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A Single Dose of Modified Vaccinia Ankara expressing Ebola Virus Like Particles Protects Nonhuman Primates from Lethal Ebola Virus Challenge.

Abstract：

:Ebola virus (EBOV), isolate Makona, was the causative agent of the West African epidemic devastating predominantly Guinea, Liberia and Sierra Leone from 2013-2016. While several experimental vaccine and treatment approaches have been accelerated through human clinical trials, there is still no approved countermeasure available against this disease. Here, we report the construction and preclinical efficacy testing of a novel recombinant modified vaccinia Ankara (MVA)-based vaccine expressing the EBOV-Makona glycoprotein GP and matrix protein VP40 (MVA-EBOV). GP and VP40 form EBOV-like particles and elicit protective immune responses. In this study, we report 100% protection against lethal EBOV infection in guinea pigs after prime/boost vaccination with MVA-EBOV. Furthermore, this MVA-EBOV protected macaques from lethal disease after a single dose or prime/boost vaccination. The vaccine elicited a variety of antibody responses to both antigens, including neutralizing antibodies and antibodies with antibody-dependent cellular cytotoxic activity specific for GP. This is the first report that a replication-deficient MVA vector can confer full protection against lethal EBOV challenge after a single dose vaccination in macaques.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Domi A,Feldmann F,Basu R,McCurley N,Shifflett K,Emanuel J,Hellerstein MS,Guirakhoo F,Orlandi C,Flinko R,Lewis GK,Hanley PW,Feldmann H,Robinson HL,Marzi A

doi

10.1038/s41598-017-19041-y

subject

Has Abstract

pub_date

2018-01-16 00:00:00

pages

864

issue

1

issn

2045-2322

pii

10.1038/s41598-017-19041-y

journal_volume

8

pub_type

杂志文章

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