Molecular dissection of transcriptional reprogramming of steviol glycosides synthesis in leaf tissue during developmental phase transitions in Stevia rebaudiana Bert.

abstract：:To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis ge...

journal_title：Scientific reports

authors： Xia EH,Yang DR,Jiang JJ,Zhang QJ,Liu Y,Liu YL,Zhang Y,Zhang HB,Shi C,Tong Y,Kim C,Chen H,Peng YQ,Yu Y,Zhang W,Eichler EE,Gao LZ

更新日期：2017-05-11 00:00:00

abstract：:Amyloids are highly organized fibril aggregates arise from inappropriately folded form of the protein or polypeptide precursors under both physiological as well as simulated ambience. Amyloid synthesis is a multistep process that involves formation of several metastable intermediates. Among various intermediate specie...

journal_title：Scientific reports

authors： Kazmi S,Mujeeb AA,Owais M

更新日期：2018-11-23 00:00:00

abstract：:Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with ant...

journal_title：Scientific reports

authors： Zhu XY,Guo DW,Lao QC,Xu YQ,Meng ZK,Xia B,Yang H,Li CQ,Li P

更新日期：2019-03-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Mei X,Glueckert R,Schrott-Fischer A,Li H,Ladak HM,Agrawal SK,Rask-Andersen H

更新日期：2020-05-01 00:00:00

abstract：:In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...

journal_title：Scientific reports

authors： Zavafer A,González-Solís A,Palacios-Bahena S,Saucedo-García M,Tapia de Aquino C,Vázquez-Santana S,King-Díaz B,Gavilanes-Ruiz M

更新日期：2020-06-25 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH deficiency on the dev...

journal_title：Scientific reports

authors： Stöhr R,Mavilio M,Marino A,Casagrande V,Kappel B,Möllmann J,Menghini R,Melino G,Federici M

更新日期：2015-03-17 00:00:00

abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...

journal_title：Scientific reports

authors： Ojha A,Nandi D,Batra H,Singhal R,Annarapu GK,Bhattacharyya S,Seth T,Dar L,Medigeshi GR,Vrati S,Vikram NK,Guchhait P

更新日期：2017-01-31 00:00:00

abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...

journal_title：Scientific reports

authors： Messner A,Werkmeister RM,Seidel G,Stegmann H,Schmetterer L,Aranha Dos Santos V

更新日期：2019-09-20 00:00:00

abstract：:We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population, can be solved exactly, even in the presence of a time-dependent infection rate. ...

journal_title：Scientific reports

authors： Dell'Anna L

更新日期：2020-09-25 00:00:00

abstract：:Acrolein, a highly toxic α, β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. One of the most promising methods for detecting acrolein involves the use of antibodies that can recognize the acrolein-lysine conjugate, 3-formyl-3, 4-dehydropi...

journal_title：Scientific reports

authors： Takamatsu M,Fukase K,Oka R,Kitazume S,Taniguchi N,Tanaka K

更新日期：2016-10-26 00:00:00

abstract：:To investigate the evolution of lung function in preterm infants with and without bronchopulmonary dysplasia (BPD) and to determine the perinatal characteristics associated with indexes of lung function in later infancy. Longitudinal lung function assessments were performed at approximately 6, 12, 18, and 24 months of...

journal_title：Scientific reports

authors： Lai SH,Chiang MC,Chu SM,Hsu JF,Yao TC,Tsai MH,Hua MC,Chiu CY,Yeh KW,Huang JL,Liao SL

更新日期：2020-01-16 00:00:00

abstract：:Exercise has been considered as treatment and a preventive modality to alleviate depressive symptoms, but sex differences regarding specific types of exercise in association with depression have not been clearly elucidated. Here, we investigated sex differences in the association between exercise type and depression i...

journal_title：Scientific reports

authors： Kim H,Jeong W,Kwon J,Kim Y,Jang SI,Park EC

更新日期：2020-10-26 00:00:00

abstract：:The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conduct...

journal_title：Scientific reports

authors： Clarelin A,Rasmussen M,Olaison L,Ragnarsson S

更新日期：2021-01-13 00:00:00

abstract：:Scattered and indirect evidence suggests that sea ice occurred as far south as the Iceland Sea during the Early Pliocene, when the global climate was warmer than present. However, conclusive evidence as well as potential mechanisms governing sea ice occurrence outside the Arctic Ocean during a time with elevated green...

journal_title：Scientific reports

authors： Clotten C,Stein R,Fahl K,Schreck M,Risebrobakken B,De Schepper S

更新日期：2019-01-30 00:00:00

abstract：:Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal's life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington's disease (HD). To date, however, there is little direct experimental evidence to support thi...

journal_title：Scientific reports

authors： Morton AJ,Skillings EA,Wood NI,Zheng Z

更新日期：2019-01-10 00:00:00

abstract：:Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...

journal_title：Scientific reports

authors： Nojima Y,Bono H,Yokoyama T,Iwabuchi K,Sato R,Arai K,Tabunoki H

更新日期：2019-10-11 00:00:00

abstract：:Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...

journal_title：Scientific reports

authors： Gmelch TJ,Sperl JM,Sieber V

更新日期：2019-08-13 00:00:00

abstract：:Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates w...

journal_title：Scientific reports

authors： Babić S,Čižmek L,Maršavelski A,Malev O,Pflieger M,Strunjak-Perović I,Popović NT,Čož-Rakovac R,Trebše P

更新日期：2021-01-28 00:00:00

abstract：:Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...

journal_title：Scientific reports

authors： Milora KA,Uppalapati SR,Sanmiguel JC,Zou W,Jensen LE

更新日期：2017-07-19 00:00:00

abstract：:Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation (ECD) kidney allografts (KA). Fifteen ECD-KA were submitted to 152 ± 92 min of end-ischemic HOPE and were compared to a matched...

journal_title：Scientific reports

authors： Meister FA,Czigany Z,Rietzler K,Miller H,Reichelt S,Liu WJ,Boecker J,Moeller MJ,Tolba RH,Hamesch K,Strnad P,Boor P,Stoppe C,Neumann UP,Lurje G

更新日期：2020-10-20 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Koo B,Koh CS,Park HY,Lee HG,Chang JW,Choi S,Shin HC

更新日期：2017-12-19 00:00:00

abstract：:Human CD4+ T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4+ T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4+ T cells by using E7/HLA...

journal_title：Scientific reports

authors： Gan Y,Wang C,Fang Y,Yao Y,Tu X,Wang J,Huang X,Tan Y,Chen T,Zhang K,Shen Y,Zhou L,Liu J,Lai X

更新日期：2018-07-02 00:00:00

abstract：:The genetic sexing of animals having long gestation periods offers significant benefits in regard to breeding management among their populations living in captivity. In our study, a new increased-sensitivity PCR method for fetal sexing was developed and tested successfully on elephants, from only a small volume of mat...

journal_title：Scientific reports

authors： Vincze B,Gáspárdy A,Biácsi A,Papp EÁ,Garamvölgyi L,Sós E,Cseh S,Kovács G,Pádár Z,Zenke P

更新日期：2019-10-24 00:00:00

abstract：:Pseudomonas aeruginosa is a major threat for immune-compromised patients. Bacterial pneumonia can induce uncontrolled and massive neutrophil recruitment ultimately leading to acute respiratory distress syndrome and epithelium damage. Interleukin-22 plays a central role in the protection of the epithelium. In this stud...

journal_title：Scientific reports

authors： Broquet A,Jacqueline C,Davieau M,Besbes A,Roquilly A,Martin J,Caillon J,Dumoutier L,Renauld JC,Heslan M,Josien R,Asehnoune K

更新日期：2017-09-08 00:00:00

abstract：:Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. An alternative is to consider freque...

journal_title：Scientific reports

authors： Liu Y,Scirica BM,Stultz CM,Guttag JV

更新日期：2016-10-06 00:00:00

abstract：:Peritoneal macrophages play a critical role in the control of infectious and inflammatory diseases. Although recent progress on murine peritoneal macrophages has revealed multiple aspects on their origin and mechanisms involved in their maintenance in this compartment, little is known on the characteristics of human p...

journal_title：Scientific reports

authors： Ruiz-Alcaraz AJ,Carmona-Martínez V,Tristán-Manzano M,Machado-Linde F,Sánchez-Ferrer ML,García-Peñarrubia P,Martínez-Esparza M

更新日期：2018-08-24 00:00:00

abstract：:Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right pari...

journal_title：Scientific reports

authors： Meeren HK,Hadjikhani N,Ahlfors SP,Hämäläinen MS,de Gelder B

更新日期：2016-04-20 00:00:00

abstract：:It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...

journal_title：Scientific reports

authors： Yu ZJ,Zeng L,Luo XQ,Geng XR,Xu R,Chen K,Yang G,Luo X,Liu ZQ,Liu ZG,Liu DB,Yang PC,Li HB

更新日期：2017-04-03 00:00:00

abstract：:Exotic pattern formation as a result of drying of an aqueous solution containing DNA and silica nanoparticles is reported. The pattern due to segregation was found to critically depend on the relative ratio of nanoparticles and DNA, as revealed by polarization microscopy, scanning electron microscopy, and fluorescence...

journal_title：Scientific reports

authors： Joksimovic R,Watanabe S,Riemer S,Gradzielski M,Yoshikawa K

更新日期：2014-01-13 00:00:00

abstract：:Neurodegeneration includes acute changes and slow-developing alterations, both of which partly involve common cellular machinery. During neurodegeneration, neuronal processes are impaired along with dysregulated post-translational modifications (PTMs) of cytoskeletal proteins. In neuronal processes, tubulin undergoes ...

journal_title：Scientific reports

authors： Vu HT,Akatsu H,Hashizume Y,Setou M,Ikegami K

更新日期：2017-01-09 00:00:00