Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres.

abstract：:Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied a...

journal_title：Scientific reports

authors： Singh G,Singh G,Singh P,Parmar R,Paul N,Vashist R,Swarnkar MK,Kumar A,Singh S,Singh AK,Kumar S,Sharma RK

更新日期：2017-09-19 00:00:00

abstract：:The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant development. It accepts ubiquitin from the E1 enzyme and interacts with the...

journal_title：Scientific reports

authors： Sharma B,Bhatt TK

更新日期：2017-08-17 00:00:00

abstract：:Nanoparticles are widely used in commodities, and pregnant women are inevitably exposed to these particles. The placenta protects the growing fetus from foreign or toxic materials, and provides energy and oxygen. Here we report that autophagy, a cellular mechanism to maintain homeostasis, engulfs platinum nanoparticle...

journal_title：Scientific reports

authors： Nakashima A,Higashisaka K,Kusabiraki T,Aoki A,Ushijima A,Ono Y,Tsuda S,Shima T,Yoshino O,Nagano K,Yoshioka Y,Tsutsumi Y,Saito S

更新日期：2019-04-02 00:00:00

abstract：:Microwave absorbers have important applications in various areas including stealth, camouflage, and antenna. Here, we have designed an ultra-broadband light absorber by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption bands due to broadba...

journal_title：Scientific reports

authors： Yin X,Long C,Li J,Zhu H,Chen L,Guan J,Li X

更新日期：2015-10-19 00:00:00

abstract：:Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Lep...

journal_title：Scientific reports

authors： Acharya KD,Gao X,Bless EP,Chen J,Tetel MJ

更新日期：2019-12-27 00:00:00

abstract：:Electrical contacts on the top surface of solar cells and light emitting diodes cause shadow losses. The phenomenon of extraordinary optical transmission through arrays of subwavelength holes suggests the possibility of engineering such contacts to reduce the shadow using plasmonics, but resonance effects occur only a...

journal_title：Scientific reports

authors： San Román E,Vitrey A,Buencuerpo J,Prieto I,Llorens JM,García-Martín A,Alén B,Chaudhuri A,Neumann A,Brueck SR,Ripalda JM

更新日期：2016-06-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zheng CM,Wang JY,Chen TT,Wu YC,Wu YL,Lin HT,Chiu SP,Chang TJ,Zheng JQ,Chu NF,Lin YM,Su SL,Lu KC,Chen JS,Sung FC,Lee CT,Yang Y,Hwang SJ,Wang MC,Hsu YH,Chiou HY,Kao S,Wu MY,Lin YF

更新日期：2020-04-15 00:00:00

abstract：:The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of phosphorylated tau. I...

journal_title：Scientific reports

authors： Kim S,Choi KJ,Cho SJ,Yun SM,Jeon JP,Koh YH,Song J,Johnson GV,Jo C

更新日期：2016-04-26 00:00:00

abstract：:Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...

journal_title：Scientific reports

authors： Creemers A,Ter Veer E,de Waal L,Lodder P,Hooijer GKJ,van Grieken NCT,Bijlsma MF,Meijer SL,van Oijen MGH,van Laarhoven HWM

更新日期：2017-06-09 00:00:00

abstract：:An accurate and efficient solution of the radiative transport equation is proposed for modeling the propagation of photons in the three-dimensional anisotropically scattering half-space medium. The exact refractive index mismatched boundary condition is considered and arbitrary rotationally invariant scattering functi...

journal_title：Scientific reports

authors： Liemert A,Kienle A

更新日期：2013-01-01 00:00:00

abstract：:Competition between simultaneously presented visual stimuli lengthens reaction time and reduces both the BOLD response and neural firing. In contrast, conditions of sequential presentation have been assumed to be free from competition. Here we manipulated the spatial proximity of stimuli (Near versus Far conditions) t...

journal_title：Scientific reports

authors： Ahmad J,Swan G,Bowman H,Wyble B,Nobre AC,Shapiro KL,McNab F

更新日期：2017-07-06 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep45235. ...

journal_title：Scientific reports

authors： Wu J,Hu S,Chen Y,Li Z,Zhang J,Yuan H,Shi Q,Shao N,Ying X

更新日期：2017-12-22 00:00:00

abstract：:Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200,...

journal_title：Scientific reports

authors： Tseng JH,Bisogna M,Hoang LN,Olvera N,Rodriguez-Aguayo C,Lopez-Berestein G,Sood AK,Levine DA,Jelinic P

更新日期：2017-06-15 00:00:00

abstract：:Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...

journal_title：Scientific reports

authors： Henssen D,Kurt E,van Walsum AVC,Kozicz T,van Dongen R,Bartels R

更新日期：2020-04-28 00:00:00

abstract：:Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

journal_title：Scientific reports

authors： Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

更新日期：2021-01-13 00:00:00

abstract：:Tumor cell invasion requires the molecular and physical adaptation of both the cell and its microenvironment. Here we show that tumor cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion through the extracellular matrix. Invadopodia formation accompanies the mesenchymal mode...

journal_title：Scientific reports

authors： Sedgwick AE,Clancy JW,Olivia Balmert M,D'Souza-Schorey C

更新日期：2015-10-13 00:00:00

abstract：:There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...

journal_title：Scientific reports

authors： Ang RRG,Lee HJ,Bae JS,Zhu CC,Berlth F,Kim TH,Park SH,Suh YS,Kong SH,Kim SH,Yang HK

更新日期：2020-04-03 00:00:00

abstract：:Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead to the generation and maintenance of supersaturated solutions, which enhance oral absorption in vivo, are poorly understood...

journal_title：Scientific reports

authors： Wilson VR,Lou X,Osterling DJ,Stolarik DF,Jenkins GJ,Nichols BLB,Dong Y,Edgar KJ,Zhang GGZ,Taylor LS

更新日期：2020-10-28 00:00:00

abstract：:CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) was identified as a susceptibility gene for type 2 diabetes and body mass index in genome-wide association studies. Although it was reported that CDKAL1 is a methylthiotransferase essential for tRNALys(UUU) and faithful translation of proinsulin generated in...

journal_title：Scientific reports

authors： Take K,Waki H,Sun W,Wada T,Yu J,Nakamura M,Aoyama T,Yamauchi T,Kadowaki T

更新日期：2017-08-04 00:00:00

abstract：:Clinical success of effective gene therapy is mainly hampered by the insufficiency of safe and efficient internalization of a transgene to the targeted cellular site. Therefore, the development of a safe and efficient nanocarrier system is one of the fundamental challenges to transfer the therapeutic genes to the dise...

journal_title：Scientific reports

authors： Tariq I,Ali MY,Sohail MF,Amin MU,Ali S,Bukhari NI,Raza A,Pinnapireddy SR,Schäfer J,Bakowsky U

更新日期：2020-12-08 00:00:00

abstract：:Undertaking behaviour is an essential activity in social insects. Corpses are often recognized by a postmortem change in a chemical signature. Reticulitermes flavipes responded to corpses within minutes of death. This undertaking behaviour did not change with longer postmortem time (24 h); however, R. flavipes exhibit...

journal_title：Scientific reports

authors： Sun Q,Haynes KF,Zhou X

更新日期：2013-01-01 00:00:00

abstract：:Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...

journal_title：Scientific reports

authors： Sun H,Santalahti M,Pumpanen J,Köster K,Berninger F,Raffaello T,Asiegbu FO,Heinonsalo J

更新日期：2016-08-30 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...

journal_title：Scientific reports

authors： Orfali RL,Yoshikawa FSY,Oliveira LMDS,Pereira NZ,de Lima JF,Ramos YÁL,Duarte AJDS,Sato MN,Aoki V

更新日期：2019-09-11 00:00:00

abstract：:Cardiac remodeling is characterized by overactivity of the renin-angiotensin system (RAS) and withdrawal of vagal activity. We hypothesized that improving vagal activity could attenuate cardiac fibrosis induced by angiotensin II (Ang II) in vivo and in vitro. Rats were subjected to abdominal aorta constriction (AAC) w...

journal_title：Scientific reports

authors： Liu JJ,Huang N,Lu Y,Zhao M,Yu XJ,Yang Y,Yang YH,Zang WJ

更新日期：2015-11-24 00:00:00

abstract：:The absorption spectra in array of Ge, Al and Ge/Al-shell nanoparticles immersed in alumina (Al2O3) matrix is calculated in framework of ab initio macroscopic dielectric model. It is demonstrated that absorption is strongly enhanced when germanium nanospheres are encapsulated by Al-shell. Two absorption peaks, appeari...

journal_title：Scientific reports

authors： Despoja V,Basioli L,Parramon JS,Mičetić M

更新日期：2020-01-09 00:00:00

abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...

journal_title：Scientific reports

authors： Kim HS,Choi JH,Lee JY,Kang J,Myung JK,Kim WH,Jang BG

更新日期：2020-03-17 00:00:00

abstract：:Leaching of nitrate from fertilisers diminishes nitrogen use efficiency (the portion of nitrogen used by a plant) and is a major source of agricultural pollution. To improve nitrogen capture, grasses such as brachiaria are increasingly used, especially in South America and Africa, as a cover crop, either via intercrop...

journal_title：Scientific reports

authors： Galdos MV,Brown E,Rosolem CA,Pires LF,Hallett PD,Mooney SJ

更新日期：2020-03-19 00:00:00

abstract：:Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...

journal_title：Scientific reports

authors： Yasir M,Dutta D,Willcox MDP

更新日期：2019-05-08 00:00:00

abstract：:The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting cargo to the manchette during sperm flagellum assembly. Here we show...

journal_title：Scientific reports

authors： Li W,Walavalkar NM,Buchwald WA,Teves ME,Zhang L,Liu H,Bilinovich S,Peterson DL,Strauss JF 3rd,Williams DC Jr,Zhang Z

更新日期：2016-01-04 00:00:00

abstract：:ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...

journal_title：Scientific reports

authors： Bua DJ,Martin GM,Binda O,Gozani O

更新日期：2013-01-01 00:00:00