Abstract:
:The quantities and proportions of protein fractions have notable effects on the nutritional and technological value of milk. Although much is known about the effects of genetic variants on milk proteins, the complex relationships among the set of genes and pathways regulating the different protein fractions synthesis and secretion into milk in dairy cows are still not completely understood. We conducted genome-wide association studies (GWAS) for milk nitrogen fractions in a cohort of 1,011 Brown Swiss cows, which uncovered 170 significant single nucleotide polymorphism (SNPs), mostly located on BTA6 and BTA11. Gene-set analysis and the network-based Associated Weight Matrix approach revealed that the milk proteins associated genes were involved in several biological functions, particularly ion and cation transmembrane transporter activity and neuronal and hormone signalling, according to the structure and function of casein micelles. Deeper analysis of the transcription factors and their predicted target genes within the network revealed that GFI1B, ZNF407 and NR5A1 might act as master regulators of milk protein synthesis and secretion. The information acquired provides novel insight into the regulatory mechanisms controlling milk protein synthesis and secretion in bovine mammary gland and may be useful in breeding programmes aimed at improving milk nutritional and/or technological properties.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pegolo S,Mach N,Ramayo-Caldas Y,Schiavon S,Bittante G,Cecchinato Adoi
10.1038/s41598-017-18916-4subject
Has Abstractpub_date
2018-01-12 00:00:00pages
566issue
1issn
2045-2322pii
10.1038/s41598-017-18916-4journal_volume
8pub_type
杂志文章abstract::The objective of this study was to determine the prevalence of sexual dysfunction in Saudi and non-Saudi female health care providers in Jeddah, Saudi Arabia. One -hundred twenty (60 Saudi and 60 non-Saudi) sexually active female health care professionals in Jeddah, Saudi Arabia, were anonymously surveyed using the En...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07905
更新日期:2015-01-20 00:00:00
abstract::Enoyl-acyl carrier protein reductase (ENR) catalyzes the last reduction step in the bacterial type II fatty acid biosynthesis cycle. ENRs include FabI, FabL, FabL2, FabK, and FabV. Previously, we reported a unique triclosan (TCL) resistant ENR homolog that was predominant in obligate intracellular pathogenic bacteria ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51895-2
更新日期:2019-10-28 00:00:00
abstract::The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04526
更新日期:2014-03-31 00:00:00
abstract::This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27607-7
更新日期:2018-07-03 00:00:00
abstract::Tendinopathy accounts for over 30% of primary care consultations and represents a growing healthcare challenge in an active and increasingly ageing population. Recognising critical cells involved in tendinopathy is essential in developing therapeutics to meet this challenge. Tendon cells are heterogenous and sparsely ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70786-5
更新日期:2020-09-03 00:00:00
abstract::Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction. This can be especially deleterious for capital breeding carnivores such as marine mammals, with potential for ecosystem-wide effects. However, the impacts and indicators of chronic stress in animals are c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39089-2
更新日期:2019-02-25 00:00:00
abstract::Poorer liver function is positively associated with diabetes in Mendelian randomization (MR) studies. Observationally, adiposity is associated with poorer liver function. To clarify the etiology, we assessed the association of liver enzymes with adiposity observationally and using two-sample MR for validation. In the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52489-8
更新日期:2019-11-14 00:00:00
abstract::Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36015
更新日期:2016-10-31 00:00:00
abstract::Coral reefs across the world's oceans are in the midst of the longest bleaching event on record (from 2014 to at least 2016). As many of the world's reefs are remote, there is limited information on how past thermal conditions have influenced reef composition and current stress responses. Using satellite temperature d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38402
更新日期:2016-12-06 00:00:00
abstract::Virtual-hand-illusion studies often use explicit and implicit measures of body ownership but no agreed-on implicit measure of agency exists. We investigated whether the Intentional Binding (IB) effect could serve as such a measure. A pilot study confirmed that current consistency increases both perceived agency and IB...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40545-2
更新日期:2019-03-07 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction &muscle atrophy. The carboxyl-terminal prion-like domain of TDP-43 can aggregate in vitro into toxic β-sheet rich amylo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39490
更新日期:2016-12-21 00:00:00
abstract::Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69681-w
更新日期:2020-07-29 00:00:00
abstract::Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector T-cells (Teff). To...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39751
更新日期:2017-01-03 00:00:00
abstract::Fibroblast growth factor-21 (FGF21) is closely related to various metabolic and cardiovascular disorders. However, the direct targets and mechanisms linking FGF21 to blood pressure control and hypertension are still elusive. Here we demonstrated a novel regulatory function of FGF21 in the baroreflex afferent pathway (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29582
更新日期:2016-07-08 00:00:00
abstract::Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09285-z
更新日期:2017-08-17 00:00:00
abstract::Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identifi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71081-z
更新日期:2020-08-26 00:00:00
abstract::Theoretical model required for the evolution of regular dislocation pattern should simultaneously take into account both static distribution and dynamic evolution of dislocation pattern. In principle, there exists a stable uniformly moving dislocation with both core and far field advancing at the same constant velocit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04257-9
更新日期:2017-06-22 00:00:00
abstract::Ocean warming increasingly endangers the fitness of marine invertebrates. Transgenerational effects (TE) potentially mitigate the impacts of environmental stress on the embryos of marine invertebrates. The molecular mechanisms, however, remain largely unknown. Using high-throughput RNA sequencing technology, we invest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64872-x
更新日期:2020-05-13 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-43786-3
更新日期:2019-10-28 00:00:00
abstract::Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α sus...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59596-x
更新日期:2020-02-17 00:00:00
abstract::We analyze a wide gravity low in the Campania Active Volcanic Area and interpret it by a large and deep source distribution of partially molten, low-density material from about 8 to 30 km depth. Given the complex spatial-temporal distribution of explosive volcanism in the area, we model the gravity data consistently w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26346-z
更新日期:2018-05-29 00:00:00
abstract::Impurities in superconductors and their induced bound states are important both for engineering novel states such as Majorana zero-energy modes and for probing bulk properties of the superconducting state. The high-temperature cuprates offer a clear advantage in a much larger superconducting order parameter, but the n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44107
更新日期:2017-03-10 00:00:00
abstract::Phages infecting Aeromonas salmonicida subsp. salmonicida, the causative agent of the fish disease furunculosis, have been isolated for decades but very few of them have been characterized. Here, the host range of 12 virulent phages, including three isolated in the present study, was evaluated against a panel of 65 A....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07401-7
更新日期:2017-08-01 00:00:00
abstract::Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18765-1
更新日期:2018-01-12 00:00:00
abstract::The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among struct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34129
更新日期:2016-09-23 00:00:00
abstract::This paper explores the empirical links between achieving the Sustainable Development Goals (SDGs) and subjective well-being. Globally, we find that in terms of well-being, there are increasing marginal returns to sustainable development. Unpacking the SDGs by looking at how each SDG relates to well-being shows, in mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71916-9
更新日期:2020-09-15 00:00:00
abstract::China's reported cases of Human Immunodeficiency Virus (HIV) and AIDS increased from over 50000 in 2011 to more than 130000 in 2017, while AIDS related search indices on Baidu from 2.1 million to 3.7 million in the same time periods. In China, people seek AIDS related knowledge from Baidu which one of the world's larg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35685-w
更新日期:2019-01-23 00:00:00
abstract::Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our res...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37612
更新日期:2016-11-22 00:00:00
abstract::High-k dielectric oxides are supposedly ideal gate-materials for ultra-high doping in graphene and other 2D-crystals. Here, we report a temperature-dependent electronic transport study on chemical vapor deposited-graphene gated with SrTiO₃ (STO) thin film substrate. At carrier densities away from charge neutrality poi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06173
更新日期:2014-08-22 00:00:00
abstract::NK cell adoptive therapy is a promising cancer therapeutic approach, but there are significant challenges that limiting its feasibility and clinical efficacy. One difficulty is the paucity of clinical grade manufacturing platforms to support the large scale expansion of highly active NK cells. We created an NK cell fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51287-6
更新日期:2019-10-17 00:00:00