Abstract:
:The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of patients with HCC after RFA. We prospectively enrolled 173 patients with HCC who underwent ARFI elastography for measurement of LS and SS on the same day of RFA. Overall survival (OS), recurrence-free survival (RFS) after adjusting for competing mortality, and presence of hepatic decompensation were investigated. Patients with LS > 1.5 m/s had significantly shorter OS and RFS than their counterparts. Anti-viral treatment (hazard ratio [HR]: 0.396, p = 0.015) and LS > 1.5 m/s (HR 4.105, p = 0.028) correlated with OS by a multivariate analysis. Besides, serum alpha fetoprotein >10 ng/mL and LS > 1.5 m/s independently predicted poorer RFS. On the other hand, anti-viral treatment (HR: 0.315, p = 0.010), creatinine > 1.5 mg/dL (HR: 9.447, p = 0.006), and SS > 2.7 m/s (HR: 2.869, p = 0.044) predicted a higher risk of hepatic decompensation. In conclusion, LS but not SS measured by ARFI elastography predicted tumor recurrence and OS in RFA-treated HCC; whereas, SS predicted development of hepatic decompensation in these patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee PC,Chiou YY,Chiu NC,Chen PH,Liu CA,Kao WY,Huo TI,Huang YH,Hou MC,Lin HC,Wu JC,Su CWdoi
10.1038/s41598-020-58988-3subject
Has Abstractpub_date
2020-02-06 00:00:00pages
2006issue
1issn
2045-2322pii
10.1038/s41598-020-58988-3journal_volume
10pub_type
杂志文章abstract::It is critical to understand how variations in chemical composition in surface seawater (SSW) affect the chemistry of marine atmospheric aerosols. We investigated the sea-to-air transfer of dissolved organic carbon (DOC) via cruise measurements of both ambient aerosols and SSW in the Oyashio and its coastal regions, t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32864-7
更新日期:2018-10-05 00:00:00
abstract::Poly(N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-base...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63228-9
更新日期:2020-04-09 00:00:00
abstract::The networks of predator-prey interactions in ecological systems are remarkably complex, but nevertheless surprisingly stable in terms of long term persistence of the system as a whole. In order to understand the mechanism driving the complexity and stability of such food webs, we developed an eco-evolutionary model i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10955
更新日期:2015-06-04 00:00:00
abstract::Surgical treatment of tendon lesions still yields unsatisfactory clinical outcomes. The use of bioresorbable scaffolds represents a way forward to improve tissue repair. Scaffolds for tendon reconstruction should have a structure mimicking that of the natural tendon, while providing adequate mechanical strength and st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35536-8
更新日期:2018-11-21 00:00:00
abstract::Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05568-7
更新日期:2017-07-11 00:00:00
abstract::Metal-organic frameworks (MOFs) formed from metals and organic ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing Ca and Sr ions. In this manuscript, the ability of MOFs to degrade and release osteogenic Ca and Sr ions was investigated. MOFs were generated by choosing os...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49536-9
更新日期:2019-09-10 00:00:00
abstract::Long non-coding RNAs (lncRNAs) regulate expression of protein-coding genes in cis through chromatin modifications including DNA methylation. Here we interrogated whether lncRNA genes may regulate transcription and methylation of their flanking or overlapping protein-coding genes in livers of mice exposed to a 12-week ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29993-4
更新日期:2018-08-01 00:00:00
abstract::The Sinorhizobium meliloti (S. meliloti) strain CCNWSX0020 displayed tolerance to high levels exposures of multiple metals and growth promotion of legume plants grown in metal-contaminated soil. However, the mechanism of metal-resistant strain remains unknown. We used five P1B-ATPases deletions by designating as ∆copA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29355
更新日期:2016-07-05 00:00:00
abstract::Even when speakers are not actively doing another task, they can be interfered in their speech planning by concurrent auditory stimuli. In this study, we used picture naming with passive hearing, or active listening, combined to high-density electroencephalographic (EEG) recordings to investigate the locus and origin ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41752-7
更新日期:2019-03-29 00:00:00
abstract::Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and selectively activated using light, has emerged as an appealing alternative to traditional cancer chemotherapy. Yet to date, PDT efficacy has been mostly characterized using 2D cultures. Compared to 2D cultures, 3D sphere culture gener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12175
更新日期:2015-07-08 00:00:00
abstract::Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but als...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46495
更新日期:2017-04-28 00:00:00
abstract::Adropin is a peptide hormone encoded by the Energy Homeostasis Associated (ENHO) gene whose physiological role in humans remains incompletely defined. Here we investigated the impact of dietary interventions that affect systemic glucose and lipid metabolism on plasma adropin concentrations in humans. Consumption of gl...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep14691
更新日期:2015-10-05 00:00:00
abstract::The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy surface colonisation. This study was designed to analyse the surface epibiome of F. vesiculosus in conjunction with the composition and spatial distribution of its surface metabolome. The amplicon sequencing, SEM and CARD-FISH ima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37914-8
更新日期:2019-01-31 00:00:00
abstract::Sporadic outbreaks caused by coxsackievirus A4 (CV-A4) have been reported worldwide. To further elucidate the detailed genetic characteristics and evolutionary recombination events of CV-A4, virus samples from nationwide hand, foot and mouth disease (HFMD) surveillance, encompassing 27 out of the 31 provinces in China...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49859-7
更新日期:2019-09-20 00:00:00
abstract::2-(1-Undecyloxy)-1-ethanol, monochamol, is a male-produced aggregation pheromone of the Monochamus species, which are efficient vectors of the pine wood nematode (PWN), Bursaphelenchus xylophilus, which cause devastating damage to pines worldwide. The nematicidal activity of synthetic monochamol and its homologues (RO...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29300
更新日期:2016-07-11 00:00:00
abstract::We propose a homomorphic search protocol based on quantum homomorphic encryption, in which a client Alice with limited quantum ability can give her encrypted data to a powerful but untrusted quantum server and let the server search for her without decryption. By outsourcing the interactive key-update process to a trus...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61791-9
更新日期:2020-03-20 00:00:00
abstract::In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29670
更新日期:2016-07-18 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12159
更新日期:2015-07-22 00:00:00
abstract::Rs1042522 (Arg72Pro) is a functional polymorphism of TP53. Pro72 has been associated with lower all-cause mortality and lower mortality after cancer. We hypothesized that TP53 Pro72 is associated with lower mortality after cancer, lower all-cause mortality, and with increased cancer incidence in the general population...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00427-x
更新日期:2017-03-23 00:00:00
abstract::In spite of intensive investigations, the role of spontaneous breathing (SB) activity in ARDS has not been well defined yet and little has been known about the different contribution of inspiratory or expiratory muscles activities during mechanical ventilation in patients with ARDS. In present study, oleic acid-induce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42785
更新日期:2017-02-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-49306-7
更新日期:2019-09-03 00:00:00
abstract::Generation and manipulation of quantum entangled electrons is an important concept in quantum mechanics, and necessary for advances in quantum information processing; but not yet established in solid state systems. A promising device is a superconductor-two quantum dots Cooper pair splitter. Early nanowire based devic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23051
更新日期:2016-03-14 00:00:00
abstract::Metal-organic frameworks (MOFs) are intriguing host materials in composite electrolytes due to their ability for tailoring host-guest interactions by chemical tuning of the MOF backbone. Here, we introduce particularly high sodium ion conductivity into the zeolitic imidazolate framework ZIF-8 by impregnation with the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60198-w
更新日期:2020-02-26 00:00:00
abstract::Emission of the trace gas dimethylsulphide (DMS) from the ocean influences the chemical and optical properties of the atmosphere, and the olfactory landscape for foraging marine birds, turtles and mammals. DMS concentration has been seen to vary across seasons and latitudes with plankton taxonomy and activity, and fol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32325
更新日期:2016-08-31 00:00:00
abstract::The existing molecular cloning methods are often limited by the availability of suitable restriction sites. It is still a challenge for simultaneous cloning of multiple fragments into different sites of a single vector. Here we developed a novel method named improved overlap extension PCR (IOEP) for restriction enzyme...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52122-8
更新日期:2019-10-30 00:00:00
abstract::Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59179-w
更新日期:2020-02-26 00:00:00
abstract::Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56571-z
更新日期:2020-01-08 00:00:00
abstract::The peptide hormone oxytocin is an established regulator of social function in mammals, and dysregulated oxytocin signaling is implicated in autism spectrum disorder (ASD). Several clinical trials examining the effects of intranasal oxytocin for improving social and behavioral function in ASD have had mixed or inclusi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49617-9
更新日期:2019-09-17 00:00:00
abstract::Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02608
更新日期:2013-01-01 00:00:00
abstract::Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPAR) to the postsynaptic membrane. PSD-95 disruption has recently been...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45971-w
更新日期:2019-07-01 00:00:00