Abstract:
:During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In this paper we study these questions by adapting an existing computational model of the development of neurons in the Xenopus tadpole spinal cord to include interactions between axons. We demonstrate that even relatively weak attraction causes bundles to appear, while if axons weakly repulse each other their trajectories diverge such that they fill the available space. We show how fasciculation can help to ensure axons grow in the correct location for proper network formation when normal growth barriers contain gaps, and use a functional spiking model to show that fasciculation allows the network to generate reliable swimming behaviour even when overall synapse counts are artificially lowered. Although we study fasciculation in one particular organism, our approach to modelling axon growth is general and can be widely applied to study other nervous systems.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Davis O,Merrison-Hort R,Soffe SR,Borisyuk Rdoi
10.1038/s41598-017-13804-3subject
Has Abstractpub_date
2017-10-19 00:00:00pages
13551issue
1issn
2045-2322pii
10.1038/s41598-017-13804-3journal_volume
7pub_type
杂志文章abstract::Stress is one of major factors that cause sleep problems. Hypocretin represents a stress-related neuropeptide and is well known in maintaining physiological wakefulness. The hypocretinergic neurons originate in the lateral hypothalamic area (LHA) and transmit to several brain regions, including the median raphe nuclei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44731-0
更新日期:2019-06-03 00:00:00
abstract::Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59750-5
更新日期:2020-02-19 00:00:00
abstract::It is urgent to find an optimised therapy regimen for the control of MDR-TB globally. This study aimed to evaluate the efficiacy and safety of a combined regimen of rhIL-2 injection and standard chemotherapy within 18-month duration in a randomized controlled trial conducted in 14 centres in eastern China. From Jan. 2...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-017-18200-5
更新日期:2017-12-19 00:00:00
abstract::Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including microRNAs (miRNAs)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32034
更新日期:2016-09-02 00:00:00
abstract::We identify graphene layer on a disordered substrate as a system where localization of phonons can be observed. Generally, observation of localization for scattering waves is not simple, because the Rayleigh scattering is inversely proportional to a high power of wavelength. The situation is radically different for th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34426-3
更新日期:2018-11-02 00:00:00
abstract::NK cell adoptive therapy is a promising cancer therapeutic approach, but there are significant challenges that limiting its feasibility and clinical efficacy. One difficulty is the paucity of clinical grade manufacturing platforms to support the large scale expansion of highly active NK cells. We created an NK cell fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51287-6
更新日期:2019-10-17 00:00:00
abstract::The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29020
更新日期:2016-07-01 00:00:00
abstract::The life-like fidelity of organisms captured in amber is unique among all kinds of fossilization and represents an invaluable source for different fields of palaeontological and biological research. One of the most challenging aspects in amber research is the study of traits related to behaviour. Here, indirect eviden...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34352
更新日期:2016-10-04 00:00:00
abstract::Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes - two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) - with distinct protein and miRNA signatures. Here, we extend our omics approach to underst...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38397
更新日期:2016-12-05 00:00:00
abstract::Polymer-derived silicon oxycarbide (SiCO) presents excellent performance for high temperature and lithium-ion battery applications. Current experiments have provided some information on nano-structure of SiCO, while it is very challenging for experiments to take further insight into the molecular structure and its rel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42705
更新日期:2017-02-14 00:00:00
abstract::The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73048-6
更新日期:2020-10-01 00:00:00
abstract::Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye has been characterized, the more recently described pathways of NO generation by nitrate (NO3-) and nitrite (NO2-) ions reduction has rec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69272-9
更新日期:2020-08-05 00:00:00
abstract::Ceramide is one of the most important intercellular components responsible for the barrier and moisture retention functions of the skin. Because of the risks involved with using products of animal origin and the low productivity of plants, the availability of ceramides is currently limited. In this study, we successfu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16319
更新日期:2015-11-17 00:00:00
abstract::The phenomenon of cation ordering is closely related to certain physical properties of complex oxides, which necessitates the search of underlying structure-property relationship at atomic resolution. Here we study the superlattices within reduced calcium titanate single crystal micro-pillars, which are unexpected fro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15120-2
更新日期:2017-11-03 00:00:00
abstract::Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33748-6
更新日期:2018-10-18 00:00:00
abstract::Plant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organole...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69014-x
更新日期:2020-07-23 00:00:00
abstract::Connecting genome-wide association study (GWAS) to biological mechanisms underlying complex traits is a major challenge. Mastitis resistance and milk production are complex traits of economic importance in the dairy sector and are associated with intra-mammary infection (IMI). Here, we integrated IMI-relevant RNA-Seq ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45560
更新日期:2017-03-30 00:00:00
abstract::There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62587-7
更新日期:2020-04-03 00:00:00
abstract::Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge. Here we study the enhancement properties by Ag nanoparticles for InGaN/GaN quantum-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06392
更新日期:2014-09-22 00:00:00
abstract::Tractography atlas-based analysis (TABS) is a new diffusion tensor image (DTI) statistical analysis method for detecting and understanding voxel-wise white matter properties along a fiber tract. An important requisite for accurate and sensitive TABS is the availability of a deformation field that is able to register D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12965-5
更新日期:2017-10-04 00:00:00
abstract::15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the stru...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27221-7
更新日期:2018-06-11 00:00:00
abstract::Staphylococcus aureus infection is a rising public health care threat. S. aureus is believed to have elaborate regulatory networks that orchestrate its virulence. Despite its importance, the systematic understanding of the transcriptional landscape of S. aureus is limited. Here, we describe the primary transcriptome l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20661-1
更新日期:2018-02-02 00:00:00
abstract::Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic denervation (SAD). In...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37970-0
更新日期:2019-02-04 00:00:00
abstract::Within the framework of precision agriculture, the determination of various soil properties is moving into focus, especially the demand for sensors suitable for in-situ measurements. Energy-dispersive X-ray fluorescence (EDXRF) can be a powerful tool for this purpose. In this study a huge diverse soil set (n = 598) fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53426-5
更新日期:2019-11-26 00:00:00
abstract::Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22309
更新日期:2016-02-29 00:00:00
abstract::This study investigated the feasibility of using polycaprolactone (PCL) nanofiber-based air filters to capture PM2.5 particles emitted from fused deposition modeling (FDM) 3D printing. Generation and aggregation of emitted particles were investigated under different testing environments. The results show that: (1) the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10995-7
更新日期:2017-09-04 00:00:00
abstract::One strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces. Nevertheless, there is a lack of studies comparing implicit and expli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49751-4
更新日期:2019-09-16 00:00:00
abstract::Various techniques are commonly used to produce nano-crystalline NiAl2O4 materials; however, their practical applications in the microwave region remain very limited. In this work, flexible substrates for metamaterials containing two different concentrations of NiAl2O4 (labelled Ni36 and Ni42) have been synthesised us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33295-0
更新日期:2018-10-08 00:00:00
abstract::Coincident climatic and human effects strongly influence water-quality properties in estuarine-coastal ecosystems around the world. Time-series data for a number of ecosystems reveal high spatio-temporal variability superimposed on secular trends traceable to nutrient over-enrichment. In this paper, we present new ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43036-6
更新日期:2019-04-30 00:00:00
abstract::There are only few studies that explore the ecological consequences of forest management on several organism groups. We studied the short-term effects of four forestry treatments including preparation cutting, clear-cutting, retention tree group and gap-cutting in a temperate managed forest on the assemblage structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35159-z
更新日期:2018-11-19 00:00:00