Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model.

Abstract:

:The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yang SH,Kim J,Lee MJ,Kim Y

doi

10.1038/srep15703

subject

Has Abstract

pub_date

2015-10-27 00:00:00

pages

15703

issn

2045-2322

pii

srep15703

journal_volume

5

pub_type

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