Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins.

Abstract:

:Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm potential of Actinidia deliciosa have been explored against S. marcescens clinical isolate (CI). A. deliciosa pulp extract significantly inhibited the virulence and biofilm production without any deleterious effect on the growth. Vanillic acid was identified as an active lead responsible for the QSI activity. Addition of vanillic acid to the growth medium significantly affected the QS regulated production of biofilm and virulence factors in a concentration dependent mode in S. marcescens CI, ATCC 14756 and MG1. Furthermore vanillic acid increased the survival of Caenorhabditis elegans upon S. marcescens infection. Proteomic analysis and mass spectrometric identification of differentially expressed proteins revealed the ability of vanillic acid to modulate the expression of proteins involved in S-layers, histidine, flagellin and fatty acid production. QSI potential of the vanillic acid observed in the current study paves the way for exploring it as a potential therapeutic candidate to treat S. marcescens infections.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sethupathy S,Ananthi S,Selvaraj A,Shanmuganathan B,Vigneshwari L,Balamurugan K,Mahalingam S,Pandian SK

doi

10.1038/s41598-017-16507-x

subject

Has Abstract

pub_date

2017-11-27 00:00:00

pages

16328

issue

1

issn

2045-2322

pii

10.1038/s41598-017-16507-x

journal_volume

7

pub_type

杂志文章
  • Architectural evolution in cocoons spun by Hyalophora (Lepidoptera; Saturniidae) silk moth species.

    abstract::Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62547-1

    authors: Guerra PA,Lawson LP,Gatto LJ,Albright ME,Smith SJ

    更新日期:2020-03-27 00:00:00

  • Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors.

    abstract::The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67748-2

    authors: Ramzy L,Metwally AA,Nasr M,Awad GAS

    更新日期:2020-07-03 00:00:00

  • Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability.

    abstract::Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65324-2

    authors: de Waal GM,de Villiers WJS,Forgan T,Roberts T,Pretorius E

    更新日期:2020-05-29 00:00:00

  • Fully printed flexible and disposable wireless cyclic voltammetry tag.

    abstract::A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08105

    authors: Jung Y,Park H,Park JA,Noh J,Choi Y,Jung M,Jung K,Pyo M,Chen K,Javey A,Cho G

    更新日期:2015-01-29 00:00:00

  • Light sintering of ultra-smooth and robust silver nanowire networks embedded in poly(vinyl-butyral) for flexible OLED.

    abstract::A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32590-0

    authors: Lee DJ,Oh Y,Hong JM,Park YW,Ju BK

    更新日期:2018-09-21 00:00:00

  • Transcriptional Regulatory Networks in Hepatitis C Virus-induced Hepatocellular Carcinoma.

    abstract::Understanding the transcriptional regulatory elements that influence the progression of liver disease in the presence of hepatitis C virus (HCV) infection is critical for the development of diagnostic and therapeutic approaches. Systems biology provides a roadmap by which these elements may be integrated. In this stud...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32464-5

    authors: Zahra M,Azzazy H,Moustafa A

    更新日期:2018-09-24 00:00:00

  • Genotyping-by-sequencing of three mapping populations for identification of candidate genomic regions for resistance to sterility mosaic disease in pigeonpea.

    abstract::Sterility mosaic disease (SMD) is one of the serious production constraints that may lead to complete yield loss in pigeonpea. Three mapping populations including two recombinant inbred lines and one F2, were used for phenotyping for SMD resistance at two locations in three different years. Genotyping-by-sequencing ap...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01535-4

    authors: Saxena RK,Kale SM,Kumar V,Parupali S,Joshi S,Singh V,Garg V,Das RR,Sharma M,Yamini KN,Ghanta A,Rathore A,Sameerkumar CV,Saxena KB,Varshney RK

    更新日期:2017-05-12 00:00:00

  • Catalytic Decarboxylation of Fatty Acids to Aviation Fuels over Nickel Supported on Activated Carbon.

    abstract::Decarboxylation of fatty acids over non-noble metal catalysts without added hydrogen was studied. Ni/C catalysts were prepared and exhibited excellent activity and maintenance for decarboxylation. Thereafter, the effects of nickel loading, catalyst loading, temperature, and carbon number on the decarboxylation of fatt...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27820

    authors: Wu J,Shi J,Fu J,Leidl JA,Hou Z,Lu X

    更新日期:2016-06-13 00:00:00

  • Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects.

    abstract::Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the compa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66031-8

    authors: Lim YRI,Preshaw PM,Lim LP,Ong MMA,Lin HS,Tan KS

    更新日期:2020-06-03 00:00:00

  • The earliest evidence for modern-style plate tectonics recorded by HP-LT metamorphism in the Paleoproterozoic of the Democratic Republic of the Congo.

    abstract::Knowing which geodynamic regimes characterised the early Earth is a fundamental question. This implies to determine when and how modern plate tectonics began. Today, the tectonic regime is dominated by mobile-lid tectonics including deep and cold subduction. However, in the early Earth (4.5 to 2 Ga) stagnant-lid tecto...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33823-y

    authors: François C,Debaille V,Paquette JL,Baudet D,Javaux EJ

    更新日期:2018-10-18 00:00:00

  • Two-magnon bound state causes ultrafast thermally induced magnetisation switching.

    abstract::There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03262

    authors: Barker J,Atxitia U,Ostler TA,Hovorka O,Chubykalo-Fesenko O,Chantrell RW

    更新日期:2013-11-20 00:00:00

  • Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies.

    abstract::Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential emergence of different genotypes and strains. Despite the likely relevance in the emergence of new PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short transmission...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33849-2

    authors: Correa-Fiz F,Franzo G,Llorens A,Segalés J,Kekarainen T

    更新日期:2018-10-19 00:00:00

  • Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.

    abstract::The major source of ATP in cancer cells remains unclear. Here, we examined energy metabolism in gastric cancer cells and found increased fatty acid oxidation and increased expression of ALDH3A1. Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production of 4-hydroxynonen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52814-1

    authors: Lee JS,Kim SH,Lee S,Kang JH,Lee SH,Cheong JH,Kim SY

    更新日期:2019-11-08 00:00:00

  • Comparative transcriptome analysis of Eogammarus possjeticus at different hydrostatic pressure and temperature exposures.

    abstract::Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39716-y

    authors: Chen J,Liu H,Cai S,Zhang H

    更新日期:2019-03-05 00:00:00

  • Association of Pre-Operative Albuminuria with Post-Operative Outcomes after Coronary Artery Bypass Grafting.

    abstract::The effect on post-operative outcomes after coronary artery bypass graft (CABG) surgery is not clear. Among 17,812 patients who underwent CABG during October 1,2006-September 28,2012 in any Department of US Veterans Affairs (VA) hospital, we identified 5,968 with available preoperative urine albumin-creatinine ratio (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16458

    authors: George LK,Molnar MZ,Lu JL,Kalantar-Zadeh K,Koshy SK,Kovesdy CP

    更新日期:2015-11-09 00:00:00

  • Mediators of the association between low socioeconomic status and poor glycemic control among type 2 diabetics in Bangladesh.

    abstract::Although low socioeconomic status (SES) is related to poor glycemic control, the underlying mechanisms remain unclear. We examined potentially modifiable factors involved in the association between low SES and poor glycemic control using data from the baseline survey of a multicenter, prospective cohort study. Five hu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63253-8

    authors: Rahman M,Nakamura K,Hasan SMM,Seino K,Mostofa G

    更新日期:2020-04-21 00:00:00

  • Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process.

    abstract::Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41180

    authors: Choi JH,Park SH,Jung JK,Cho WJ,Ahn B,Yun CY,Choi YP,Yeo JH,Lee H,Hong JT,Han SB,Kim Y

    更新日期:2017-02-01 00:00:00

  • Mapping the Surface Microbiome and Metabolome of Brown Seaweed Fucus vesiculosus by Amplicon Sequencing, Integrated Metabolomics and Imaging Techniques.

    abstract::The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy surface colonisation. This study was designed to analyse the surface epibiome of F. vesiculosus in conjunction with the composition and spatial distribution of its surface metabolome. The amplicon sequencing, SEM and CARD-FISH ima...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37914-8

    authors: Parrot D,Blümel M,Utermann C,Chianese G,Krause S,Kovalev A,Gorb SN,Tasdemir D

    更新日期:2019-01-31 00:00:00

  • Pushing the limit: examining factors that affect anoxia tolerance in a single genotype of adult D. melanogaster.

    abstract::Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09204

    authors: Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

    更新日期:2015-03-17 00:00:00

  • Discovering communities in complex networks by edge label propagation.

    abstract::The discovery of the community structure of real-world networks is still an open problem. Many methods have been proposed to shed light on this problem, and most of these have focused on discovering node community. However, link community is also a powerful framework for discovering overlapping communities. Here we pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22470

    authors: Liu W,Jiang X,Pellegrini M,Wang X

    更新日期:2016-03-01 00:00:00

  • Three tandem promoters, together with IHF, regulate growth phase dependent expression of the Escherichia coli kps capsule gene cluster.

    abstract::In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17891-0

    authors: Jia J,King JE,Goldrick MC,Aldawood E,Roberts IS

    更新日期:2017-12-20 00:00:00

  • Magnetic-flux-driven topological quantum phase transition and manipulation of perfect edge states in graphene tube.

    abstract::We study the tight-binding model for a graphene tube with perimeter N threaded by a magnetic field. We show exactly that this model has different nontrivial topological phases as the flux changes. The winding number, as an indicator of topological quantum phase transition (QPT) fixes at N/3 if N/3 equals to its intege...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31953

    authors: Lin S,Zhang G,Li C,Song Z

    更新日期:2016-08-24 00:00:00

  • Comparative transcriptome analysis of Sclerotinia sclerotiorum revealed its response mechanisms to the biological control agent, Bacillus amyloliquefaciens.

    abstract::Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69434-9

    authors: Yang X,Zhang L,Xiang Y,Du L,Huang X,Liu Y

    更新日期:2020-07-28 00:00:00

  • Uniform two-dimensional crystals of polystyrene nanospheres fabricated by a surfactant-assisted spin-coating method with polyoxyethylene tridecyl ether.

    abstract::Spin-coated self-assemblies of colloidal particles have been developed recently as an attractive close-packed monolayer of the particles for a variety of applications, but they are limited by the small area of their monolayers, especially given their low uniformity and monolayer coverage on large-area substrates. We r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47990-z

    authors: Park B,Na SY,Bae IG

    更新日期:2019-08-07 00:00:00

  • High inhaled oxygen concentration quadruples exhaled CO in healthy volunteers monitored by a highly sensitive laser spectrometer.

    abstract::Carbon monoxide (CO) monitoring in human breath is the focus of many investigations as CO could possibly be used as a marker of various diseases. Detecting CO in human breath remains a challenge because low concentrations (

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-019-48789-8

    authors: Brenckmann V,Ventrillard I,Romanini D,Jaulin K,Calabrèse P,Briot R

    更新日期:2019-08-22 00:00:00

  • Interleukin-34 overexpression mediated through tumor necrosis factor-alpha reflects severity of synovitis in knee osteoarthritis.

    abstract::This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64932-2

    authors: Udomsinprasert W,Jinawath A,Teerawattanapong N,Honsawek S

    更新日期:2020-05-14 00:00:00

  • KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.

    abstract::Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the underlying mechanism of the neuronal cell death of these conditions. We previously synthesized Kyoto University substances (KUSs) as modulator...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44873

    authors: Hata M,Ikeda HO,Kikkawa C,Iwai S,Muraoka Y,Hasegawa T,Kakizuka A,Yoshimura N

    更新日期:2017-03-20 00:00:00

  • Monitoring Tumor Hypoxia Using (18)F-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy.

    abstract::Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDT-induced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31551

    authors: Tong X,Srivatsan A,Jacobson O,Wang Y,Wang Z,Yang X,Niu G,Kiesewetter DO,Zheng H,Chen X

    更新日期:2016-08-22 00:00:00

  • Online quantitative partial discharge monitor based on interferometry.

    abstract::Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76134-x

    authors: Xue L,Zhu Y,Yang C,Kumarawadu S

    更新日期:2020-11-04 00:00:00

  • Microbiome of Pacific Whiteleg shrimp reveals differential bacterial community composition between Wild, Aquacultured and AHPND/EMS outbreak conditions.

    abstract::Crustaceans form the second largest subphylum on Earth, which includes Litopeneaus vannamei (Pacific whiteleg shrimp), one of the most cultured shrimp worldwide. Despite efforts to study the shrimp microbiota, little is known about it from shrimp obtained from the open sea and the role that aquaculture plays in microb...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11805-w

    authors: Cornejo-Granados F,Lopez-Zavala AA,Gallardo-Becerra L,Mendoza-Vargas A,Sánchez F,Vichido R,Brieba LG,Viana MT,Sotelo-Mundo RR,Ochoa-Leyva A

    更新日期:2017-09-18 00:00:00