Regulation of immunoproteasome function in the lung.

abstract：:Hydraulic extended-reach limit (HERL) model of horizontal extended-reach well (ERW) can predict the maximum measured depth (MMD) of the horizontal ERW. The HERL refers to the well's MMD when drilling fluid cannot be normally circulated by drilling pump. Previous model analyzed the following two constraint conditions, ...

journal_title：Scientific reports

authors： Li X,Gao D,Chen X

更新日期：2017-06-08 00:00:00

abstract：:The dynamics of cell wall polysaccharides may modulate the cell wall mechanics and thus control the expansion growth of plant cells. The unique composition of type II primary cell wall characteristic of grasses suggests that they employ specific mechanisms for cell enlargement. We characterized the transcriptomes in f...

journal_title：Scientific reports

authors： Kozlova LV,Nazipova AR,Gorshkov OV,Petrova AA,Gorshkova TA

更新日期：2020-07-02 00:00:00

abstract：:The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method an...

journal_title：Scientific reports

authors： Sharifi M,Hasan A,Nanakali NMQ,Salihi A,Qadir FA,Muhammad HA,Shekha MS,Aziz FM,Amen KM,Najafi F,Yousefi-Manesh H,Falahati M

更新日期：2020-04-03 00:00:00

abstract：:Baiyacha (BYC) is a kind of wild tea plant growing and utilizing in the remote mountain area of Fujian province, Southeastern China. However, scientific studies on this plant remain limited. Our results showed that BYC exhibits the typical morphological characteristics of Camellia gymnogyna Chang, a closely related sp...

journal_title：Scientific reports

authors： Jin JQ,Jiang CK,Yao MZ,Chen L

更新日期：2020-06-16 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin. The loss of dystrophin expression is not limited to muscle weakness but has multiple systemic consequences. Managing the nutr...

journal_title：Scientific reports

authors： Strakova J,Kamdar F,Kulhanek D,Razzoli M,Garry DJ,Ervasti JM,Bartolomucci A,Townsend D

更新日期：2018-09-11 00:00:00

abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...

journal_title：Scientific reports

authors： Katayama N,Yamamori S,Fukaya M,Kobayashi S,Watanabe M,Takahashi M,Manabe T

更新日期：2017-08-11 00:00:00

abstract：:The extraction of renewable energy resources particularly from earth abundant materials has always been a matter of significance in industrial products. Herein, we report a novel simultaneous extraction of nano-silicon with activated carbons (nano-Si@ACs) from rice husk (RH) by chemical activation method. As-extracted...

journal_title：Scientific reports

authors： Ahmad W,Bahrani MR,Yang Z,Khan J,Jing W,Jiang F,Chu L,Liu N,Li L,Gao Y

更新日期：2016-12-21 00:00:00

abstract：:Functional interplays of microbial activity, genetic diversity and contaminant transformation are poorly understood in reactors for mineralizing halogenated aromatics anaerobically. Here, we investigated abundance and distribution of potential microbes and functional genes associated with pentachlorophenol (PCP) anaer...

journal_title：Scientific reports

authors： Li ZL,Nan J,Huang C,Liang B,Liu WZ,Cheng HY,Zhang C,Zhang D,Kong D,Kanamaru K,Kobayashi T,Wang AJ,Katayama A

更新日期：2016-01-11 00:00:00

abstract：:Emergence of new molecules acting directly on the hepatitic C virus (HCV) has improved treatment outcomes. However, there is a risk of selecting viral escape mutants, so a new combination is needed using different inhibitors that target different steps of the HCV infectious cycle. Novel single tablet formulations were...

journal_title：Scientific reports

authors： Shiha G,Soliman R,Elbasiony M,Darwish NHE,Mousa SA

更新日期：2019-09-19 00:00:00

abstract：:Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...

journal_title：Scientific reports

authors： De Gennaro L,Gorgoni M,Reda F,Lauri G,Truglia I,Cordone S,Scarpelli S,Mangiaruga A,D'atri A,Lacidogna G,Ferrara M,Marra C,Rossini PM

更新日期：2017-01-03 00:00:00

abstract：:Studies focusing on biofilm assembly in deep-sea environments are rarely conducted. To examine the effects of substrate type on microbial community assembly, biofilms were developed on different substrates for different durations at two locations in the Red Sea: in a brine pool and in nearby bottom water (NBW) adjacen...

journal_title：Scientific reports

authors： Zhang WP,Wang Y,Tian RM,Bougouffa S,Yang B,Cao HL,Zhang G,Wong YH,Xu W,Batang Z,Al-Suwailem A,Zhang XX,Qian PY

更新日期：2014-10-17 00:00:00

abstract：:Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...

journal_title：Scientific reports

authors： Gatto F,Rossi B,Tarallo A,Polishchuk E,Polishchuk R,Carrella A,Nusco E,Alvino FG,Iacobellis F,De Leonibus E,Auricchio A,Diez-Roux G,Ballabio A,Parenti G

更新日期：2017-11-08 00:00:00

abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...

journal_title：Scientific reports

authors： Kuang Q,Xu X,Li R,Dong Y,Li Y,Huang Z,Li Y,Li M

更新日期：2015-09-09 00:00:00

abstract：:The innovation of iconic gestures is essential to establishing the vocabularies of signed languages, but might iconicity also play a role in the origin of spoken words? Can people create novel vocalizations that are comprehensible to naïve listeners without prior convention? We launched a contest in which participants...

journal_title：Scientific reports

authors： Perlman M,Lupyan G

更新日期：2018-02-08 00:00:00

abstract：:In mosquitoes, precise and efficient finding of a host animal is crucial for survival. One of the poorly understood aspects of mosquito blood-feeding behavior is how these insects target an optimal site in order to penetrate the skin and blood vessels without alerting the host animal. Here we provide new findings that...

journal_title：Scientific reports

authors： Jung JW,Baeck SJ,Perumalsamy H,Hansson BS,Ahn YJ,Kwon HW

更新日期：2015-08-26 00:00:00

abstract：:microRNAs are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landscape of a cell. Similar to mRNA, they often exhibit cell type enriched expression and serve to reinforce cellular identity. In tissue with high cellular complexity, such as the central nervous system (CNS), it ...

journal_title：Scientific reports

authors： Pomper N,Liu Y,Hoye ML,Dougherty JD,Miller TM

更新日期：2020-03-18 00:00:00

abstract：:The spreading of invasive species in new continents can vary from slow and limited diffusion to fast colonisations over vast new areas. We studied the sacred ibis Threskiornis aethiopicus along a 31-year period, from 1989 to 2019, with particular attention to the first area of release in NW Italy. We collected data on...

journal_title：Scientific reports

authors： Cucco M,Alessandria G,Bissacco M,Carpegna F,Fasola M,Gagliardi A,Gola L,Volponi S,Pellegrino I

更新日期：2021-01-08 00:00:00

abstract：:Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile. Unlike the mechanisms of clathrin-dependent endocytosis (CDE), the mechanisms underlying the control of GPCR signaling by clathrin-independent endocytos...

journal_title：Scientific reports

authors： Wan M,Zhang W,Tian Y,Xu C,Xu T,Liu J,Zhang R

更新日期：2015-06-22 00:00:00

abstract：:Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...

journal_title：Scientific reports

authors： Khumairoh U,Lantinga EA,Schulte RPO,Suprayogo D,Groot JCJ

更新日期：2018-10-03 00:00:00

abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

journal_title：Scientific reports

authors： Reeves KG,Kanai Y

更新日期：2017-01-13 00:00:00

abstract：:Most members of the poly(ADP-ribose)polymerase family, PARP family, have a catalytic activity that involves the transfer of ADP-ribose from a beta-NAD+-molecule to protein acceptors. It was recently discovered by Talhaoui et al. that DNA-dependent PARP1 and PARP2 can also modify DNA. Here, we demonstrate that DNA-depe...

journal_title：Scientific reports

authors： Belousova EA,Ishchenko АA,Lavrik OI

更新日期：2018-03-08 00:00:00

abstract：:The bronchoscopy, though usually safe, is occasionally associated with complications, such as pneumonia. However, the use of prophylactic antibiotics is not recommended by the guidelines of the British Thoracic Society. Thus far there are few reports of the risk factors for post-bronchoscopy pneumonia; the purpose of ...

journal_title：Scientific reports

authors： Sato Y,Murata K,Yamamoto M,Ishiwata T,Kitazono-Saitoh M,Wada A,Takamori M

更新日期：2020-11-17 00:00:00

abstract：:Polarity-sensitive fluorescent probes are powerful chemical tools for studying biomolecular structures and activities both in vitro and in vivo. However, the lack of "off-on" polarity-sensing probes has limited the accurate monitoring of biological processes that involve an increase in local hydrophilicity. Here, we d...

journal_title：Scientific reports

authors： Zhu H,Fan J,Mu H,Zhu T,Zhang Z,Du J,Peng X

更新日期：2016-10-21 00:00:00

abstract：:The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among struct...

journal_title：Scientific reports

authors： Ren Z,Ren PX,Balusu R,Yang X

更新日期：2016-09-23 00:00:00

abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...

journal_title：Scientific reports

authors： Zaoui A,Sekkal W

更新日期：2015-03-06 00:00:00

abstract：:Most studies examining the relationships between vitamin D and disease or health focus on the main 25-hydroxyvitamin D3 (25(OH)D3) metabolite, thus potentially overlooking contributions and dynamic effects of other vitamin D metabolites, the crucial roles of several of which have been previously demonstrated. The idea...

journal_title：Scientific reports

authors： Müller MJ,Stokes CS,Lammert F,Volmer DA

更新日期：2016-02-11 00:00:00

abstract：:The most common surgical emergency is suspected acute appendicitis, the lifetime risk of acute appendicitis is estimated to be 8.6% for men and 6.7% for women, with a male to female ratio of 1.4:1; correct diagnosis can be made in 70-80% of patients after the operations about 32% of appendectomies revealed normal appe...

journal_title：Scientific reports

authors： Ahmed HO,Muhedin R,Boujan A,Aziz AHS,Abdulla AM,Hardi RA,Abdulla AA,Sidiq TA

更新日期：2020-02-06 00:00:00

abstract：:Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...

journal_title：Scientific reports

authors： Dakouri A,Zhang X,Peng G,Falk KC,Gossen BD,Strelkov SE,Yu F

更新日期：2018-12-05 00:00:00

abstract：:Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

journal_title：Scientific reports

authors： Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

更新日期：2020-11-18 00:00:00

abstract：:Using 137Cs and 210Pb dating and multi-proxy evidence from a 41-cm sediment core from Bosten Lake in China, the responses of sediment grain size to environmental changes were reconstructed over the past 150 years. After the end of the Little Ice Age, the climate of the Bosten Lake region became warmer and drier, and t...

journal_title：Scientific reports

authors： Ma L,Abuduwaili J,Liu W

更新日期：2020-01-22 00:00:00