Abstract:
:In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages retain any persistent memory of past polarization states which may then impact their future repolarization to new states. Here, we perform deep transcriptomic profiling at high temporal resolution as macrophages are polarized with cytokines that drive them into "M1" and "M2" molecular states. We find through trajectory analysis of their global transcriptomic profiles that macrophages which are first polarized to M1 or M2 and then subsequently repolarized demonstrate little to no memory of their polarization history. We observe complete repolarization both from M1 to M2 and vice versa, and we find that macrophage transcriptional phenotypes are defined by the current cell microenvironment, rather than an amalgamation of past and present states.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu SX,Gustafson HH,Jackson DL,Pun SH,Trapnell Cdoi
10.1038/s41598-020-68766-wsubject
Has Abstractpub_date
2020-07-23 00:00:00pages
12273issue
1issn
2045-2322pii
10.1038/s41598-020-68766-wjournal_volume
10pub_type
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