Abstract：
:During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information exists at the protein level. The aim of this study was to identify the proteins at the embryo-maternal interface around signalling of MRP in the horse (day 13) by means of mass spectrometry. A distinct influence of pregnancy was established, with 119 proteins differentially expressed in the uterine fluid of pregnant mares compared to cyclic mares and with upregulation of several inhibitors of the prostaglandin synthesis during pregnancy. By creating an overview of the proteins at the embryo-maternal interface in the horse, this study provides a solid foundation for further targeted studies of proteins potentially involved in embryo-maternal interactions, MRP and pregnancy loss in the horse.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Smits K,Willems S,Van Steendam K,Van De Velde M,De Lange V,Ververs C,Roels K,Govaere J,Van Nieuwerburgh F,Peelman L,Deforce D,Van Soom Adoi
10.1038/s41598-018-23537-6subject
Has Abstractpub_date
2018-03-27 00:00:00pages
5249issue
1issn
2045-2322pii
10.1038/s41598-018-23537-6journal_volume
8pub_type
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