Abstract:
:Liver resection remains the popular treatment for hepatocellular carcinoma (HCC). The aim of this study was to explore the alteration of immune cells in HCC patients with liver resections. Nineteen patients were included and their peripheral blood samples were taken before and after liver resections for immune-cell analysis. The clinical characteristics showed that the median diameter of the resected tumors was 7.5 cm with a range from 1.4 to 16.5 cm. The analysis of immune cells showed that the percentage of CD4+ T-cells were not altered by liver resection, but the percentage of CD8+ T-cell was decreased from 31.7 ± 12.4% to 20.2 ± 10.4% at one week after liver resection (p = 0.006). For immunosuppressor cells, regulatory T-cells were not altered, but myeloid-derived suppressor cells (MDSC) were decreased from 7.75 ± 8.16% to 1.51 ± 1.32% at one month after liver resection (p = 0.022) in 10 of 19 patients with high frequency of MDSC. Furthermore, it was also found that MDSC population was linearly correlated to tumor volume. In conclusion, CD8+ T-cells and MDSC were altered by liver resection. The percentage of CD8+ T-cells was decreased by surgery, but the accumulation of MDSC was abrogated.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee WC,Wang YC,Cheng CH,Wu TH,Lee CF,Wu TJ,Chou HS,Chan KMdoi
10.1038/s41598-019-38785-3subject
Has Abstractpub_date
2019-02-19 00:00:00pages
2269issue
1issn
2045-2322pii
10.1038/s41598-019-38785-3journal_volume
9pub_type
临床试验,杂志文章abstract::Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25430-8
更新日期:2018-05-04 00:00:00
abstract::Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44181
更新日期:2017-03-10 00:00:00
abstract::A three-year-long field experiment was conducted in a continuous grazing system with a variable stocking rate to evaluate effects of increasing nitrogen levels in Marandu grass (Brachiaria brizantha Hochst ex A. Rich Stapf "marandu") on herbage mass, forage accumulation rate (FAR), forage quality, stocking rate (SR), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44138-x
更新日期:2019-05-20 00:00:00
abstract::Atomic hydrogen exists ubiquitously in graphene materials made by chemical methods. Yet determining the effect of hydrogen on the electrochemical performance of graphene remains a significant challenge. Here we report the experimental observations of high rate capacity in hydrogen-treated 3-dimensional (3D) graphene n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16190
更新日期:2015-11-05 00:00:00
abstract::The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16563-3
更新日期:2017-11-24 00:00:00
abstract::Biochar can influence native soil organic carbon (SOC) mineralisation through "priming effects". However, the long-term direction, persistence and extent of SOC priming by biochar remain uncertain. Using natural (13)C abundance and under controlled laboratory conditions, we show that biochar-stimulated SOC mineralisat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03687
更新日期:2014-01-21 00:00:00
abstract::The killer toxin K1 is a virally encoded fungal A/B toxin acting by disrupting plasma membrane integrity. The connection of α and β constitutes a critical feature for toxin biology and for decades the formation of three disulphide bonds linking the major toxin subunits was accepted as status quo. Due to the absence of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49621-z
更新日期:2019-09-11 00:00:00
abstract::Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22128-9
更新日期:2018-02-28 00:00:00
abstract::Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26161
更新日期:2016-05-17 00:00:00
abstract::All real networks are different, but many have some structural properties in common. There seems to be no consensus on what the most common properties are, but scale-free degree distributions, strong clustering, and community structure are frequently mentioned without question. Surprisingly, there exists no simple gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09421
更新日期:2015-04-29 00:00:00
abstract::Time-encoding MRI is a single-scan method that uses traditional k-encoding only in one direction. In the orthogonal "time-encoding" direction, a string of echoes appears in an order that depends on the position of the corresponding spin packets. In one variant of time-encoding, this is achieved by using a series of se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28460-4
更新日期:2018-07-18 00:00:00
abstract::Melon (Cucumis melo L.) is a very important crop throughout the world and has great economic importance, in part due to its nutritional properties. It prefers well-drained soil with low acidity and has a strong demand for water during fruit set. Therefore, a correct water balance-involving aquaporins-is necessary to m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79250-w
更新日期:2020-12-17 00:00:00
abstract::Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22964
更新日期:2016-03-11 00:00:00
abstract::Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24096
更新日期:2016-06-14 00:00:00
abstract::The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75929-2
更新日期:2020-11-03 00:00:00
abstract::We aimed to assess feasibility of a support vector machine (SVM) texture classifier to discriminate pathologic infiltration patterns from the normal bone marrows in MRI. This retrospective study included 467 cases, which were split into a training (n = 360) and a test set (n = 107). A sagittal T1-weighted lumbar spina...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42579-y
更新日期:2019-04-15 00:00:00
abstract::Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28166-7
更新日期:2018-07-11 00:00:00
abstract::Breast cancer is the most common cancer among women, and its incidence is on a constant rise. Previous studies suggest that higher levels of plasma prolactin are associated with escalated risk of breast cancer, however, these results are contradictory and inconclusive. PubMed and Medline were used to search and identi...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep25998
更新日期:2016-05-17 00:00:00
abstract::Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27923
更新日期:2016-06-13 00:00:00
abstract::Aquaporin 9 (AQP9), as an aquaglyceroporin, is expressed in many immune cells and plays important role in tumor initiation and progression. However, the relationship between AQP9 and tumor-infiltrating cells, and its prognostic value in cancers still require comprehensive understanding. Herein, we aimed to elucidate t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77657-z
更新日期:2020-11-27 00:00:00
abstract::L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes. Proteolytic shedding of the ectodomain is thought to redirect activated T-cells from lymph nodes to sites of infection. However, we have shown that activated T-cells re-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41811-z
更新日期:2019-04-02 00:00:00
abstract::The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02735
更新日期:2013-01-01 00:00:00
abstract::Given new distribution patterns of the endangered North Atlantic right whale (NARW; Eubalaena glacialis) population in recent years, an improved understanding of spatio-temporal movements are imperative for the conservation of this species. While so far visual data have provided most information on NARW movements, pas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13359-3
更新日期:2017-10-18 00:00:00
abstract::Free carriers, polarons (P), in conjugated polymers play a key role in the performance of optoelectronic devices. Here, we present solid evidence that P can be predominantly generated from polaron pairs (PP) in a poly(3-hexylthiophene) (P3HT) film under zero electric field. P formation from PP strongly depends on temp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08436
更新日期:2015-02-13 00:00:00
abstract::Here we proposed a novel architectural design of a ternary MnO2-based electrode - a hierarchical Co3O4@Pt@MnO2 core-shell-shell structure, where the complemental features of the three key components (a well-defined Co3O4 nanowire array on the conductive Ti substrate, an ultrathin layer of small Pt nanoparticles, and a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02978
更新日期:2013-10-17 00:00:00
abstract::Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33748-6
更新日期:2018-10-18 00:00:00
abstract::Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37051-2
更新日期:2019-01-24 00:00:00
abstract::Lack of standardization and unblinding threaten the research of mechanisms involved in expectancy effects on pain. We evaluated a computer-controlled virtual experimenter (VEx) to avoid these issues. Fifty-four subjects underwent a baseline-retest heat pain protocol. Between sessions, they received an expectancy manip...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77453-9
更新日期:2020-11-23 00:00:00
abstract::The common facets of anatase crystals are the (001) and (101) planes. However, the phase transformation from lepidocrocite-type titanate into anatase by hydrothermal processing yields an anatase microstructure with high concentration of exposed (010) planes. The phase transformation of a lepidocrocite-type protonated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04584
更新日期:2014-04-03 00:00:00
abstract::Traumatic brain injury (TBI) causes brain edema that induces increased intracranial pressure and decreased cerebral perfusion. Decompressive craniectomy has been recommended as a surgical procedure for the management of swollen brain and intracranial hypertension. Proper location and size of a decompressive craniectom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75479-7
更新日期:2020-10-29 00:00:00