Immune cell type, cell activation, and single cell heterogeneity revealed by label-free optical methods.

abstract：:Three-dimensional (3D) remote imaging attracts increasing attentions in capturing a target's characteristics. Although great progress for 3D remote imaging has been made with methods such as scanning imaging lidar and pulsed floodlight-illumination imaging lidar, either the detection range or application mode are limi...

journal_title：Scientific reports

authors： Gong W,Zhao C,Yu H,Chen M,Xu W,Han S

更新日期：2016-05-17 00:00:00

abstract：:In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...

journal_title：Scientific reports

authors： Mohammadi I,Shahrabi T,Mahdavian M,Izadi M

更新日期：2020-03-19 00:00:00

abstract：:Inelastic electron tunneling spectroscopy is a powerful technique for investigating lattice dynamics of nanoscale systems including graphene and small molecules, but establishing a stable tunnel junction is considered as a major hurdle in expanding the scope of tunneling experiments. Hexagonal boron nitride is a pivot...

journal_title：Scientific reports

authors： Jung S,Park M,Park J,Jeong TY,Kim HJ,Watanabe K,Taniguchi T,Ha DH,Hwang C,Kim YS

更新日期：2015-11-13 00:00:00

abstract：:A new family of 99mTc(I)- tricarbonyl complexes and 125I-heteroaromatic compounds bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy. Characterization of the DNA interaction, performed with the non-radioactive Re and 127I congeners, confirmed that all compounds act as DNA intercalators....

journal_title：Scientific reports

authors： Pereira E,do Quental L,Palma E,Oliveira MC,Mendes F,Raposinho P,Correia I,Lavrado J,Di Maria S,Belchior A,Vaz P,Santos I,Paulo A

更新日期：2017-02-13 00:00:00

abstract：:Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and al...

journal_title：Scientific reports

authors： Sookrung N,Reamtong O,Poolphol R,Indrawattana N,Seesuay W,Saelim N,Tantilipikorn P,Bunnag C,Chaicumpa W,Tungtrongchitr A

更新日期：2018-01-11 00:00:00

abstract：:Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression wa...

journal_title：Scientific reports

authors： Zhang SF,Chen JC,Zhang J,Xu JG

更新日期：2017-08-16 00:00:00

abstract：:An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...

journal_title：Scientific reports

authors： Kozakai Y,Kamada R,Furuta J,Kiyota Y,Chuman Y,Sakaguchi K

更新日期：2016-09-13 00:00:00

abstract：:The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on HBV infection. A chronic HBV ...

journal_title：Scientific reports

authors： Tong S,Liu G,Li M,Li X,Liu Q,Peng H,Li S,Ren H,Yin W

更新日期：2017-03-22 00:00:00

abstract：:The genetics underlying autism spectrum disorder (ASD) are complex. Approximately 3-5% of ASD cases arise from maternally inherited duplications of 15q11.2-q13.1, termed Duplication 15q syndrome (Dup15q). 15q11.2-q13.1 includes the gene UBE3A which is believed to underlie ASD observed in Dup15q syndrome. UBE3A is an E...

journal_title：Scientific reports

authors： Hope KA,McGinn A,Reiter LT

更新日期：2019-02-20 00:00:00

abstract：:Compression of optical pulses to ultrashort pulse widths using methods of nonlinear optics is a well-established technology of modern laser science. Extending these methods to pulses with high peak powers, which become available due to the rapid progress of laser technologies, is, however, limited by the universal phy...

journal_title：Scientific reports

authors： Voronin AA,Zheltikov AM

更新日期：2017-04-03 00:00:00

abstract：:The structural and magnetic properties of seven CeMn2Ge(2-x)Six compounds with x = 0.0-2.0 have been investigated in detail. Substitution of Ge with Si leads to a monotonic decrease of both a and c along with concomitant contraction of the unit cell volume and significant modifications of the magnetic states - a cross...

journal_title：Scientific reports

authors： Md Din MF,Wang JL,Cheng ZX,Dou SX,Kennedy SJ,Avdeev M,Campbell SJ

更新日期：2015-06-19 00:00:00

abstract：:Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...

journal_title：Scientific reports

authors： Cools P,van de Wijgert JHHM,Jespers V,Crucitti T,Sanders EJ,Verstraelen H,Vaneechoutte M

更新日期：2017-10-23 00:00:00

abstract：:Towards exploring advanced applications of terahertz (THz) electromagnetic waves, great efforts are being applied to develop a compact and sensitive THz receiver. Here, we propose a simple coherent detection system using a single resonant tunnelling diode (RTD) oscillator through self-oscillating mixing with an RTD os...

journal_title：Scientific reports

authors： Nishida Y,Nishigami N,Diebold S,Kim J,Fujita M,Nagatsuma T

更新日期：2019-12-02 00:00:00

abstract：:This study analyzed hourly mass concentration observations of PM2.5 (particulate matters with diameter less than 2.5 μm) at 512 stations in China from December 2013 to May 2015. We found that the mean concentrations of PM2.5 during the winter and spring of 2015 Dec. 2014 to Feb. 2015 and Mar. 2015 to May 2015) decreas...

journal_title：Scientific reports

authors： Wang X,Wang K,Su L

更新日期：2016-11-02 00:00:00

abstract：:Owing to the growing infectious diseases caused by eukaryotic and prokaryotic pathogens, it is urgent to develop novel antimicrobial agents against clinical pathogenic infections. Biofilm formation and invasion into the host cells are vital processes during pathogenic colonization and infection. In this study, we test...

journal_title：Scientific reports

authors： Yu Q,Li J,Zhang Y,Wang Y,Liu L,Li M

更新日期：2016-05-25 00:00:00

abstract：:We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5' and 3' LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells. Comprehensive assessment of whole-genome sequencing of HIV-1 eradicated cells ruled out any off-target ...

journal_title：Scientific reports

authors： Kaminski R,Chen Y,Fischer T,Tedaldi E,Napoli A,Zhang Y,Karn J,Hu W,Khalili K

更新日期：2016-03-04 00:00:00

abstract：:MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patien...

journal_title：Scientific reports

authors： Lutz P,M Haimid M,Pohlmann A,Lehmann J,Jansen C,Schierwagen R,Klein S,Strassburg CP,Spengler U,Trebicka J

更新日期：2017-01-11 00:00:00

abstract：:Swarming bacteria are an example of a complex, active biological system, where high cell density and super-diffusive cell mobility confer survival advantages to the group as a whole. Previous studies on the dynamics of the swarm have been limited to easily observable regions at the advancing edge of the swarm where ce...

journal_title：Scientific reports

authors： Partridge JD,Ariel G,Schvartz O,Harshey RM,Be'er A

更新日期：2018-10-25 00:00:00

abstract：:Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...

journal_title：Scientific reports

authors： Mackenzie LE,Goode JA,Vakurov A,Nampi PP,Saha S,Jose G,Millner PA

更新日期：2018-01-18 00:00:00

abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...

journal_title：Scientific reports

authors： Bhandare VV,Kumbhar BV,Kunwar A

更新日期：2019-07-25 00:00:00

abstract：:Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...

journal_title：Scientific reports

authors： Zhao YR,Li X,Yu KQ,Cheng F,He Y

更新日期：2016-06-10 00:00:00

abstract：:Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD molecules, and thus we tested for visualization of the intrac...

journal_title：Scientific reports

authors： Kaji T,Koga H,Kuroha M,Akimoto T,Hayata K

更新日期：2020-02-20 00:00:00

abstract：:The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling. We utilized functional magnetic resonance imaging on NaV1.8-deficient (NaV1.8-/-) compared with wildtype (WT) mice to identify brain struct...

journal_title：Scientific reports

authors： Heindl-Erdmann C,Zimmermann K,Reeh P,Brune K,Hess A

更新日期：2017-04-03 00:00:00

abstract：:The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple tissues where its function is critical in establishing and maintaining epithelial integrity. Here, we analysed awd gene function in Drosophila epithelial cells using transgene-mediated RNA i...

journal_title：Scientific reports

authors： Romani P,Duchi S,Gargiulo G,Cavaliere V

更新日期：2017-12-04 00:00:00

abstract：:In community ecology, it is important to understand the distribution of communities along environmental and spatial gradients. However, it is common for the residuals of models investigating those relationships to be very high (> 50%). It is believed that species' intrinsic characteristics such as rarity can contribut...

journal_title：Scientific reports

authors： Brasil LS,Vieira TB,Andrade AFA,Bastos RC,Montag LFA,Juen L

更新日期：2020-11-13 00:00:00

abstract：:The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse eff...

journal_title：Scientific reports

authors： Ong HS,Tey KY,Ke M,Tan B,Chua J,Schmetterer L,Mehta JS,Ang M

更新日期：2021-01-13 00:00:00

abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

journal_title：Scientific reports

authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

更新日期：2017-01-17 00:00:00

abstract：:GSK3α has been identified as a new target in the treatment of acute myeloid leukemia (AML). However, most GSK3 inhibitors lack specificity for GSK3α over GSK3β and other kinases. We have previously shown in lung cancer cells that GSK3α and to a lesser extent GSK3β are inhibited by the advanced clinical candidate tivan...

journal_title：Scientific reports

authors： Kuenzi BM,Remsing Rix LL,Kinose F,Kroeger JL,Lancet JE,Padron E,Rix U

更新日期：2019-01-24 00:00:00

abstract：:Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and caly...

journal_title：Scientific reports

authors： Lin PL,Li ZC,Xie RF,Wang YH,Zhou X

更新日期：2017-03-22 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...

journal_title：Scientific reports

authors： Wang Y,Zhang Z,Ji D,Chen GF,Feng X,Gong LL,Guo J,Li ZW,Chen CF,Zhao BB,Li ZG,Li QJ,Yan HP,Sempowski G,Wang FS,He YW

更新日期：2015-07-22 00:00:00