Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.

abstract：:Next Generation Sequencing is dramatically increasing the number of known protein sequences, with related experimentally determined protein structures lagging behind. Structural bioinformatics is attempting to close this gap by developing approaches that predict structure-level characteristics for uncharacterized prot...

journal_title：Scientific reports

authors： Orlando G,Raimondi D,Vranken WF

更新日期：2016-11-18 00:00:00

abstract：:Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic s...

journal_title：Scientific reports

authors： Xie D,Zhao J,Guo R,Jiao L,Zhang Y,Lau WB,Lopez B,Christopher T,Gao E,Cao J,Ma X,Wang Y

更新日期：2020-01-08 00:00:00

abstract：:Epstein-Barr virus-encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs consistently expressed in all EBV infected cells, but their function remains poorly understood. Conventional in situ hybridization studies have indicated that these RNAs are present exclusively in the nucleus. We have re...

journal_title：Scientific reports

authors： Ahmed W,Tariq S,Khan G

更新日期：2018-10-18 00:00:00

abstract：:Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. Little is known about flicker-induced changes of activity of retinal neurons themselves. We non-invasively investigated flicker-induc...

journal_title：Scientific reports

authors： Chou TH,Toft-Nielsen J,Porciatti V

更新日期：2019-12-05 00:00:00

abstract：:Tandem solar cells are suited for space applications due to their high performance, but also have to be designed in such a way to minimize influence of degradation by the high energy particle flux in space. The analysis of the subcell performance is crucial to understand the device physics and achieve optimized design...

journal_title：Scientific reports

authors： Tex DM,Nakamura T,Imaizumi M,Ohshima T,Kanemitsu Y

更新日期：2017-05-16 00:00:00

abstract：:Efficiently detecting and characterizing individual spins in solid-state hosts is an essential step to expand the fields of quantum sensing and quantum information processing. While selective detection and control of a few 13C nuclear spins in diamond have been demonstrated using the electron spin of nitrogen-vacancy ...

journal_title：Scientific reports

authors： Oh H,Yun J,Abobeih MH,Jung KH,Kim K,Taminiau TH,Kim D

更新日期：2020-09-10 00:00:00

abstract：:Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. The...

journal_title：Scientific reports

authors： Lewis MC,Merrifield CA,Berger B,Cloarec O,Duncker S,Mercenier A,Nicholson JK,Holmes E,Bailey M

更新日期：2017-07-13 00:00:00

abstract：:Rare earths, e.g. neodymium (Nd), praseodymium (Pr) and dysprosium (Dy), are abundant in the rare earth sintered magnet scrap (Nd-Fe-B scrap), but their recycling is tedious and costly due to the high content of impurity Fe. Herein, a novel approach was developed to effectively recycle rare earths from the scrap via a...

journal_title：Scientific reports

authors： Lin X,Qu Z,Chen Y,Jin R,Su T,Yu Y,Zhu S,Huo M,Peng J,Wang Z

更新日期：2019-12-04 00:00:00

abstract：:Transport of self-propelled particles in a two-dimensional (2D) separate channel is investigated in the presence of the combined forces. By applying an ac force, the particles will be trapped by the separate walls. A dc force produces the asymmetry of the system and induces the longitudinal directed transport. Due to ...

journal_title：Scientific reports

authors： Wu JC,Ai BQ

更新日期：2016-04-01 00:00:00

abstract：:We investigated the dynamics of the interaction between spin-polarized photo-created carriers and Mn ions on InGaAs/GaAs: Mn structures. The carriers are confined in an InGaAs quantum well and the Mn ions come from a Mn delta-layer grown at the GaAs barrier close to the well. Even though the carriers and the Mn ions a...

journal_title：Scientific reports

authors： Balanta MA,Brasil MJ,Iikawa F,Mendes UC,Brum JA,Danilov YA,Dorokhin MV,Vikhrova OV,Zvonkov BN

更新日期：2016-04-15 00:00:00

abstract：:Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The...

journal_title：Scientific reports

authors： Yu M,Jia HM,Zhou C,Yang Y,Sun LL,Zou ZM

更新日期：2017-04-20 00:00:00

abstract：:Deubiquitinase MYSM1 has been shown to play a critical role in hematopoietic cell differentiation and hematopoietic stem cell (HSC) maintenance. Mesenchymal stem cells (MSCs) are multipotent stromal cells within the bone marrow. MSCs are progenitors to osteoblasts, chondrocytes, adipocytes, and myocytes. Although, MSC...

journal_title：Scientific reports

authors： Li P,Yang YM,Sanchez S,Cui DC,Dang RJ,Wang XY,Lin QX,Wang Y,Wang C,Chen DF,Chen SY,Jiang XX,Wen N

更新日期：2016-02-26 00:00:00

abstract：:It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...

journal_title：Scientific reports

authors： Li FF,Liu BL,Yin GP,Zhang DF,Zhai XF,Chen MY,Su XF,Wu JD,Ye L,Ma JH

更新日期：2017-11-27 00:00:00

abstract：:Deconvolution is widely used to improve the contrast and clarity of a 3D focal stack collected using a fluorescence microscope. But despite being extensively studied, deconvolution algorithms can introduce reconstruction artifacts when their underlying noise models or priors are violated, such as when imaging biologic...

journal_title：Scientific reports

authors： Ikoma H,Broxton M,Kudo T,Wetzstein G

更新日期：2018-07-31 00:00:00

abstract：:Arterial/venous thrombosis is the major cardiovascular disorder accountable for substantial mortality; and the current demand for antithrombotic agents is extensive. Heparinases depolymerize unfractionated heparin (UFH) for the production of low molecular-weight heparins (LMWHs; used as anticoagulants against thrombos...

journal_title：Scientific reports

authors： Singh V,Haque S,Kumari V,El-Enshasy HA,Mishra BN,Somvanshi P,Tripathi CKM

更新日期：2019-04-24 00:00:00

abstract：:The human pathogen Legionella pneumophila delivers a large array of the effector proteins into host cells using the Dot/Icm type IVB secretion system. Among the proteins composing the Dot/Icm system, an inner membrane protein DotI is known to be crucial for the secretion function but its structure and role in type IV ...

journal_title：Scientific reports

authors： Kuroda T,Kubori T,Thanh Bui X,Hyakutake A,Uchida Y,Imada K,Nagai H

更新日期：2015-06-03 00:00:00

abstract：:Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTLV-1-infected T-cells after a long infection period. To examine the mechanism of ...

journal_title：Scientific reports

authors： Sarkar B,Nishikata I,Nakahata S,Ichikawa T,Shiraga T,Saha HR,Fujii M,Tanaka Y,Shimoda K,Morishita K

更新日期：2019-03-05 00:00:00

abstract：:The spreading of cooperation in structured population is a challenging problem which can be observed at different scales of social and biological organization. Generally, the problem is studied by evaluating the chances that few initial invading cooperators, randomly appearing in a network, can lead to the spreading o...

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2021-01-13 00:00:00

abstract：:Osteoarthritis (OA) is characterized by a slowly progressing, irreversible loss of articular cartilage. Tissue engineering approaches for cartilage regeneration include stem cell-based strategies but not much is known about their repair capacity in an OA microenvironment. The aim of the present study was to identify f...

journal_title：Scientific reports

authors： Mayer U,Benditz A,Grässel S

更新日期：2017-10-16 00:00:00

abstract：:Polymer derived ceramic (PDC) composite coatings were deposited on AISI 304 substrates using siloxane based preceramic polymer polymethlysilsquioxane (PMS) and ZrSi2 as active filler or Ag as passive filler. The tribological performance of the composite coatings was evaluated at room temperature and moderately high te...

journal_title：Scientific reports

authors： Alvi SA,Akhtar F

更新日期：2018-10-10 00:00:00

abstract：:Investigation of climatic conditions prior to the Sturtian glaciations is critical to understanding the trigger mechanism for the series of Neoproterozoic global glaciations. In this study, we report high-resolution chemical index of alteration (CIA) records in the sediments of South China prior to the Sturtian glacia...

journal_title：Scientific reports

authors： Huang J,Feng L,Lu D,Zhang Q,Sun T,Chu X

更新日期：2014-10-31 00:00:00

abstract：:The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of pa...

journal_title：Scientific reports

authors： Lee PC,Chiou YY,Chiu NC,Chen PH,Liu CA,Kao WY,Huo TI,Huang YH,Hou MC,Lin HC,Wu JC,Su CW

更新日期：2020-02-06 00:00:00

abstract：:Recently, a concept of digital metamaterials has been proposed to manipulate field distribution through proper spatial mixtures of digital metamaterial bits. Here, we present a design of 2-bit digitally-controlled coding metasurface that can effectively modulate the scattered electromagnetic wave and realize different...

journal_title：Scientific reports

authors： Huang C,Sun B,Pan W,Cui J,Wu X,Luo X

更新日期：2017-02-08 00:00:00

abstract：:A novel suite of instrumentation for the characterisation of materials held inside an air-tight tube furnace operated up to 250 °C has been developed. Real-time detection of released gases (volatile organic compounds (VOCs), CO2, NO, NO2, SO2, CO and O2) was achieved combining commercial off-the-shelf (COTS) gas senso...

journal_title：Scientific reports

authors： Lourenço C,Bergin S,Hodgkinson J,Francis D,Staines SE,Saffell JR,Walton C,Tatam RP

更新日期：2020-05-26 00:00:00

abstract：:Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. ...

journal_title：Scientific reports

authors： Deluyker D,Ferferieva V,Driesen RB,Verboven M,Lambrichts I,Bito V

更新日期：2017-11-22 00:00:00

abstract：:Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...

journal_title：Scientific reports

authors： Tsukamoto S,Mizuta T,Fujimoto M,Ohte S,Osawa K,Miyamoto A,Yoneyama K,Murata E,Machiya A,Jimi E,Kokabu S,Katagiri T

更新日期：2014-12-23 00:00:00

abstract：:Fresh produce vegetables are colonized by different bacterial species, some of which are antagonistic to microbes that cause postharvest losses. However, no comprehensive assessment of the diversity and composition of bacteria inhabiting surfaces of fresh pepper plants grown under different conditions has been conduct...

journal_title：Scientific reports

authors： Mamphogoro TP,Maboko MM,Babalola OO,Aiyegoro OA

更新日期：2020-05-22 00:00:00

abstract：:In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis remains a life-threatening condition for which highly effective treatment is still lacking. Towards improving the success-rate of bench-to-bedside translation, we investigated in vivo µCT-derived biomarkers to repeatedly q...

journal_title：Scientific reports

authors： Dekoster K,Decaesteker T,Berghen N,Van den Broucke S,Jonckheere AC,Wouters J,Krouglov A,Lories R,De Langhe E,Hoet P,Verbeken E,Vanoirbeek J,Vande Velde G

更新日期：2020-09-30 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) can be beneficial for improving restoration of radioactive-cesium (137Cs)-contaminated soils through soil remediation. However, there has been no information on species diversity and the composition of AMF communities in 137Cs-contaminated soil after the Fukushima-Daiichi Nuclear Pow...

journal_title：Scientific reports

authors： Higo M,Kang DJ,Isobe K

更新日期：2019-06-03 00:00:00

abstract：:Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...

journal_title：Scientific reports

authors： Xue H,Jiang Y,Yuan K,Yang T,Hou J,Cao C,Feng K,Wang X

更新日期：2016-07-19 00:00:00