Abstract：
:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell responses in the lymphoid organs are largely unknown due to the infeasibility of obtaining lymphoid organs from CHB patients. Here we demonstrate that the percentage of HBV-specific CD8(+) T cells is higher in the spleen of CHB patients than that from peripheral blood and liver. Although they do respond to TCR stimulation and produce IFNγ, the cells proliferate poorly. Furthermore, miR-720 expression is upregulated in HBV-specific CD8(+) T cells. Overexpression of miR-720 in primary human CD8(+) T cells inhibits TCR stimulation-induced proliferation. We also demonstrate that TGFβ sustains miR-720 upregulation after TCR stimulation, and blood TGFβ levels are associated with the outcome of type I interferon treatment of CHB patients. Thus, therapies targeting miR-720 may help restore impaired immunity in CHB patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang Y,Zhang Z,Ji D,Chen GF,Feng X,Gong LL,Guo J,Li ZW,Chen CF,Zhao BB,Li ZG,Li QJ,Yan HP,Sempowski G,Wang FS,He YWdoi
10.1038/srep12159subject
Has Abstractpub_date
2015-07-22 00:00:00pages
12159issn
2045-2322pii
srep12159journal_volume
5pub_type
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