An unexpected genetic diversity pattern and a complex demographic history of a rare medicinal herb, Chinese asparagus (Asparagus cochinchinensis) in Korea.

abstract：:The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and cerebrovascular impairments in vitro. Recent technological advancements in BBB modeling using induced pluripotent stem cells (iPSCs) allowed to overcome some of ...

journal_title：Scientific reports

authors： Roux GL,Jarray R,Guyot AC,Pavoni S,Costa N,Théodoro F,Nassor F,Pruvost A,Tournier N,Kiyan Y,Langer O,Yates F,Deslys JP,Mabondzo A

更新日期：2019-11-05 00:00:00

abstract：:Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructura...

journal_title：Scientific reports

authors： Labounek R,Valošek J,Horák T,Svátková A,Bednařík P,Vojtíšek L,Horáková M,Nestrašil I,Lenglet C,Cohen-Adad J,Bednařík J,Hluštík P

更新日期：2020-10-16 00:00:00

abstract：:Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...

journal_title：Scientific reports

authors： Kano F,Noguchi Y,Murata M

更新日期：2017-11-09 00:00:00

abstract：:Much of atmospheric water originates from transpiration, the process by which plants release H2O from pores, known as stomata, that simultaneously intake CO2 for photosynthesis. Controlling stomatal aperture can regulate the extent of water transport in response to dynamic environmental factors including osmotic stres...

journal_title：Scientific reports

authors： Seo M,Park DH,Lee CW,Jaworski J,Kim JM

更新日期：2016-08-31 00:00:00

abstract：:GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...

journal_title：Scientific reports

authors： Kumar N,Dubey AK,Upadhyay AK,Gautam A,Ranjan R,Srikishna S,Sahu N,Behera SK,Mallick S

更新日期：2017-08-18 00:00:00

abstract：:An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plas...

journal_title：Scientific reports

authors： V Zohoori F,Innerd A,Azevedo LB,Whitford GM,Maguire A

更新日期：2015-11-19 00:00:00

abstract：:Dispersion engineering of metamaterials is critical yet not fully released in applications where broadband and multispectral responses are desirable. Here we propose a strategy to circumvent the bandwidth limitation of metamaterials by implementing two-dimensional dispersion engineering in the meta-atoms. Lorentzian r...

journal_title：Scientific reports

authors： Guo Y,Wang Y,Pu M,Zhao Z,Wu X,Ma X,Wang C,Yan L,Luo X

更新日期：2015-02-13 00:00:00

abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...

journal_title：Scientific reports

authors： Carrasco-Garcia E,Lopez L,Aldaz P,Arevalo S,Aldaregia J,Egaña L,Bujanda L,Cheung M,Sampron N,Garcia I,Matheu A

更新日期：2016-08-30 00:00:00

abstract：:The serum macrophage inhibitory cytokine-1 (MIC-1) levels are elevated in some inflammatory conditions and cancers. We thus compared the levels of biliary and serum MIC-1 and conventional tumour markers between 23 biliary tract cancer (BTC) patients (malignant group) and 29 benign biliary disease patients (benign grou...

journal_title：Scientific reports

authors： Sugimoto M,Takagi T,Konno N,Suzuki R,Asama H,Watanabe K,Nakamura J,Waragai Y,Kikuchi H,Takasumi M,Sato Y,Hikichi T,Ohira H

更新日期：2017-08-23 00:00:00

abstract：:Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-re...

journal_title：Scientific reports

authors： Lochab V,Jones TH,Dusane DH,Peters CW,Stoodley P,Wozniak DJ,Subramaniam VV,Prakash S

更新日期：2020-06-18 00:00:00

abstract：:Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii. The lytic cycle, driven by the tachyzoite life stage, is respon...

journal_title：Scientific reports

authors： Ovciarikova J,Lemgruber L,Stilger KL,Sullivan WJ,Sheiner L

更新日期：2017-02-16 00:00:00

abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...

journal_title：Scientific reports

authors： Long L,Xu L,Xiao Z,Hu S,Luo R,Wang H,Lu X,Xu Z,Yao X,Zhou L,Long H,Gong J,Song Y,Zhao L,Luo K,Zhang M,Feng L,Yang L,Sheng X,Fan X,Xiao B

更新日期：2016-03-22 00:00:00

abstract：:Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...

journal_title：Scientific reports

authors： Inserra A,Choo JM,Lewis MD,Rogers GB,Wong ML,Licinio J

更新日期：2019-04-23 00:00:00

abstract：:To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We iden...

journal_title：Scientific reports

authors： Polimanti R,Jensen KP,Gelernter J

更新日期：2017-04-21 00:00:00

abstract：:Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...

journal_title：Scientific reports

authors： Dinh TA,Vitucci EC,Wauthier E,Graham RP,Pitman WA,Oikawa T,Chen M,Silva GO,Greene KG,Torbenson MS,Reid LM,Sethupathy P

更新日期：2017-03-17 00:00:00

abstract：:Time-series metabolomics studies can provide insight into the dynamics of disease development and facilitate the discovery of prospective biomarkers. To improve the performance of early risk identification, a new strategy for analyzing time-series data based on dynamic networks (ATSD-DN) in a systematic time dimension...

journal_title：Scientific reports

authors： Huang X,Zeng J,Zhou L,Hu C,Yin P,Lin X

更新日期：2016-08-31 00:00:00

abstract：:The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...

journal_title：Scientific reports

authors： Darthy RR,Venkateswaran C,Subramanian V,Ouyang Z,Yogesh N

更新日期：2020-07-06 00:00:00

abstract：:Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day 1 to week 111) using high-sensitivity and high-resolution mass spectrometry. Totally 380 metabolit...

journal_title：Scientific reports

authors： Zheng X,Chen T,Zhao A,Wang X,Xie G,Huang F,Liu J,Zhao Q,Wang S,Wang C,Zhou M,Panee J,He Z,Jia W

更新日期：2016-04-11 00:00:00

abstract：:Increased p66Shc expression has been associated with diabetic nephropathy (DN). However, whether p66Shc can serve as a potential biomarker for tubular oxidative injury in DN is unknown. We measured the expression of p66Shc in peripheral blood monocytes (PBMs) and renal biopsy tissues from DN patients and then analysed...

journal_title：Scientific reports

authors： Xu X,Zhu X,Ma M,Han Y,Hu C,Yuan S,Yang Y,Xiao L,Liu F,Kanwar YS,Sun L

更新日期：2016-07-05 00:00:00

abstract：:A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether the...

journal_title：Scientific reports

authors： Zhang H,Shi X,Wang L,Li X,Zheng C,Gao B,Xu X,Lin X,Wang J,Lin Y,Shi J,Huang Q,Luo Z,Yang L

更新日期：2018-03-01 00:00:00

abstract：:Ebola virus (EBOV), isolate Makona, was the causative agent of the West African epidemic devastating predominantly Guinea, Liberia and Sierra Leone from 2013-2016. While several experimental vaccine and treatment approaches have been accelerated through human clinical trials, there is still no approved countermeasure ...

journal_title：Scientific reports

authors： Domi A,Feldmann F,Basu R,McCurley N,Shifflett K,Emanuel J,Hellerstein MS,Guirakhoo F,Orlandi C,Flinko R,Lewis GK,Hanley PW,Feldmann H,Robinson HL,Marzi A

更新日期：2018-01-16 00:00:00

abstract：:Our aim was to evaluate intervention components of an alcohol reduction app: Drink Less. Excessive drinkers (AUDIT>=8) were recruited to test enhanced versus minimal (reduced functionality) versions of five app modules in a 25 factorial trial. Modules were: Self-monitoring and Feedback, Action Planning, Identity Chang...

journal_title：Scientific reports

authors： Crane D,Garnett C,Michie S,West R,Brown J

更新日期：2018-03-12 00:00:00

abstract：:The sedimentary record, and associated micropalaeontological proxies, is one tool that has been employed to quantify a region's tropical cyclone history. Doing so has largely relied on the identification of allochthonous deposits (sediments and microfossils), sourced from deeper water and entrained by tropical cyclone...

journal_title：Scientific reports

authors： Strotz LC,Mamo BL,Dominey-Howes D

更新日期：2016-04-29 00:00:00

abstract：:Spin fluctuations are widely believed to play an important role in the superconducting mechanisms of unconventional high temperature superconductors. Spin fluctuations have been observed in iron-based superconductors as well. However, in some iron-based superconductors such as LaFePO0.9, they have not been observed by...

journal_title：Scientific reports

authors： Ishikado M,Shamoto SI,Kodama K,Kajimoto R,Nakamura M,Hong T,Mutka H

更新日期：2018-11-05 00:00:00

abstract：:Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. ...

journal_title：Scientific reports

authors： Reyer H,Varley PF,Murani E,Ponsuksili S,Wimmers K

更新日期：2017-08-22 00:00:00

abstract：:Previous studies suggest vergence and saccade abnormalities in dyslexic adolescents. However, these studies are mainly clinically based and do not provide objective measurements of eye movements, but rather subjectively evaluate vergence using haplosopic conditions in which the two eyes are dissociated (via polarizers...

journal_title：Scientific reports

authors： Ward LM,Kapoula Z

更新日期：2020-12-17 00:00:00

abstract：:Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...

journal_title：Scientific reports

authors： Farhat M,Kais S,Alharbi FH

更新日期：2017-10-27 00:00:00

abstract：:Experimental models that recapitulate mutational landscapes of human cancers are needed to decipher the rapidly expanding data on human somatic mutations. We demonstrate that mutation patterns in immortalised cell lines derived from primary murine embryonic fibroblasts (MEFs) exposed in vitro to carcinogens recapitula...

journal_title：Scientific reports

authors： Olivier M,Weninger A,Ardin M,Huskova H,Castells X,Vallée MP,McKay J,Nedelko T,Muehlbauer KR,Marusawa H,Alexander J,Hazelwood L,Byrnes G,Hollstein M,Zavadil J

更新日期：2014-03-27 00:00:00

abstract：:Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females ...

journal_title：Scientific reports

authors： Cai K,Yie S,Zhang Z,Wang J,Cai Z,Luo L,Liu Y,Wang H,Huang H,Wang C,Huang X,Lan J,Hou R

更新日期：2017-01-16 00:00:00

abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...

journal_title：Scientific reports

authors： Rashmi D,Barvkar VT,Nadaf A,Mundhe S,Kadoo NY

更新日期：2019-01-30 00:00:00