Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.

abstract：:Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) in terms of morphology, cytoskeleton organization and stiffness, and evaluated their invasive poten...

journal_title：Scientific reports

authors： Louca M,Stylianou A,Minia A,Pliaka V,Alexopoulos LG,Gkretsi V,Stylianopoulos T

更新日期：2019-05-23 00:00:00

abstract：:Standard electroporation with pulses in milliseconds has been used as an effective tool to deliver drugs or genetic probes into cells, while irreversible electroporation with nanosecond pulses is explored to alter intracellular activities for pulse-induced apoptosis. A combination treatment, long nanosecond pulses fol...

journal_title：Scientific reports

authors： Chang AY,Liu X,Tian H,Hua L,Yang Z,Wang S

更新日期：2020-04-08 00:00:00

abstract：:Biofilm formation in flea gut is important for flea-borne transmission of Yersinia pestis. There are enhancing factors (HmsHFRS, HmsCDE, and HmsT) and inhibiting one (HmsP) for Yersinia pestis biofilm formation. The RcsAB regulatory complex acts as a repressor of Yesinia biofilm formation, and adaptive pseudogenizatio...

journal_title：Scientific reports

authors： Fang N,Yang H,Fang H,Liu L,Zhang Y,Wang L,Han Y,Zhou D,Yang R

更新日期：2015-04-01 00:00:00

abstract：:We present a study of precessional magnetization switching in orthogonal spin-torque spin-valve devices at low temperatures. The samples consist of a spin-polarizing layer that is magnetized out-of-the film plane and an in-plane magnetized free and reference magnetic layer separated by non-magnetic metallic layers. We...

journal_title：Scientific reports

authors： Rowlands GE,Ryan CA,Ye L,Rehm L,Pinna D,Kent AD,Ohki TA

更新日期：2019-01-28 00:00:00

abstract：:Protein-based drug discovery strategies have the distinct advantage of providing insights into the molecular mechanisms of chemical effectors. Currently, there are no known trehalose-6-phosphate phosphatase (TPP) inhibitors that possess reasonable inhibition constants and chemical scaffolds amenable to convenient modi...

journal_title：Scientific reports

authors： Cross M,York M,Długosz E,Straub JH,Biberacher S,Herath HMPD,Logan SA,Kim JS,Gasser RB,Ryan JH,Hofmann A

更新日期：2019-11-07 00:00:00

abstract：:Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has an important role in glucose homeostasis. Zip14 knockout mice display hyperinsu...

journal_title：Scientific reports

authors： Maxel T,Smidt K,Petersen CC,Honoré B,Christensen AK,Jeppesen PB,Brock B,Rungby J,Palmfeldt J,Larsen A

更新日期：2019-06-13 00:00:00

abstract：:The benefits that physical exercise confers on cardiovascular health are well known, whereas the notion that physical exercise can also improve cognitive performance has only recently begun to be explored and has thus far yielded only controversial results. In the present study, we used a sample of young male subjects...

journal_title：Scientific reports

authors： Perini R,Bortoletto M,Capogrosso M,Fertonani A,Miniussi C

更新日期：2016-05-05 00:00:00

abstract：:Propagation of coherent light through a disordered network is accompanied by randomization and possible conversion into thermal light. Here, we show that network topology plays a decisive role in determining the statistics of the emerging field if the underlying lattice is endowed with chiral symmetry. In such lattice...

journal_title：Scientific reports

authors： Kondakci HE,Abouraddy AF,Saleh BEA

更新日期：2017-08-21 00:00:00

abstract：:Switches in heterogamety are known to occur in both animals and plants. Although plant sex determination systems probably often evolved more recently than those in several well-studied animals, including mammals, and have had less time for switches to occur, we previously detected a switch in heterogamety in the plant...

journal_title：Scientific reports

authors： Balounova V,Gogela R,Cegan R,Cangren P,Zluvova J,Safar J,Kovacova V,Bergero R,Hobza R,Vyskot B,Oxelman B,Charlesworth D,Janousek B

更新日期：2019-01-31 00:00:00

abstract：:One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relie...

journal_title：Scientific reports

authors： Chung HJ,Lee HK,Kwon KB,Kim HJ,Hong ST

更新日期：2018-09-10 00:00:00

abstract：:At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfacto...

journal_title：Scientific reports

authors： Klimenkov IV,Sudakov NP,Pastukhov MV,Svinov MM,Kositsyn NS

更新日期：2018-02-27 00:00:00

abstract：:Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the conse...

journal_title：Scientific reports

authors： Omarjee L,Roy C,Leboeuf C,Favre J,Henrion D,Mahe G,Leftheriotis G,Martin L,Janin A,Kauffenstein G

更新日期：2019-11-08 00:00:00

abstract：:The oral microflora is composed of both health-promoting as well as disease-initiating bacteria. Many of the disease-initiating bacteria are anaerobic and include organisms such as Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Tannerella forsythia. Here we investigated a novel therapeut...

journal_title：Scientific reports

authors： Hutcherson JA,Sinclair KM,Belvin BR,Gui Q,Hoffman PS,Lewis JP

更新日期：2017-09-05 00:00:00

abstract：:Host-generalist pathogens sporadically infect naive hosts, potentially triggering epizootics. The waterborne fungus Batrachochytrium dendrobatidis (Bd) is linked to declines of hundreds of amphibian species with aquatic larvae. Although several population declines and extinctions attributed to Bd have been reported am...

journal_title：Scientific reports

authors： Mesquita AFC,Lambertini C,Lyra M,Malagoli LR,James TY,Toledo LF,Haddad CFB,Becker CG

更新日期：2017-11-30 00:00:00

abstract：:We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...

journal_title：Scientific reports

authors： Dou LY,Cao DZ,Xu DQ,Zhang AN,Song XB

更新日期：2021-01-28 00:00:00

abstract：:This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiot...

journal_title：Scientific reports

authors： Yang J,Xu H,Guo X,Zhang J,Ye X,Yang Y,Ma X

更新日期：2018-02-14 00:00:00

abstract：:Soil water retention curve (SWRC) plays an important role in simulating soil water movement and assessing soil water holding capacity and availability. Comparison of fitness between different models to determine the best SWRC model of specific regions is required. In this study, three popular models, van Genuchten, Br...

journal_title：Scientific reports

authors： Pan T,Hou S,Liu Y,Tan Q

更新日期：2019-12-05 00:00:00

abstract：:We propose a new method to extend the path length tunability of rotary delay-lines. This method was shown to achieve a duty cycle of >80% and repetition rates of over 40 kHz. The new method relies on a new multi-segmented micro-machined mirror and serial injection of a single reflection onto separate segments of this ...

journal_title：Scientific reports

authors： Fleddermann R,Lee WM,Huang K,Campbell GT,Lam PK,Chow JH

更新日期：2017-08-24 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) offer tremendous promise in tissue engineering and cell-based therapies due to their unique combination of two properties: pluripotency and unlimited proliferative capacity. However, directed differentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goa...

journal_title：Scientific reports

authors： Randolph LN,Bao X,Zhou C,Lian X

更新日期：2017-05-08 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated...

journal_title：Scientific reports

authors： Steinacker P,Blennow K,Halbgebauer S,Shi S,Ruf V,Oeckl P,Giese A,Kuhle J,Slivarichova D,Zetterberg H,Otto M

更新日期：2016-12-08 00:00:00

abstract：:Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) withou...

journal_title：Scientific reports

authors： Katagiri R,Goto A,Budhathoki S,Yamaji T,Yamamoto H,Kato Y,Iwasaki M,Tsugane S

更新日期：2018-01-18 00:00:00

abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...

journal_title：Scientific reports

authors： Eriksson O,Haack T,Hijazi Y,Teichert L,Tavernier V,Laitinen I,Berglund JE,Antoni G,Velikyan I,Johansson L,Pierrou S,Wagner M,Tillner J

更新日期：2020-10-07 00:00:00

abstract：:Current saliva testing methods rely on cutting edge yet expensive techniques for the detection and analysis of genetic material, proteins and biomarkers for clinical use. However, these techniques are limited in scope and often cannot be used with complex food materials. We propose an efficient ex-vivo tool for evalua...

journal_title：Scientific reports

authors： Dinu V,Liu C,Ali J,Ayed C,Gershkovich P,Adams GG,Harding SE,Fisk ID

更新日期：2018-09-06 00:00:00

abstract：:Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented by 'self' major histocompatibility complex (pMHC) molecules. Structures of unligated and ligated MHC class-I-restricted TCRs with different ligands, supplemente...

journal_title：Scientific reports

authors： Holland CJ,Rizkallah PJ,Vollers S,Calvo-Calle JM,Madura F,Fuller A,Sewell AK,Stern LJ,Godkin A,Cole DK

更新日期：2012-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Zhang H,Li G,Su B,Deng M,Liu YX,Gu YC,Wang QM

更新日期：2018-03-06 00:00:00

abstract：:The local flexibility of an enzyme's active center plays pivotal roles in catalysis, however, little is known about how the flexibility of these flexible residues affects stability. In this study, we proposed an active center stabilization (ACS) strategy to improve the kinetic thermostability of Candida rugosa lipase1...

journal_title：Scientific reports

authors： Zhang XF,Yang GY,Zhang Y,Xie Y,Withers SG,Feng Y

更新日期：2016-09-26 00:00:00

abstract：:Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we s...

journal_title：Scientific reports

authors： Yu YP,Liu P,Nelson J,Hamilton RL,Bhargava R,Michalopoulos G,Chen Q,Zhang J,Ma D,Pennathur A,Luketich J,Nalesnik M,Tseng G,Luo JH

更新日期：2019-01-31 00:00:00

abstract：:Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the relaxivity and sensitivity for detection of native ferritin is relatively low. We report here on a novel chimeric magneto-ferritin reporter...

journal_title：Scientific reports

authors： Radoul M,Lewin L,Cohen B,Oren R,Popov S,Davidov G,Vandsburger MH,Harmelin A,Bitton R,Greneche JM,Neeman M,Zarivach R

更新日期：2016-05-23 00:00:00

abstract：:Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...

journal_title：Scientific reports

authors： Yuan S,Yin S,Liu M,Kong JQ

更新日期：2018-04-12 00:00:00

abstract：:When a rat is on a limited fixed-time food schedule with full access to a running wheel (activity-based anorexia model, ABA), its activity level will increase hours prior to the feeding period. This activity, called food-anticipatory activity (FAA), is a hypothesized parallel to the hyperactivity symptom in human anor...

journal_title：Scientific reports

authors： Wu H,van Kuyck K,Tambuyzer T,Luyten L,Aerts JM,Nuttin B

更新日期：2014-01-29 00:00:00