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The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.

Abstract：

:Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a need for a thorough understanding of the transcriptional regulatory network involved in adipose tissue pathophysiology. Recent advances in the functional annotation of the genome has highlighted the role of non-coding RNAs in cellular differentiation processes in coordination with transcription factors. Using an unbiased genome-wide approach, we identified and characterized a novel long intergenic non-coding RNA (lincRNA) strongly induced during adipocyte differentiation. This lincRNA favors adipocyte differentiation and coactivates the master adipogenic regulator peroxisome proliferator-activated receptor gamma (PPARγ) through interaction with the paraspeckle component and hnRNP-like RNA binding protein 14 (RBM14/NCoAA), and was therefore called PPARγ-activator RBM14-associated lncRNA (Paral1). Paral1 expression is restricted to adipocytes and decreased in humans with increasing body mass index. A decreased expression was also observed in diet-induced or genetic mouse models of obesity and this down-regulation was mimicked in vitro by TNF treatment. In conclusion, we have identified a novel component of the adipogenic transcriptional regulatory network defining the lincRNA Paral1 as an obesity-sensitive regulator of adipocyte differentiation and function.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Firmin FF,Oger F,Gheeraert C,Dubois-Chevalier J,Vercoutter-Edouart AS,Alzaid F,Mazuy C,Dehondt H,Alexandre J,Derudas B,Dhalluin Q,Ploton M,Berthier A,Woitrain E,Lefebvre T,Venteclef N,Pattou F,Staels B,Eeckhoute J,L

doi

10.1038/s41598-017-14570-y

subject

Has Abstract

pub_date

2017-10-26 00:00:00

pages

14087

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14570-y

journal_volume

7

pub_type

临床试验,杂志文章

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