Updating of attentional and premotor allocation resources as function of previous trial outcome.

abstract：:We developed a new technique to observe macroautophagy in the brain in vivo, and examined whether fasting induced macroautophagy in neurons and how the induction was different between Alzheimer's disease (AD) model and control mice. Lentivirus for EGFP-LC3 injected into the brain successfully visualized autophagosome ...

journal_title：Scientific reports

authors： Chen X,Kondo K,Motoki K,Homma H,Okazawa H

更新日期：2015-07-14 00:00:00

abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

journal_title：Scientific reports

authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

更新日期：2016-08-25 00:00:00

abstract：:Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. In this context, compromises between sensitivity, degree of multiplexing, throughput, and invasiveness are often u...

journal_title：Scientific reports

authors： Pavillon N,Smith NI

更新日期：2019-11-19 00:00:00

abstract：:A Disintegrin and Metalloproteinase-15 (ADAM15) is a transmembrane protein involved in protein ectodomain shedding, cell adhesion and signalling. We previously cloned and characterised alternatively spliced variants of ADAM15 that differ in their intracellular domains and demonstrated correlation of the expression of ...

journal_title：Scientific reports

authors： Mattern J,Roghi CS,Hurtz M,Knäuper V,Edwards DR,Poghosyan Z

更新日期：2019-08-29 00:00:00

abstract：:Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of mitochondrial disease including impaired mitochondrial respiration and hematopoetic abnormalities. We sought to explore the function of this protein. We show t...

journal_title：Scientific reports

authors： Paul BT,Tesfay L,Winkler CR,Torti FM,Torti SV

更新日期：2019-12-23 00:00:00

abstract：:The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrated that the capsular surface-associated pneumococcal serine rich repea...

journal_title：Scientific reports

authors： Schulte T,Mikaelsson C,Beaussart A,Kikhney A,Deshmukh M,Wolniak S,Pathak A,Ebel C,Löfling J,Fogolari F,Henriques-Normark B,Dufrêne YF,Svergun D,Nygren PÅ,Achour A

更新日期：2016-09-01 00:00:00

abstract：:We report on an angle resolved photoemission (ARPES) study of bulk electron-doped perovskite iridate, (Sr(1-x)La(x))3Ir2O7. Fermi surface pockets are observed with a total electron count in keeping with that expected from La substitution. Depending on the energy and polarization of the incident photons, these pockets ...

journal_title：Scientific reports

authors： He J,Hafiz H,Mion TR,Hogan T,Dhital C,Chen X,Lin Q,Hashimoto M,Lu DH,Zhang Y,Markiewicz RS,Bansil A,Wilson SD,He RH

更新日期：2015-02-23 00:00:00

abstract：:PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity double-strand break ho...

journal_title：Scientific reports

authors： Principe DR,Narbutis M,Koch R,Rana A

更新日期：2020-11-19 00:00:00

abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

journal_title：Scientific reports

authors： Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

更新日期：2016-03-11 00:00:00

abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

journal_title：Scientific reports

authors： Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

更新日期：2017-05-30 00:00:00

abstract：:CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of...

journal_title：Scientific reports

authors： Alisson-Silva F,Mantuano NR,Lopes AL,Vasconcelos-Dos-Santos A,Vale AM,Costa MM,Cannon JL,Oliveira AC,Todeschini AR

更新日期：2019-06-13 00:00:00

abstract：:A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...

journal_title：Scientific reports

authors： Chen CY,Sano T,Tsuda T,Ui K,Oshima Y,Yamagata M,Ishikawa M,Haruta M,Doi T,Inaba M,Kuwabata S

更新日期：2016-10-26 00:00:00

abstract：:Frequencies of CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable to those of vertebrate RNA viruses. While pathways that target CpG and UpAs in HIV-1 and echovirus 7 genomes and restrict their replication have been partly characterised, whether an analogous process drives...

journal_title：Scientific reports

authors： Ibrahim A,Fros J,Bertran A,Sechan F,Odon V,Torrance L,Kormelink R,Simmonds P

更新日期：2019-12-04 00:00:00

abstract：:The growth of epitaxial Si nanowires by a metal-catalyst-free process has been investigated as an alternative to the more common metal-catalyzed vapor-liquid-solid process. The well-aligned Si nanowires are successfully grown on a (111)-oriented Si substrate without any metal catalysts by a thermal treatment using sil...

journal_title：Scientific reports

authors： Ishiyama T,Nakagawa S,Wakamatsu T

更新日期：2016-07-28 00:00:00

abstract：:Insects harbor a wide variety of microorganisms that form complex and changing communities and play an important role in the biology and evolution of their hosts. Aphids have been used as model organisms to study microorganism-insect interactions. Almost all aphids are infected with the obligate endosymbiont Buchnera ...

journal_title：Scientific reports

authors： Gallo-Franco JJ,Duque-Gamboa DN,Toro-Perea N

更新日期：2019-04-08 00:00:00

abstract：:This study aimed to assess the validity and functional relevance of a standardized procedure to assess lower limb muscle power by means of the 30-s sit-to-stand (STS) test when compared to leg extension power (LEP), traditional STS performance and handgrip strength. A total of 628 community-dwelling older subjects (60...

journal_title：Scientific reports

authors： Alcazar J,Kamper RS,Aagaard P,Haddock B,Prescott E,Ara I,Suetta C

更新日期：2020-10-01 00:00:00

abstract：:The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach r...

journal_title：Scientific reports

authors： Filippi F,Somigliana E,Busnelli A,Guarneri C,Noli S,Restelli L,Vercellini P

更新日期：2020-06-22 00:00:00

abstract：:The aim of this study was to estimate the influence of regenerated tobacco on the extraction of Cd from two acidic soils as well as to address the problem of how to deal with contaminated leaves following phytoextraction. Results showed that a coppicing tobacco led to a decline in Cd concentration in regenerated leave...

journal_title：Scientific reports

authors： Yang Y,Ge Y,Zeng H,Zhou X,Peng L,Zeng Q

更新日期：2017-08-03 00:00:00

abstract：:Birds play unique functional roles in the maintenance of ecosystems, such as pollination and seed dispersal, and thus monitoring bird species diversity is a first step towards avoiding undesirable consequences of anthropogenic impacts on bird communities. In the present study, we hypothesized that birds, regardless of...

journal_title：Scientific reports

authors： Ushio M,Murata K,Sado T,Nishiumi I,Takeshita M,Iwasaki W,Miya M

更新日期：2018-03-14 00:00:00

abstract：:Formation-free multi-level resistive switching characteristics by using 10 nm-thick polycrystalline GeOx film in a simple W/GeOx/W structure and understanding of switching mechanism through redox reaction in H2O2/sarcosine sensing (or changing Ge°/Ge4+ oxidation states under external bias) have been reported for the f...

journal_title：Scientific reports

authors： Samanta S,Rahaman SZ,Roy A,Jana S,Chakrabarti S,Panja R,Roy S,Dutta M,Ginnaram S,Prakash A,Maikap S,Cheng HM,Tsai LN,Qiu JT,Ray SK

更新日期：2017-09-11 00:00:00

abstract：:Tumor necrosis factor (TNF) is best known for inducing a rapid but transient NF-κB-mediated inflammatory response. We investigated later phases of TNF signaling, after the initial transient induction of inflammatory genes has subsided, in primary human macrophages. TNF signaling induced expression of late response gen...

journal_title：Scientific reports

authors： Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB

更新日期：2016-08-25 00:00:00

abstract：:The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...

journal_title：Scientific reports

authors： Lee J,Kwon G,Lim YH

更新日期：2015-11-25 00:00:00

abstract：:How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

journal_title：Scientific reports

authors： Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

更新日期：2012-01-01 00:00:00

abstract：:Neonatal animal models are increasingly employed in order to unravel age-specific disease mechanisms. Appropriate tools objectifying the clinical condition of murine neonates are lacking. In this study, we tested a scoring system specifically designed for newborn mice that relies on clinical observation and examinatio...

journal_title：Scientific reports

authors： Fehlhaber B,Heinemann AS,Rübensam K,Willers M,Völlger L,Pfeifer S,von Köckritz-Blickwede M,Viemann D

更新日期：2019-04-11 00:00:00

abstract：:Late embryogenesis abundant (LEA) proteins are a large and highly diverse gene family present in a wide range of plant species. LEAs are proposed to play a role in various stress tolerance responses. Our study represents the first-ever survey of LEA proteins and their encoding genes in a widely distributed pine (Pinus...

journal_title：Scientific reports

authors： Gao J,Lan T

更新日期：2016-01-19 00:00:00

abstract：:Vitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of ...

journal_title：Scientific reports

authors： Thakkinstian A,Anothaisintawee T,Chailurkit L,Ratanachaiwong W,Yamwong S,Sritara P,Ongphiphadhanakul B

更新日期：2015-09-29 00:00:00

abstract：:Recently proposed tumor fitness measures, based on profiling neoepitopes for reactive viral epitope similarity, have been proposed to predict response to immune checkpoint inhibitors in melanoma and small-cell lung cancer. Here we applied these checkpoint based fitness measures to the matched checkpoint treatment naiv...

journal_title：Scientific reports

authors： Bubie A,Gonzalez-Kozlova E,Akers N,Villanueva A,Losic B

更新日期：2020-03-19 00:00:00

abstract：:Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...

journal_title：Scientific reports

authors： Hulme CH,Nicolaou A,Murphy SA,Heazell AEP,Myers JE,Westwood M

更新日期：2019-10-01 00:00:00

abstract：:Study aimed to assess long-term bowel function in patients who underwent low anterior resection for cancer five and more years ago. Patients who underwent low anterior resection for rectal cancer from 2010 to 2015 at National Cancer Institute were prospectively included in our study. They were interviewed using low an...

journal_title：Scientific reports

authors： Dulskas A,Kavaliauskas P,Pilipavicius L,Jodinskas M,Mikalonis M,Samalavicius NE

更新日期：2020-07-17 00:00:00

abstract：:Using species distribution models and information on genetic structure and within-population variance observed in a series of common garden trials, we reconstructed a historical biogeography of trembling aspen in North America. We used an ensemble classifier modelling approach (RandomForest) to reconstruct palaeoclima...

journal_title：Scientific reports

authors： Ding C,Schreiber SG,Roberts DR,Hamann A,Brouard JS

更新日期：2017-07-05 00:00:00