The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols.

Abstract:

:The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Filippi F,Somigliana E,Busnelli A,Guarneri C,Noli S,Restelli L,Vercellini P

doi

10.1038/s41598-020-67151-x

subject

Has Abstract

pub_date

2020-06-22 00:00:00

pages

10083

issue

1

issn

2045-2322

pii

10.1038/s41598-020-67151-x

journal_volume

10

pub_type

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