Mechanical forces induce an asthma gene signature in healthy airway epithelial cells.

abstract：:Animal models are indispensible to investigate the pathogenesis and treatments of non-alcoholic fatty liver diseases (NAFLD). Altered cholesterol metabolism has been implicated into the pathogenesis of NAFLD. Here, using high fat, cholesterol and cholate diet (HFHC), we generated a novel tree shrew (Tupaia belangeri c...

journal_title：Scientific reports

authors： Zhang L,Zhang Z,Li Y,Liao S,Wu X,Chang Q,Liang B

更新日期：2015-11-02 00:00:00

abstract：:The protein interface is key to understand protein function, providing a vital insight on how proteins interact with each other and with other molecules. Over the years, many computational methods to compare protein structures were developed, yet evaluating interface similarity remains a very difficult task. Here, we ...

journal_title：Scientific reports

authors： Budowski-Tal I,Kolodny R,Mandel-Gutfreund Y

更新日期：2018-05-29 00:00:00

abstract：:This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...

journal_title：Scientific reports

authors： Kalashnikova M,Peter V,Di Liberto GM,Lalor EC,Burnham D

更新日期：2018-09-13 00:00:00

abstract：:Nanopore-based sensing has emerged as a promising candidate for affordable and powerful DNA sequencing technologies. Herein, we demonstrate that nanopores can be successfully fabricated in Mg alloys via focused electron beam (e-beam) technology. Employing in situ high-resolution transmission electron microscopy techni...

journal_title：Scientific reports

authors： Zheng H,Liu Y,Cao F,Wu S,Jia S,Cao A,Zhao D,Wang J

更新日期：2013-01-01 00:00:00

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00

abstract：:Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate into the epidermis and modify endogenous proteins, thereby triggering an immunogenic reaction. Phenyl isothiocyanate (PITC) and ethyl isothio...

journal_title：Scientific reports

authors： Karlsson I,Samuelsson K,Ponting DJ,Törnqvist M,Ilag LL,Nilsson U

更新日期：2016-02-17 00:00:00

abstract：:Near-critical plasmas irradiated at ultra-high laser intensities (I > 1018W/cm2) allow to improve the performances of laser-driven particle and radiation sources and to explore scenarios of great astrophysical interest. Near-critical plasmas with controlled properties can be obtained with nanostructured low-density ma...

journal_title：Scientific reports

authors： Fedeli L,Formenti A,Cialfi L,Pazzaglia A,Passoni M

更新日期：2018-03-01 00:00:00

abstract：:Normalization procedures for the qRT-PCR analysis of miRNA in biological samples are recommended to reduce the variability caused by pre-analytical factors. Since there is no universal standardized normalization strategy for miRNA qRT-PCR studies, we conducted a throughout study to evaluate a panel of small non-coding...

journal_title：Scientific reports

authors： Pratama MY,Cavalletto L,Tiribelli C,Chemello L,Pascut D

更新日期：2020-02-21 00:00:00

abstract：:Two yellow luminescence bands related to different defects have been revealed in undoped GaN grown by hydride vapor phase epitaxy (HVPE). One of them, labeled YL1, has the zero-phonon line (ZPL) at 2.57 eV and the band maximum at 2.20 eV at low temperature. This luminescence band is the ubiquitous yellow band observed...

journal_title：Scientific reports

authors： Reshchikov MA,McNamara JD,Helava H,Usikov A,Makarov Y

更新日期：2018-05-25 00:00:00

abstract：:Genes that encode for enzymes that can degrade petroleum hydrocarbons (PHs) are critical for the ability of microorganisms to bioremediate soils contaminated with PHs. Distributions of two petroleum-degrading genes AlkB and Nah in soils collected from three zones of the Dagang Oilfield, Tianjin, China were investigate...

journal_title：Scientific reports

authors： Liu Q,Tang J,Bai Z,Hecker M,Giesy JP

更新日期：2015-06-18 00:00:00

abstract：:An industrial waste, 1,2,3-trichloropropane (TCP), is toxic and extremely recalcitrant to biodegradation. To date, no natural TCP degraders able to mineralize TCP aerobically have been isolated. In this work, we engineered a biosafety Pseudomonas putida strain KT2440 for aerobic mineralization of TCP by implantation o...

journal_title：Scientific reports

authors： Gong T,Xu X,Che Y,Liu R,Gao W,Zhao F,Yu H,Liang J,Xu P,Song C,Yang C

更新日期：2017-08-01 00:00:00

abstract：:During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

journal_title：Scientific reports

authors： Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

更新日期：2017-11-24 00:00:00

abstract：:The detection and assessment of intravascular filling defects is important, because they may represent a process central to cerebral malaria pathogenesis: neurovascular sequestration. We have developed and validated a framework that can automatically detect intravascular filling defects in fluorescein angiogram images...

journal_title：Scientific reports

authors： Zhao Y,MacCormick IJ,Parry DG,Beare NA,Harding SP,Zheng Y

更新日期：2015-06-08 00:00:00

abstract：:We demonstrate application of the method of higher-order operators to nonlinear standard optomechanics. It is shown that a symmetry breaking in frequency shifts exists, corresponding to inequivalency of red and blue side-bands. This arises from nonlinear higher-order processes leading to inequal detunings. Similarly, ...

journal_title：Scientific reports

authors： Khorasani S

更新日期：2018-08-01 00:00:00

abstract：:Since their first appearance, organic-inorganic perovskite absorbers have been capturing the attention of the scientific community. While high efficiency devices highlight the importance of band level alignment, very little is known on the origin of the strong n-doping character observed in the perovskite. Here, by me...

journal_title：Scientific reports

authors： Caputo M,Cefarin N,Radivo A,Demitri N,Gigli L,Plaisier JR,Panighel M,Di Santo G,Moretti S,Giglia A,Polentarutti M,De Angelis F,Mosconi E,Umari P,Tormen M,Goldoni A

更新日期：2019-10-22 00:00:00

abstract：:Extracellular vesicles (EVs) carry information between cells in the form of biomolecules. Such molecules have been found to serve as biomarkers. Glycans attached to surface molecules on EVs are involved in their cellular uptake. In this study, we examined glycan profiles of small EVs which are generally termed exosome...

journal_title：Scientific reports

authors： Shimoda A,Sawada SI,Sasaki Y,Akiyoshi K

更新日期：2019-08-08 00:00:00

abstract：:Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...

journal_title：Scientific reports

authors： Rendo V,Kundu S,Rameika N,Ljungström V,Svensson R,Palin K,Aaltonen L,Stoimenov I,Sjöblom T

更新日期：2020-12-31 00:00:00

abstract：:The sequential paradigm of data acquisition and analysis in next-generation sequencing leads to high turnaround times for the generation of interpretable results. We combined a novel real-time read mapping algorithm with fast variant calling to obtain reliable variant calls still during the sequencing process. Thereby...

journal_title：Scientific reports

authors： Loka TP,Tausch SH,Renard BY

更新日期：2019-11-11 00:00:00

abstract：:Delivering liquid through the void spaces in porous metals is a daunting challenge for a variety of emerging interface technologies ranging from battery electrodes to evaporation surfaces. Hydraulic transport characteristics of well-ordered porous media are governed by the pore distribution, porosity, and morphology. ...

journal_title：Scientific reports

authors： Pham QN,Barako MT,Tice J,Won Y

更新日期：2017-09-05 00:00:00

abstract：:Freeze-thaw cycles are predicted to increase in cold temperate regions. The potential influence of the interactions of freeze-thaw cycles and agrochemicals on the release of Cd into river water is unknown. In this study, the interactions of freeze-thaw cycles and chlorpyrifos (FC) on Cd mobility in soils were analysed...

journal_title：Scientific reports

authors： Wang F,Ouyang W,Hao F,Jiao W,Shan Y,Lin C

更新日期：2016-06-02 00:00:00

abstract：:Honey bees are under pressure due to abnormal high colony death rates, especially during the winter. The infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally considered as the bees' most important biological threats. Almost all efforts to remedy this dual infection h...

journal_title：Scientific reports

authors： de Graaf DC,Laget D,De Smet L,Claeys Boúúaert D,Brunain M,Veerkamp RF,Brascamp EW

更新日期：2020-08-31 00:00:00

abstract：:Antimicrobial peptides (AMPs) are peptide antibiotics with a broad spectrum of antimicrobial activities. Activity prediction of AMPs from their amino acid sequences is of great therapeutic importance but imposes challenges on prediction methods due to label interactions. In this paper we propose a novel multi-label le...

journal_title：Scientific reports

authors： Wang P,Ge R,Liu L,Xiao X,Li Y,Cai Y

更新日期：2017-05-19 00:00:00

abstract：:Anthropogenic radionuclides contaminate a range of environments as a result of nuclear activities, for example, leakage from waste storage tanks/ponds (e.g. Hanford, USA or Sellafield sites, UK) or as a result of large scale nuclear accidents (e.g. Chernobyl, Ukraine or Fukushima, Japan). One of the most widely applie...

journal_title：Scientific reports

authors： Handley-Sidhu S,Mullan TK,Grail Q,Albadarneh M,Ohnuki T,Macaskie LE

更新日期：2016-03-18 00:00:00

abstract：:Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibi...

journal_title：Scientific reports

authors： Ciarlo E,Heinonen T,Herderschee J,Fenwick C,Mombelli M,Le Roy D,Roger T

更新日期：2016-11-29 00:00:00

abstract：:Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...

journal_title：Scientific reports

authors： Li J,Xiao X,Xu X,Lin J,Huang Y,Xue Y,Jin P,Zou J,Tang C

更新日期：2013-11-13 00:00:00

abstract：:Free-ocean CO2 enrichment (FOCE) experiments have been deployed in marine ecosystems to manipulate carbonate system conditions to those predicted in future oceans. We investigated whether the pH/carbonate chemistry of extremely cold polar waters can be manipulated in an ecologically relevant way, to represent conditio...

journal_title：Scientific reports

authors： Stark JS,Roden NP,Johnstone GJ,Milnes M,Black JG,Whiteside S,Kirkwood W,Newbery K,Stark S,van Ooijen E,Tilbrook B,Peltzer ET,Berry K,Roberts D

更新日期：2018-02-12 00:00:00

abstract：:Biomarkers are measurable changes associated with the disease. Urine can reflect the changes of the body while blood is under control of the homeostatic mechanisms; thus, urine is considered an important source for early and sensitive disease biomarker discovery. A comprehensive profile of the urinary proteome will pr...

journal_title：Scientific reports

authors： Zhao M,Li M,Yang Y,Guo Z,Sun Y,Shao C,Li M,Sun W,Gao Y

更新日期：2017-06-08 00:00:00

abstract：:A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...

journal_title：Scientific reports

authors： Ziegler M,Alt K,Paterson BM,Kanellakis P,Bobik A,Donnelly PS,Hagemeyer CE,Peter K

更新日期：2016-12-02 00:00:00

abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...

journal_title：Scientific reports

authors： Uziela K,Shu N,Wallner B,Elofsson A

更新日期：2016-10-04 00:00:00

abstract：:MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases...

journal_title：Scientific reports

authors： Yau TO,Tang CM,Harriss EK,Dickins B,Polytarchou C

更新日期：2019-07-01 00:00:00