Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo.

abstract：:In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...

journal_title：Scientific reports

authors： Fuwa M,Shimazaki A,Mieda M,Yamashita N,Akaishi T,Taniguchi T,Kato M

更新日期：2019-05-16 00:00:00

abstract：:To evaluate and improve datasets of anthropogenic land cover change used in local and global climate models, great efforts were made to reconstruct historical land use, including the LandCover 6k project which dedicated to reconstructing human land use over the past 10,000 years. In this study, we utilized historical ...

journal_title：Scientific reports

authors： Li M,He F,Li S,Yang F

更新日期：2018-09-10 00:00:00

abstract：:We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population, can be solved exactly, even in the presence of a time-dependent infection rate. ...

journal_title：Scientific reports

authors： Dell'Anna L

更新日期：2020-09-25 00:00:00

abstract：:Superconductivity in noncentrosymmetric compounds has attracted sustained interest in the last decades. Here we present a detailed study on the transport, thermodynamic properties and the band structure of the noncentrosymmetric superconductor La 7 Ir 3 (T c  ~ 2.3 K) that was recently proposed to break the time-rever...

journal_title：Scientific reports

authors： Li B,Xu CQ,Zhou W,Jiao WH,Sankar R,Zhang FM,Hou HH,Jiang XF,Qian B,Chen B,Bangura AF,Xu X

更新日期：2018-01-12 00:00:00

abstract：:Development of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array show...

journal_title：Scientific reports

authors： Liu M,Wang H,Tang Q,Zhao X,Tong Y,Liu Y

更新日期：2018-11-09 00:00:00

abstract：:Maximal rate of heart rate (HR) increase (rHRI) as a measure of HR acceleration during the transition from rest to exercise, or during an increase in workload, tracks exercise performance. rHRI assessed at relative rather than absolute workloads may track performance better, and a field test would increase applicabili...

journal_title：Scientific reports

authors： Bellenger CR,Thomson RL,Robertson EY,Davison K,Nelson MJ,Karavirta L,Buckley JD

更新日期：2020-09-03 00:00:00

abstract：:A fundamental assumption in bioacoustics is that large animals tend to produce vocalizations with lower frequencies than small animals. This inverse relationship between body size and vocalization frequencies is widely considered to be foundational in animal communication, with prominent theories arguing that it playe...

journal_title：Scientific reports

authors： Bowling DL,Garcia M,Dunn JC,Ruprecht R,Stewart A,Frommolt KH,Fitch WT

更新日期：2017-01-24 00:00:00

abstract：:The most obvious method to observe transplanted islets in the liver is direct biopsy, but the distribution and location of the best biopsy site in the recipient's liver are poorly understood. Islets transplanted into the whole liver of five diabetic cynomolgus monkeys that underwent insulin-independent survival for an...

journal_title：Scientific reports

authors： Kim GS,Lee JH,Shin DY,Lee HS,Park H,Lee KW,Yang HM,Kim SJ,Park JB

更新日期：2020-01-21 00:00:00

abstract：:We propose a method to accelerate small-angle scattering experiments by exploiting spatial correlation in two-dimensional data. We applied kernel density estimation to the average of a hundred short scans and evaluated noise reduction effects of kernel density estimation (smoothing). Although there is no advantage of ...

journal_title：Scientific reports

authors： Saito K,Yano M,Hino H,Shoji T,Asahara A,Morita H,Mitsumata C,Kohlbrecher J,Ono K

更新日期：2019-02-06 00:00:00

abstract：:Multinational corporations use highly complex structures of parents and subsidiaries to organize their operations and ownership. Offshore Financial Centers (OFCs) facilitate these structures through low taxation and lenient regulation, but are increasingly under scrutiny, for instance for enabling tax avoidance. There...

journal_title：Scientific reports

authors： Garcia-Bernardo J,Fichtner J,Takes FW,Heemskerk EM

更新日期：2017-07-24 00:00:00

abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...

journal_title：Scientific reports

authors： Radhakrishnan C,Chen PW,Jambulingam S,Byrnes T,Ali MM

更新日期：2019-02-20 00:00:00

abstract：:Current reports on the changes in peripheral blood regulatory T cell (Tregs) to CD4+ T cell ratio in systemic sclerosis (SSc) patients are varied in their conclusions. We therefore performed a meta-analysis to identify the actual change in the proportion of peripheral Tregs in SSc. Three databases, namely EMBASE, ISI ...

journal_title：Scientific reports

authors： Deng C,Li W,Chen S,Li Y

更新日期：2017-03-02 00:00:00

abstract：:Nucleoporins have been reported to regulate pluripotent biology, but how they do so remains partially characterized. This study examined the effects of nup155 gene disruption on mouse embryonic stem cells to gain insights into possible mechanisms by which nucleoporins regulate pluripotency in a pro-arrhythmogenic stem...

journal_title：Scientific reports

authors： Preston CC,Storm EC,Burdine RD,Bradley TA,Uttecht AD,Faustino RS

更新日期：2019-09-03 00:00:00

abstract：:The Glycoside hydrolase (GH) family 70 originally was established for glucansucrases of lactic acid bacteria (LAB) converting sucrose into α-glucan polymers. In recent years we have identified 3 subfamilies of GH70 enzymes (designated GtfB, GtfC and GtfD) as 4,6-α-glucanotransferases, cleaving (α1 → 4)-linkages in mal...

journal_title：Scientific reports

authors： Gangoiti J,van Leeuwen SS,Meng X,Duboux S,Vafiadi C,Pijning T,Dijkhuizen L

更新日期：2017-08-30 00:00:00

abstract：:The manuscript highlights the efficacy of silver ions to act as a unique probe for the detection of bacterial contamination in water samples. The bacterial cell membrane adherence property of the silver ions was employed to develop two different bacterial detection assays employing colorimetric and electrochemical tec...

journal_title：Scientific reports

authors： Kumar V,Chopra A,Bisht B,Bhalla V

更新日期：2020-07-20 00:00:00

abstract：:Social immunity forms an essential part of the defence repertoire of social insects. In response to infestation by the parasitic mite Varroa destructor and its associated viruses, honey bees (Apis mellifera L.) have developed a specific behaviour (varroa-sensitive hygiene, or VSH) that helps protect the colony from th...

journal_title：Scientific reports

authors： Mondet F,Kim SH,de Miranda JR,Beslay D,Le Conte Y,Mercer AR

更新日期：2016-05-03 00:00:00

abstract：:Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In recent years a surge of evidence has suggested that the gut micr...

journal_title：Scientific reports

authors： Kiraly DD,Walker DM,Calipari ES,Labonte B,Issler O,Pena CJ,Ribeiro EA,Russo SJ,Nestler EJ

更新日期：2016-10-18 00:00:00

abstract：:The Ebola filovirus causes severe hemorrhagic fever with a high fatality rate in humans. The primary structural matrix protein VP40 displays transformer-protein characteristics and exists in different conformational and oligomeric states. VP40 plays crucial roles in viral assembly and budding at the plasma membrane of...

journal_title：Scientific reports

authors： Pavadai E,Gerstman BS,Chapagain PP

更新日期：2018-06-27 00:00:00

abstract：:Multidrug resistance (MDR) is a major impediment to cancer treatment. Here, for the first time, we investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction with docetaxel (DTX) to overcome drug resistance of triple negative breast cancer (TNBC). In vitro experiments showed that...

journal_title：Scientific reports

authors： Doddapaneni R,Patel K,Chowdhury N,Singh M

更新日期：2017-11-20 00:00:00

abstract：:A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhes...

journal_title：Scientific reports

authors： Ouellette M,Masse F,Lefebvre-Demers M,Maestracci Q,Grenier P,Millar R,Bertrand N,Prieto M,Boisselier É

更新日期：2018-09-25 00:00:00

abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...

journal_title：Scientific reports

authors： Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SK

更新日期：2019-03-01 00:00:00

abstract：:Inherited retinal dystrophy (IRD) patients often experience photophobia. However, its mechanism has not been elucidated. This study aimed to investigate the main wavelength of light causing photophobia in IRD and difference among patients with different phenotypes. Forty-seven retinitis pigmentosa (RP) and 22 cone-rod...

journal_title：Scientific reports

authors： Otsuka Y,Oishi A,Miyata M,Oishi M,Hasegawa T,Numa S,Ikeda HO,Tsujikawa A

更新日期：2020-09-09 00:00:00

abstract：:Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

journal_title：Scientific reports

authors： Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

更新日期：2017-08-29 00:00:00

abstract：:Seeing with two eyes usually helps one respond faster. Here we show that with ambiguous stimuli, binocular viewing can paradoxically slow down reaction time. This is explained by the observers basing their decision on a noisy neuronal representation within the visual system, with the added noise breaking the symmetry ...

journal_title：Scientific reports

authors： Yehezkel O,Sterkin A,Sagi D,Polat U

更新日期：2015-11-18 00:00:00

abstract：:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs...

journal_title：Scientific reports

authors： Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté J

更新日期：2017-07-11 00:00:00

abstract：:Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptid...

journal_title：Scientific reports

authors： Choy SL,Bernin H,Aiba T,Bifeld E,Lender SC,Mühlenpfordt M,Noll J,Eick J,Marggraff C,Niss H,Roldán NG,Tanaka S,Kitamura M,Fukase K,Clos J,Tannich E,Fujimoto Y,Lotter H

更新日期：2017-08-25 00:00:00

abstract：:The family Trichomycteridae is one of the most diverse groups of freshwater catfishes in South and Central America with eight subfamilies, 41 genera and more than 300 valid species. Its members are widely distributed throughout South America, reaching Costa Rica in Central America and are recognized by extraordinary a...

journal_title：Scientific reports

authors： Ochoa LE,Datovo A,DoNascimiento C,Roxo FF,Sabaj MH,Chang J,Melo BF,Silva GSC,Foresti F,Alfaro M,Oliveira C

更新日期：2020-02-14 00:00:00

abstract：:The visual hierarchy of the ventral stream has been widely studied. However, it remains unclear how the hierarchical system organizes its functional coupling during top-down cognitive process. The present fMRI study investigated task-dependent functional connectivity along the ventral stream, while twenty-eight partic...

journal_title：Scientific reports

authors： Jo HG,Ito J,Schulte Holthausen B,Baumann C,Grün S,Habel U,Kellermann T

更新日期：2019-06-27 00:00:00

abstract：:Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutua...

journal_title：Scientific reports

authors： Chen J,Wang N,Cui L,Li X,Lin Z,Ng J

更新日期：2016-06-13 00:00:00

abstract：:CSNK2B, which encodes the beta subunit of casein kinase II (CK2), plays an important role in neuron morphology and synaptic transmission. Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. Among the 816 probands suspected here...

journal_title：Scientific reports

authors： Li J,Gao K,Cai S,Liu Y,Wang Y,Huang S,Zha J,Hu W,Yu S,Yang Z,Xie H,Yan H,Wang J,Wu Y,Jiang Y

更新日期：2019-11-29 00:00:00