Abstract：
:Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that miRNA might be released to participate in cell-to-cell communication. Despite its importance of extracellular miRNA, the molecular mechanisms by which miRNA can be stored in vesicles and released by vesicle fusion remain enigmatic. Using next-generation sequencing, vesicle purification techniques, and synthetic neurotransmission, we observe that large dense-core vesicles (LDCVs) contain a variety of miRNAs including miR-375. Furthermore, miRNA exocytosis is mediated by the SNARE complex and accelerated by Ca2+. Our results suggest that miRNA can be a novel neuromodulator that can be stored in vesicles and released by vesicle fusion together with classical neurotransmitters.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gümürdü A,Yildiz R,Eren E,Karakülah G,Ünver T,Genç Ş,Park Ydoi
10.1038/srep45661subject
Has Abstractpub_date
2017-03-30 00:00:00pages
45661issn
2045-2322pii
srep45661journal_volume
7pub_type
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更新日期：2017-03-06 00:00:00
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pub_type： 已发布勘误
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