Abstract：
:The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of phosphorylated tau. In addition, fisetin decreased the levels of sarkosyl-insoluble tau in an active GSK-3β-induced tau aggregation model. However, there was no difference in activities of tau kinases and phosphatases such as protein phosphatase 2A, irrespective of fisetin treatment. Fisetin activated autophagy together with the activation of transcription factor EB (TFEB) and Nrf2 transcriptional factors. The activation of autophagy including TFEB is likely due to fisetin-mediated mammalian target of rapamycin complex 1 (mTORC1) inhibition, since the phosphorylation levels of p70S6 kinase and 4E-BP1 were decreased in the presence of fisetin. Indeed, fisetin-induced phosphorylated tau degradation was attenuated by chemical inhibitors of the autophagy-lysosome pathway. Together the results indicate that fisetin reduces levels of phosphorylated tau through the autophagy pathway activated by TFEB and Nrf2. Our result suggests fisetin should be evaluated further as a potential preventive and therapeutic drug candidate for AD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim S,Choi KJ,Cho SJ,Yun SM,Jeon JP,Koh YH,Song J,Johnson GV,Jo Cdoi
10.1038/srep24933subject
Has Abstractpub_date
2016-04-26 00:00:00pages
24933issn
2045-2322pii
srep24933journal_volume
6pub_type
杂志文章abstract：:Light's polarisation contains information about its source and interactions, from distant stars to biological samples. Polarimeters can recover this information, but reliance on birefringent or rotating optical elements limits their wavelength range and stability. Here we present a static, single-shot polarimeter base...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39118-0
更新日期：2019-02-25 00:00:00
abstract：:This paper reports the fabrication and operation of a transmission-type polarization rotator for visible light with a wavelength of 450 nm using indirect-transition-type semiconductor crystalline SiC in which Al atoms were implanted as a p-type dopant. A novel dressed-photon-phonon (DPP)-assisted annealing method was ...
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28989-4
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54414-5
更新日期：2019-12-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11399-3
更新日期：2017-09-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-19 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28506-7
更新日期：2018-07-10 00:00:00
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pub_type： 杂志文章
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更新日期：2018-07-20 00:00:00
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更新日期：2020-03-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22960
更新日期：2016-03-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70276-8
更新日期：2020-08-07 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03011
更新日期：2013-10-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51159-z
更新日期：2019-10-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31188-w
更新日期：2018-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-02-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-05-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-11-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-03-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33699-y
更新日期：2018-10-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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