Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.

Abstract:

:We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal markers, suggesting a mesenchymal origin. Of the five cases expressing Ki-67, two of three patients with axillary lymph node involvement died between 6-8 months, and two died at 17 and 26 months after diagnosis. The two remaining cases, with low Ki-67 expression, had no recurrent or metastatic disease at 145 months after diagnosis. Previous studies have shown that surgery is the primary treatment of choice, but no clear benefit from adjuvant chemotherapy was observed. We demonstrate that axillary lymph node involvement and high expression of Ki-67 are associated with poorer prognosis. A literature review indicates surgery remains the first choice for MFH, but benefits from adjuvant chemotherapy remain unclear.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Qiu SQ,Wei XL,Huang WH,Wu MY,Qin YS,Li YK,Zhang GJ

doi

10.1038/srep02529

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2529

issn

2045-2322

pii

srep02529

journal_volume

3

pub_type

临床试验,杂志文章,评审
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