Abstract:
:Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm potential of Actinidia deliciosa have been explored against S. marcescens clinical isolate (CI). A. deliciosa pulp extract significantly inhibited the virulence and biofilm production without any deleterious effect on the growth. Vanillic acid was identified as an active lead responsible for the QSI activity. Addition of vanillic acid to the growth medium significantly affected the QS regulated production of biofilm and virulence factors in a concentration dependent mode in S. marcescens CI, ATCC 14756 and MG1. Furthermore vanillic acid increased the survival of Caenorhabditis elegans upon S. marcescens infection. Proteomic analysis and mass spectrometric identification of differentially expressed proteins revealed the ability of vanillic acid to modulate the expression of proteins involved in S-layers, histidine, flagellin and fatty acid production. QSI potential of the vanillic acid observed in the current study paves the way for exploring it as a potential therapeutic candidate to treat S. marcescens infections.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sethupathy S,Ananthi S,Selvaraj A,Shanmuganathan B,Vigneshwari L,Balamurugan K,Mahalingam S,Pandian SKdoi
10.1038/s41598-017-16507-xsubject
Has Abstractpub_date
2017-11-27 00:00:00pages
16328issue
1issn
2045-2322pii
10.1038/s41598-017-16507-xjournal_volume
7pub_type
杂志文章abstract::Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62547-1
更新日期:2020-03-27 00:00:00
abstract::The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67748-2
更新日期:2020-07-03 00:00:00
abstract::Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65324-2
更新日期:2020-05-29 00:00:00
abstract::A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08105
更新日期:2015-01-29 00:00:00
abstract::A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32590-0
更新日期:2018-09-21 00:00:00
abstract::Understanding the transcriptional regulatory elements that influence the progression of liver disease in the presence of hepatitis C virus (HCV) infection is critical for the development of diagnostic and therapeutic approaches. Systems biology provides a roadmap by which these elements may be integrated. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32464-5
更新日期:2018-09-24 00:00:00
abstract::Sterility mosaic disease (SMD) is one of the serious production constraints that may lead to complete yield loss in pigeonpea. Three mapping populations including two recombinant inbred lines and one F2, were used for phenotyping for SMD resistance at two locations in three different years. Genotyping-by-sequencing ap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01535-4
更新日期:2017-05-12 00:00:00
abstract::Decarboxylation of fatty acids over non-noble metal catalysts without added hydrogen was studied. Ni/C catalysts were prepared and exhibited excellent activity and maintenance for decarboxylation. Thereafter, the effects of nickel loading, catalyst loading, temperature, and carbon number on the decarboxylation of fatt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27820
更新日期:2016-06-13 00:00:00
abstract::Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66031-8
更新日期:2020-06-03 00:00:00
abstract::Knowing which geodynamic regimes characterised the early Earth is a fundamental question. This implies to determine when and how modern plate tectonics began. Today, the tectonic regime is dominated by mobile-lid tectonics including deep and cold subduction. However, in the early Earth (4.5 to 2 Ga) stagnant-lid tecto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33823-y
更新日期:2018-10-18 00:00:00
abstract::There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03262
更新日期:2013-11-20 00:00:00
abstract::Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential emergence of different genotypes and strains. Despite the likely relevance in the emergence of new PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short transmission...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33849-2
更新日期:2018-10-19 00:00:00
abstract::The major source of ATP in cancer cells remains unclear. Here, we examined energy metabolism in gastric cancer cells and found increased fatty acid oxidation and increased expression of ALDH3A1. Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production of 4-hydroxynonen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52814-1
更新日期:2019-11-08 00:00:00
abstract::Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39716-y
更新日期:2019-03-05 00:00:00
abstract::The effect on post-operative outcomes after coronary artery bypass graft (CABG) surgery is not clear. Among 17,812 patients who underwent CABG during October 1,2006-September 28,2012 in any Department of US Veterans Affairs (VA) hospital, we identified 5,968 with available preoperative urine albumin-creatinine ratio (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16458
更新日期:2015-11-09 00:00:00
abstract::Although low socioeconomic status (SES) is related to poor glycemic control, the underlying mechanisms remain unclear. We examined potentially modifiable factors involved in the association between low SES and poor glycemic control using data from the baseline survey of a multicenter, prospective cohort study. Five hu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63253-8
更新日期:2020-04-21 00:00:00
abstract::Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41180
更新日期:2017-02-01 00:00:00
abstract::The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy surface colonisation. This study was designed to analyse the surface epibiome of F. vesiculosus in conjunction with the composition and spatial distribution of its surface metabolome. The amplicon sequencing, SEM and CARD-FISH ima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37914-8
更新日期:2019-01-31 00:00:00
abstract::Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09204
更新日期:2015-03-17 00:00:00
abstract::The discovery of the community structure of real-world networks is still an open problem. Many methods have been proposed to shed light on this problem, and most of these have focused on discovering node community. However, link community is also a powerful framework for discovering overlapping communities. Here we pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22470
更新日期:2016-03-01 00:00:00
abstract::In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17891-0
更新日期:2017-12-20 00:00:00
abstract::We study the tight-binding model for a graphene tube with perimeter N threaded by a magnetic field. We show exactly that this model has different nontrivial topological phases as the flux changes. The winding number, as an indicator of topological quantum phase transition (QPT) fixes at N/3 if N/3 equals to its intege...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31953
更新日期:2016-08-24 00:00:00
abstract::Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69434-9
更新日期:2020-07-28 00:00:00
abstract::Spin-coated self-assemblies of colloidal particles have been developed recently as an attractive close-packed monolayer of the particles for a variety of applications, but they are limited by the small area of their monolayers, especially given their low uniformity and monolayer coverage on large-area substrates. We r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47990-z
更新日期:2019-08-07 00:00:00
abstract::Carbon monoxide (CO) monitoring in human breath is the focus of many investigations as CO could possibly be used as a marker of various diseases. Detecting CO in human breath remains a challenge because low concentrations ( journal_title:Scientific reports pub_type: 临床试验,杂志文章 doi:10.1038/s41598-019-48789-8 更新日期:2019-08-22 00:00:00
abstract::This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64932-2
更新日期:2020-05-14 00:00:00
abstract::Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the underlying mechanism of the neuronal cell death of these conditions. We previously synthesized Kyoto University substances (KUSs) as modulator...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44873
更新日期:2017-03-20 00:00:00
abstract::Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDT-induced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31551
更新日期:2016-08-22 00:00:00
abstract::Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76134-x
更新日期:2020-11-04 00:00:00
abstract::Crustaceans form the second largest subphylum on Earth, which includes Litopeneaus vannamei (Pacific whiteleg shrimp), one of the most cultured shrimp worldwide. Despite efforts to study the shrimp microbiota, little is known about it from shrimp obtained from the open sea and the role that aquaculture plays in microb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11805-w
更新日期:2017-09-18 00:00:00