The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity.

abstract：:Nanoscale real-time molecular sensing requires large signal enhancement, small background, short detection time and high spectral resolution. We demonstrate a new vibrational spectroscopic technique which satisfies all of these conditions. This time-resolved surface-enhanced coherent anti-Stokes Raman scattering (tr-S...

journal_title：Scientific reports

authors： Voronine DV,Sinyukov AM,Hua X,Wang K,Jha PK,Munusamy E,Wheeler SE,Welch G,Sokolov AV,Scully MO

更新日期：2012-01-01 00:00:00

abstract：:The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...

journal_title：Scientific reports

authors： Aubanel V,Schwartz JL

更新日期：2020-11-11 00:00:00

abstract：:Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion pr...

journal_title：Scientific reports

authors： Löf L,Arngården L,Olsson-Strömberg U,Siart B,Jansson M,Dahlin JS,Thörn I,Christiansson L,Hermansson M,Larsson A,Ahlstrand E,Wålinder G,Söderberg O,Rosenquist R,Landegren U,Kamali-Moghaddam M

更新日期：2017-04-04 00:00:00

abstract：:The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditio...

journal_title：Scientific reports

authors： B Arroyo A,Salloum-Asfar S,Pérez-Sánchez C,Teruel-Montoya R,Navarro S,García-Barberá N,Luengo-Gil G,Roldán V,Hansen JB,López-Pedrera C,Vicente V,González-Conejero R,Martínez C

更新日期：2017-02-27 00:00:00

abstract：:The Ganges Brahmaputra Meghna Delta (GBMD) is a large and complex coastal system whose channel network is vulnerable to morphological changes caused by sea level rise, subsidence, anthropogenic modifications, and changes to water and sediment loads. Locating and characterizing change is particularly challenging becaus...

journal_title：Scientific reports

authors： Jarriel T,Isikdogan LF,Bovik A,Passalacqua P

更新日期：2020-07-30 00:00:00

abstract：:HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role of HUWE1 in early embryo development. Here we demonstrate that Huwe1 is expressed in both nucleus and cytoplasm of preimplantation mouse emb...

journal_title：Scientific reports

authors： Chen LJ,Xu WM,Yang M,Wang K,Chen Y,Huang XJ,Ma QH

更新日期：2016-11-30 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been considered as one of the pivotal type of cells composing the tumor microenvironment. Although contact-dependent mechanisms and paracrine factors are thought to collaborate in governing the MSCs-based effects on tumors progression, the underlying mechanisms remain largely unkn...

journal_title：Scientific reports

authors： Wang J,Yang W,Wang T,Chen X,Wang J,Zhang X,Cai C,Zhong B,Wu J,Chen Z,Xiang AP,Huang W

更新日期：2018-04-03 00:00:00

abstract：:Nitric oxide (NO), a vascular signaling molecule, is primarily produced by endothelial NO synthase. Recently, a functional endothelial NO synthase (eNOS) was described in red blood cells (RBC). The RBC-eNOS contributes to the intravascular NO pool and regulates physiological functions. However the regulatory mechanism...

journal_title：Scientific reports

authors： Nagarajan S,Raj RK,Saravanakumar V,Balaguru UM,Behera J,Rajendran VK,Shathya Y,Ali BM,Sumantran V,Chatterjee S

更新日期：2016-06-27 00:00:00

abstract：:Ossification of the posterior longitudinal ligament (OPLL) can occur throughout the entire spine and can sometimes lead to spinal disorder. Although patients with OPLL sometimes develop physical limitations because of pain, the characteristics of pain and effects on activities of daily living (ADL) have not been preci...

journal_title：Scientific reports

authors： Hirai T,Yoshii T,Ushio S,Mori K,Maki S,Katsumi K,Nagoshi N,Takeuchi K,Furuya T,Watanabe K,Nishida N,Watanabe K,Kaito T,Kato S,Nagashima K,Koda M,Ito K,Imagama S,Matsuoka Y,Wada K,Kimura A,Ohba T,Katoh H,Mats

更新日期：2020-03-26 00:00:00

abstract：:A new, efficient method based on a series of matrices is introduced to completely describe the detailed topology of individual domains and their topology evolution in three-dimensional cellular structures. With this approach, we found a lot of new topological grain forms which are never reported before, i.e., there ar...

journal_title：Scientific reports

authors： Xue W,Wang H,Liu G,Meng L,Xiang S,Ma G,Li W

更新日期：2016-05-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Alam MK,Zheng L,Liu R,Papagerakis S,Papagerakis P,Geyer CR

更新日期：2020-09-09 00:00:00

abstract：:Establishing robust genome engineering methods in the malarial parasite, Plasmodium falciparum, has the potential to substantially improve the efficiency with which we gain understanding of this pathogen's biology to propel treatment and elimination efforts. Methods for manipulating gene expression and engineering the...

journal_title：Scientific reports

authors： Nasamu AS,Falla A,Pasaje CFA,Wall BA,Wagner JC,Ganesan SM,Goldfless SJ,Niles JC

更新日期：2021-01-11 00:00:00

abstract：:PP2A(Cdc55) is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2A(Cdc55) activity undergo a premature exit from meiosis I which results in a failure to form bipolar spindles and divide nuclei. This defect is largely due t...

journal_title：Scientific reports

authors： Kerr GW,Wong JH,Arumugam P

更新日期：2016-07-26 00:00:00

abstract：:In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages retain any persistent memory of past polarization states which may then impact their future repolarization to new states. Here, we perform deep transcriptomic p...

journal_title：Scientific reports

authors： Liu SX,Gustafson HH,Jackson DL,Pun SH,Trapnell C

更新日期：2020-07-23 00:00:00

abstract：:In music, the perception of pitch is governed largely by its tonal function given the preceding harmonic structure of the music. While behavioral research has advanced our understanding of the perceptual representation of musical pitch, relatively little is known about its representational structure in the brain. Usin...

journal_title：Scientific reports

authors： Sankaran N,Thompson WF,Carlile S,Carlson TA

更新日期：2018-01-16 00:00:00

abstract：:MicroRNAs (miRNAs) have been considered to be potent biomarkers for early disease diagnosis and for cancer therapy. The rapid and selective detection of miRNAs without reverse transcription and labelling is highly desired. Herein, we report a simple and label-free miRNA detection method that is based on the Duplex-Spe...

journal_title：Scientific reports

authors： Yan L,Yan Y,Pei L,Wei W,Zhao J

更新日期：2014-12-10 00:00:00

abstract：:The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumu...

journal_title：Scientific reports

authors： Jing D,Hao X,Xu F,Liu J,Xu F,Luo E,Meng G

更新日期：2016-06-22 00:00:00

abstract：:The current study was conducted to assess the effects of microinjection of different dosages of guide RNA (gRNA)/Cas9 protein on the mutation rate, embryo survival, embryonic development, hatchability and early fry survival in channel catfish, Ictalurus punctatus. Guide RNAs targeting two of the channel catfish immune...

journal_title：Scientific reports

authors： Elaswad A,Khalil K,Ye Z,Liu Z,Liu S,Peatman E,Odin R,Vo K,Drescher D,Gosh K,Qin G,Bugg W,Backenstose N,Dunham R

更新日期：2018-11-07 00:00:00

abstract：:Rapid urbanization is a global phenomenon that has altered many ecosystems, generating ecological risks such as causing a decline in many ecosystem services. In this study, ecosystem service oriented risk assessment combined with PSR were quantifying how urbanization influences the ecosystem services about Beijing-Tia...

journal_title：Scientific reports

authors： Kang P,Chen W,Hou Y,Li Y

更新日期：2019-11-14 00:00:00

abstract：:Soil microbial communities directly affect soil functionality through their roles in the cycling of soil nutrients and carbon storage. Microbial communities vary substantially in space and time, between soil types and under different land management. The mechanisms that control the spatial distributions of soil microb...

journal_title：Scientific reports

authors： Xue PP,Carrillo Y,Pino V,Minasny B,McBratney AB

更新日期：2018-08-06 00:00:00

abstract：:Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study a...

journal_title：Scientific reports

authors： Yang HJ,Ju F,Guo XX,Ma SP,Wang L,Cheng BF,Zhuang RJ,Zhang BB,Shi X,Feng ZW,Wang M

更新日期：2017-01-30 00:00:00

abstract：:CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-depende...

journal_title：Scientific reports

authors： Zhang R,Zhang G,Xiang B,Chen X,Tang L,Shi S,Liu Y,Ai X,Xie P,Li Z

更新日期：2017-12-07 00:00:00

abstract：:The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. How...

journal_title：Scientific reports

authors： Dai Z,Xu L,Duan G,Li T,Zhang H,Li Y,Wang Y,Wang Y,Cai W

更新日期：2013-01-01 00:00:00

abstract：:Obesity is associated with a high prevalence of mood disorders such as anxiety and depression. Both stress and high fat diet can alter the gut microbiota and contribute to obesity. To examine the interrelationships between obesity, stress, gut microbiota and mood disorders, obesity was induced in mice using a high fat...

journal_title：Scientific reports

authors： Bridgewater LC,Zhang C,Wu Y,Hu W,Zhang Q,Wang J,Li S,Zhao L

更新日期：2017-09-07 00:00:00

abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...

journal_title：Scientific reports

authors： Chen L,Pan X,Ma Q,Yang J,Xu Y,Zheng J,Wang H,Zhou X,Jiang T,Jiang J,He L,Jiang J

更新日期：2017-02-15 00:00:00

abstract：:Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...

journal_title：Scientific reports

authors： Qin Z,Pugno NM,Buehler MJ

更新日期：2014-05-27 00:00:00

abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...

journal_title：Scientific reports

authors： Örd M,Faustova I,Loog M

更新日期：2020-10-09 00:00:00

abstract：:Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or ...

journal_title：Scientific reports

authors： Cao H,Ma W

更新日期：2017-03-23 00:00:00

abstract：:An appropriate tillage method must be implemented by maize growers to improve phosphorus dynamics in the soil in order to increase phosphorus uptake by plant. The objective of this study was to investigate the effects of tillage systems on phosphorus and its fractions in rhizosphere and non-rhizosphere soils under mai...

journal_title：Scientific reports

authors： Xomphoutheb T,Jiao S,Guo X,Mabagala FS,Sui B,Wang H,Zhao L,Zhao X

更新日期：2020-04-20 00:00:00

abstract：:High operating temperatures can have very deleterious effects on the long-term performance of high-Cr, creep-resistant steels used, for example, in the structural components of power plants. For the popular creep-resistant steel X20CrMoV12.1 we analysed the processes of carbide growth using a variety of analytical tec...

journal_title：Scientific reports

authors： Godec M,Skobir Balantič DA

更新日期：2016-07-13 00:00:00