Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.

abstract：:The accurate staging of liver fibrosis is of paramount importance to determine the state of disease progression, therapy responses, and to optimize disease treatment strategies. Non-linear optical microscopy techniques such as two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) can image the...

journal_title：Scientific reports

authors： Stanciu SG,Xu S,Peng Q,Yan J,Stanciu GA,Welsch RE,So PT,Csucs G,Yu H

更新日期：2014-04-10 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic pathogen which causes zoonotic disease in humans. Recently, there have been an increasing number of infected cases and there are no clinically approved vaccines or effective drugs to treat WNV infections in humans. The purpose of this study was to facilitate vaccine and antiviral...

journal_title：Scientific reports

authors： Li W,Ma L,Guo LP,Wang XL,Zhang JW,Bu ZG,Hua RH

更新日期：2017-06-12 00:00:00

abstract：:Seed setting is an important trait that contributes to seed yield and relies greatly on starch accumulation. In this study, a sulfoquinovosyl transferase-like protein, designated as SQD2.2 involved in seed setting and flavonoid accumulation, was identified and characterized in rice. Rice SQD2.2 is localized to the cyt...

journal_title：Scientific reports

authors： Zhan X,Shen Q,Wang X,Hong Y

更新日期：2017-07-05 00:00:00

abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

journal_title：Scientific reports

authors： Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

更新日期：2018-02-12 00:00:00

abstract：:Our previous studies indicated that combination of Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and PPARγ ligand Troglitazone (TZD), can induce significant apoptosis in various TRAIL-resistant prostate and hepatocellular carcinoma (HCC) cells. These also suggested serine/threonine kinase AMP-activat...

journal_title：Scientific reports

authors： Ke R,Vishnoi K,Viswakarma N,Santha S,Das S,Rana A,Rana B

更新日期：2018-04-03 00:00:00

abstract：:Recent studies have reported the ectopic expression of olfactory receptors (ORs) in non-olfactory tissues, however, their physiological roles were not well elucidated. ORs are expressed in and function in different types of cancers. Here, we identified that the H3K9me2 levels of several OR promoters decreased during d...

journal_title：Scientific reports

authors： Jung H,Chae YC,Kim JY,Jeong OS,Kook H,Seo SB

更新日期：2017-04-07 00:00:00

abstract：:Resistance to adjuvant systemic treatment, including taxanes (docetaxel and paclitaxel) is a major clinical problem for breast cancer patients. lncRNAs (long non-coding RNAs) are non-coding transcripts, which have recently emerged as important players in a variety of biological processes, including cancer development ...

journal_title：Scientific reports

authors： Huang P,Li F,Li L,You Y,Luo S,Dong Z,Gao Q,Wu S,Brünner N,Stenvang J

更新日期：2018-12-19 00:00:00

abstract：:Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...

journal_title：Scientific reports

authors： Wlodarska M,Willing BP,Bravo DM,Finlay BB

更新日期：2015-03-19 00:00:00

abstract：:Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brain...

journal_title：Scientific reports

authors： Morfin N,Goodwin PH,Hunt GJ,Guzman-Novoa E

更新日期：2019-03-26 00:00:00

abstract：:A novel design of thin-film crystalline silicon solar cell (TF C-Si-SC) is proposed and numerically analyzed. The reported SC has 1.0 µm thickness of C-Si with embedded dielectric silicon dioxide nanowires (NWs). The introduced NWs increase the light scattering in the active layer which improves the optical path lengt...

journal_title：Scientific reports

authors： Elrabiaey MA,Hussein M,Hameed MFO,Obayya SSA

更新日期：2020-10-16 00:00:00

abstract：:Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...

journal_title：Scientific reports

authors： Wang K,Liu Y,Wu C,Li D,Lv S,Zhang Y,Zhou X,Guo T

更新日期：2020-05-15 00:00:00

abstract：:Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...

journal_title：Scientific reports

authors： Tamm S,Nilsonne G,Schwarz J,Lamm C,Kecklund G,Petrovic P,Fischer H,Åkerstedt T,Lekander M

更新日期：2017-09-25 00:00:00

abstract：:Near-infrared up-conversion lasing in erbium(Er)-yttrium(Y) chloride silicate nanowires was demonstrated when pumped by 1476 nm laser at room temperature. The emission covers a very wide wavelength range (400-1000 nm). A clear threshold for 985 nm peak was observed at a launched average pump power of approximately 7 m...

journal_title：Scientific reports

authors： Ye R,Xu C,Wang X,Cui J,Zhou Z

更新日期：2016-10-05 00:00:00

abstract：:We propose and demonstrate a type of a broadband half-wave plate that operates in the reflective mode. It consists of a metal grating embedded in a dielectric slab and placed on top of a grounded metal surface. We theoretically show that owing to the optical feedback effect which originates from the wave reflections a...

journal_title：Scientific reports

authors： Zhou G,Zhu B,Zhao J,Zhu G,Jin B,Feng Y,Kang L,Xu W,Chen J,Wu P

更新日期：2017-08-22 00:00:00

abstract：:Ultra-high resolution optical coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement the thicknesses. The purpose of this study was to validate the diagnostic power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT in the diagnosis...

journal_title：Scientific reports

authors： Xu Z,Jiang J,Yang C,Huang S,Peng M,Li W,Cui L,Wang J,Lu F,Shen M

更新日期：2016-08-11 00:00:00

abstract：:Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Ac...

journal_title：Scientific reports

authors： Garscha U,Romp E,Pace S,Rossi A,Temml V,Schuster D,König S,Gerstmeier J,Liening S,Werner M,Atze H,Wittmann S,Weinigel C,Rummler S,Scriba GK,Sautebin L,Werz O

更新日期：2017-08-24 00:00:00

abstract：:The quantities and proportions of protein fractions have notable effects on the nutritional and technological value of milk. Although much is known about the effects of genetic variants on milk proteins, the complex relationships among the set of genes and pathways regulating the different protein fractions synthesis ...

journal_title：Scientific reports

authors： Pegolo S,Mach N,Ramayo-Caldas Y,Schiavon S,Bittante G,Cecchinato A

更新日期：2018-01-12 00:00:00

abstract：:The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disor...

journal_title：Scientific reports

authors： Basu S,Saha PK,Roszkowska M,Magnowska M,Baczynska E,Das N,Plewczynski D,Wlodarczyk J

更新日期：2018-02-23 00:00:00

abstract：:Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly enco...

journal_title：Scientific reports

authors： Yu W,Yao D,Yu S,Wang X,Li X,Wang M,Liu S,Feng Z,Chen X,Li W,Wang L,Liu W,Ma J,Yu L,Tong C,Song B,Cui Y

更新日期：2018-02-26 00:00:00

abstract：:The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...

journal_title：Scientific reports

authors： Kao LT,Hung SH,Lin HC,Liu CK,Huang HM,Wu CS

更新日期：2016-02-10 00:00:00

abstract：:Solution-based methods represent the most widespread approach used to deposit hybrid organic-inorganic perovskite films for low-cost but efficient solar cells. However, solution-process techniques offer limited control over film morphology and crystallinity, and most importantly do not allow sequential film deposition...

journal_title：Scientific reports

authors： Bonomi S,Marongiu D,Sestu N,Saba M,Patrini M,Bongiovanni G,Malavasi L

更新日期：2018-10-18 00:00:00

abstract：:El Niño-Southern Oscillation (ENSO), which is one of the main drivers of Earth's inter-annual climate variability, often causes a wide range of climate anomalies, and the advance prediction of ENSO is always an important and challenging scientific issue. Since a unified and complete ENSO theory has yet to be establish...

journal_title：Scientific reports

authors： Yan J,Mu L,Wang L,Ranjan R,Zomaya AY

更新日期：2020-05-15 00:00:00

abstract：:MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis wa...

journal_title：Scientific reports

authors： Areeshi MY,Mandal RK,Akhter N,Dar SA,Jawed A,Wahid M,Mahto H,Panda AK,Lohani M,Haque S

更新日期：2016-11-23 00:00:00

abstract：:Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...

journal_title：Scientific reports

authors： Woo JM,Jeon EY,Seo EJ,Seo JH,Lee DY,Yeon YJ,Park JB

更新日期：2018-07-06 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability in diabetic retinopathy (DR). However, the distinct signaling driven by VEGF and PlGF in the pathogenesis of DR remains unclear. In this study, we investi...

journal_title：Scientific reports

authors： Jiao W,Ji JF,Xu W,Bu W,Zheng Y,Ma A,Zhao B,Fan Q

更新日期：2019-10-25 00:00:00

abstract：:This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients w...

journal_title：Scientific reports

authors： Kamiya K,Kobashi H,Igarashi A,Shoji N,Shimizu K

更新日期：2016-04-18 00:00:00

abstract：:Spin-coated self-assemblies of colloidal particles have been developed recently as an attractive close-packed monolayer of the particles for a variety of applications, but they are limited by the small area of their monolayers, especially given their low uniformity and monolayer coverage on large-area substrates. We r...

journal_title：Scientific reports

authors： Park B,Na SY,Bae IG

更新日期：2019-08-07 00:00:00

abstract：:With the reduction of oil and gas reserves and the increase of mining difficulty in Northern China, the carbonate rocks in Southern North China Basin are becoming a significant exploration target for carbonate reservoirs. However, the development characteristics, formation stages, formation environments and mechanisms...

journal_title：Scientific reports

authors： Zhang H,Xu G,Liu M,Wang M

更新日期：2021-01-12 00:00:00

abstract：:To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclea...

journal_title：Scientific reports

authors： Bikbov MM,Kazakbaeva GM,Gilmanshin TR,Zainullin RM,Nuriev IF,Zaynetdinov AF,Israfilova GZ,Panda-Jonas S,Arslangareeva II,Rakhimova EM,Rusakova IA,Jonas JB

更新日期：2020-10-23 00:00:00

abstract：:Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses CCR5 protein as a co-receptor. Recently, the crystal structure of CCR5-bound complex with an approved anti-retroviral drug (maroviroc) was r...

journal_title：Scientific reports

authors： Salmas RE,Yurtsever M,Durdagi S

更新日期：2015-08-24 00:00:00