Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model.

Abstract:

:The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yang SH,Kim J,Lee MJ,Kim Y

doi

10.1038/srep15703

subject

Has Abstract

pub_date

2015-10-27 00:00:00

pages

15703

issn

2045-2322

pii

srep15703

journal_volume

5

pub_type

杂志文章
  • Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy.

    abstract:ABSTARCT:This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14633-0

    authors: Dias CSB,Hanchuk TDM,Wender H,Shigeyosi WT,Kobarg J,Rossi AL,Tanaka MN,Cardoso MB,Garcia F

    更新日期:2017-11-01 00:00:00

  • Sweet taste in apple: the role of sorbitol, individual sugars, organic acids and volatile compounds.

    abstract::Sweetness is one of the main drivers of consumer preference, and thus is given high priority in apple breeding programmes. Due to the complexity of sweetness evaluation, soluble solid content (SSC) is commonly used as an estimation of this trait. Nevertheless, it has been demonstrated that SSC and sweet taste are poor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44950

    authors: Aprea E,Charles M,Endrizzi I,Laura Corollaro M,Betta E,Biasioli F,Gasperi F

    更新日期:2017-03-21 00:00:00

  • Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats.

    abstract::Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N3O2) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investigate the inhibitory efficiency...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12379

    authors: Hajrezaie M,Shams K,Moghadamtousi SZ,Karimian H,Hassandarvish P,Emtyazjoo M,Zahedifard M,Majid NA,Mohd Ali H,Abdulla MA

    更新日期:2015-07-23 00:00:00

  • Author Correction: High-throughput format for the phenotyping of fungi on solid substrates.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-61396-2

    authors: Cánovas D,Studt L,Marcos AT,Strauss J

    更新日期:2020-03-06 00:00:00

  • Classification of colorectal tissue images from high throughput tissue microarrays by ensemble deep learning methods.

    abstract::Tissue microarray (TMA) core images are a treasure trove for artificial intelligence applications. However, a common problem of TMAs is multiple sectioning, which can change the content of the intended tissue core and requires re-labelling. Here, we investigate different ensemble methods for colorectal tissue classifi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81352-y

    authors: Nguyen HG,Blank A,Dawson HE,Lugli A,Zlobec I

    更新日期:2021-01-27 00:00:00

  • Impact of benzodiazepine consumption reduction on future burden of dementia.

    abstract::Dementia is a major public health issue worldwide and chronic use of benzodiazepine, which is very frequent in northern countries, was found to be a risk factor of dementia. This work aims at evaluating the impact of a reduction in chronic use of benzodiazepine on the future burden of dementia in France. Using estimat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71482-0

    authors: Jacqmin-Gadda H,Guillet F,Mathieu C,Helmer C,Pariente A,Joly P

    更新日期:2020-09-04 00:00:00

  • Cryptic species in the parasitic Amoebophrya species complex revealed by a polyphasic approach.

    abstract::As critical primary producers and recyclers of organic matter, the diversity of marine protists has been extensively explored by high-throughput barcode sequencing. However, classification of short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known by their ge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59524-z

    authors: Cai R,Kayal E,Alves-de-Souza C,Bigeard E,Corre E,Jeanthon C,Marie D,Porcel BM,Siano R,Szymczak J,Wolf M,Guillou L

    更新日期:2020-02-13 00:00:00

  • Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer's-like scopolamine-induced amnesic mice model.

    abstract::The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and ch...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25381-0

    authors: Karthivashan G,Park SY,Kweon MH,Kim J,Haque ME,Cho DY,Kim IS,Cho EA,Ganesan P,Choi DK

    更新日期:2018-05-08 00:00:00

  • Effects of elevational range shift on the morphology and physiology of a carabid beetle invading the sub-Antarctic Kerguelen Islands.

    abstract::Climatic changes can induce geographic expansion and altitudinal shifts in the distribution of invasive species by offering more thermally suitable habitats. At the remote sub-Antarctic Kerguelen Islands, the predatory insect Merizodus soledadinus (Coleoptera: Carabidae), introduced in 1913, rapidly invaded coastal ha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57868-0

    authors: Ouisse T,Day E,Laville L,Hendrickx F,Convey P,Renault D

    更新日期:2020-01-27 00:00:00

  • Ionic Driven Embedment of Hyaluronic Acid Coated Liposomes in Polyelectrolyte Multilayer Films for Local Therapeutic Delivery.

    abstract::The ability to control the spatial distribution and temporal release of a therapeutic remains a central challenge for biomedical research. Here, we report the development and optimization of a novel substrate mediated therapeutic delivery system comprising of hyaluronic acid covalently functionalized liposomes (HALNPs...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14683

    authors: Hayward SL,Francis DM,Sis MJ,Kidambi S

    更新日期:2015-10-01 00:00:00

  • Proteome Profiling of Urinary Exosomes Identifies Alpha 1-Antitrypsin and H2B1K as Diagnostic and Prognostic Biomarkers for Urothelial Carcinoma.

    abstract::MALDI-TOF spectrometry has not been used for urinary exosome analysis. We used it for determining UC biomarkers. From 2012 to 2015, we enrolled 129 consecutive patients with UC and 62 participants without UC. Exosomes from their urine were isolated, and analyzed through MALDI-TOF spectrometry. Immunohistochemical (IHC...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34446

    authors: Lin SY,Chang CH,Wu HC,Lin CC,Chang KP,Yang CR,Huang CP,Hsu WH,Chang CT,Chen CJ

    更新日期:2016-09-30 00:00:00

  • Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers.

    abstract::Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal mi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06675-1

    authors: Vesterbacka J,Rivera J,Noyan K,Parera M,Neogi U,Calle M,Paredes R,Sönnerborg A,Noguera-Julian M,Nowak P

    更新日期:2017-07-24 00:00:00

  • Author Correction: Comprehensive analysis of correlations among codon usage bias, gene expression, and substitution rate in Arachis duranensis and Arachis ipaënsis orthologs.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-60582-6

    authors: Song H,Gao H,Liu J,Tian P,Nan Z

    更新日期:2020-02-27 00:00:00

  • Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting.

    abstract::The Aspergillus niger-derived prolyl endoprotease (AN-PEP) has previously been shown to degrade gluten in healthy subjects when added to an intragastrically infused meal. The current study investigated the efficacy of AN-PEP in a physiological meal setting. In this randomized placebo-controlled crossover study, 18 glu...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-017-13587-7

    authors: König J,Holster S,Bruins MJ,Brummer RJ

    更新日期:2017-10-12 00:00:00

  • Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.

    abstract::Toll-like receptor 7 (TLR7) mediates autoantigen and viral RNA-induced cytokine production. Increased TLR7 expression in human atherosclerotic lesions suggests its involvement in atherogenesis. Here we demonstrated TLR7 expression in macrophages, smooth muscle cells (SMCs), and endothelial cells from mouse atheroscler...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00977-0

    authors: Liu CL,Santos MM,Fernandes C,Liao M,Iamarene K,Zhang JY,Sukhova GK,Shi GP

    更新日期:2017-04-12 00:00:00

  • Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model.

    abstract::Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46686

    authors: Khodanovich MY,Sorokina IV,Glazacheva VY,Akulov AE,Nemirovich-Danchenko NM,Romashchenko AV,Tolstikova TG,Mustafina LR,Yarnykh VL

    更新日期:2017-04-24 00:00:00

  • Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.

    abstract::Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-017-01907-w

    authors: Kullmann S,Heni M,Veit R,Scheffler K,Machann J,Häring HU,Fritsche A,Preissl H

    更新日期:2017-05-09 00:00:00

  • A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.

    abstract::Single nucleotide polymorphisms (SNPs) in the 3'-untranslated regions targeted by putative mircoRNA can change its binding strength, affecting the susceptibility and prognosis of cancer. We aimed to investigate the associations between SNPs within miR-148a binding sites and gastric cancer (GC) risk and prognosis. Usin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07080

    authors: Song P,Zhu H,Zhang D,Chu H,Wu D,Kang M,Wang M,Gong W,Zhou J,Zhang Z,Zhao Q

    更新日期:2014-11-17 00:00:00

  • Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging.

    abstract::The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35888-1

    authors: Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

    更新日期:2018-11-26 00:00:00

  • Quantifying quantum coherence with quantum Fisher information.

    abstract::Quantum coherence is one of the old but always important concepts in quantum mechanics, and now it has been regarded as a necessary resource for quantum information processing and quantum metrology. However, the question of how to quantify the quantum coherence has just been paid the attention recently (see, e.g., Bau...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15323-7

    authors: Feng XN,Wei LF

    更新日期:2017-11-14 00:00:00

  • High-frequency, low-coverage "false positives" mutations may be true in GS Junior sequencing studies.

    abstract::The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13116-6

    authors: Yang Z,Sun G

    更新日期:2017-10-23 00:00:00

  • Optical scheme for generating hyperentanglement having photonic qubit and time-bin via quantum dot and cross-Kerr nonlinearity.

    abstract::We design an optical scheme to generate hyperentanglement correlated with degrees of freedom (DOFs) via quantum dots (QDs), weak cross-Kerr nonlinearities (XKNLs), and linearly optical apparatuses (including time-bin encoders). For generating hyperentanglement having its own correlations for two DOFs (polarization and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19970-2

    authors: Hong CH,Heo J,Kang MS,Jang J,Yang HJ

    更新日期:2018-02-07 00:00:00

  • Early antiretroviral therapy on reducing HIV transmission in China: strengths, weaknesses and next focus of the program.

    abstract::Early antiretroviral therapy (ART) initiation is a recommended public health approach for the prevention of HIV-1 transmission. In this cohort study, we included 13132 serodiscordant couples. ART was initiated for patients with CD4+ T cell counts less than 200 cells/uL, 350 cells/uL, and 500 cells/uL respectively. Thi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21791-2

    authors: Liu P,Tang Z,Lan G,Zhu Q,Chen H,You Y,Yang X,Liang S,Chen Y,Xing H,Liao L,Feng Y,Shen Z,Ruan Y,Shao Y

    更新日期:2018-02-21 00:00:00

  • Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.

    abstract::Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12624

    authors: Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M

    更新日期:2015-07-29 00:00:00

  • Time trends of esophageal and gastric cancer mortality in China, 1991-2009: an age-period-cohort analysis.

    abstract::Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease Surveillance Points system ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07071-5

    authors: Li M,Wan X,Wang Y,Sun Y,Yang G,Wang L

    更新日期:2017-07-28 00:00:00

  • Metabotropic Acetylcholine and Glutamate Receptors Mediate PI(4,5)P2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ.

    abstract::The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31322-8

    authors: Hackelberg S,Oliver D

    更新日期:2018-08-28 00:00:00

  • Security of a kind of quantum secret sharing with entangled states.

    abstract::We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02543-0

    authors: Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

    更新日期:2017-05-30 00:00:00

  • Computer simulation study of the penetration of pulsed 30, 60 and 90 GHz radiation into the human ear.

    abstract::There is increasing interest in applications which use the 30 to 90 GHz frequency range, including automotive radar, 5 G cellular networks and wireless local area links. This study investigated pulsed 30-90 GHz radiation penetration into the human ear canal and tympanic membrane using computational phantoms. Modelling...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58091-7

    authors: Vilagosh Z,Lajevardipour A,Wood A

    更新日期:2020-01-30 00:00:00

  • Autophagy-related protein MoAtg14 is involved in differentiation, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.

    abstract::Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40018

    authors: Liu XH,Zhao YH,Zhu XM,Zeng XQ,Huang LY,Dong B,Su ZZ,Wang Y,Lu JP,Lin FC

    更新日期:2017-01-09 00:00:00

  • Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus.

    abstract::Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01432-w

    authors: Zang L,Shimada Y,Nishimura N

    更新日期:2017-05-03 00:00:00