当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.

Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.

Abstract：

:This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intracellular lipid accumulation as shown by lower triglyceride levels and both Oil Red O and Nile Red staining in palmitate (PA, 0.75 mM)-treated hepatocytes. Immunobloting, mRNA expression, and knock-down studies demonstrated the role of AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 signaling pathways in facilitating the beneficial role of HIET against lipid accumulation in PA-treated hepatocytes. Animal studies further showed a positive effect of HIET (20 µg/kg BW, 8 weeks, daily) in regulating AMPK/SREBP/PPARα signaling pathways and reducing body weight gain, plasma lipid levels, and hepatic steatosis in high fat diet (HFD)-fed mice. Histological analyses also revealed the beneficial effect of HIET in reducing hepatic fat accumulation in HFD mice. Chemical profiling (HRMS, IR, and HPLC) demonstrated the presence of menaquinone-7 (vitamin K2) as one of the bio-active principle(s) in HIET. Combining all, this study demonstrates the positive effect of HIET on reducing hepatic steatosis via regulating AMPK/SREBP/PPARα signaling pathway.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dihingia A,Bordoloi J,Dutta P,Kalita J,Manna P

doi

10.1038/s41598-018-27607-7

subject

Has Abstract

pub_date

2018-07-03 00:00:00

pages

10021

issue

1

issn

2045-2322

pii

10.1038/s41598-018-27607-7

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • (Neo)adjuvant chemotherapy and interdigitated split-course hyperfractionated radiation in high risk soft tissue sarcoma - Results from a large single-institution series.

    abstract：:A single-institution series using a (neo)adjuvant chemotherapy and interdigitated hyperfractionated split-course radiation therapy (CRT) treatment protocol for soft tissue sarcoma was reviewed. Our specific aims were to study recurrence rates and long-term toxicity. Between 1998 and 2016, 89 patients with non-metastat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43794-3

    authors： Nevala R,Tukiainen E,Tarkkanen M,Böhling T,Blomqvist C,Sampo M

    更新日期：2019-05-13 00:00:00

  • Effects of rice straw and rice straw ash on rice growth and α-diversity of bacterial community in rare-earth mining soils.

    abstract：:Pot experiments were carried out to study the effects of rice straw (RS) and rice straw ash (RSA) on the growth of early rice and α-diversity of bacterial community in soils around rare earth mining areas of Xunwu and Xinfeng counties in South Jiangxi of China. The results showed that the exploitation of rare earth re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67160-w

    authors： Jin S,Jin W,Dong C,Bai Y,Jin D,Hu Z,Huang Y

    更新日期：2020-06-25 00:00:00

  • Biases in ecological research: attitudes of scientists and ways of control.

    abstract：:The properties of the human mind affect the quality of scientific knowledge through the insertion of unconscious biases during the research process. These biases frequently cause overestimation of the effects under study, thereby violating the reproducibility of the research and potentially leading to incorrect conclu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80677-4

    authors： Zvereva EL,Kozlov MV

    更新日期：2021-01-08 00:00:00

  • Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation.

    abstract：:The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial dysfunction. Furthermore, it can be activated in the cytosol by mitochondrial oxidative str...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41108-1

    authors： Blignaut M,Loos B,Botchway SW,Parker AW,Huisamen B

    更新日期：2019-03-18 00:00:00

  • Novel risk models to predict acute kidney disease and its outcomes in a Chinese hospitalized population with acute kidney injury.

    abstract：:Acute kidney disease (AKD) is a state between acute kidney injury (AKI) and chronic kidney disease (CKD), but the prognosis of AKD is unclear and there are no risk-prediction tools to identify high-risk patients. 2,556 AKI patients were selected from 277,898 inpatients of three affiliated hospitals of Central South Un...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72651-x

    authors： Xiao YQ,Cheng W,Wu X,Yan P,Feng LX,Zhang NY,Li XW,Duan XJ,Wang HS,Peng JC,Liu Q,Zhao F,Deng YH,Yang SK,Feng S,Duan SB

    更新日期：2020-09-24 00:00:00

  • Fast non-Abelian geometric gates via transitionless quantum driving.

    abstract：:A practical quantum computer must be capable of performing high fidelity quantum gates on a set of quantum bits (qubits). In the presence of noise, the realization of such gates poses daunting challenges. Geometric phases, which possess intrinsic noise-tolerant features, hold the promise for performing robust quantum ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18414

    authors： Zhang J,Kyaw TH,Tong DM,Sjöqvist E,Kwek LC

    更新日期：2015-12-21 00:00:00

  • Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females.

    abstract：:Sexual dimorphisms are recognized in cardiovascular conditions such as hypertension, stroke, thrombosis and vasculitis. B-type natriuretic peptide (BNP) is a guanylyl cyclase A (GC-A) agonist. The anti-hypertensive, vasodilatory, anti-fibrotic, and anti-hypertrophic properties of BNP are well established in male anima...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25623

    authors： Holditch SJ,Schreiber CA,Burnett JC,Ikeda Y

    更新日期：2016-05-10 00:00:00

  • Environmental Intervention as a Therapy for Adverse Programming by Ancestral Stress.

    abstract：:Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37814

    authors： McCreary JK,Erickson ZT,Hao Y,Ilnytskyy Y,Kovalchuk I,Metz GA

    更新日期：2016-11-24 00:00:00

  • Population genetics and forensic utility of 23 autosomal PowerPlex Fusion 6C STR loci in the Kuwaiti population.

    abstract：:This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from the Kuwaiti population, of which four markers (D10S1248, D22S1045, D2S441 and SE33) are reported for the first time for Kuwait. All the markers were shown to exhibit no deviation from Hardy-Weinberg equilibrium, n...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81425-y

    authors： Haidar M,Abbas FA,Alsaleh H,Haddrill PR

    更新日期：2021-01-21 00:00:00

  • Multi-Channel 3D Deep Feature Learning for Survival Time Prediction of Brain Tumor Patients Using Multi-Modal Neuroimages.

    abstract：:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37387-9

    authors： Nie D,Lu J,Zhang H,Adeli E,Wang J,Yu Z,Liu L,Wang Q,Wu J,Shen D

    更新日期：2019-01-31 00:00:00

  • Tuning of nanoparticle biological functionality through controlled surface chemistry and characterisation at the bioconjugated nanoparticle surface.

    abstract：:We have used a silica - PEG based bionanoconjugate synthetic scheme to study the subtle connection between cell receptor specific recognition and architecture of surface functionalization chemistry. Extensive physicochemical characterization of the grafted architecture is capable of capturing significant levels of det...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17040

    authors： Hristov DR,Rocks L,Kelly PM,Thomas SS,Pitek AS,Verderio P,Mahon E,Dawson KA

    更新日期：2015-12-01 00:00:00

  • Using already-solved cases of a mass disaster event for prioritizing the search among remaining victims: a Bayesian approach.

    abstract：:This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59841-3

    authors： Caridi I,Alvarez EE,Somigliana C,Puerto MS

    更新日期：2020-03-19 00:00:00

  • Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.

    abstract：:The potential for epigenetic changes in host cells following microbial infection has been widely suggested, but few examples have been reported. We assessed genome-wide patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathoge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30861

    authors： Cizmeci D,Dempster EL,Champion OL,Wagley S,Akman OE,Prior JL,Soyer OS,Mill J,Titball RW

    更新日期：2016-08-03 00:00:00

  • Substantial blue carbon in overlooked Australian kelp forests.

    abstract：:Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69258-7

    authors： Filbee-Dexter K,Wernberg T

    更新日期：2020-07-23 00:00:00

  • Impacts of monocular, binocular, and functional visual acuity on vision-related quality of life in patients with type 2 diabetes.

    abstract：:Although the association between visual acuity (VA) and vision-related quality of life (VRQoL) has been well reported in patients with type 2 diabetes mellitus (T2DM), little is known about how unilateral and bilateral VA affects daily performance in such patients. For this cross-sectional study, patients were recruit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79483-9

    authors： Liao KM,Wu WC,Jang Y,Su FY,Tsai LT

    更新日期：2021-01-11 00:00:00

  • Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

    abstract：:Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on trans...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10403-0

    authors： Zitti B,Molfetta R,Fionda C,Quatrini L,Stabile H,Lecce M,de Turris V,Ricciardi MR,Petrucci MT,Cippitelli M,Gismondi A,Santoni A,Paolini R

    更新日期：2017-09-05 00:00:00

  • NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium.

    abstract：:This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy control...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61331-5

    authors： Manuel Sánchez-Maldonado J,Martínez-Bueno M,Canhão H,Ter Horst R,Muñoz-Peña S,Moñiz-Díez A,Rodríguez-Ramos A,Escudero A,Sorensen SB,Hetland ML,Ferrer MA,Glintborg B,Filipescu I,Pérez-Pampin E,Conesa-Zamora P,García A,den

    更新日期：2020-03-09 00:00:00

  • Publisher Correction: Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62065-0

    authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

    更新日期：2020-04-22 00:00:00

  • Phylogenetic relationships of subfamilies in the family Hesperiidae (Lepidoptera: Hesperioidea) from China.

    abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11140

    authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

    更新日期：2015-06-10 00:00:00

  • A generalised framework for detailed classification of swimming paths inside the Morris Water Maze.

    abstract：:The Morris Water Maze is commonly used in behavioural neuroscience for the study of spatial learning with rodents. Over the years, various methods of analysing rodent data collected during this task have been proposed. These methods span from classical performance measurements to more sophisticated categorisation tech...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33456-1

    authors： Vouros A,Gehring TV,Szydlowska K,Janusz A,Tu Z,Croucher M,Lukasiuk K,Konopka W,Sandi C,Vasilaki E

    更新日期：2018-10-10 00:00:00

  • High precision computer-generated moiré profilometry.

    abstract：:Recently, a computer-generated moiré profilometry was proposed by our research group. It can effectively avoid the influence of the transient caused by moiré fringes' direct acquisition and generally owns a higher accuracy. But when the spatial spectrum of the captured deformed pattern is severely aliased caused by th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44186-3

    authors： Li C,Cao Y,Wang L,Wan Y,Fu G,Wang Y,Chen C

    更新日期：2019-05-24 00:00:00

  • Achieving sub-wavelength imaging through a flat hyperlens in a modified anodic aluminum oxide template.

    abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62243-0

    authors： Tao CW,Yen TJ,Huang TY

    更新日期：2020-03-24 00:00:00

  • Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis.

    abstract：:Lysophospholipids (LPLs) are known to have potentially important roles in the initiation and maintenance of neuropathic pain in animal models. This study investigated the association between the clinical severity of lumbar spinal stenosis (LSS) and the cerebrospinal fluid (CSF) levels of LPLs, using human samples. We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45742-7

    authors： Hayakawa K,Kurano M,Ohya J,Oichi T,Kano K,Nishikawa M,Uranbileg B,Kuwajima K,Sumitani M,Tanaka S,Aoki J,Yatomi Y,Chikuda H

    更新日期：2019-06-24 00:00:00

  • Effect of Bacillus subtilis on corrosion behavior of 10MnNiCrCu steel in marine environment.

    abstract：:Bacillus widely exists in wet natural environment such as soil, water and air, and is often studied as one of representative microorganisms for microbiologically influenced corrosion(MIC) research. In this paper, the growth curve of Bacillus subtilis isolated from marine environment was determined by turbidimetry and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62809-y

    authors： Wang YS,Liu L,Fu Q,Sun J,An ZY,Ding R,Li Y,Zhao XD

    更新日期：2020-04-01 00:00:00

  • Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes.

    abstract：:Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09307-w

    authors： Zhou JX,Taramelli R,Pedrini E,Knijnenburg T,Huang S

    更新日期：2017-08-18 00:00:00

  • Exciton Emission Intensity Modulation of Monolayer MoS2 via Au Plasmon Coupling.

    abstract：:Modulation of photoluminescence of atomically thin transition metal dichalcogenide two-dimensional materials is critical for their integration in optoelectronic and photonic device applications. By coupling with different plasmonic array geometries, we have shown that the photoluminescence intensity can be enhanced an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41175

    authors： Mukherjee B,Kaushik N,Tripathi RP,Joseph AM,Mohapatra PK,Dhar S,Singh BP,Kumar GV,Simsek E,Lodha S

    更新日期：2017-01-30 00:00:00

  • Author Correction: Surface plasmon enhanced Organic color image sensor with Ag nanoparticles coated with silicon oxynitride.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59906-3

    authors： Heo S,Lee J,Lee GH,Heo CJ,Kim SH,Yun DJ,Park JB,Kim K,Kim Y,Lee D,Park GS,Cho HY,Shin T,Yun SY,Kim S,Jin YW,Park KB

    更新日期：2020-02-13 00:00:00

  • Quantitative multiplexing with nano-self-assemblies in SERS.

    abstract：:Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06785

    authors： Kasera S,Herrmann LO,del Barrio J,Baumberg JJ,Scherman OA

    更新日期：2014-10-30 00:00:00

  • Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome.

    abstract：:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54461-y

    authors： Weinberg RP,Koledova VV,Subramaniam A,Schneider K,Artamonova A,Sambanthamurthi R,Hayes KC,Sinskey AJ,Rha C

    更新日期：2019-12-09 00:00:00

  • Evolution and Determinants of Lung Function until Late Infancy among Infants Born Preterm.

    abstract：:To investigate the evolution of lung function in preterm infants with and without bronchopulmonary dysplasia (BPD) and to determine the perinatal characteristics associated with indexes of lung function in later infancy. Longitudinal lung function assessments were performed at approximately 6, 12, 18, and 24 months of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57359-x

    authors： Lai SH,Chiang MC,Chu SM,Hsu JF,Yao TC,Tsai MH,Hua MC,Chiu CY,Yeh KW,Huang JL,Liao SL

    更新日期：2020-01-16 00:00:00