Abstract：
:Sepsis is associated with thrombocytopenia and microvascular thrombosis. Studies have described platelets implication in this pathology but their kinetics of activation and behavior remain poorly known. We show in a mouse model of peritonitis, the appearance of platelet-rich thrombi in organ microvessels and organ damage. Complementary methods are necessary to characterize platelet activation during sepsis as circulating soluble markers and platelet-monocyte aggregates revealed early platelet activation, while surface activation markers were detected at later stage. A microfluidic based ex-vivo thrombosis assay demonstrated that platelets from septic mice have a prothrombotic behavior at shear rate encountered in microvessels. Interestingly, we found that even though phosphoinositide-3-kinase β-deficient platelet mice formed less thrombi in liver microcirculation, peritoneal sepsis activates a platelet alternative pathway to compensate the otherwise mandatory role of this lipid-kinase to form stable thrombi at high shear rate. Platelets are rapidly activated during sepsis. Thrombocytopenia can be attributed in part to platelet-rich thrombi formation in capillaries and platelet-leukocytes interactions. Platelets from septic mice have a prothrombotic phenotype at a shear rate encountered in arterioles. Further studies are necessary to unravel molecular mechanisms leading to this prothrombotic state of platelets in order to guide the development of future treatments of polymicrobial sepsis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vardon Bounes F,Mémier V,Marcaud M,Jacquemin A,Hamzeh-Cognasse H,Garcia C,Series J,Sié P,Minville V,Gratacap MP,Payrastre Bdoi
10.1038/s41598-018-31910-8subject
Has Abstractpub_date
2018-09-10 00:00:00pages
13536issue
1issn
2045-2322pii
10.1038/s41598-018-31910-8journal_volume
8pub_type
杂志文章abstract：:The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian Polycarpa mytiligera, to eviscerate and regenerate its gut within 12 days, and to rebuild its branchial sac within 19 days. Evisceration occur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09614
更新日期：2015-04-16 00:00:00
abstract：:CHF5633 is a novel synthetic clinical pulmonary surfactant preparation composed by two phospholipid species, dipalmitoyl phosphatidylcholine (DPPC) and palmitoyloleoyl phosphatidylglycerol (POPG), and synthetic analogues of the hydrophobic surfactant proteins SP-B and SP-C. In this study, the interfacial properties of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58248-4
更新日期：2020-01-28 00:00:00
abstract：:The brew temperature is widely considered a key parameter affecting the final quality of coffee, with a temperature near 93 °C often described as optimal. In particular, drip brewers that do not achieve a minimum brew temperature of 92 °C within a prescribed time period fail their certification. There is little empiri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73341-4
更新日期：2020-10-05 00:00:00
abstract：:Many human introns carry out a function, in the sense that they are critical to maintain normal cellular activity. Their identification is fundamental to understanding cellular processes and disease. However, being noncoding elements, such functional introns are poorly predicted based on traditional approaches of sequ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04476-0
更新日期：2017-06-23 00:00:00
abstract：:Sodefrin, a decapeptide isolated from the male dorsal gland of the Japanese fire belly newt Cynops pyrrhogaster, was the first peptide pheromone identified from a vertebrate. The fire belly salamander and sodefrin have become a model for sex pheromone investigation in aquatically courting salamanders ever since. Subse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21880
更新日期：2016-03-03 00:00:00
abstract：:Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference gene transcripts is instrumental. In T cell immunology, suitable refer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66367-1
更新日期：2020-06-10 00:00:00
abstract：:Activation of different slip systems in hexagonal close packed (h.c.p.) metals depends primarily on the c/a ratio, which is an intrinsic property that can be altered through alloying addition. In conventional h.c.p. alloys where there is no diffusion-less phase transformation and associated transformation volume chang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49904-5
更新日期：2019-09-12 00:00:00
abstract：:The role of non-bilayer lipids and non-lamellar lipid phases in biological membranes is an enigmatic problem of membrane biology. Non-bilayer lipids are present in large amounts in all membranes; in energy-converting membranes they constitute about half of their total lipid content-yet their functional state is a bila...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68854-x
更新日期：2020-07-20 00:00:00
abstract：:Real-valued functions of complex arguments violate the Cauchy-Riemann conditions and, consequently, do not have Taylor series expansion. Therefore, optimization methods based on derivatives cannot be directly applied to this class of functions. This is circumvented by mapping the problem to the field of the real numbe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52289-0
更新日期：2019-11-06 00:00:00
abstract：:Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05089-3
更新日期：2017-07-10 00:00:00
abstract：:Mayaro virus (MAYV) causes an acute febrile illness similar to that produced by chikungunya virus (CHIKV), an evolutionary relative in the Semliki Forest virus complex of alphaviruses. MAYV emergence is typically sporadic, but recent isolations and outbreaks indicate that the virus remains a public health concern. Giv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56551-3
更新日期：2019-12-31 00:00:00
abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40546-1
更新日期：2019-03-11 00:00:00
abstract：:To explore soil organic carbon (SOC) accumulation mechanisms, the dynamics of C functional groups and macroaggregation were studied synchronously through aggregate fractionation and (13)C NMR spectroscopy in sandy loam soil following an 18-year application of compost and fertilizer in China. Compared with no fertilize...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13804
更新日期：2015-09-11 00:00:00
abstract：:Here we report a method for improving the magnetic field sensitivity of an ensemble of Nitrogen-Vacancy (NV) centres in 12C-enriched diamond aligned along the [111] crystal axis. The preferentially-aligned NV centres are fabricated by a Plasma Enhanced Chemical Vapour Deposition (PECVD) process and their concentration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42314-7
更新日期：2019-04-08 00:00:00
abstract：:In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06439
更新日期：2014-09-22 00:00:00
abstract：:Advances in Big Data make it possible to make short-term forecasts for market trends from previously unexplored sources. Trading strategies were recently developed by exploiting a link between the online search activity of certain terms semantically related to finance and market movements. Here we build on these earli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50131-1
更新日期：2019-09-18 00:00:00
abstract：:Accurate and precise structural ensembles of proteins and macromolecular complexes can be obtained with metainference, a recently proposed Bayesian inference method that integrates experimental information with prior knowledge and deals with all sources of errors in the data as well as with sample heterogeneity. The s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31232
更新日期：2016-08-26 00:00:00
abstract：:Protein glycosylation has been described as the most abundant and complex post-translational modification occurring in nature. Recent studies have enhanced our view of how this modification occurs in bacteria highlighting the role of protein glycosylation in various processes such as biofilm formation, virulence and h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23170-3
更新日期：2018-03-16 00:00:00
abstract：:The advantages of the digital PCR technology are already well documented until now. One way to achieve better cost efficiency of the technique is to use it in a multiplexing strategy. Droplet digital PCR platforms, which include two fluorescence filters, support at least duplex reactions and with some developments and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35451
更新日期：2016-10-14 00:00:00
abstract：:The recent breakthrough in the discovery of Weyl fermions in monopnictide semimetals provides opportunities to explore the exotic properties of relativistic fermions in condensed matter. The chiral anomaly-induced negative magnetoresistance and π Berry phase are two fundamental transport properties associated with the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18674
更新日期：2016-01-04 00:00:00
abstract：:Staphylococcus aureus infection is a rising public health care threat. S. aureus is believed to have elaborate regulatory networks that orchestrate its virulence. Despite its importance, the systematic understanding of the transcriptional landscape of S. aureus is limited. Here, we describe the primary transcriptome l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20661-1
更新日期：2018-02-02 00:00:00
abstract：:The physiological effects of caesium (Cs) on living cells are poorly understood. Here, we examined the physiological role of Cs+ on the activity of the potassium transporters in E. coli. In the absence of potassium (K+), Kup-mediated Cs+ uptake partially supported cell growth, however, at a much lower rate than with s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02164-7
更新日期：2017-05-18 00:00:00
abstract：:Determining the success of eradication of an invasive species requires a way to decide when its risk of reoccurrence has become acceptably low. In Japan, the area populated by the Argentine ant, Linepithema humile (Mayr), is expanding, and eradication via chemical treatment is ongoing at various locations. One such pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03516-z
更新日期：2017-06-13 00:00:00
abstract：:A new method combining aqueous solution printing with UV Laser crystallization (UVLC) and post annealing is developed to deposit highly transparent and conductive Aluminum doped Zinc Oxide (AZO) films. This technique is able to rapidly produce large area AZO films with better structural and optoelectronic properties t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15517
更新日期：2015-10-30 00:00:00
abstract：:Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69681-w
更新日期：2020-07-29 00:00:00
abstract：:In this paper we present a detailed theoretical investigation of the electric field induced mixing effect, in which the up and down frequency-conversion processes are obtained by inducing an effective second order susceptibility via the periodic spatial distribution of reversed biased p-i-n junctions. The possibility ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03485-3
更新日期：2017-06-13 00:00:00
abstract：:The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human ability to control stability significantly increasing the risk of fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46721
更新日期：2017-05-11 00:00:00
abstract：:The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple tissues where its function is critical in establishing and maintaining epithelial integrity. Here, we analysed awd gene function in Drosophila epithelial cells using transgene-mediated RNA i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17217-0
更新日期：2017-12-04 00:00:00
abstract：:The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in discovery of novel antibacterial agents has created a global public health crisis. Repurposing existing drugs presents an alternative strategy to potentially expedite the discovery of new antimicrobial drugs. The present stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16407
更新日期：2015-11-10 00:00:00
abstract：:Horizontal gene transfer (HGT) was attributed as a major driving force for the innovation and evolution of prokaryotic genomes. Previously, multiple research endeavors were undertaken to decipher HGT in different bacterial lineages. The genus Mycobacterium houses some of the most deadly human pathogens; however, the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33261-w
更新日期：2018-10-04 00:00:00
