Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits.

abstract：:Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, b...

journal_title：Scientific reports

authors： Liu X,Yu P,Cheng C,Potash JB,Han S

更新日期：2016-09-14 00:00:00

abstract：:The oral microflora is composed of both health-promoting as well as disease-initiating bacteria. Many of the disease-initiating bacteria are anaerobic and include organisms such as Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Tannerella forsythia. Here we investigated a novel therapeut...

journal_title：Scientific reports

authors： Hutcherson JA,Sinclair KM,Belvin BR,Gui Q,Hoffman PS,Lewis JP

更新日期：2017-09-05 00:00:00

abstract：:Acoustic manipulation by an ultrasonic phased array provides an entirely new approach to processes such as coalescence, mixing, separation, and evaporation occurring in the generation of new materials, physical property measurement, the biomedical industry, etc. However, to date, ultrasonic phased arrays have not been...

journal_title：Scientific reports

authors： Watanabe A,Hasegawa K,Abe Y

更新日期：2018-07-05 00:00:00

abstract：:Phototherapy was introduced in the early 1950's, and is the primary treatment of severe neonatal jaundice or Crigler-Najjar syndrome. Nevertheless, the potential biological effects of the products generated from the photodegradation of bilirubin during phototherapy remain unknown. This is very relevant in light of rec...

journal_title：Scientific reports

authors： Jašprová J,Dal Ben M,Hurný D,Hwang S,Žížalová K,Kotek J,Wong RJ,Stevenson DK,Gazzin S,Tiribelli C,Vítek L

更新日期：2018-05-10 00:00:00

abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...

journal_title：Scientific reports

authors： Wang H,Qin M,Liu R,Ding X,Chen ISY,Jiang Y

更新日期：2019-12-11 00:00:00

abstract：:Angiosperm mitochondrial genomes (mtDNA) exhibit variable quantities of alien sequences. Many of these sequences are acquired by intracellular gene transfer (IGT) from the plastid. In addition, frequent events of horizontal gene transfer (HGT) between mitochondria of different species also contribute to their expanded...

journal_title：Scientific reports

authors： Gandini CL,Sanchez-Puerta MV

更新日期：2017-03-06 00:00:00

abstract：:Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...

journal_title：Scientific reports

authors： Cao S,Wang T,Yang J,Hu B,Levy U,Yu W

更新日期：2017-05-02 00:00:00

abstract：:The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...

journal_title：Scientific reports

authors： Zeng Y,Wu Z,Zhang C,Meng Z,Jiang Z,Zhang J

更新日期：2016-11-23 00:00:00

abstract：:In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H+-cotransport has remained elusive. Here, we used a combin...

journal_title：Scientific reports

authors： Pujol-Giménez J,Hediger MA,Gyimesi G

更新日期：2017-07-28 00:00:00

abstract：:A new simple method is proposed to extract the ambipolar diffusion length for two-dimensional (2D) electronic transport in thin film structures using a scanning photoluminescence microscopy (SPLM) setup. No spatially-resolved photoluminescence detection methods are required. By measuring the excitation-position-depend...

journal_title：Scientific reports

authors： Chu CH,Mao MH,Lin YR,Lin HH

更新日期：2020-03-23 00:00:00

abstract：:This study aimed to observe the morphological characteristics of a PGLA [poly(glycolide-co-L-lactide)] nerve conduit and regenerated nerve bundle in the human body using high-frequency ultrasound and examine functional recovery of the regenerated nerve using functional magnetic resonance imaging (fMRI) after neural pr...

journal_title：Scientific reports

authors： Gao D,Jiang JJ,Gu SH,Lu JZ,Xu L

更新日期：2017-04-13 00:00:00

abstract：:The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ...

journal_title：Scientific reports

authors： Kozono N,Honda S,Tada M,Kirihara K,Zhao Z,Jinde S,Uka T,Yamada H,Matsumoto M,Kasai K,Mihara T

更新日期：2019-06-11 00:00:00

abstract：:C. canimorsus and C. cynodegmi are dog and cat commensals which can be transmitted to humans via bites or scratches and can cause sepsis, meningitis, endocarditis, and eye- or wound infections. Recently an additional Capnocytophaga species was identified as part of the oral flora of healthy dogs and was given the name...

journal_title：Scientific reports

authors： Zangenah S,Abbasi N,Andersson AF,Bergman P

更新日期：2016-03-07 00:00:00

abstract：:Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) withou...

journal_title：Scientific reports

authors： Katagiri R,Goto A,Budhathoki S,Yamaji T,Yamamoto H,Kato Y,Iwasaki M,Tsugane S

更新日期：2018-01-18 00:00:00

abstract：:Radopholus similis is an important migratory endoparasitic nematode, severely harms banana, citrus and many other commercial crops. Little is known about the molecular mechanism of infection and pathogenesis of R. similis. In this study, 64761 unigenes were generated from eggs, juveniles, females and males of R. simil...

journal_title：Scientific reports

authors： Huang X,Xu CL,Yang SH,Li JY,Wang HL,Zhang ZX,Chen C,Xie H

更新日期：2019-04-18 00:00:00

abstract：:The ability to predict the magnitude of an earthquake caused by deep fluid injections is an important factor for assessing the safety of the reservoir storage and the seismic hazard. Here, we propose a new approach to evaluate the seismic energy released during fluid injection by integrating injection parameters, indu...

journal_title：Scientific reports

authors： De Barros L,Cappa F,Guglielmi Y,Duboeuf L,Grasso JR

更新日期：2019-03-21 00:00:00

abstract：:The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondri...

journal_title：Scientific reports

authors： Kandoussi A,Boujenane I,Auger C,Serranito B,Germot A,Piro M,Maftah A,Badaoui B,Petit D

更新日期：2020-06-23 00:00:00

abstract：:Understanding of avian nocturnal flight comes mainly from northern hemisphere species in seasonal temperate ecosystems where nocturnal flight is often precisely timed and entrained by annual photoperiod. Here we investigate patterns of nocturnal flight in waterbirds of Australian desert ecosystems that fly considerabl...

journal_title：Scientific reports

authors： McEvoy JF,Ribot RFH,Wingfield JC,Bennett ATD

更新日期：2017-12-14 00:00:00

abstract：:Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell M...

journal_title：Scientific reports

authors： Barth TFE,Kraus JM,Lausser L,Flossbach L,Schulte L,Holzmann K,Kestler HA,Möller P

更新日期：2017-07-20 00:00:00

abstract：:Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isola...

journal_title：Scientific reports

authors： Kenyon JJ,Notaro A,Hsu LY,De Castro C,Hall RM

更新日期：2017-09-12 00:00:00

abstract：:Longitudinal developmental fMRI studies just recently began to focus on within-subject reliability using the intraclass coefficient (ICC). It remains largely unclear which degree of reliability can be achieved in developmental studies and whether this depends on the type of task used. Therefore, we aimed to systematic...

journal_title：Scientific reports

authors： Vetter NC,Steding J,Jurk S,Ripke S,Mennigen E,Smolka MN

更新日期：2017-05-23 00:00:00

abstract：:Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities ...

journal_title：Scientific reports

authors： Renaut C,Cluzel B,Dellinger J,Lalouat L,Picard E,Peyrade D,Hadji E,de Fornel F

更新日期：2013-01-01 00:00:00

abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...

journal_title：Scientific reports

authors： Liviero F,Scarpa MC,De Stefani D,Folino F,Campisi M,Mason P,Iliceto S,Pavanello S,Maestrelli P

更新日期：2020-09-16 00:00:00

abstract：:Channelrhodopsin-2 (ChR2)-based optogenetic technique has been increasingly applied to cardiovascular research. However, the potential effects of ChR2 protein overexpression on cardiomyocytes are not completely understood. The present work aimed to examine how the doxycycline-inducible lentiviral-mediated ChR2 express...

journal_title：Scientific reports

authors： Li Q,Ni RR,Hong H,Goh KY,Rossi M,Fast VG,Zhou L

更新日期：2017-05-08 00:00:00

abstract：:Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to elucidate the mecha...

journal_title：Scientific reports

authors： Zhou TY,Zhuang LH,Hu Y,Zhou YL,Lin WK,Wang DD,Wan ZQ,Chang LL,Chen Y,Ying MD,Chen ZB,Ye S,Lou JS,He QJ,Zhu H,Yang B

更新日期：2016-08-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (aSAH)-induced cerebral vasospasm and delayed ischemic neurological deficit (DIND) are the major causes of morbidity and mortality in patients with aSAH. The effects of statins-use for patients with aSAH remain controversial. Here,a total of 249 patients from six randomized controlle...

journal_title：Scientific reports

authors： Su SH,Xu W,Hai J,Wu YF,Yu F

更新日期：2014-04-25 00:00:00

abstract：:MITF is a known gene underlying autosomal dominant hearing loss, Waardenburg syndrome (WS). Biallelic MITF mutations have been found associated with a rare hearing loss syndrome consisting eye abnormalities and albinism; and a more severe type of WS whose heterozygous parents were affected with classic WS in both case...

journal_title：Scientific reports

authors： Thongpradit S,Jinawath N,Javed A,Noojarern S,Khongkraparn A,Tim-Aroon T,Lertsukprasert K,Suktitipat B,Jensen LT,Wattanasirichaigoon D

更新日期：2020-07-29 00:00:00

abstract：:Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities with known proteins. How rust fungal effectors function in host cells remains elusi...

journal_title：Scientific reports

authors： de Guillen K,Lorrain C,Tsan P,Barthe P,Petre B,Saveleva N,Rouhier N,Duplessis S,Padilla A,Hecker A

更新日期：2019-12-02 00:00:00

abstract：:We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) - (EtO)3Si(CH2)nN = CHPhX where n = 3 or 11 and X = 4-CF3, 3,5-CF3, 3-F-4-CF3, 4-F, or 2,3,4,5,6-F, and explore their rectification behavior in relation to their molecular structure. The electrical proper...

journal_title：Scientific reports

authors： Lamport ZA,Broadnax AD,Harrison D,Barth KJ,Mendenhall L,Hamilton CT,Guthold M,Thonhauser T,Welker ME,Jurchescu OD

更新日期：2016-11-29 00:00:00

abstract：:In the present study, the synergistic effect on the corrosion protection properties of Mg alloys subjected to plasma electrolytic oxidation and chemically treated with thiourea as an inhibitor is investigated by surface microstructure analysis, evaluation of the electrochemical performance, and chemical quantum calcul...

journal_title：Scientific reports

authors： Al Zoubi W,Ko YG

更新日期：2018-07-19 00:00:00