Tumor fitness, immune exhaustion and clinical outcomes: impact of immune checkpoint inhibitors.

abstract：:Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge. Here we study the enhancement properties by Ag nanoparticles for InGaN/GaN quantum-...

journal_title：Scientific reports

authors： Fadil A,Iida D,Chen Y,Ma J,Ou Y,Petersen PM,Ou H

更新日期：2014-09-22 00:00:00

abstract：:Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 a...

journal_title：Scientific reports

authors： Wang H,Yuan Q,Sun M,Niu M,Wen L,Fu H,Zhou F,Chen Z,Yao C,Hou J,Shen R,Lin Q,Liu W,Jia R,Li Z,He Z

更新日期：2017-04-07 00:00:00

abstract：:Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a need for a thorough understanding of the transcriptional regulatory network involved in adipos...

journal_title：Scientific reports

authors： Firmin FF,Oger F,Gheeraert C,Dubois-Chevalier J,Vercoutter-Edouart AS,Alzaid F,Mazuy C,Dehondt H,Alexandre J,Derudas B,Dhalluin Q,Ploton M,Berthier A,Woitrain E,Lefebvre T,Venteclef N,Pattou F,Staels B,Eeckhoute J,L

更新日期：2017-10-26 00:00:00

abstract：:Liver resection remains the popular treatment for hepatocellular carcinoma (HCC). The aim of this study was to explore the alteration of immune cells in HCC patients with liver resections. Nineteen patients were included and their peripheral blood samples were taken before and after liver resections for immune-cell an...

journal_title：Scientific reports

authors： Lee WC,Wang YC,Cheng CH,Wu TH,Lee CF,Wu TJ,Chou HS,Chan KM

更新日期：2019-02-19 00:00:00

abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

journal_title：Scientific reports

authors： Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

更新日期：2018-06-11 00:00:00

abstract：:Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of ...

journal_title：Scientific reports

authors： Jia X,Hou Y,Xu M,Zhao Z,Xuan L,Wang T,Li M,Xu Y,Lu J,Bi Y,Wang W,Chen Y

更新日期：2019-04-02 00:00:00

abstract：:During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In t...

journal_title：Scientific reports

authors： Davis O,Merrison-Hort R,Soffe SR,Borisyuk R

更新日期：2017-10-19 00:00:00

abstract：:It has been recently ascribed to several inflammatory cytokines (i.e. TGF-β3, TNF-α, and IL-1) a functional role in regulating Sertoli cell blood-testis barrier (BTB) dynamics. In the testis, IL-6 inhibits meiotic DNA synthesis during the seminiferous epithelium cycle, reduces sperm motility and influences the secreti...

journal_title：Scientific reports

authors： Zhang H,Yin Y,Wang G,Liu Z,Liu L,Sun F

更新日期：2014-03-03 00:00:00

abstract：:A frequency reconfigurable dipole antenna based on a silicon radiator is presented. The silicon radiator is activated with the aid of highly dense solid-state plasma by injecting carriers into the intrinsic region of p-i-n diodes. The fabrication and design guideline of the reconfigurable dipole antenna with this plas...

journal_title：Scientific reports

authors： Kim DJ,Jo ES,Cho YK,Hur J,Kim CK,Kim CH,Park B,Kim D,Choi YK

更新日期：2018-10-09 00:00:00

abstract：:Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellular factors leading ...

journal_title：Scientific reports

authors： Kumar M,Belcaid M,Nerurkar VR

更新日期：2016-05-23 00:00:00

abstract：:A novel process for improving tar yield through catalytic depolymerization of a typical lignite was put forward. The catalytic depolymerization of the lignite over CoCl2 and ZnCl2 catalyst in different concentrations were investigated by a Gray-King apparatus. The optimal catalyst concentrations of CoCl2 and ZnCl2 cat...

journal_title：Scientific reports

authors： Liang L,Huai J,Zhang Q,Liu J,Huang W,Zhang Z,Hao X,Guan G

更新日期：2017-10-31 00:00:00

abstract：:Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute live...

journal_title：Scientific reports

authors： Sydor S,Manka P,Best J,Jafoui S,Sowa JP,Zoubek ME,Hernandez-Gea V,Cubero FJ,Kälsch J,Vetter D,Fiel MI,Hoshida Y,Bian CB,Nelson LJ,Moshage H,Faber KN,Paul A,Baba HA,Gerken G,Friedman SL,Canbay A,Bechmann LP

更新日期：2017-08-14 00:00:00

abstract：:Application of acute kidney injury (AKI) biomarkers with consideration of nonrenal conditions and systemic severity has not been sufficiently determined. Herein, urinary neutrophil gelatinase-associated lipocalin (NGAL), L-type fatty acid-binding protein (L-FABP) and nonrenal disorders, including inflammation, hypoper...

journal_title：Scientific reports

authors： Asada T,Isshiki R,Hayase N,Sumida M,Inokuchi R,Noiri E,Nangaku M,Yahagi N,Doi K

更新日期：2016-09-08 00:00:00

abstract：:An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...

journal_title：Scientific reports

authors： Kutrovskaya S,Kucherik A,Osipov A,Samyshkin V,Istratov A,Kavokin AV

更新日期：2019-05-07 00:00:00

abstract：:Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...

journal_title：Scientific reports

authors： Xu C,Wu S,Zhao W,Mipam T,Liu J,Liu W,Yi C,Shah MA,Yu S,Cai X

更新日期：2018-01-12 00:00:00

abstract：:We have systematically investigated the influence of oxygen vacancy defects on the structural, electronic and magnetic properties of La(1-x)Sr(x)MnO3 (x = 1/3) film by means of ab initio calculations using bare GGA as well as GGA+U formalism, in the latter of which, the on-site Coulombic repulsion parameter U for Mn 3...

journal_title：Scientific reports

authors： Li J

更新日期：2016-03-01 00:00:00

abstract：:This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...

journal_title：Scientific reports

authors： Caridi I,Alvarez EE,Somigliana C,Puerto MS

更新日期：2020-03-19 00:00:00

abstract：:Tractography atlas-based analysis (TABS) is a new diffusion tensor image (DTI) statistical analysis method for detecting and understanding voxel-wise white matter properties along a fiber tract. An important requisite for accurate and sensitive TABS is the availability of a deformation field that is able to register D...

journal_title：Scientific reports

authors： Mu J,Xu Q,Tian J,Liu J

更新日期：2017-10-04 00:00:00

abstract：:The rapid spread of the SARS-CoV-2 in the COVID-19 pandemic had raised questions on the route of transmission of this disease. Initial understanding was that transmission originated from respiratory droplets from an infected host to a susceptible host. However, indirect contact transmission of viable virus by fomites ...

journal_title：Scientific reports

authors： Nor NSM,Yip CW,Ibrahim N,Jaafar MH,Rashid ZZ,Mustafa N,Hamid HHA,Chandru K,Latif MT,Saw PE,Lin CY,Alhasa KM,Hashim JH,Nadzir MSM

更新日期：2021-01-28 00:00:00

abstract：:Cerebral malaria (CM), a complication of malaria infection, is the cause of the majority of malaria-associated deaths in African children. The standard clinical case definition for CM misclassifies ~25% of patients, but when malarial retinopathy (MR) is added to the clinical case definition, the specificity improves f...

journal_title：Scientific reports

authors： Joshi V,Agurto C,Barriga S,Nemeth S,Soliz P,MacCormick IJ,Lewallen S,Taylor TE,Harding SP

更新日期：2017-02-15 00:00:00

abstract：:Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...

journal_title：Scientific reports

authors： Xie H,Yin F,Yu T,Wang JT,Liang C

更新日期：2014-08-04 00:00:00

abstract：:Overuse of nitrogen (N) fertilizer has led to low N use efficiency (NUE) and high N loss in single rice cropping systems in southeast China. Application of controlled-release urea (CRU) is considered as an effective N fertilizer practice for improving crop yields and NUE. Here, field experiments were conducted during ...

journal_title：Scientific reports

authors： Chen Z,Wang Q,Ma J,Zou P,Jiang L

更新日期：2020-06-26 00:00:00

abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...

journal_title：Scientific reports

authors： Omardien S,Ter Beek A,Vischer N,Montijn R,Schuren F,Brul S

更新日期：2018-06-14 00:00:00

abstract：:Following radiation induced DNA damage, several repair pathways are activated to help preserve genome integrity. Double Strand Breaks (DSBs), which are highly toxic, have specified repair pathways to address them. The main repair pathways used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recomb...

journal_title：Scientific reports

authors： Ingram SP,Warmenhoven JW,Henthorn NT,Smith EAK,Chadwick AL,Burnet NG,Mackay RI,Kirkby NF,Kirkby KJ,Merchant MJ

更新日期：2019-04-23 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is exacerbated by glial activation. Cassia seed (Jue-ming-zi) is a traditional herbal medicine commonly used to treat ocular diseases in Asia. In this report, we investigated the retina-protective effect of ch...

journal_title：Scientific reports

authors： Lin FL,Lin CH,Ho JD,Yen JL,Chang HM,Chiou GC,Cheng YW,Hsiao G

更新日期：2017-01-23 00:00:00

abstract：:Maintaining energy balance over a wide range of temperatures is critical for an active pelagic fish species such as the mahi-mahi (Coryphaena hippurus), which can experience rapid changes in temperature during vertical migrations. Due to the profound effect of temperature on mitochondrial function, this study was desi...

journal_title：Scientific reports

authors： Lau GY,Cox GK,Stieglitz JD,Benetti DD,Grosell M

更新日期：2020-09-10 00:00:00

abstract：:The aquatic and semiaquatic invertebrates in fossiliferous amber have been reported, including taxa in a wide range of the subphylum Crustacea of Arthropoda. However, no caridean shrimp has been discovered so far in the world. The shrimp Palaemon aestuarius sp. nov. (Palaemonidae) preserved in amber from Chiapas, Mexi...

journal_title：Scientific reports

authors： Du BJ,Chen R,Li XZ,Tao WT,Bu WJ,Xiao JH,Huang DW

更新日期：2019-10-29 00:00:00

abstract：:To explore the feasibility of 3D-printed navigation template in proximal femoral varus rotation and shortening osteotomy for older children with developmental dysplasia of the hip (DDH). Between June 2014 and May 2015, navigation templates were designed and used for 12 DDH patients. Surgical information and outcomes w...

journal_title：Scientific reports

authors： Zheng P,Xu P,Yao Q,Tang K,Lou Y

更新日期：2017-03-21 00:00:00

abstract：:Tetrandrine (Tet) could enhance the antitumor effect of Paclitaxel (Ptx) by increasing intracellular Reactive Oxygen Species (ROS) levels, which leads to the possibility of co-delivery of both drugs for synergistic antitumor effect. In the current study, we reported an efficient, local therapeutic strategy employing e...

journal_title：Scientific reports

authors： Zhang H,Tian Y,Zhu Z,Xu H,Li X,Zheng D,Sun W

更新日期：2016-05-26 00:00:00

abstract：:The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role in colitis. We report that LXN is a suppressor of colitis. LXN deficiency leads to the severity of colitis in DSS-induced mice, and LXN is required for the therapeutic effect of retinoic acid on col...

journal_title：Scientific reports

authors： Li Y,Huang B,Yang H,Kan S,Yao Y,Liu X,Pu S,He G,Khan TM,Qi G,Zhou Z,Shu W,Chen M

更新日期：2020-06-17 00:00:00