Abstract：
:In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular surface using human corneal epithelial cells. TAF/TIM was found to be more effective in lowering IOP for a longer duration compared to LAT/CAR. We found that the difference in the intensity of IOP-lowering effect was because of the differences in the strength of timolol compared with that of carteolol as a beta-adrenergic antagonist and strength of tafluprost compared with that of latanoprost as a prostaglandin analogue. In addition, TAF/TIM showed much less cytotoxic effects compared to LAT/CAR on the human corneal epithelial cells. Our findings showed that TAF/TIM is better than LAT/CAR with regard to the IOP-lowering effect in monkeys and toxicity on ocular surface.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fuwa M,Shimazaki A,Mieda M,Yamashita N,Akaishi T,Taniguchi T,Kato Mdoi
10.1038/s41598-019-44028-2subject
Has Abstractpub_date
2019-05-16 00:00:00pages
7491issue
1issn
2045-2322pii
10.1038/s41598-019-44028-2journal_volume
9pub_type
杂志文章abstract：:This article puts forward a technique for extracting the density of trap states (DOST) distribution based on the transient photo-voltage (TPV) measurement result. We prove that when the TPV result is linear, the DOST distribution is exponential type and vice versa. Compared to the approach based on the space charge li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69914-y
更新日期：2020-07-30 00:00:00
abstract：:Chiral optical response is an inherent property of molecules and nanostructures, which cannot be superimposed on their mirror images. In specific cases, optical chirality can be observed also for symmetric structures. This so-called extrinsic chirality requires that the mirror symmetry is broken by the geometry of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41615-1
更新日期：2019-03-25 00:00:00
abstract：:The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72880-0
更新日期：2020-09-25 00:00:00
abstract：:Cold-temperate seagrass (Zostera marina) meadows provide several important ecosystem services, including trapping and storage of sedimentary organic carbon and nutrients. However, seagrass meadows are rapidly decreasing worldwide and there is a pressing need for protective management of the meadows and the organic mat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70403-5
更新日期：2020-08-12 00:00:00
abstract：:Pre-stimulus alpha (8-12 Hz) and beta (16-20 Hz) oscillations have been frequently linked to the prediction of upcoming sensory input. Do these frequency bands serve as a neural marker of linguistic prediction as well? We hypothesized that if pre-stimulus alpha and beta oscillations index language predictions, their p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56600-x
更新日期：2019-12-27 00:00:00
abstract：:Pristine and functionalized multi-walled carbon nanotubes (MWCNTs) were investigated as adsorbent materials inside solid-phase extraction (SPE) cartridges for extraction and preconcentration of 8 EU-relevant organic micropollutants (with different pKa and polarity) before chromatographic analysis of surface water. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79244-8
更新日期：2020-12-18 00:00:00
abstract：:Decadal climate predictability in the South Atlantic is explored by performing reforecast experiments using a coupled general circulation model with two initialization schemes; one is assimilated with observed sea surface temperature (SST) only, and the other is additionally assimilated with observed subsurface ocean ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26899-z
更新日期：2018-06-04 00:00:00
abstract：:The properties of the human mind affect the quality of scientific knowledge through the insertion of unconscious biases during the research process. These biases frequently cause overestimation of the effects under study, thereby violating the reproducibility of the research and potentially leading to incorrect conclu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80677-4
更新日期：2021-01-08 00:00:00
abstract：:Sensory organs are thought to sample the environment rhythmically thereby providing periodic perceptual input. Whisking and sniffing are governed by oscillators which impose rhythms on the motor-control of sensory acquisition and consequently on sensory input. Saccadic eye movements are the main visual sampling mechan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00881-7
更新日期：2017-04-20 00:00:00
abstract：:Evolutionary processes, speciation in woody bamboos are presently little understood. Here we used Dendrocalamus sinicus Chia & J.L. Sun as a model species to investigate dispersal or vicariance speciation in woody bamboos. Variation in three chloroplast DNA (cpDNA) fragments and eight simple sequence repeat markers (S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35269-8
更新日期：2018-11-16 00:00:00
abstract：:Targetting the ubiquitin pathway is an attractive strategy for cancer therapy. The inhibitor of the ubiquitin-like molecule NEDD8 pathway, MLN4924 (Pevonedistat) is in Phase II clinical trials. Protection of healthy cells from the induced toxicity of the treatment while preserving anticancer efficacy is a highly antic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37775
更新日期：2016-11-30 00:00:00
abstract：:Published data have shown inconsistent results about the pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy. This meta-analysis aimed to summarize published findings and provide more reliable association. A total of 53 eligible studies includin...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep16482
更新日期：2015-11-20 00:00:00
abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05510
更新日期：2014-07-01 00:00:00
abstract：:Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and grap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76495-3
更新日期：2020-12-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60470-z
更新日期：2020-03-10 00:00:00
abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68978-0
更新日期：2020-07-27 00:00:00
abstract：:Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21365
更新日期：2016-02-25 00:00:00
abstract：:The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of amphiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42898
更新日期：2017-02-23 00:00:00
abstract：:The regeneration of WPAC through pyrolysis and its adsorption capacity of phosphorus were studied. The optimum conditions for WPAC regeneration were 650 °C and 2 h which resulted in a recovery of BET surface and total pore volume with a value of 1161.4 m2/g and 1.2176 m3/g. WPAC had a maximum PO43--P adsorption capaci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19131-x
更新日期：2018-01-15 00:00:00
abstract：:ZnO/SiC heterojunctions show great potential for various optoelectronic applications (e.g., ultraviolet light emitting diodes, photodetectors, and solar cells). However, the lack of a detailed understanding of the ZnO/SiC interface prevents an efficient and rapid optimization of these devices. Here, intrinsic (but inh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23106
更新日期：2016-03-15 00:00:00
abstract：:Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities with known proteins. How rust fungal effectors function in host cells remains elusi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53816-9
更新日期：2019-12-02 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24178-5
更新日期：2018-04-17 00:00:00
abstract：:Tetrameric coiled-coil structures are present in many ion channels, often adjacent to a calmodulin (CaM) binding site, although the relationship between the two is not completely understood. Here we examine the dynamic properties of the ABCD domain located in the intracellular C-terminus of tetrameric, voltage-depende...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13811-4
更新日期：2017-10-18 00:00:00
abstract：:Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one is based on the regulation of miRNA biogenesis, in particular that of the let-7 family, who...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81429-8
更新日期：2021-01-27 00:00:00
abstract：:In this study, electromechanical characteristics of (1-x) Bi0.5Na0.5TiO3-xSrTiO3 (ST26, x = 0.26)/(1-y) Bi0.5Na0.5TiO3-ySrTiO3 (ST10, y = 0.1) (matrix/seed) composites were studied. The ST26 (high relaxor phase) and ST10 (a relaxor ferroelectric (RF), high ferroelectric phase) composite with large (r-ST26-ST10) and sm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32133-7
更新日期：2018-09-20 00:00:00
abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08316
更新日期：2015-02-09 00:00:00
abstract：:Novel mesoporous silicas rolled with silica sheets with 2D regular spacing were prepared using a self-assembled graphene oxide (GO) template formed by mixing GO with Pluronic123 (P123). Self-assembled GO templated mesoporous silicas (SGT-PMS) showed well-developed X-ray diffraction peaks with d-spacings of 9.8-10.8 nm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63017-4
更新日期：2020-04-10 00:00:00
abstract：:Myodural bridges have been described in various species as connective tissue structures "bridging" small cranio-cervical muscles to the dura. Myodural bridges are thought to stabilize the dural sac during head and neck movements and promote cerebrospinal fluid motion; however, their role in neurological diseases has n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46444-w
更新日期：2019-07-10 00:00:00
abstract：:While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. Carbon dots (CDs) as a respectively new member have been extensively explored in nucleus directed delivery and bioimaging due to their intrinsic fluorescence p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70796-3
更新日期：2020-08-17 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-69653-0
更新日期：2020-07-24 00:00:00
