Abstract：
:This paper presents the design, simulation and low-cost fabrication of microfluidic channel for biomedical application. Channel is fabricated using soft lithography technique. Printed Circuit Board (PCB) is used to make the master for the channel. Channel pattern is transferred on PCB plate using toner transfer technique followed by ferric chloride etching. Paper also discusses, the issues involved in PCB based master fabrication and their viable solutions. Glass is used as substrate material and the channel is made of Sylgard 184 Polydimethylsiloxane (PDMS). Channel is interfaced with a syringe pump to observe the fluid flow. To predict the behavior of the channel, FEM simulation is performed using COMSOL Multiphysics 5.2a. There is a good match between the theoretical, simulation and test results. Finally, to test the biocompatibility of the channel, genomic DNA is passed through the channel and gel electrophoresis analysis is performed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tiwari SK,Bhat S,Mahato KKdoi
10.1038/s41598-020-65995-xsubject
Has Abstractpub_date
2020-06-08 00:00:00pages
9215issue
1issn
2045-2322pii
10.1038/s41598-020-65995-xjournal_volume
10pub_type
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