors： Thimsen V,John N,Buchfelder M,Flitsch J,Fahlbusch R,Stefanits H,Knosp E,Losa M,Buslei R,Hölsken A

更新日期：2017-11-20 00:00:00

abstract：:The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...

journal_title：Scientific reports

authors： Cain SW,McGlashan EM,Vidafar P,Mustafovska J,Curran SPN,Wang X,Mohamed A,Kalavally V,Phillips AJK

更新日期：2020-11-05 00:00:00

abstract：:Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...

journal_title：Scientific reports

authors： Nayak S,Sridhara A,Melo R,Richer L,Chee NH,Kim J,Linder V,Steinmiller D,Sia SK,Gomes-Solecki M

更新日期：2016-10-11 00:00:00

abstract：:Retrotransposons can represent half of eukaryotic genomes. Retrotransposon dysregulation destabilizes genomes and has been linked to various human diseases. Emerging regulators of retromobility include RNA-DNA hybrid-containing structures known as R-loops. Accumulation of these structures at the transposons of yeast 1...

journal_title：Scientific reports

authors： Todd LA,Hall AC,Pietrobon V,Chan JNY,Laflamme G,Mekhail K

更新日期：2020-09-29 00:00:00

abstract：:The volcanic eruption of Santorini in the Bronze Age left detectable debris across the Mediterranean, serving as an anchor in time for the region, synchronizing chronologies of different sites. However, dating the eruption has been elusive for decades, as radiocarbon indicates a date about a century earlier than archa...

journal_title：Scientific reports

authors： Ehrlich Y,Regev L,Boaretto E

更新日期：2021-01-12 00:00:00

abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

journal_title：Scientific reports

authors： Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

更新日期：2016-02-10 00:00:00

abstract：:We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal markers, suggesting a mesenchymal o...

journal_title：Scientific reports

authors： Qiu SQ,Wei XL,Huang WH,Wu MY,Qin YS,Li YK,Zhang GJ

更新日期：2013-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Alflen A,Prüfer S,Ebner K,Reuter S,Lopez PA,Scharrer I,Banno F,Stassen M,Schild H,Jurk K,Bosmann M,Beckert H,Radsak MP

更新日期：2018-09-26 00:00:00

abstract：:Mathematical models of metabolism from bacterial systems biology have proven their utility across multiple fields, for example metabolic engineering, growth phenotype simulation, and biological discovery. The usefulness of the models stems from their ability to compute a link between genotype and phenotype, but their ...

journal_title：Scientific reports

authors： Aziz RK,Monk JM,Lewis RM,In Loh S,Mishra A,Abhay Nagle A,Satyanarayana C,Dhakshinamoorthy S,Luche M,Kitchen DB,Andrews KA,Fong NL,Li HJ,Palsson BO,Charusanti P

更新日期：2015-11-04 00:00:00

abstract：:During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis....

journal_title：Scientific reports

authors： Rademakers T,van der Vorst EP,Daissormont IT,Otten JJ,Theodorou K,Theelen TL,Gijbels M,Anisimov A,Nurmi H,Lindeman JH,Schober A,Heeneman S,Alitalo K,Biessen EA

更新日期：2017-03-28 00:00:00

abstract：:Electrochemical pre-doping of a silicon electrode was investigated to create a new class of rechargeable battery with higher energy density. The electrochemical reaction during pre-doping formed a high-quality solid electrolyte interface (SEI) on the surface of silicon particles, which improved the charge and discharg...

journal_title：Scientific reports

authors： Wang Y,Satoh M,Arao M,Matsumoto M,Imai H,Nishihara H

更新日期：2020-02-21 00:00:00

abstract：:Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580) to investigate the genetic basis for brain weights, activi...

journal_title：Scientific reports

authors： Janecka M,Marzi SJ,Parsons MJ,Liu L,Paya-Cano JL,Smith RG,Fernandes C,Schalkwyk LC

更新日期：2017-02-01 00:00:00

abstract：:Achieving 180° magnetization reversal with an electric field rather than a current or magnetic field is a fundamental challenge and represents a technological breakthrough towards new memory cell designs. Here we propose a mesoscale morphological engineering approach to accomplishing full 180° magnetization reversals ...

journal_title：Scientific reports

authors： Wang JJ,Hu JM,Ma J,Zhang JX,Chen LQ,Nan CW

更新日期：2014-12-16 00:00:00

abstract：:The use of electricity generated from clean and renewable sources, such as water, wind, or sunlight, requires efficiently distributed electrical energy storage by high-power and high-energy secondary batteries using abundant, low-cost materials in sustainable processes. American Science Policy Reports state that the n...

journal_title：Scientific reports

authors： Xu C,Chen Y,Shi S,Li J,Kang F,Su D

更新日期：2015-09-14 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Pham TQ,Kawaue T,Hoshi T,Tanaka Y,Miyata T,Sano A

更新日期：2018-09-07 00:00:00

abstract：:We show a hybrid structure consisting of Si film with photonic crystal surface and random triangular gold grooves reflector at the bottom, which is capable of realizing efficient, broad-band, wide-angle optical absorption. It is numerically demonstrated that the enhanced absorption in a broad wavelength range (0.3-9.9...

journal_title：Scientific reports

authors： Chen ZH,Qiao N,Yang Y,Ye H,Liu S,Wang W,Wang Y

更新日期：2015-08-04 00:00:00

abstract：:Attraction to infants is a common feature of non-human primates. Frequent affiliative male-infant interactions have been observed in many multimale, multifemale groups of macaques, including a behaviour termed 'bridging' in which two male macaques simultaneously lift an infant. This behaviour has been suggested to ser...

journal_title：Scientific reports

authors： Zhang D,Xia DP,Wang X,Zhang QX,Sun BH,Li JH

更新日期：2018-11-02 00:00:00

abstract：:Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metal...

journal_title：Scientific reports

authors： Yan H,Hu Y,Akk A,Ye K,Bacon J,Pham CTN

更新日期：2019-07-18 00:00:00

abstract：:Lead (Pb) toxicity is a major environmental concern affirming the need of proper mitigation strategies. In the present work, potential of combined treatment of 24-Epibrassinolide (24-EBL) and Salicylic acid (SA) against Pb toxicity to Brassica juncea L. seedlings were evaluated. Seedlings pre-imbibed in EBL (0.1 mM) a...

journal_title：Scientific reports

authors： Kohli SK,Bali S,Tejpal R,Bhalla V,Verma V,Bhardwaj R,Alqarawi AA,Abd Allah EF,Ahmad P

更新日期：2019-03-05 00:00:00

abstract：:Multiphoton excitation microscopy (MPM) is regarded as an effective tool that enables the visualization of deep regions within living tissues and organs, with little damage. Here, we report novel non-labeling MPM (NL-MPM) imaging of fresh human colorectal mucosa, which is useful for discriminating cancer lesions from ...

journal_title：Scientific reports

authors： Matsui T,Mizuno H,Sudo T,Kikuta J,Haraguchi N,Ikeda JI,Mizushima T,Yamamoto H,Morii E,Mori M,Ishii M

更新日期：2017-07-31 00:00:00

abstract：:Accurately representing the Indian Ocean Dipole (IOD) is crucial for reliable climate predictions and future projections. However, El Niño-Southern Oscillation (ENSO) and IOD interact, making it necessary to evaluate ENSO and IOD simultaneously. Using the historical simulation from 32 fifth phase of Coupled Model Inte...

journal_title：Scientific reports

authors： McKenna S,Santoso A,Gupta AS,Taschetto AS,Cai W

更新日期：2020-07-13 00:00:00

abstract：:Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...

journal_title：Scientific reports

authors： Zheng M,Qu D,Wang H,Sun Z,Liu X,Chen J,Li C,Li X,Chen Z

更新日期：2016-06-29 00:00:00

abstract：:The lithium-sulfur battery, which offers a high energy density and is environmental friendly, is a promising next generation of rechargeable energy storage system. However, despite these attractive attributes, the commercialization of lithium-sulfur battery is primarily hindered by the parasitic reactions between the ...

journal_title：Scientific reports

authors： Zhang Y,Peng Y,Wang Y,Li J,Li H,Zeng J,Wang J,Hwang BJ,Zhao J

更新日期：2017-09-12 00:00:00

abstract：:Urothelial carcinoma (UC) is a common disease causing significant morbidity and mortality as well as considerable costs for health systems. Extensive aberrant methylation of DNA is broadly documented in early UC, contributing to genetic instability, altered gene expression and tumor progression. However the triggers i...

journal_title：Scientific reports

authors： Erichsen L,Seifert HH,Schulz WA,Hoffmann MJ,Niegisch G,Araúzo-Bravo MJ,Bendhack ML,Poyet C,Hermanns T,Beermann A,Hassan M,Theis L,Mahmood W,Santourlidis S

更新日期：2020-03-02 00:00:00

abstract：:Advancements in microfabrication has enabled manufacturing of microscopic neurostimulation electrodes with smaller footprint than ever possible. The smaller electrodes can potentially reduce tissue damage and allow better spatial resolution for neural stimulation. Although electrodes of any shape can easily be fabrica...

journal_title：Scientific reports

authors： Park H,Takmakov P,Lee H

更新日期：2018-03-12 00:00:00

abstract：:Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Ac...

journal_title：Scientific reports

authors： Garscha U,Romp E,Pace S,Rossi A,Temml V,Schuster D,König S,Gerstmeier J,Liening S,Werner M,Atze H,Wittmann S,Weinigel C,Rummler S,Scriba GK,Sautebin L,Werz O

更新日期：2017-08-24 00:00:00

abstract：:Two hundred and six strains of avian infectious bronchitis virus (IBV) were isolated from chickens showing signs of disease in southern China during the period from 2013-2015. The nucleotide and amino acid sequences from the isolated field strains were compared to 42 published references. Nucleotide homologies ranged ...

journal_title：Scientific reports

authors： Feng K,Wang F,Xue Y,Zhou Q,Chen F,Bi Y,Xie Q

更新日期：2017-07-26 00:00:00

abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

journal_title：Scientific reports

authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

更新日期：2017-07-27 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...

journal_title：Scientific reports

authors： Beske PH,Hoffman KM,Machamer JB,Eisen MR,McNutt PM

更新日期：2017-11-20 00:00:00

abstract：:Corticotropin releasing factor (CRF), a peptide hormone involved in the stress response, holds a key position in cardiovascular regulation. Here, we report that the central effect of CRF on cardiovascular activities is mediated by the posterior hypothalamic nucleus (PH), an important structure responsible for stress-i...

journal_title：Scientific reports

authors： Gao HR,Zhuang QX,Li B,Li HZ,Chen ZP,Wang JJ,Zhu JN

更新日期：2016-02-01 00:00:00