The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration.

abstract：:Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we ...

journal_title：Scientific reports

authors： de Laat-Kremers RMW,Yan Q,Ninivaggi M,de Maat M,de Laat B

更新日期：2020-07-27 00:00:00

abstract：:Individuals who are well integrated into society have greater access to resources and tend to live longer. Why some individuals are socially isolated and others are not is therefore puzzling from an evolutionary perspective. Answering this question requires establishing the mix of intrinsic and contextual factors that...

journal_title：Scientific reports

authors： Brent LJN,Ruiz-Lambides A,Platt ML

更新日期：2017-12-19 00:00:00

abstract：:The helicase Twinkle is indispensable for mtDNA replication in nucleoids. Previously, we showed that Twinkle is tightly membrane-associated even in the absence of mtDNA, which suggests that Twinkle is part of a membrane-attached replication platform. Here we show that this platform is a cholesterol-rich membrane struc...

journal_title：Scientific reports

authors： Gerhold JM,Cansiz-Arda Ş,Lõhmus M,Engberg O,Reyes A,van Rennes H,Sanz A,Holt IJ,Cooper HM,Spelbrink JN

更新日期：2015-10-19 00:00:00

abstract：:Current strategies to treat tuberculosis (TB) and co-morbidities involve multidrug combination therapies. Rifamycin antibiotics are a key component of TB therapy and a common source of drug-drug interactions (DDIs) due to induction of drug metabolizing enzymes (DMEs). Management of rifamycin DDIs are complex, particul...

journal_title：Scientific reports

authors： Dyavar SR,Mykris TM,Winchester LC,Scarsi KK,Fletcher CV,Podany AT

更新日期：2020-07-28 00:00:00

abstract：:The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide po...

journal_title：Scientific reports

authors： Paun CC,Lechanteur YTE,Groenewoud JMM,Altay L,Schick T,Daha MR,Fauser S,Hoyng CB,den Hollander AI,de Jong EK

更新日期：2016-05-31 00:00:00

abstract：:Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...

journal_title：Scientific reports

authors： Mulvaney JF,Thompkins C,Noda T,Nishimura K,Sun WW,Lin SY,Coffin A,Dabdoub A

更新日期：2016-08-23 00:00:00

abstract：:Acclimation and adaptation, which are key to species survival in a changing climate, can be observed in terms of membrane lipid composition. Remodelling membrane lipids, via homeoviscous adaptation (HVA), counteracts membrane dysfunction due to temperature in poikilotherms. In order to assess the potential for acclima...

journal_title：Scientific reports

authors： Muir AP,Nunes FL,Dubois SF,Pernet F

更新日期：2016-10-20 00:00:00

abstract：:A novel and convenient copper (II) bromide and 1,8-diazabicyclo[5.4.1]undec-7-ene (DBU) or 1,10-phenanthroline catalysis protocol for the construction of α-alkyl-β-keto sulfones via C(sp(3))-H bond functionalization followed by C(sp(3))-S bond formation between aryl ketones and sodium sulfinates at room temperature ha...

journal_title：Scientific reports

authors： Lan XW,Wang NX,Bai CB,Zhang W,Xing Y,Wen JL,Wang YJ,Li YH

更新日期：2015-12-18 00:00:00

abstract：:We derive the stationary probability distribution for a non-equilibrium system composed by an arbitrary number of degrees of freedom that are subject to Gaussian colored noise and a conservative potential. This is based on a multidimensional version of the Unified Colored Noise Approximation. By comparing theory with ...

journal_title：Scientific reports

authors： Maggi C,Marconi UM,Gnan N,Di Leonardo R

更新日期：2015-05-29 00:00:00

abstract：:We present the synthesis of new composite materials based on copper nanoparticles (Cu NPs) deposited onto montmorillonite (MK10) and quartz sand, for degradation of atrazine, in the context of an advanced oxidation process (AOP). The synthesis involves a first step in which polyethylenimine (PEI) capped Cu NPs (PEI_Cu...

journal_title：Scientific reports

authors： Kalidhasan S,Dror I,Berkowitz B

更新日期：2017-05-03 00:00:00

abstract：:The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumu...

journal_title：Scientific reports

authors： Jing D,Hao X,Xu F,Liu J,Xu F,Luo E,Meng G

更新日期：2016-06-22 00:00:00

abstract：:Features from Electrovestibulography (EVestG) recordings have been used to classify and measure the severity of both persistent post-concussion syndrome (PCS) and major depressive disorder. Herein, we examined the effect of comorbid depression on the detection of persistent PCS using EVestG. To validate our previously...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Mansouri B,Moussavi Z

更新日期：2018-09-27 00:00:00

abstract：:Intensive research has been focused on the synthesis of long-lasting SrAl2O4:EuDy in luminescent materials field. Traditionally, SrAl2O4:EuDy is synthesized in bulk form by solid state. However, their development remains restrained due to this technique is not compatible with large-scale production, sustainability and...

journal_title：Scientific reports

authors： Rojas-Hernandez RE,Rubio-Marcos F,Serrano A,Del Campo A,Fernandez JF

更新日期：2017-03-28 00:00:00

abstract：:IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 ...

journal_title：Scientific reports

authors： Sun J,Fang LX,Wu Z,Deng H,Yang RS,Li XP,Li SM,Liao XP,Feng Y,Liu YH

更新日期：2017-03-24 00:00:00

abstract：:Although semantic processing has traditionally been associated with brain responses maximal at 350-400 ms, recent studies reported that words of different semantic types elicit topographically distinct brain responses substantially earlier, at 100-200 ms. These earlier responses have, however, been achieved using insu...

journal_title：Scientific reports

authors： Moseley RL,Pulvermüller F,Shtyrov Y

更新日期：2013-01-01 00:00:00

abstract：:How the human auditory system learns to map complex pinna-induced spectral-shape cues onto veridical estimates of sound-source elevation in the median plane is still unclear. Earlier studies demonstrated considerable sound-localisation plasticity after applying pinna moulds, and to altered vision. Several factors may ...

journal_title：Scientific reports

authors： Zonooz B,Arani E,Opstal AJV

更新日期：2018-12-18 00:00:00

abstract：:There is a pressing need for novel and innovative therapeutic strategies to address infections caused by intracellular pathogens. Peptide nucleic acids (PNAs) present a novel method to target intracellular pathogens due to their unique mechanism of action and their ability to be conjugated to cell penetrating peptides...

journal_title：Scientific reports

authors： Abushahba MF,Mohammad H,Thangamani S,Hussein AA,Seleem MN

更新日期：2016-02-10 00:00:00

abstract：:Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effec...

journal_title：Scientific reports

authors： Qiu P,Poehlein CH,Marton MJ,Laterza OF,Levitan D

更新日期：2019-01-14 00:00:00

abstract：:Entanglement is at the heart of many unusual and counterintuitive features of quantum mechanics. Once two quantum subsystems have become entangled, it is no longer possible to ascribe an independent state to either; instead, the subsystems are completely described only as part of a greater, composite system. As a cons...

journal_title：Scientific reports

authors： Bouchard F,Harris J,Mand H,Bent N,Santamato E,Boyd RW,Karimi E

更新日期：2015-10-15 00:00:00

abstract：:Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the framework of network evolution and comparative genomic analysis. We foun...

journal_title：Scientific reports

authors： Kim J,Kim I,Han SK,Bowie JU,Kim S

更新日期：2012-01-01 00:00:00

abstract：:The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix prot...

journal_title：Scientific reports

authors： Feng D,Li Q,Yu H,Kong L,Du S

更新日期：2017-04-04 00:00:00

abstract：:Singlet oxygen (1O2) is a type of reactive oxygen species involved in numerous physiological activities. We previously reported that 1O2-specific oxidation products are increased in patients with prediabetes, suggesting that measurement of 1O2 may be an important indicator of physiological and pathological conditions....

journal_title：Scientific reports

authors： Murotomi K,Umeno A,Sugino S,Yoshida Y

更新日期：2020-06-30 00:00:00

abstract：:Adherence to cardioprotective medications following myocardial infarction (MI) is commonly assessed using a binary threshold of 80%. We investigated the relationship between medication adherence as a continuous measure and outcomes in MI survivors using restricted cubic splines (RCS). We identified all patients aged ≥...

journal_title：Scientific reports

authors： Greenland M,Knuiman MW,Hung J,Nedkoff L,Arnet I,Rankin JM,Kilkenny MF,Sanfilippo FM

更新日期：2020-03-09 00:00:00

abstract：:The CoCrMo matrix composites with nano-TiO2 particle (2 wt.%, 4 wt.% and 6 wt.%) were fabricated by using a powder metallurgy technique (P/M), and the nano-TiO2 content was optimized in matrix. The microstructures, mechanical and high-temperature tribological properties of the synthesized composites were systematicall...

journal_title：Scientific reports

authors： Cui G,Liu Y,Li S,Liu H,Gao G,Kou Z

更新日期：2020-04-22 00:00:00

abstract：:Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...

journal_title：Scientific reports

authors： Guschinskaya N,Brunel R,Tourte M,Lipscomb GL,Adams MWW,Oger P,Charpentier X

更新日期：2016-11-08 00:00:00

abstract：:To investigate the influence of chemical weathering on CO2 consumption, an analysis was performed of water chemistry by applying water chemistry equilibria methods in the Bishuiyan subterranean basin, SW China. The average value of total ion concentrations (TZ+) was 1,854.97 μEq/L, which was significantly higher than ...

journal_title：Scientific reports

authors： Jiang P,Yu G,Zhang Q,Zou Y,Tang Q,Kang Z,Sytharith P,Xiao H

更新日期：2020-07-15 00:00:00

abstract：:Here we developed an orange light-absorbing chromoprotein named ShadowR as a novel acceptor for performing fluorescence lifetime imaging microscopy-based Förster resonance energy transfer (FLIM-FRET) measurement in living cells. ShadowR was generated by replacing hydrophobic amino acids located at the surface of the c...

journal_title：Scientific reports

authors： Murakoshi H,Horiuchi H,Kosugi T,Onda M,Sato A,Koga N,Nabekura J

更新日期：2019-08-19 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 immunoglobulin fusion protein (CTLA4Ig, abatacept) is a B7/CD28 costimulation inhibitor that can ward off the immune response by preventing the activation of naïve T cells. This therapeutic agent is administered to patients with autoimmune diseases such as rheumatoid arthrit...

journal_title：Scientific reports

authors： Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH

更新日期：2014-11-06 00:00:00

abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...

journal_title：Scientific reports

authors： Peksel B,Gombos I,Péter M,Vigh L Jr,Tiszlavicz Á,Brameshuber M,Balogh G,Schütz GJ,Horváth I,Vigh L,Török Z

更新日期：2017-11-15 00:00:00

abstract：:The functional heterogeneity of T cell responses to diverse antigens expressed at different stages of Mycobacterium tuberculosis (Mtb) infection, in particular early secreted versus dormancy related latency antigens expressed later, that distinguish subjects with latent (LTBI), pulmonary (PTB) or extrapulmonary (EPTB)...

journal_title：Scientific reports

authors： Rakshit S,Adiga V,Nayak S,Sahoo PN,Sharma PK,van Meijgaarden KE,Uk J AJ,Dhar C,Souza GD,Finak G,De Rosa SC,Ottenhoff THM,Vyakarnam A

更新日期：2017-09-20 00:00:00