Abstract:
:Spontaneous preterm birth (sPTB, delivery <37 weeks gestation), accounts for approximately 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infection being one contributing factor. This study aimed to determine whether asymptomatic women with a history of sPTB or cervical surgery have altered levels of inflammatory/antimicrobial mediators and/or microflora within cervical fluid at 22-24 weeks gestation. External cervical fluid was collected from women with history of previous sPTB and/or cervical surgery at 22-24 weeks gestation (n = 135). Cytokine and antimicrobial peptides were measured on a multiplex platform or by ELISA. qPCR was performed for detection of 7 potentially pathogenic bacterial species. IL-8 and IL-1β levels were lower in women who delivered preterm compared to those who delivered at term (IL-8 P = 0.02; IL-1β P = 0.04). There were no differences in elafin or human beta defensin-1 protein levels between the two groups. Multiple bacterial species were detected in a higher proportion of women who delivered preterm than in those who delivered at term (P = 0.005). Cervical fluid IL-8 and IL-1β and microflora have the potential to be used as biomarkers to predict sPTB in high risk women.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Manning R,James CP,Smith MC,Innes BA,Stamp E,Peebles D,Bajaj-Elliott M,Klein N,Bulmer JN,Robson SC,Lash GEdoi
10.1038/s41598-019-47756-7subject
Has Abstractpub_date
2019-08-02 00:00:00pages
11246issue
1issn
2045-2322pii
10.1038/s41598-019-47756-7journal_volume
9pub_type
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