Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies.

abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...

journal_title：Scientific reports

authors： Qiao L,Du M,Liang X,Hao Y,He X,Si F,Mei T,Chen B

更新日期：2016-07-15 00:00:00

abstract：:Full-endoscopic transforaminal lumbar discectomy (FETD) is increasingly used in patients with lumbar disc herniation (LDH). There is little knowledge on the related factors, including the straight leg raising test (SLR), that influence the operation. Consecutive patients with LDH who came to our hospital from August 2...

journal_title：Scientific reports

authors： Wei FL,Gao H,Yan X,Yuan Y,Qian S,Gao Q,Guo S,Xue W,Qian J,Zhou C

更新日期：2020-10-05 00:00:00

abstract：:18-flurodesoxyglucose position emission tomography (FDG-PET) with computed tomography (CT) or magnetic resonance imaging (MRI) is a broadly accepted tool for pretherapeutic staging and post-therapeutic assessment of response. The prognostic value of sequential post-therapeutic FDG-PETs and the impact of change in meta...

journal_title：Scientific reports

authors： Stadler TM,Hüllner MW,Broglie MA,Morand GB

更新日期：2020-10-07 00:00:00

abstract：:Fluid strategy is the key to the successful management of patients with sepsis. However, previous studies failed to consider individualized treatment strategy, and clinical trials typically included patients with sepsis as a homogeneous study population. We aimed to develop sequential decision rules for managing fluid...

journal_title：Scientific reports

authors： Zhang Z,Zheng B,Liu N

更新日期：2020-10-21 00:00:00

abstract：:The proinflammatory cytokine Interleukin 17A (hereafter named IL-17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(-) or triple negative tumors and reduced Disease Free Survival. However, the pathophysiological role of IL-...

journal_title：Scientific reports

authors： Cochaud S,Giustiniani J,Thomas C,Laprevotte E,Garbar C,Savoye AM,Curé H,Mascaux C,Alberici G,Bonnefoy N,Eliaou JF,Bensussan A,Bastid J

更新日期：2013-12-09 00:00:00

abstract：:Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

journal_title：Scientific reports

authors： Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

更新日期：2018-03-20 00:00:00

abstract：:In this study, the anatomical and ultrastructural responses of Capsicum annuum to iron nanoparticles (Fe NPs) were determined. The results showed that the bio-effects of Fe NPs on plants could be positive or negative, depending on the additive concentrations. Low concentrations of Fe NPs were found to promote plant gr...

journal_title：Scientific reports

authors： Yuan J,Chen Y,Li H,Lu J,Zhao H,Liu M,Nechitaylo GS,Glushchenko NN

更新日期：2018-02-19 00:00:00

abstract：:We have investigated the rotating magnetocaloric effect (R-MCE) of TmB4 - an anisotropic magnetic system with geometrical frustration of Shastry-Sutherland type. The R-MCE was obtained from detailed temperature dependencies of heat capacity in various magnetic fields of a single crystalline sample for crystal axes ori...

journal_title：Scientific reports

authors： Orendáč M,Gabáni S,Gažo E,Pristáš G,Shitsevalova N,Siemensmeyer K,Flachbart K

更新日期：2018-07-19 00:00:00

abstract：:Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes with COL6A3 mRNA...

journal_title：Scientific reports

authors： Dankel SN,Grytten E,Bjune JI,Nielsen HJ,Dietrich A,Blüher M,Sagen JV,Mellgren G

更新日期：2020-11-19 00:00:00

abstract：:We explore the effect of temperature on the interaction of polydisperse mixtures of nonionic poly(ethylene glycol) (PEG) polymers of different average molar masses with the biological nanopore α-hemolysin. In contrast with what has been previously observed with various nanopores and analytes, we find that, for PEGs la...

journal_title：Scientific reports

authors： Piguet F,Ouldali H,Discala F,Breton MF,Behrends JC,Pelta J,Oukhaled A

更新日期：2016-12-07 00:00:00

abstract：:Ergothioneine (ERG), a unique thiol compound, is suggested to function as an antioxidant and cytoprotectant. Despite several recent attempts to produce ERG using various organisms, its yield was still very low and the costs remained high. Since the level of ERG produced depends strictly on the availability of three di...

journal_title：Scientific reports

authors： Tanaka N,Kawano Y,Satoh Y,Dairi T,Ohtsu I

更新日期：2019-02-13 00:00:00

abstract：:Cell counts decrease with sediment depth. Typical explanations consider limiting factors such as water availability and chemistry, carbon source, nutrients, energy and temperature, and overlook the role of pore size. Our analyses consider sediment self-compaction, the evolution of pore size with depth, and the probabi...

journal_title：Scientific reports

authors： Park J,Santamarina JC

更新日期：2020-12-10 00:00:00

abstract：:Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and...

journal_title：Scientific reports

authors： Irzyniec T,Jeż W,Lepska K,Maciejewska-Paszek I,Frelich J

更新日期：2019-11-04 00:00:00

abstract：:The study was aimed at assessing the diagnostic performance of 68Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4-20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with...

journal_title：Scientific reports

authors： Li Y,Han D,Wu P,Ren J,Ma S,Zhang J,Song W,Lin X,Jiao D,Shi S,Yang F,Wu J,Meng P,Wen W,Kang F,Wang J,Qin W

更新日期：2020-07-03 00:00:00

abstract：:Over the years, electrophysiological recordings in macaque monkeys performing visuomotor tasks brought about accumulating evidence for the expression of neuronal properties (e.g., selectivity in the visuospatial and somatosensory domains, encoding of visual affordances and motor cues) in the posterior parietal area V6...

journal_title：Scientific reports

authors： Santandrea E,Breveglieri R,Bosco A,Galletti C,Fattori P

更新日期：2018-05-02 00:00:00

abstract：:Enterococcus faecalis, an organism generally not pathogenic for healthy humans, has the potential to cause disease in susceptible hosts. While it seems to be equipped to interact with and circumvent host immune defense, most of the molecular and cellular mechanisms underlying the enterococcal infectious process remain...

journal_title：Scientific reports

authors： Nunez N,Derré-Bobillot A,Gaubert S,Herry JM,Deschamps J,Wei Y,Baranek T,Si-Tahar M,Briandet R,Serror P,Archambaud C

更新日期：2018-01-29 00:00:00

abstract：:A series of nanocomposites of cobalt embedded in N-doped nanoporous carbons, carbon nanotubes or hollow carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67. The effect of the carbonization temperature on the structural evolution of the resulting nanocomposites has been inv...

journal_title：Scientific reports

authors： Chen B,Ma G,Zhu Y,Xia Y

更新日期：2017-07-13 00:00:00

abstract：:The clinical significance of STIM proteins and Orai Ca2+ channels in tumor progression has been demonstrated in different types of cancers. Podosomes are dynamic actin-rich cellular protrusions that facilitate cancer cell invasiveness by degrading extracellular matrix. Whether STIM1-dependent Ca2+ signaling facilitate...

journal_title：Scientific reports

authors： Chen YW,Lai CS,Chen YF,Chiu WT,Chen HC,Shen MR

更新日期：2017-09-14 00:00:00

abstract：:Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has an important role in glucose homeostasis. Zip14 knockout mice display hyperinsu...

journal_title：Scientific reports

authors： Maxel T,Smidt K,Petersen CC,Honoré B,Christensen AK,Jeppesen PB,Brock B,Rungby J,Palmfeldt J,Larsen A

更新日期：2019-06-13 00:00:00

abstract：:Histone deacetylases (HDACs) can enzymatically transferred acetyl functional group from protein or lysine residues of histone, so they can regulate the expression of lots of genes. Now HDACs are used as drug targets and many HDAC inhibitors (HDACis) were approved for cancer therapy or in clinical trials. However, the ...

journal_title：Scientific reports

authors： Song Q,Li M,Fan C,Liu Y,Zheng L,Bao Y,Sun L,Yu C,Song Z,Sun Y,Wang G,Huang Y,Li Y

更新日期：2019-02-20 00:00:00

abstract：:Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...

journal_title：Scientific reports

authors： Xue H,Jiang Y,Yuan K,Yang T,Hou J,Cao C,Feng K,Wang X

更新日期：2016-07-19 00:00:00

abstract：:Transit-time flow measurement (TTFM) is frequently used to evaluate intraoperative quality control during coronary artery bypass grafting (CABG) and has the ability to assess graft failure intraoperatively. However, perioperative factors affecting TTFM during CABG remain poorly understood. Patients who underwent CABG ...

journal_title：Scientific reports

authors： Lee SW,Jo JY,Kim WJ,Choi DK,Choi IC

更新日期：2020-07-31 00:00:00

abstract：:The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 publis...

journal_title：Scientific reports

authors： Lee JH,Jeong H,Choi JW,Oh H,Kim YS

更新日期：2017-05-11 00:00:00

abstract：:The establishment of clinically relevant models for tumor metastasis and drug testing is a major challenge in cancer research. Here we report a physiologically relevant assay enabling quantitative analysis of metastatic capacity of tumor cells following implantation into the chorioallantoic membrane (CAM). Engraftment...

journal_title：Scientific reports

authors： Pawlikowska P,Tayoun T,Oulhen M,Faugeroux V,Rouffiac V,Aberlenc A,Pommier AL,Honore A,Marty V,Bawa O,Lacroix L,Scoazec JY,Chauchereau A,Laplace-Builhe C,Farace F

更新日期：2020-10-09 00:00:00

abstract：:We have earlier shown that Plumbagin (PB) can induce selective cytotoxicity to BRCA1 defective ovarian cancer cells; however, the effect of this molecule in BRCA1 mutated breast cancers has not been analyzed yet. Here, we report that reactive oxygen species (ROS) induced by PB resulted in DNA DSB and activates downstr...

journal_title：Scientific reports

authors： Nair RS,Kumar JM,Jose J,Somasundaram V,Hemalatha SK,Sengodan SK,Nadhan R,Anilkumar TV,Srinivas P

更新日期：2016-05-25 00:00:00

abstract：:The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catalytic activity obser...

journal_title：Scientific reports

authors： Emperle M,Dukatz M,Kunert S,Holzer K,Rajavelu A,Jurkowska RZ,Jeltsch A

更新日期：2018-09-05 00:00:00

abstract：:Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus bengalensis) and the Asiatic golden cat (AGC; Catopuma temminckii) are two important yet increasingly endangered carnivore species in the tem...

journal_title：Scientific reports

authors： Xiong M,Wang D,Bu H,Shao X,Zhang D,Li S,Wang R,Yao M

更新日期：2017-02-14 00:00:00

abstract：:Hyaluronic acid (HA) is a glycosaminoglycan that plays many roles in health and disease and is a key biomarker of certain cancers. Therefore, its detection at an early stage, by histochemical methods, is of importance. However, intracellular HA can be masked by other HA-binding macromolecules, rendering its visualizat...

journal_title：Scientific reports

authors： Medina Rangel PX,Laclef S,Xu J,Panagiotopoulou M,Kovensky J,Tse Sum Bui B,Haupt K

更新日期：2019-03-08 00:00:00

abstract：:Aconiti Lateralis Radix Praeparata (Fuzi) and Fritillariae Thunbergii bulbus (Beimu) have been widely used clinically to treat cardiopulmonary related diseases in China. However, according to the classic rules of traditional Chinese medicine, Fuzi and Beimu should be prohibited to use as a combination for their incomp...

journal_title：Scientific reports

authors： Zhuang P,Huang Y,Lu Z,Yang Z,Xu L,Sun F,Zhang Y,Duan J

更新日期：2016-10-14 00:00:00

abstract：:Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+)  T cells that are activated by MHC I-mediated presen...

journal_title：Scientific reports

authors： Keller IE,Vosyka O,Takenaka S,Kloß A,Dahlmann B,Willems LI,Verdoes M,Overkleeft HS,Marcos E,Adnot S,Hauck SM,Ruppert C,Günther A,Herold S,Ohno S,Adler H,Eickelberg O,Meiners S

更新日期：2015-05-19 00:00:00