Abstract:
:Emergence of new molecules acting directly on the hepatitic C virus (HCV) has improved treatment outcomes. However, there is a risk of selecting viral escape mutants, so a new combination is needed using different inhibitors that target different steps of the HCV infectious cycle. Novel single tablet formulations were developed: Dactavira, composed of sofosbuvir (SOF) 400 mg/daclatisvir (DCV) 60 mg/epigallocatechin gallate (EGCG) 400 mg without ribavirin (RBV); and Dactavira plus, which includes RBV 800 mg. A randomized, open-label study was carried out on treatment-naïve non-cirrhotic (Group A, n = 50) and treatment-naïve cirrhotic (Group B, n = 22) patients with genotype 4 HCV infection. Group A was randomly assigned to receive a single daily fixed-dose (Dactavira, n = 25) or the standard of care [SOF 400 mg/DCV 60 mg] (n = 25) daily for 12 weeks. Group B was randomly assigned to receive a single daily fixed-dose (Dactavira plus, n = 11) or the standard of care + RBV 800 mg (n = 11) daily for 12 weeks. Patients receiving Dactavira or Dactavira plus had a significantly more rapid rate of viral load decline as compared to patients receiving the standard of care therapy. Sustained virological response for 12 weeks for Dactavira or Dactavira plus showed no statistically significant difference when compared to the standard of care. Also, they did not affect normal hemoglobin levels (p < 0.001) versus the standard of care. The incorporated EGCG interferes with the viral entry mechanisms, as reported by several investigators, and in turn enhances efficacy and prevents relapse as compared to the standard of care. Also, its antihemeolytic and antifibrotic activities may improve the safety and tolerability of the therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shiha G,Soliman R,Elbasiony M,Darwish NHE,Mousa SAdoi
10.1038/s41598-019-49973-6subject
Has Abstractpub_date
2019-09-19 00:00:00pages
13593issue
1issn
2045-2322pii
10.1038/s41598-019-49973-6journal_volume
9pub_type
杂志文章abstract::Traditional risk assessment and source apportionment of sediments based on bulk polycyclic aromatic hydrocarbons (PAHs) can introduce biases due to unknown aging effects in various sediments. We used a mild solvent (hydroxypropyl-β-cyclodextrin) to extract the bioavailable fraction of PAHs (a-PAHs) from sediment sampl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23134
更新日期:2016-03-15 00:00:00
abstract::A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28896
更新日期:2016-07-01 00:00:00
abstract::In 1842 Charles Darwin claimed that vertical growth on a subsiding foundation caused fringing reefs to transform into barrier reefs then atolls. Yet historically no transition between reef types has been discovered and they are widely considered to develop independently from antecedent foundations during glacio-eustat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04997
更新日期:2014-05-21 00:00:00
abstract::The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24622
更新日期:2016-04-19 00:00:00
abstract::Gene overexpression through the targeting of transcription activation domains to regulatory DNA via catalytically defective Cas9 (dCas9) represents a powerful approach to investigate gene function as well as the mechanisms of gene control. To date, the most efficient dCas9-based activator is the Synergistic Activation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54179-x
更新日期:2019-12-02 00:00:00
abstract::CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) was identified as a susceptibility gene for type 2 diabetes and body mass index in genome-wide association studies. Although it was reported that CDKAL1 is a methylthiotransferase essential for tRNALys(UUU) and faithful translation of proinsulin generated in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06469-5
更新日期:2017-08-04 00:00:00
abstract::The distribution of corals in Japan covers a wide range of latitudes, encompassing tropical to temperate zones. However, coral communities in temperate zones contain only a small subset of species. Among the parameters that determine the distribution of corals, temperature plays an important role. We tested the resili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18467
更新日期:2015-12-18 00:00:00
abstract::Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34990
更新日期:2016-10-11 00:00:00
abstract::HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplifica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43275-7
更新日期:2019-05-08 00:00:00
abstract::The Saccharomyces cerevisiae kinesin-5 Cin8 performs essential mitotic functions in spindle assembly and anaphase B spindle elongation. Recent work has shown that Cin8 is a bi-directional motor which moves towards the minus-end of microtubules (MTs) under high ionic strength (IS) conditions and changes directionality ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25597
更新日期:2016-05-24 00:00:00
abstract::Trophic variation in food web structure occurs among and within ecosystems. The magnitude of variation, however, differs from system to system. In ephemeral pond ecosystems, temporal dynamics are relatively more important than in many systems given that hydroperiod is the ultimate factor determining the presence of an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08026-6
更新日期:2017-08-08 00:00:00
abstract::Orexins are originally characterized as orexigenic hypothalamic neuropeptides in mammals. Subsequent studies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals. In avian (non-mammalian) species, however, orexin seemed to not affect feeding behavior and its physiological roles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76329-2
更新日期:2020-11-05 00:00:00
abstract::The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39413
更新日期:2016-12-19 00:00:00
abstract::Because of the lack of cell wall, Micoplasma species require a fine control of membrane fluidity and integrity. mg517 is an essential gene of Mycoplasma genitalium responsible for the biosynthesis of membrane glycoglycerolipids. It encodes for a unique glycosyltransferase (MG517) with processive activity, transferring...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42970-9
更新日期:2019-05-08 00:00:00
abstract::Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45515-2
更新日期:2019-06-21 00:00:00
abstract::Many aspects of song learning in songbirds resemble characteristics of speech acquisition in humans. Genetic, anatomical and behavioural parallels have most recently been extended with demonstrated similarities in hemispheric dominance between humans and songbirds: the avian higher order auditory cortex is left-latera...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11359
更新日期:2015-06-22 00:00:00
abstract::Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05588
更新日期:2014-07-07 00:00:00
abstract::To investigate the mechanism underlying AT1-AA-induced retinopathy in severe preeclampsia by measuring the positive rate and titer of AT1-AA in plasma from women with severe preeclampsia and normal pregnant women to see whether AT1-AA titer was correlated with the grade of retinopathy. A preeclampsia rat model was als...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29036
更新日期:2016-07-06 00:00:00
abstract::Mutations in the Norrin (NDP) gene cause severe developmental blood vessel defects in the retina leading to congenital blindness. In the retina of Ndph-knockout mice only the superficial capillary network develops. Here, a detailed characterization of this mouse model at late stages of the disease using in vivo retina...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24476-y
更新日期:2018-04-13 00:00:00
abstract::Optical clearing methods can facilitate deep optical imaging in biological tissue by reducing light scattering and this has enabled accurate three-dimensional signal visualization and quantification of complex biological structures. Unfortunately, existing optical clearing approaches present a compromise between maxim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12484-3
更新日期:2017-09-22 00:00:00
abstract::The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68106-y
更新日期:2020-07-14 00:00:00
abstract::The typical photodetectors can only detect one specific optical spectral band, such as InGaAs and graphene-PbS quantum dots for near-infrared (NIR) light detection, CdS and Si for visible light detection, and ZnO and III-nitrides for UV light detection. So far, none of the developed photodetector can achieve the multi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02368
更新日期:2013-01-01 00:00:00
abstract::A connection between airway and gut microbiota related to allergen exposure in childhood allergies was not well addressed. We aimed to identify the microbiota alterations in the airway and gut related to mite-specific IgE responses in young children with airway allergies. This study enrolled 60 children, including 38 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70528-7
更新日期:2020-08-10 00:00:00
abstract::Current investigation was endeavoured to overcome problem of poor palatability and bioavailability of centrally acting analgesic, tapentadol (TAP) by formulating controlled release drug-resin complexes (DRCs). The technology encompassed in preparation of DRCs involved chemisorption of TAP to weak cationic resins (Kyro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21214-2
更新日期:2018-02-12 00:00:00
abstract::The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc -/- and Optc +/+ mice. Ten weeks post-surgery, cartilage was processed for histology and immu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18047-w
更新日期:2018-01-11 00:00:00
abstract::Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19649
更新日期:2016-01-20 00:00:00
abstract::There is emerging evidence that microRNAs (miRNAs) dysregulation is involved in the genesis and the progression of Prostate Cancer (PCa), thus potentially increasing their use in urological clinical practice. This is the first pilot study which utilizes Illumina Deep Sequencing to examine the entire miRNAs spectrum ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24236-y
更新日期:2018-05-08 00:00:00
abstract::Psychopathic traits of conduct disorder (CD) have a core callous-unemotional (CU) component and an impulsive-antisocial component. Previous task-driven fMRI studies have suggested that psychopathic traits are associated with dysfunction of several brain areas involved in different cognitive functions (e.g., empathy, r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11775-z
更新日期:2017-09-12 00:00:00
abstract::Doping with the optimum concentration of carriers (electrons or holes) can modify the physical properties of materials. Therefore, improved ways to achieve carrier doping have been pursued extensively for more than 50 years. Metal-intercalation is one of the most important techniques for electron doping of organic / i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18931
更新日期:2016-01-06 00:00:00
abstract::Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16788-2
更新日期:2017-12-07 00:00:00