Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

abstract：:Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a wel...

journal_title：Scientific reports

authors： Sano MB,Arena CB,Bittleman KR,DeWitt MR,Cho HJ,Szot CS,Saur D,Cissell JM,Robertson J,Lee YW,Davalos RV

更新日期：2015-10-13 00:00:00

abstract：:Sleep, in addition to its brain restorative processes, plays an important role in memory transfer from its temporary store in the hippocampus to the more permanent storage in the neocortex. Alzheimer's disease (AD) affects memory and sleep. The aim of this study was to explore disturbances in global and local synchron...

journal_title：Scientific reports

authors： Zhurakovskaya E,Ishchenko I,Gureviciene I,Aliev R,Gröhn O,Tanila H

更新日期：2019-03-29 00:00:00

abstract：:High-resolution microscopy is a valuable tool for studying cellular processes, such as signalling, membrane trafficking, or cytoskeleton remodelling. Several techniques of inclined illumination microscopy allow imaging at a near single molecular level; however, the application of these methods to plant cells is limite...

journal_title：Scientific reports

authors： Kozgunova E,Goshima G

更新日期：2019-10-23 00:00:00

abstract：:Saccharomyces cerevisiae strains vary in their ability to develop and enhance sensory attributes of alcoholic beverages and are often found growing in mixed strain fermentations; however, quantifying individual strains is challenging due to quantification inaccuracies, low marker longevity, and compromised kinetics. W...

journal_title：Scientific reports

authors： Gustafsson FS,Whiteside MD,Jiranek V,Durall DM

更新日期：2014-11-10 00:00:00

abstract：:Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated with cognitive decline. However, the correlation between FGF21 and cognitive decline in elderly and nonelderly MetS patients has not been investigated. 116 non-elderly patients (age ...

journal_title：Scientific reports

authors： Phrommintikul A,Sa-Nguanmoo P,Sripetchwandee J,Vathesatogkit P,Chattipakorn N,Chattipakorn SC

更新日期：2018-03-26 00:00:00

abstract：:Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...

journal_title：Scientific reports

authors： Siu GK,Zhou F,Yu MK,Zhang L,Wang T,Liang Y,Chen Y,Chan HC,Yu S

更新日期：2016-03-24 00:00:00

abstract：:We herein present a novel and sustainable technology for mercury recycling, with the maximum observed uptake capacity. Facile synthesis of the most efficient (~1.9 gg-1) nano-trap, made of montmorillonite-Fe-iron oxides, was performed to instantaneously remove mercury(II) ions from water. Elemental Hg was recovered fr...

journal_title：Scientific reports

authors： Ganguly M,Dib S,Ariya PA

更新日期：2018-11-02 00:00:00

abstract：:Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous factors. So far, root exudates have mainly been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated for polar and semi-pol...

journal_title：Scientific reports

authors： Dietz S,Herz K,Gorzolka K,Jandt U,Bruelheide H,Scheel D

更新日期：2020-07-01 00:00:00

abstract：:Marsupials have a functional placenta for a shorter period of time compared to that of eutherian species, and their altricial young reach the teats without any help from the mother. We have monitored the short intrauterine development of one marsupial, the tammar wallaby, with high-resolution ultrasound from reactivat...

journal_title：Scientific reports

authors： Drews B,Roellig K,Menzies BR,Shaw G,Buentjen I,Herbert CA,Hildebrandt TB,Renfree MB

更新日期：2013-01-01 00:00:00

abstract：:The major human pathogen Mycobacterium tuberculosis is rarely reported to cause disease in other animals. Cases in livestock are thought to occur through contact with infected handlers, but previous studies evaluating putative livestock-human transmission used typing techniques with limited resolution. Here, we undert...

journal_title：Scientific reports

authors： Palaniyandi K,Kumar N,Veerasamy M,Kabir Refaya A,Dolla C,Balaji S,Baskaran D,Thiruvengadam K,Rajendran A,Narayanan S,Raj D,Swaminathan S,Peacock SJ

更新日期：2019-11-29 00:00:00

abstract：:The ammonia removal as well as the current efficiency during electrolysis was investigated by using a vermiculite-packed electrochemical reactor under continuous mode. Experimental results showed that adsorption of ammonia by vermiculite and electrolytic desorption of ammonia simultaneously existed in the reactor, lea...

journal_title：Scientific reports

authors： Li L,Yao J,Fang X,Huang Y,Mu Y

更新日期：2017-01-19 00:00:00

abstract：:Accumulating evidence indicates that cancer cells show specific alterations in phospholipid metabolism that contribute to tumour progression in several types of cancer, including colorectal cancer. Questions still remain as to what lipids characterize the outer edge of cancer tissues and whether those cancer outer edg...

journal_title：Scientific reports

authors： Hiraide T,Ikegami K,Sakaguchi T,Morita Y,Hayasaka T,Masaki N,Waki M,Sugiyama E,Shinriki S,Takeda M,Shibasaki Y,Miyazaki S,Kikuchi H,Okuyama H,Inoue M,Setou M,Konno H

更新日期：2016-07-20 00:00:00

abstract：:Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred...

journal_title：Scientific reports

authors： Sello MM,Jafta N,Nelson DR,Chen W,Yu JH,Parvez M,Kgosiemang IKR,Monyaki R,Raselemane SC,Qhanya LB,Mthakathi NT,Sitheni Mashele S,Syed K

更新日期：2015-07-01 00:00:00

abstract：:Species and populations are disappearing at an alarming rate as a direct result of human activities. Loss of genetic diversity associated with population decline directly impacts species' long-term survival. Therefore, preserving genetic diversity is of considerable conservation importance. However, to assist in conse...

journal_title：Scientific reports

authors： van der Valk T,Sandoval-Castellanos E,Caillaud D,Ngobobo U,Binyinyi E,Nishuli R,Stoinski T,Gilissen E,Sonet G,Semal P,Kalthoff DC,Dalén L,Guschanski K

更新日期：2018-04-25 00:00:00

abstract：:Engineered nanomaterials hold great promise for the future development of innovative products but their adverse health effects are a major concern. Recent studies have indicated that certain nanomaterials, including carbon nanotubes (CNTs), may be carcinogenic. However, the underlying mechanisms behind their potential...

journal_title：Scientific reports

authors： Voronkova MA,Luanpitpong S,Rojanasakul LW,Castranova V,Dinu CZ,Riedel H,Rojanasakul Y

更新日期：2017-09-14 00:00:00

abstract：:Understanding source-sink dynamics is important for conservation management, particularly when climatic events alter species' distributions. Following a 2011 'marine heatwave' in Western Australia, we observed high recruitment of the endemic fisheries target species Choerodon rubescens, towards the cooler (southern) e...

journal_title：Scientific reports

authors： Cure K,Thomas L,Hobbs JA,Fairclough DV,Kennington WJ

更新日期：2017-08-17 00:00:00

abstract：:Osteosarcoma (OS) is the most common bone tumor characterized with a high risk of amputation and malignant morbidity among teenagers and adolescents. However, relevant pathogenic/biological mechanisms underlying OS-genesis remains to be ambiguous. The aim of this study was to elucidate functional relationship about mi...

journal_title：Scientific reports

authors： Wang H,Tang M,Ou L,Hou M,Feng T,Huang YE,Jin Y,Zhang H,Zuo G

更新日期：2017-07-14 00:00:00

abstract：:The interfacial Dzyaloshinskii-Moriya interaction (DMI) is an essential ingredient for stabilizing chiral spin configurations in spintronic applications. Here, via first-principles calculations, we reveal the influence of lattice strain on DMI in Co/Pt interface. We observed a considerable enhancement for a certain la...

journal_title：Scientific reports

authors： Deger C

更新日期：2020-07-23 00:00:00

abstract：:Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...

journal_title：Scientific reports

authors： Kuzmanović N,Smalla K,Gronow S,Puławska J

更新日期：2018-06-13 00:00:00

abstract：:An aberrant expression of integrin β1 has been implicated in breast cancer progression. Here, we compared the cell behaviors of wild-type (WT), β1 gene deleted (KO), and β1 gene restored (Res) MDA-MB-231 cells. Surprisingly, the expression of β1 exhibited opposite effects on cell proliferation. These effects were depe...

journal_title：Scientific reports

authors： Hou S,Isaji T,Hang Q,Im S,Fukuda T,Gu J

更新日期：2016-01-05 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...

journal_title：Scientific reports

authors： Ntasis VF,Panousis NI,Tektonidou MG,Dermitzakis ET,Boumpas DT,Bertsias GK,Nikolaou C

更新日期：2020-10-06 00:00:00

abstract：:Monolayer molybdenum disulfide (MoS2) has recently attracted intense interests due to its remarkable optical properties of valley-selected optical response, strong nonlinear wave mixing and photocurrent/photovoltaic generation and many corresponding potential applications. However, the nature of atomic-thin thickness ...

journal_title：Scientific reports

authors： Li J,Ji Q,Chu S,Zhang Y,Li Y,Gong Q,Liu K,Shi K

更新日期：2016-03-31 00:00:00

abstract：:Vertically aligned radial-junction solar cell designs offer potential improvements over planar geometries, as carrier generation occurs close to the junction for all absorption depths, but most production methods still require a single crystal substrate. Here, we report on the fabrication of such solar cells from poly...

journal_title：Scientific reports

authors： Martinsen FA,Smeltzer BK,Nord M,Hawkins T,Ballato J,Gibson UJ

更新日期：2014-09-04 00:00:00

abstract：:Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to as lipid rafts, where signalling molecules are enriched or that ordered TCR-containing membrane nanodomains coalesce upon TCR engagement. That...

journal_title：Scientific reports

authors： Dinic J,Riehl A,Adler J,Parmryd I

更新日期：2015-05-08 00:00:00

abstract：:Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...

journal_title：Scientific reports

authors： White CW,Vanyai HK,See HB,Johnstone EKM,Pfleger KDG

更新日期：2017-06-09 00:00:00

abstract：:Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There is an urgent need to identify markers of lung carcinogenesis and new targets for therapy. Given the recent successes of immune modulators in c...

journal_title：Scientific reports

authors： Baird AM,Gray SG,Richard DJ,O'Byrne KJ

更新日期：2016-01-13 00:00:00

abstract：:Because of the small particle number of intracellular species participating in genetic circuits, stochastic fluctuations are inevitable. This intracellular noise is detrimental to precise regulation. To maintain the proper function of a cell, some natural motifs attenuate the noise at the protein level. In many biolog...

journal_title：Scientific reports

authors： Liu FY,Lo SC,Shu CC

更新日期：2019-03-04 00:00:00

abstract：:Orb2 is a functional amyloid that plays a key role in Drosophila long-term memory formation. Orb2 has two isoforms that differ in their N-termini. The N-terminus of the A isoform (Orb2A) that precedes its Q-rich prion-like domain has been shown to be important for Orb2 aggregation and long-term memory. However, beside...

journal_title：Scientific reports

authors： Cervantes SA,Bajakian TH,Soria MA,Falk AS,Service RJ,Langen R,Siemer AB

更新日期：2016-12-06 00:00:00

abstract：:The use of entomopathogenic fungi for biocontrol of plant pests is recently receiving an increased interest due to the need of reducing the impact of agricultural practices on the environment. Biocontrol efficacy could be improved by co-inoculation of different microorganisms. However, interactions between the fungal ...

journal_title：Scientific reports

authors： Canfora L,Abu-Samra N,Tartanus M,Łabanowska BH,Benedetti A,Pinzari F,Malusà E

更新日期：2017-10-12 00:00:00

abstract：:Aquaporin 9 (AQP9), as an aquaglyceroporin, is expressed in many immune cells and plays important role in tumor initiation and progression. However, the relationship between AQP9 and tumor-infiltrating cells, and its prognostic value in cancers still require comprehensive understanding. Herein, we aimed to elucidate t...

journal_title：Scientific reports

authors： Liu X,Xu Q,Li Z,Xiong B

更新日期：2020-11-27 00:00:00