Predictive assessment in pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy.

abstract：:Cell survival is facilitated by the maintenance of mitochondrial membrane potential (MMP). B cell activating factor (BAFF) plays a role in survival, differentiation, and maturation of B cells. In the present study, we examined whether BAFF could attenuate oxidative stress-induced B cell death by the regulation of MMP ...

journal_title：Scientific reports

authors： Park S,Jang JW,Moon EY

更新日期：2020-07-16 00:00:00

abstract：:Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

journal_title：Scientific reports

authors： Zhou B,Rybski D,Kropp JP

更新日期：2017-07-06 00:00:00

abstract：:Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...

journal_title：Scientific reports

authors： Song W,Xu C,Smith MP,Kynicky J,Huang K,Wei C,Zhou L,Shu Q

更新日期：2016-11-18 00:00:00

abstract：:Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The 'shock and kill' strategy has been broadly explored to purge the latent reservoir; however, none of the current latency-reversing agents (LRAs) can safely and effectively activate the latent virus in patients. In this study, we report ...

journal_title：Scientific reports

authors： Wang P,Lu P,Qu X,Shen Y,Zeng H,Zhu X,Zhu Y,Li X,Wu H,Xu J,Lu H,Ma Z,Zhu H

更新日期：2017-08-25 00:00:00

abstract：:Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...

journal_title：Scientific reports

authors： Feng G,Mi X,Eiserhardt WL,Jin G,Sang W,Lu Z,Wang X,Li X,Li B,Sun I,Ma K,Svenning JC

更新日期：2015-03-23 00:00:00

abstract：:Lower cervical dislocation with facet interlocking is one of the most drastic injuries to the cervical spine. The early reduction is thought critical in preventing progressive secondary spinal cord injury. The authors report a new surgical procedure in the management of lower cervical dislocation with facet interlocki...

journal_title：Scientific reports

authors： Li Y,Zhou P,Cui W,Li C,Xiao W,Wen Y,Wang H,Wang H

更新日期：2019-02-04 00:00:00

abstract：:The physical properties of polycrystalline materials depend on their microstructure, which is the nano- to centimeter scale arrangement of phases and defects in their interior. Such microstructure depends on the shape, crystallographic phase and orientation, and interfacing of the grains constituting the material. Thi...

journal_title：Scientific reports

authors： Cereser A,Strobl M,Hall SA,Steuwer A,Kiyanagi R,Tremsin AS,Knudsen EB,Shinohara T,Willendrup PK,da Silva Fanta AB,Iyengar S,Larsen PM,Hanashima T,Moyoshi T,Kadletz PM,Krooß P,Niendorf T,Sales M,Schmahl WW,Schmidt S

更新日期：2017-08-25 00:00:00

abstract：:Prolactin (PRL) is an anterior pituitary hormone with a broad range of functions. Its ability to stimulate lactogenesis, maternal behavior, growth and development, osmoregulation, and epithelial ion transport has been reported in many vertebrates. In our present study, we have targeted the zebrafish prl locus via tran...

journal_title：Scientific reports

authors： Shu Y,Lou Q,Dai Z,Dai X,He J,Hu W,Yin Z

更新日期：2016-01-04 00:00:00

abstract：:Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...

journal_title：Scientific reports

authors： Boulding T,McCuaig RD,Tan A,Hardy K,Wu F,Dunn J,Kalimutho M,Sutton CR,Forwood JK,Bert AG,Goodall GJ,Malik L,Yip D,Dahlstrom JE,Zafar A,Khanna KK,Rao S

更新日期：2018-01-08 00:00:00

abstract：:With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting...

journal_title：Scientific reports

authors： Pastorino R,Puggina A,Carreras-Torres R,Lagiou P,Holcátová I,Richiardi L,Kjaerheim K,Agudo A,Castellsagué X,Macfarlane TV,Barzan L,Canova C,Thakker NS,Conway DI,Znaor A,Healy CM,Ahrens W,Zaridze D,Szeszenia-Dabrowska

更新日期：2018-03-14 00:00:00

abstract：:Quantum phase transition is one of the most interesting aspects in quantum many-body systems. Recently, geometric quantum discord has been introduced to signature the critical behavior of various quantum systems. However, it is well-known that topological quantum phase transition can not be described by the convention...

journal_title：Scientific reports

authors： Shan CJ,Cheng WW,Liu JB,Cheng YS,Liu TK

更新日期：2014-03-26 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society...

journal_title：Scientific reports

authors： Son SJ,Kim M,Park H

更新日期：2016-11-30 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In this study, treatment with either of two BMP inhibitors reduced hepa...

journal_title：Scientific reports

authors： Thayer TE,Lino Cardenas CL,Martyn T,Nicholson CJ,Traeger L,Wunderer F,Slocum C,Sigurslid H,Shakartzi HR,O'Rourke C,Shelton G,Buswell MD,Barnes H,Neitzel LR,Ledsky CD,Li JP,Burke MF,Farber-Eger E,Perrien DS,Kumar R,

更新日期：2020-06-19 00:00:00

abstract：:Some herbivore-induced-plant volatiles (HIPVs) compounds are vital for the functioning of an ecosystem, by triggering multi-trophic interactions for natural enemies, plants and herbivores. However, the effect of these chemicals, which play a crucial role in regulating the multi-trophic interactions between plant-herbi...

journal_title：Scientific reports

authors： Lin Y,Qasim M,Hussain M,Akutse KS,Avery PB,Dash CK,Wang L

更新日期：2017-01-12 00:00:00

abstract：:Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in vivo electrotransfer-mediated overexpression of the adiponectin receptors, AdipoR1 or AdipoR2, into tibialis...

journal_title：Scientific reports

authors： Keshvari S,Henstridge DC,Ng C,Febbraio MA,Whitehead JP

更新日期：2017-02-01 00:00:00

abstract：:The next-generation logic and memory devices using magnetic skyrmions as spintronic information carriers are frequently studied, thanks to their remarkable magnetic stability, extremely compact size and very-low-cost driving forces within nanotracks. In order to realize skyrmion-based spintronic devices, understanding...

journal_title：Scientific reports

authors： Deger C,Yavuz I,Yildiz F

更新日期：2019-03-05 00:00:00

abstract：:There is increasing evidence that extracellular cGMP modulates glutamatergic neurotransmission and some forms of learning. However, the underlying mechanisms remain unknown. We proposed the hypotheses that extracellular cGMP may regulate membrane expression of AMPA receptors. To do this extracellular cGMP should act o...

journal_title：Scientific reports

authors： Cabrera-Pastor A,Taoro-González L,Cuñat AN,Canet-López D,Balzano T,Felipo V

更新日期：2017-12-15 00:00:00

abstract：:This research presents an analysis of the frequencies and vibration modes of the structure of the superficial seiches of Lake Chapala using mathematical modelling and measurements. The HAMSOM model was run with wind fields from coastal meteorological stations and for different lake storage levels. The lake water level...

journal_title：Scientific reports

authors： Avalos Cueva D,Monzón CO,Filonov A,Tereshchenko I,Limón Covarrubias P,Galaviz González JR

更新日期：2019-08-14 00:00:00

abstract：:Statins present many beneficial effects in chronic liver disease, but concerns about safety exist. We evaluated the hepatic effects of a nitric oxide-releasing atorvastatin (NCX 6560) compared to conventional statins. Simvastatin, atorvastatin and NCX 6560 were evaluated in four-week bile duct-ligated rats (BDL) simul...

journal_title：Scientific reports

authors： Rodríguez S,Raurell I,Torres-Arauz M,García-Lezana T,Genescà J,Martell M

更新日期：2017-01-13 00:00:00

abstract：:Halyomorpha halys is a global invasive species, native to Southeast Asia, that is threatening agriculture in invaded regions. Our objectives were to: 1) establish the attractiveness of semiochemical stimuli paired with field-deployed traps in Europe (Greece, Hungary, Italy, and Switzerland), compared with Maryland, US...

journal_title：Scientific reports

authors： Morrison WR 3rd,Milonas P,Kapantaidaki DE,Cesari M,Di Bella E,Guidetti R,Haye T,Maistrello L,Moraglio ST,Piemontese L,Pozzebon A,Ruocco G,Short BD,Tavella L,Vétek G,Leskey TC

更新日期：2017-12-05 00:00:00

abstract：:Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (A...

journal_title：Scientific reports

authors： Nunes AS,Vakorin VA,Kozhemiako N,Peatfield N,Ribary U,Doesburg SM

更新日期：2020-07-06 00:00:00

abstract：:Although the association between social support and postpartum depression has been previously investigated, its causal relationship remains unclear. Therefore, we examined prospectively whether social support during pregnancy affected postpartum depression. Social support and depressive symptoms were assessed by Japan...

journal_title：Scientific reports

authors： Morikawa M,Okada T,Ando M,Aleksic B,Kunimoto S,Nakamura Y,Kubota C,Uno Y,Tamaji A,Hayakawa N,Furumura K,Shiino T,Morita T,Ishikawa N,Ohoka H,Usui H,Banno N,Murase S,Goto S,Kanai A,Masuda T,Ozaki N

更新日期：2015-05-29 00:00:00

abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...

journal_title：Scientific reports

authors： Zhang S,Xu M,Qiu Z,Wang K,Du Y,Gu L,Cui X

更新日期：2016-03-18 00:00:00

abstract：:The chloride gradient plays an important role in regulating cell volume, membrane potential, pH, secretion, and the reversal potential of inhibitory glycine and GABAA receptors. Measurement of intracellular chloride activity, [Formula: see text], using liquid membrane ion-selective microelectrodes (ISM), however, has ...

journal_title：Scientific reports

authors： DiFranco M,Quinonez M,Dziedzic RM,Spokoyny AM,Cannon SC

更新日期：2019-12-11 00:00:00

abstract：:Glycolipids had received increasing attention because of their uses in various industries like cosmetics, pharmaceuticals, food and machinery manufacture. Microalgae were competitive organisms to accumulate metabolic substance. However, using microalgae to produce glycolipid was rare at present. In this study, glycoli...

journal_title：Scientific reports

authors： Wang X,Shen Z,Miao X

更新日期：2016-07-21 00:00:00

abstract：:The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial dec...

journal_title：Scientific reports

authors： Boehm D,Heslin C,Cullen PJ,Bourke P

更新日期：2016-02-24 00:00:00

abstract：:Developmental changes in salamander skulls, before and after metamorphosis, affect the feeding capabilities of these animals. How changes in cranial morphology and tissue properties affect the function of the skull are key to decipher the early evolutionary history of the crown-group of salamanders. Here, 3D cranial b...

journal_title：Scientific reports

authors： Zhou Z,Fortuny J,Marcé-Nogué J,Skutschas PP

更新日期：2017-08-31 00:00:00

abstract：:Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...

journal_title：Scientific reports

authors： Harada K,Akashi T,Niitsu K,Shimada K,Ono YA,Shindo D,Shinada H,Mori S

更新日期：2018-01-17 00:00:00

abstract：:Ankle arthrodesis with the Ilizarov method is an accepted form of treatment of advanced degenerative changes of the ankle joint. Incorrect balance and load distribution on the lower limbs may result in pain and dysfunction. The aim of the study was to assess the change of balance and load distribution in lower extremi...

journal_title：Scientific reports

authors： Morasiewicz P,Konieczny G,Dejnek M,Urbański W,Dragan SŁ,Kulej M,Dragan SF,Pawik Ł

更新日期：2018-10-24 00:00:00

abstract：:The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...

journal_title：Scientific reports

authors： Espana-Agusti J,Tuveson DA,Adams DJ,Matakidou A

更新日期：2015-06-05 00:00:00