Abstract：
:Over the years, electrophysiological recordings in macaque monkeys performing visuomotor tasks brought about accumulating evidence for the expression of neuronal properties (e.g., selectivity in the visuospatial and somatosensory domains, encoding of visual affordances and motor cues) in the posterior parietal area V6A that characterize it as an ideal neural substrate for online control of prehension. Interestingly, neuroimaging studies suggested a role of putative human V6A also in action preparation; moreover, pre-movement population activity in monkey V6A has been recently shown to convey grip-related information for upcoming grasping. Here we directly test whether macaque V6A neurons encode preparatory signals that effectively differentiate between dissimilar actions before movement. We recorded the activity of single V6A neurons during execution of two visuomotor tasks requiring either reach-to-press or reach-to-grasp movements in different background conditions, and described the nature and temporal dynamics of V6A activity preceding movement execution. We found striking consistency in neural discharges measured during pre-movement and movement epochs, suggesting that the former is a preparatory activity exquisitely linked to the subsequent execution of particular motor actions. These findings strongly support a role of V6A beyond the online guidance of movement, with preparatory activity implementing suitable motor programs that subsequently support action execution.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Santandrea E,Breveglieri R,Bosco A,Galletti C,Fattori Pdoi
10.1038/s41598-018-25117-0subject
Has Abstractpub_date
2018-05-02 00:00:00pages
6926issue
1issn
2045-2322pii
10.1038/s41598-018-25117-0journal_volume
8pub_type
杂志文章abstract：:More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20389-y
更新日期：2018-02-01 00:00:00
abstract：:(R-)miniCHOP therapy, which delivers approximately half-doses of the (R-)CHOP regimen, has shown efficacy and safety in patients who are more than 80 years old. This study aimed to compare the area under the plasma concentration-time curves (AUCs) of vincristine (VCR), doxorubicin (DXR), and cyclophosphamide (CPA) bet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80706-2
更新日期：2021-01-12 00:00:00
abstract：:Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40869-z
更新日期：2019-03-13 00:00:00
abstract：:Organometallic trihalide perovskites are promising materials for photovoltaic applications, which have demonstrated a rapid rise in photovoltaic performance in a short period of time. We report a facile one-step method to fabricate planar heterojunction perovskite solar cells by chemical vapor deposition (CVD), with a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14083
更新日期：2015-09-22 00:00:00
abstract：:To investigate the applicability of compound specific stable carbon isotope ratios (δ13C) of organics in assessment of their photochemical aging in the atmosphere, batch UV irradiation experiments were conducted on two ambient (anthropogenic and biogenic) aerosol samples in aqueous phase for 0.5-120 h. The irradiated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36467
更新日期：2016-11-04 00:00:00
abstract：:Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09894-8
更新日期：2017-08-25 00:00:00
abstract：:We present here a broadband, wide-angle, and polarization-independent nearly perfect absorber consisting of mirror-backed nanoporous alumina. By electrochemically anodizing the disordered multicomponent aluminum and properly tailoring the thickness and air-filling fraction of nanoporous alumina, according to the Maxwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19984
更新日期：2016-01-28 00:00:00
abstract：:The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40783
更新日期：2017-01-18 00:00:00
abstract：:Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36242-1
更新日期：2018-12-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62685-6
更新日期：2020-04-02 00:00:00
abstract：:Warburg effect or aerobic glycolysis provides selective growth advantage to aggressive cancers. However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude of cells. In this study, we present ADP-dependent glucokinase (ADPGK)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70014-0
更新日期：2020-08-12 00:00:00
abstract：:This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a cer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60011-8
更新日期：2020-02-21 00:00:00
abstract：:This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37729-7
更新日期：2019-02-04 00:00:00
abstract：:We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00931-0
更新日期：2017-04-11 00:00:00
abstract：:Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04966
更新日期：2014-05-27 00:00:00
abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28818-8
更新日期：2018-07-13 00:00:00
abstract：:Through combined three-dimensional electromagnetic and particle tracking simulations we demonstrate a THz driven electron streak camera featuring a temporal resolution on the order of a femtosecond. The ultrafast streaking field is generated in a resonant THz sub-wavelength antenna which is illuminated by an intense s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05645
更新日期：2014-07-10 00:00:00
abstract：:Strongly interacting one-dimensional quantum systems often behave in a manner that is distinctly different from their higher-dimensional counterparts. When a particle attempts to move in a one-dimensional environment it will unavoidably have to interact and 'push' other particles in order to execute a pattern of motio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10675
更新日期：2015-06-15 00:00:00
abstract：:Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quanti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27300
更新日期：2016-06-06 00:00:00
abstract：:Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29353
更新日期：2016-07-07 00:00:00
abstract：:A coherent anti-Stokes Raman scattering (CARS) rigid endoscope was developed to visualize peripheral nerves without labeling for nerve-sparing endoscopic surgery. The developed CARS endoscope had a problem with low imaging speed, i.e. low imaging rate. In this study, we demonstrate that noise reduction with deep learn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72241-x
更新日期：2020-09-16 00:00:00
abstract：:The aim of the present study was to compare the clinical, radiological and histomorphometrical outcome of simultaneous implant placement following augmentation of atrophic maxillary sinuses using allograft (block or particles). Consecutive patients with maxillary residual alveolar ridge height ≤3 mm, scheduled for sin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65874-5
更新日期：2020-06-03 00:00:00
abstract：:Graphene-based materials have been studied in many applications, owing to the excellent electrical, mechanical, and thermal properties of graphene. In the current study, an environmentally friendly approach to the preparation of a reduced graphene oxide-gold nanoparticle (rGO-AuNP) nanocomposite was developed by using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15210-1
更新日期：2017-11-03 00:00:00
abstract：:Whether the retinal process alone or retinal and cortical processes jointly determine afterimage (AI) formation has long been debated. Based on the retinal rebound responses, recent work proposes that afterimage signals are exclusively generated in the retina, although later modified by cortical mechanisms. We tested ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41101
更新日期：2017-01-23 00:00:00
abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17777-1
更新日期：2017-12-11 00:00:00
abstract：:We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarizat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16837-w
更新日期：2017-11-29 00:00:00
abstract：:Range-wide population studies of wide spread species are often associated with complex diversity patterns resulting from genetically divergent evolutionary significant units (ESUs). The compound evolutionary history creating such a pattern of diversity can be inferred through molecular analyses. Asparagus cochinchinen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46275-9
更新日期：2019-07-05 00:00:00
abstract：:Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70259-9
更新日期：2020-08-07 00:00:00
abstract：:Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26938
更新日期：2016-06-01 00:00:00
abstract：:It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54718-6
更新日期：2019-12-13 00:00:00
