Abstract:
:Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg/mL against influenza virus A/WSN/33. TDSWex had excellent antiviral efficacy against various strains of human influenza A and B viruses, particularly oseltamivir-resistant clinical isolates and a swine-origin influenza strain. We observed that the synthesis of viral RNA and protein were inhibited in the presence of TDSWex. The results of the time-of-addition assay suggested that TDSWex inhibited viral entry and budding. In the hemagglutination inhibition assay, TDSWex inhibited the hemagglutination of red blood cells, implying that the extract targeted hemagglutin-related functions such as viral entry. In the attachment and penetration assay, TDSWex showed antiviral activity with EC50s of 0.045 ± 0.026 and 0.012 ± 0.003 mg/mL, respectively. In addition, TDSWex blocked neuraminidase activity. We conclude that TDSWex has bimodal activities against both hemagglutinin and neuraminidase during viral replication.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hsieh CF,Chen YL,Lin CF,Ho JY,Huang CH,Chiu CH,Hsieh PW,Horng JTdoi
10.1038/srep36015subject
Has Abstractpub_date
2016-10-31 00:00:00pages
36015issn
2045-2322pii
srep36015journal_volume
6pub_type
杂志文章abstract::Epstein-Barr virus-encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs consistently expressed in all EBV infected cells, but their function remains poorly understood. Conventional in situ hybridization studies have indicated that these RNAs are present exclusively in the nucleus. We have re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33758-4
更新日期:2018-10-18 00:00:00
abstract::NGS (Next Generation Sequencing) technologies allows us to determine key gene expression signatures that correlate with resistance (and responsiveness) to anti-cancer therapeutics. We have undertaken a transcriptomic and chromatin immunoprecipitation followed by sequencing (ChIP-seq) approach to describe differences i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41672-6
更新日期:2019-03-26 00:00:00
abstract::Captive breeding programs and aquaculture production have commenced worldwide for the globally distributed yellowtail kingfish (Seriola lalandi), and captive bred fingerlings are being shipped from the Southern Hemisphere to be farmed in the Northern Hemisphere. It was recently proposed that Pacific S. lalandi compris...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07419-x
更新日期:2017-08-24 00:00:00
abstract::Metamagnetism occuring inside a ferromagnetic phase is peculiar. Therefore, Sr4Ru3O10, a T C = 105 K ferromagnet, has attracted much attention in recent years, because it develops a pronounced metamagnetic anomaly below T C for magnetic fields applied in the crystallographic ab-plane. The metamagnetic transition move...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03648-2
更新日期:2017-06-20 00:00:00
abstract::Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by the SFTS phlebovirus (SFTSV). SFTS patients were first reported in China, followed by Japan and South Korea. In 2017, cats were diagnosed with SFTS for the first time, suggesting that these animals are susceptible to SFTSV. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48317-8
更新日期:2019-08-19 00:00:00
abstract::Changes associated with cognitive function in the high-fat high-carbohydrate diet-induced prediabetes animal model and effect of exercise remain unclear. Rats were randomly assigned to the following groups (n = 6): non-diabetic (ND), prediabetic (PD), intermittent exercising PD (PD + IE) and regular exercising PD (PD ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72098-0
更新日期:2020-09-14 00:00:00
abstract::The circuit complexity of quantum qubit system evolution as a primitive problem in quantum computation has been discussed widely. We investigate this problem in terms of qudit system. Using the Riemannian geometry the optimal quantum circuits are equivalent to the geodetic evolutions in specially curved parametrizatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04044
更新日期:2014-02-10 00:00:00
abstract::In this paper, we present an evolutionary trust game, taking punishment and protection into consideration, to investigate the formation of trust in the so-called sharing economy from a population perspective. This sharing economy trust model comprises four types of players: a trustworthy provider, an untrustworthy pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55384-4
更新日期:2019-12-24 00:00:00
abstract::Fungi play a key role in the functioning of soil in terrestrial ecosystems, and in particular in the remediation of degraded soils. The contribution of fungi to carbon and nutrient cycles, along with their capability to mobilise soil trace elements, is well-known. However, the importance of life history strategy for t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63194-2
更新日期:2020-04-15 00:00:00
abstract::Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium-hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurodegeneration. Little...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60262-5
更新日期:2020-02-27 00:00:00
abstract::Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42205-x
更新日期:2019-04-10 00:00:00
abstract::Efficient control of magnetism with electric means is a central issue of current spintronics research, which opens an opportunity to design integrated spintronic devices. However, recent well-studied methods are mostly based on electric-current injection, and they are inevitably accompanied by considerable energy loss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46009-x
更新日期:2019-07-02 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57947-2
更新日期:2020-01-30 00:00:00
abstract::We report highly efficient continuous-wave terahertz (THz) photoconductive antenna based photomixer employing nano-gap electrodes in the active region. The tip-to-tip nano-gap electrode structure provides strong THz field enhancement and acts as a nano-antenna to radiate the THz wave generated in the active region of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02824
更新日期:2013-10-08 00:00:00
abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16219
更新日期:2015-11-18 00:00:00
abstract::Saccharomyces cerevisiae is a robust host for heterologous protein expression. The efficient expression of cellulases in S. cerevisiae is important for the consolidated bioprocess that directly converts lignocellulose into valuable products. However, heterologous proteins are often N-hyperglycosylated in S. cerevisiae...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25654
更新日期:2016-05-09 00:00:00
abstract::The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29940
更新日期:2016-07-15 00:00:00
abstract::The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00248
更新日期:2012-01-01 00:00:00
abstract::Biological sulfate-reducing bacteria (SRB) may be effective in removing toxic lead and mercury ions (Pb(II) and Hg(II)) from wet flue gas desulfurization (FGD) wastewater through anaerobic sulfite reduction. To confirm this hypothesis, a sulfite-reducing up-flow anaerobic sludge blanket reactor was set up to treat FGD...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30455
更新日期:2016-07-26 00:00:00
abstract::Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45661
更新日期:2017-03-30 00:00:00
abstract::In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33180
更新日期:2016-09-12 00:00:00
abstract::MicroRNAs play critical role in the development and progression of various diseases. Predicting potential miRNA-disease associations from vast amount of biological data is an important problem in the biomedical research. Considering the limitations in previous methods, we developed Regularized Least Squares for MiRNA-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05501
更新日期:2014-06-30 00:00:00
abstract::A novel design of thin-film crystalline silicon solar cell (TF C-Si-SC) is proposed and numerically analyzed. The reported SC has 1.0 µm thickness of C-Si with embedded dielectric silicon dioxide nanowires (NWs). The introduced NWs increase the light scattering in the active layer which improves the optical path lengt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74453-7
更新日期:2020-10-16 00:00:00
abstract::An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 °C on multiple length ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23137
更新日期:2016-03-16 00:00:00
abstract::Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45514-3
更新日期:2019-06-20 00:00:00
abstract::We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22025
更新日期:2016-02-25 00:00:00
abstract::A simple, economically viable and fast method has been utilized for the preparation of highly active metal nanoparticles (MNPs) in coating layer of chitosan (CH) over cellulose microfibers of cotton cloth (CC). 2 wt% of CH solution was used for the coating of CC strips (CC-CH), and were kept in aqueous solutions of me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16815-2
更新日期:2017-12-05 00:00:00
abstract::Diabetes mellitus (DM) exhibits a higher sensitivity to myocardial ischemia/reperfusion (I/R) injury and may compromise the effectiveness of cardioprotective interventions, including ischemic preconditioning. We previously found that liver ischemic preconditioning (RLIPC) could limit infarct size post I/R in non-diabe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81422-1
更新日期:2021-01-21 00:00:00
abstract::Aneuploidy has been reported to occur at remarkably high levels in normal somatic tissues using Fluorescence In Situ Hybridization (FISH). Recently, these reports were contradicted by single-cell low-coverage whole genome sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46606-w
更新日期:2019-07-19 00:00:00
abstract::There is a need for noninvasive repeatable biomarkers to detect early cancer treatment response and spare non-responders unnecessary morbidities and costs. Here, we introduce three-dimensional (3D) dynamic contrast enhanced ultrasound (DCE-US) perfusion map characterization as inexpensive, bedside and longitudinal ind...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63810-1
更新日期:2020-04-24 00:00:00