Abstract:
:Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Leptin-deficient mice (ob/ob) exhibit morbid obesity and insulin resistance. The gut microbiome is also critical in regulating metabolism. The present study investigates whether estrogens and leptin modulate gut microbiota in ovariectomized ob/ob (obese) or heterozygote (lean) mice fed high-fat diet (HFD) that received either 17β-Estradiol (E2) or vehicle implants. E2 attenuated weight gain in both genotypes. Moreover, both obesity (ob/ob mice) and E2 were associated with reduced gut microbial diversity. ob/ob mice exhibited lower species richness than control mice, while E2-treated mice had reduced evenness compared with vehicle mice. Regarding taxa, E2 was associated with an increased abundance of the S24-7 family, while leptin was associated with increases in Coriobacteriaceae, Clostridium and Lactobacillus. Some taxa were affected by both E2 and leptin, suggesting these hormones alter gut microbiota of HFD-fed female mice. Understanding the role of E2 and leptin in regulating gut microbiota will provide important insights into hormone-dependent metabolic disorders in women.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Acharya KD,Gao X,Bless EP,Chen J,Tetel MJdoi
10.1038/s41598-019-56723-1subject
Has Abstractpub_date
2019-12-27 00:00:00pages
20192issue
1issn
2045-2322pii
10.1038/s41598-019-56723-1journal_volume
9pub_type
杂志文章abstract::The study of network topology provides insight into the function and behavior of physical, social, and biological systems. A natural step towards discovering the organizing principles of these complex topologies is to identify a reduced network representation using cohesive subgroups or communities. This procedure oft...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30401-0
更新日期:2018-08-09 00:00:00
abstract::Inverse Compton scattering between ultra-relativistic electrons and an intense laser field has been proposed as a major route to generate compact high-brightness and high-energy γ-rays. Attributed to the inherent synchronization mechanism, an all-optical Compton scattering γ-ray source, using one laser to both acceler...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29518
更新日期:2016-07-13 00:00:00
abstract::We report on a combined photoluminescence imaging and atomic force microscopy study of single, isolated self-assembled InAs quantum dots. The motivation of this work is to determine an approach that allows to assess single quantum dots as candidates for quantum nanophotonic devices. By combining optical and scanning p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06566-5
更新日期:2017-07-24 00:00:00
abstract::We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square micro-aquariums of lab-on-chip size. The interaction was realized by interlinking two identical optical feedback systems, which measured the cell distribut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24602
更新日期:2016-04-21 00:00:00
abstract::Auxin response factors (ARFs) are the transcription factors that regulate auxin responses in various aspects of plant growth and development. Although genome-wide analysis of ARF gene family has been done in some species, no information is available regarding ARF genes in chickpea. In this study, we identified 28 ARF ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11327-5
更新日期:2017-09-07 00:00:00
abstract::The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple rou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41005-7
更新日期:2019-03-14 00:00:00
abstract::The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47440-w
更新日期:2019-07-29 00:00:00
abstract::X-linked Alport syndrome (XLAS) is a congenital renal disease caused by mutations in COL4A5. In XLAS cases suspected of being caused by aberrant splicing, transcript analysis needs to be conducted to determine splicing patterns and assess the pathogenicity. However, such analysis is not always available. We conducted ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48990-9
更新日期:2019-09-03 00:00:00
abstract::Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19765-5
更新日期:2018-01-24 00:00:00
abstract::Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08267-5
更新日期:2017-08-15 00:00:00
abstract::Agricultural soils are the primary anthropogenic source of atmospheric nitrous oxide (N2O), contributing to global warming and depletion of stratospheric ozone. Biochar addition has shown potential to lower soil N2O emission, with the mechanisms remaining unclear. We incubated eucalypt biochar (550 °C)--0, 1 and 5% (w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16773
更新日期:2015-11-30 00:00:00
abstract::Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15805
更新日期:2015-10-29 00:00:00
abstract::Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14110-8
更新日期:2017-10-23 00:00:00
abstract::Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73654-4
更新日期:2020-10-06 00:00:00
abstract::Aurantiochytrium is a promising docosahexaenoic acid (DHA) production candidate due to its fast growth rate and high proportions of lipid and DHA content. In this study, high-throughput RNA sequencing technology was employed to explore the acclimatization of this DHA producer under cold stress at the transcriptional l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14446
更新日期:2015-09-25 00:00:00
abstract::Nanoparticles are widely used in commodities, and pregnant women are inevitably exposed to these particles. The placenta protects the growing fetus from foreign or toxic materials, and provides energy and oxygen. Here we report that autophagy, a cellular mechanism to maintain homeostasis, engulfs platinum nanoparticle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41927-2
更新日期:2019-04-02 00:00:00
abstract::A high level of plasma low-density lipoprotein (LDL) cholesterol is considered a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) is essential for clearing plasma LDL cholesterol, activation of LDLR is a promising therapeutic target for patients with atherosclerotic disease. Here we demonstrate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24940
更新日期:2016-04-25 00:00:00
abstract::A compact analysis platform for detecting liquid absorption and emission spectra using a set of optical linear variable filters atop a CMOS image sensor is presented. The working spectral range of the analysis platform can be extended without a reduction in spectral resolution by utilizing multiple linear variable fil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29117
更新日期:2016-07-08 00:00:00
abstract::HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to be revealed. We examined HIF-1α protein expression and the hypoxic condition during mouse osteoarthritis (OA) development us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62463-4
更新日期:2020-03-25 00:00:00
abstract::Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. live...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05782
更新日期:2014-07-22 00:00:00
abstract::Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19687-2
更新日期:2018-01-19 00:00:00
abstract::Pachychoroid spectrum diseases have attracted increasing attention, though their pathophysiology has yet to be fully elucidated. In this study, we assessed the vascular diameters of vortex veins in pachychoroid spectrum diseases such as central serous chorioretinopathy (CSC), pachychoroid neovasculopathy without polyp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75789-w
更新日期:2020-11-11 00:00:00
abstract::The herb Centella asiatica has long been considered a memory tonic. A recent review found no strong evidence for improvement of cognitive function, suggesting negative results were due to limitations in dose, standardization and product variation. We used a standardized extract of C. asiatica (ECa 233) to study behavi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44867-z
更新日期:2019-06-10 00:00:00
abstract::Clarifying the fundamental adsorption and diffusion process of CO2 on single crystal ZnO surfaces is critical in understanding CO2 activation and transformation over ZnO-based catalysts. By using ultrahigh vacuum-Fourier transform infrared spectroscopy (UHV-FTIRS), we observed the fine structures of CO2 vibrational ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43442
更新日期:2017-03-06 00:00:00
abstract::In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2(-)), hydroxyl radical (HO·), and hydrogen per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08587
更新日期:2015-02-26 00:00:00
abstract::Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32407-0
更新日期:2018-10-04 00:00:00
abstract::A novel type of transparent monitor with high-resolution images based on Si-SiO2 core-shell nanoparticles is presented in this contribution. In this monitor, a quasi-array of nanoparticles was used to obtain a very sharp scattering profile. For this purpose, the Si-SiO2 nanoparticles were synthesized and with controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38771-9
更新日期:2019-02-19 00:00:00
abstract::Currently little is known about structure-function mappings in the human subcortex. Here we present a large-scale automated meta-analysis on the literature to understand the structure-function mapping in the human subcortex. The results provide converging evidence into unique large scale structure-function mappings of...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-33796-y
更新日期:2018-10-26 00:00:00
abstract::An intact cell wall is critical for cellular interactions with the environment and protecting the cell from environmental challenges. Signaling mechanisms are necessary to monitor cell wall integrity and to regulate cell wall production and remodeling during growth and division cycles. The green alga, Chlamydomonas, h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48523-4
更新日期:2019-08-21 00:00:00
abstract::The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18106
更新日期:2015-12-15 00:00:00