Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model.

Abstract:

:The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yang SH,Kim J,Lee MJ,Kim Y

doi

10.1038/srep15703

subject

Has Abstract

pub_date

2015-10-27 00:00:00

pages

15703

issn

2045-2322

pii

srep15703

journal_volume

5

pub_type

杂志文章
  • Delta/Theta band EEG activity shapes the rhythmic perceptual sampling of auditory scenes.

    abstract::Many studies speak in favor of a rhythmic mode of listening, by which the encoding of acoustic information is structured by rhythmic neural processes at the time scale of about 1 to 4 Hz. Indeed, psychophysical data suggest that humans sample acoustic information in extended soundscapes not uniformly, but weigh the ev...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-82008-7

    authors: Kubetschek C,Kayser C

    更新日期:2021-01-27 00:00:00

  • Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins.

    abstract::Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16507-x

    authors: Sethupathy S,Ananthi S,Selvaraj A,Shanmuganathan B,Vigneshwari L,Balamurugan K,Mahalingam S,Pandian SK

    更新日期:2017-11-27 00:00:00

  • Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies.

    abstract::Given that bisphenols have an endocrine-disrupting effect on human bodies, thoroughly exposing their potential effects at the molecular level is important. Saturation transfer difference (STD) NMR-based binding studies were performed to investigate the binding potential of two bisphenol representatives, namely, bisphe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11604-3

    authors: Yang H,Huang Y,Liu J,Tang P,Sun Q,Xiong X,Tang B,He J,Li H

    更新日期:2017-09-11 00:00:00

  • Controlled Deposition of Particles in Porous Media for Effective Aquifer Nanoremediation.

    abstract::In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13423-y

    authors: Bianco C,Patiño Higuita JE,Tosco T,Tiraferri A,Sethi R

    更新日期:2017-10-11 00:00:00

  • Cargo binding promotes KDEL receptor clustering at the mammalian cell surface.

    abstract::Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from ch...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28940

    authors: Becker B,Shaebani MR,Rammo D,Bubel T,Santen L,Schmitt MJ

    更新日期:2016-06-29 00:00:00

  • Controlled Structure and Growth Mechanism behind Hydrothermal Growth of TiO2 Nanorods.

    abstract::Fabrication of uniform vertically-aligned titanium dioxide nanorods (TiO2 NRs) was achieved by hydrothermal growth on a fluorine-doped tin oxide (FTO) glass substrate. The substrate was coated by a TiO2 seed layer composed of titanium (IV) butoxide (TBO) as a precursor in an HCl solution. To reduce the amount of toxic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64510-6

    authors: Prathan A,Sanglao J,Wang T,Bhoomanee C,Ruankham P,Gardchareon A,Wongratanaphisan D

    更新日期:2020-05-15 00:00:00

  • Chromatic Mechanical Response in 2-D Layered Transition Metal Dichalcogenide (TMDs) based Nanocomposites.

    abstract::The ability to convert photons of different wavelengths directly into mechanical motion is of significant interest in many energy conversion and reconfigurable technologies. Here, using few layer 2H-MoS2 nanosheets, layer by layer process of nanocomposite fabrication, and strain engineering, we demonstrate a reversibl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34831

    authors: Rahneshin V,Khosravi F,Ziolkowska DA,Jasinski JB,Panchapakesan B

    更新日期:2016-10-07 00:00:00

  • The effect of anxiety on brain activation patterns in response to inspiratory occlusions: an fMRI study.

    abstract::Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. Ho...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51396-2

    authors: Chan PS,Wu YT,Hsu AL,Li CW,Wu CW,von Leupoldt A,Hsu SC

    更新日期:2019-10-21 00:00:00

  • Experimental and thermodynamic modeling decitabine anti cancer drug solubility in supercritical carbon dioxide.

    abstract::Design and development of efficient processes for continuous manufacturing of solid dosage oral formulations is of crucial importance for pharmaceutical industry in order to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be utilized in pharmaceutical processing owing to its inh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80399-7

    authors: Pishnamazi M,Zabihi S,Jamshidian S,Borousan F,Hezave AZ,Marjani A,Shirazian S

    更新日期:2021-01-13 00:00:00

  • Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.

    abstract::Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases the risk of cirrhosis and hepatocellular carcinoma (HCC). Although increasing evidence points to the therapeutic implications of certain types of anti-diabetic agents in NASH, it remains to be elucidated whether their e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57935-6

    authors: Kawakubo M,Tanaka M,Ochi K,Watanabe A,Saka-Tanaka M,Kanamori Y,Yoshioka N,Yamashita S,Goto M,Itoh M,Shirakawa I,Kanai S,Suzuki H,Sawada M,Ito A,Ishigami M,Fujishiro M,Arima H,Ogawa Y,Suganami T

    更新日期:2020-01-22 00:00:00

  • The freezing Rènyi quantum discord.

    abstract::As a universal quantum character of quantum correlation, the freezing phenomenon is researched by geometry and quantum discord methods, respectively. In this paper, the properties of Rènyi discord is studied for two independent Dimer System coupled to two correlated Fermi-spin environments under the non-Markovian cond...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51206-9

    authors: Li XY,Zhu QS,Zhu MZ,Wu H,Wu SY,Zhu MC

    更新日期:2019-10-14 00:00:00

  • Quantifying site-specific chromatin mechanics and DNA damage response.

    abstract::DNA double-strand breaks pose a direct threat to genomic stability. Studies of DNA damage and chromatin dynamics have yielded opposing results that support either increased or decreased chromatin motion after damage. In this study, we independently measure the dynamics of transcriptionally active or repressed chromati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36343-x

    authors: Whitefield DB,Spagnol ST,Armiger TJ,Lan L,Dahl KN

    更新日期:2018-12-27 00:00:00

  • Starfish Apaf-1 activates effector caspase-3/9 upon apoptosis of aged eggs.

    abstract::Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19845-6

    authors: Tamura R,Takada M,Sakaue M,Yoshida A,Ohi S,Hirano K,Hayakawa T,Hirohashi N,Yura K,Chiba K

    更新日期:2018-01-25 00:00:00

  • Allocation of photosynthesized carbon in an intensively farmed winter wheat-soil system as revealed by 14CO2 pulse labelling.

    abstract::Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21547-y

    authors: Sun Z,Chen Q,Han X,Bol R,Qu B,Meng F

    更新日期:2018-02-16 00:00:00

  • Near-instant automatic access to visually presented words in the human neocortex: neuromagnetic evidence.

    abstract::Rapid and efficient processing of external information by the brain is vital to survival in a highly dynamic environment. The key channel humans use to exchange information is language, but the neural underpinnings of its processing are still not fully understood. We investigated the spatio-temporal dynamics of neural...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26558

    authors: Shtyrov Y,MacGregor LJ

    更新日期:2016-05-24 00:00:00

  • Origins and transformations of dissolved organic matter in large Arctic rivers.

    abstract::Arctic river watersheds are important components of the global climate system and show an amplified response to climate change. Here, we characterize origins and transformations of dissolved organic matter (DOM) in five major Arctic rivers (Kolyma, Lena, Yenisei, Ob, Mackenzie) over 3 years with seasonal sampling peri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12729-1

    authors: Kaiser K,Canedo-Oropeza M,McMahon R,Amon RMW

    更新日期:2017-10-19 00:00:00

  • Adolescent dental arch development among Southern Chinese in Hong Kong: a geometric morphometric approach.

    abstract::This study aimed to investigate changes in types of dental arch form during adolescence and explore adolescent changes in size and form of dental arch. Hong Kong Chinese were recruited and digital dental arch models were obtained at ages 12, 15, and 18 years. Geometric morphometrics was used to investigate adolescent ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55073-2

    authors: Wen YF,Wong HM,Pei T,McGrath C

    更新日期:2019-12-06 00:00:00

  • Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.

    abstract::Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45515-2

    authors: Wilkerson BA,Chitsazan AD,VandenBosch LS,Wilken MS,Reh TA,Bermingham-McDonogh O

    更新日期:2019-06-21 00:00:00

  • Risk factors of treatment failure and 30-day mortality in patients with bacteremia due to MRSA with reduced vancomycin susceptibility.

    abstract::Bacteremia caused by MRSA with reduced vancomycin susceptibility (MRSA-RVS) frequently resulted in treatment failure and mortality. The relation of bacterial factors and unfavorable outcomes remains controversial. We retrospectively reviewed clinical data of patients with bacteremia caused by MRSA with vancomycin MIC ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26277-9

    authors: Yang CC,Sy CL,Huang YC,Shie SS,Shu JC,Hsieh PH,Hsiao CH,Chen CJ

    更新日期:2018-05-18 00:00:00

  • Human pericentromeric tandemly repeated DNA is transcribed at the end of oocyte maturation and is associated with membraneless mitochondria-associated structures.

    abstract::Most of the human genome is non-coding. However, some of the non-coding part is transcriptionally active. In humans, the tandemly repeated (TR) pericentromeric non-coding DNA-human satellites 2 and 3 (HS2, HS3)-are transcribed in somatic cells. These transcripts are also found in pre- and post-implantation embryos. Th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76628-8

    authors: Dobrynin MA,Korchagina NM,Prjibelski AD,Shafranskaya D,Ostromyshenskii DI,Shunkina K,Stepanova I,Kotova AV,Podgornaya OI,Enukashvily NI

    更新日期:2020-11-12 00:00:00

  • Extracting quantum coherence via steering.

    abstract::As the precious resource for quantum information processing, quantum coherence can be created remotely if the involved two sites are quantum correlated. It can be expected that the amount of coherence created should depend on the quantity of the shared quantum correlation, which is also a resource. Here, we establish ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34380

    authors: Hu X,Fan H

    更新日期:2016-09-29 00:00:00

  • Orientation toward humans predicts cognitive performance in orang-utans.

    abstract::Non-human animals sometimes show marked intraspecific variation in their cognitive abilities that may reflect variation in external inputs and experience during the developmental period. We examined variation in exploration and cognitive performance on a problem-solving task in a large sample of captive orang-utans (P...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40052

    authors: Damerius LA,Forss SI,Kosonen ZK,Willems EP,Burkart JM,Call J,Galdikas BM,Liebal K,Haun DB,van Schaik CP

    更新日期:2017-01-09 00:00:00

  • HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study.

    abstract::The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) - a main carrier of cholesterol in the blood stream - to cells, is highly complex. HDL particles are captured from the blood stream by the scavenger receptor, class B, type I (SR-BI), the so-called HDL receptor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15949-7

    authors: Plochberger B,Röhrl C,Preiner J,Rankl C,Brameshuber M,Madl J,Bittman R,Ros R,Sezgin E,Eggeling C,Hinterdorfer P,Stangl H,Schütz GJ

    更新日期:2017-11-21 00:00:00

  • Drug-Delivery System Based on Salmon DNA Nano- and Micro-Scale Structures.

    abstract::Microneedles, fabricated by nano-moulding technology show great promise in the field of drug delivery by enabling the painless self-administration of drugs in a patient-friendly manner. In this study, double-stranded salmon DNA (SDNA) was used as both a drug-delivery vehicle and structural material with a microneedle ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09904-9

    authors: Lee Y,Dugansani SR,Jeon SH,Hwang SH,Kim JH,Park SH,Jeong JH

    更新日期:2017-08-29 00:00:00

  • Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme.

    abstract::Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45282-0

    authors: Hsieh JY,Shih WT,Kuo YH,Liu GY,Hung HC

    更新日期:2019-06-24 00:00:00

  • Charge carrier mobility in hybrid halide perovskites.

    abstract::The charge transport properties of hybrid halide perovskites are investigated with a combination of density functional theory including van der Waals interaction and the Boltzmann theory for diffusive transport in the relaxation time approximation. We find the mobility of electrons to be in the range 5-10 cm(2)V(-1)s(...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12746

    authors: Motta C,El-Mellouhi F,Sanvito S

    更新日期:2015-08-03 00:00:00

  • Vasoconstriction by electrical stimulation: new approach to control of non-compressible hemorrhage.

    abstract::Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be indu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02111

    authors: Mandel Y,Manivanh R,Dalal R,Huie P,Wang J,Brinton M,Palanker D

    更新日期:2013-01-01 00:00:00

  • Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells.

    abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38550

    authors: Li JJ,Wang R,Lama R,Wang X,Floyd ZE,Park EA,Liao FF

    更新日期:2016-12-05 00:00:00

  • Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.

    abstract::Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We inves...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16391-5

    authors: Fiorito G,Polidoro S,Dugué PA,Kivimaki M,Ponzi E,Matullo G,Guarrera S,Assumma MB,Georgiadis P,Kyrtopoulos SA,Krogh V,Palli D,Panico S,Sacerdote C,Tumino R,Chadeau-Hyam M,Stringhini S,Severi G,Hodge AM,Giles GG,Mar

    更新日期:2017-11-24 00:00:00

  • Spatio-temporal dynamics of soil bacterial communities as a function of Amazon forest phenology.

    abstract::Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22380-z

    authors: Buscardo E,Geml J,Schmidt SK,Freitas H,da Cunha HB,Nagy L

    更新日期:2018-03-12 00:00:00