Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens.

abstract：:Graphite-coated magnetic cobalt nanoparticles (CoNPs) decorated with hindered phenolic antioxidant analogues of 2,6-di-tert-butyl-4-methylphenol (BHT, E321) provided easily removable nanoantioxidants capable of preventing the autoxidation of organic solvents as tetrahydrofuran (THF). ...

journal_title：Scientific reports

authors： Viglianisi C,Scarlini A,Tofani L,Menichetti S,Baschieri A,Amorati R

更新日期：2019-11-20 00:00:00

abstract：:Spermatogenesis in the mouse has been extensively studied for decades. Previous methods, such as histological staining or bulk transcriptome analysis, either lacked resolution at the single-cell level or were focused on a very narrowly defined set of factors. Here, we present the first comprehensive, unbiased single-c...

journal_title：Scientific reports

authors： Lukassen S,Bosch E,Ekici AB,Winterpacht A

更新日期：2018-04-25 00:00:00

abstract：:Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...

journal_title：Scientific reports

authors： Gopalakrishnan K,Aushev VN,Manservisi F,Falcioni L,Panzacchi S,Belpoggi F,Parada H Jr,Garbowski G,Hibshoosh H,Santella RM,Gammon MD,Teitelbaum SL,Chen J

更新日期：2020-04-27 00:00:00

abstract：:Lung fibrosis is an unabated wound healing response characterized by the loss and aberrant function of lung epithelial cells. Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained epithelium viability during lung repair. Unlike normal and COPD lung...

journal_title：Scientific reports

authors： Habiel DM,Camelo A,Espindola M,Burwell T,Hanna R,Miranda E,Carruthers A,Bell M,Coelho AL,Liu H,Pilataxi F,Clarke L,Grant E,Lewis A,Moore B,Knight DA,Hogaboam CM,Murray LA

更新日期：2017-11-13 00:00:00

abstract：:Leaf flattening influences plant photosynthesis, thereby affecting product yield and quality. Here, we obtained a stably inherited leaf crinkled mutant (lcm), derived from the Chinese cabbage doubled haploid (DH) 'FT' line using EMS mutagenesis combined with isolated microspore culture. The crinkled phenotype was cont...

journal_title：Scientific reports

authors： Zhang M,Huang S,Gao Y,Fu W,Qu G,Zhao Y,Shi F,Liu Z,Feng H

更新日期：2020-08-18 00:00:00

abstract：:Edible insects are often considered a nutritious, protein-rich, environmentally sustainable alternative to traditional livestock with growing popularity among North American consumers. While the nutrient composition of several insects is characterized, all potential health impacts have not been evaluated. In addition ...

journal_title：Scientific reports

authors： Stull VJ,Finer E,Bergmans RS,Febvre HP,Longhurst C,Manter DK,Patz JA,Weir TL

更新日期：2018-07-17 00:00:00

abstract：:Width-controlled M-type hexagonal SrFe12O19 nanoribbons were synthesized for the first time via polyvinylpyrrolidone (PVP) sol assisted electrospinning followed by heat treatment in air, and their chemical composition, microstructure and magnetic performance were investigated. Results demonstrated that as-obtained SrF...

journal_title：Scientific reports

authors： Jing P,Du J,Wang J,Wei J,Pan L,Li J,Liu Q

更新日期：2015-10-14 00:00:00

abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...

journal_title：Scientific reports

authors： Jiang Y,Ji J,Huang J,Marchi S,Li Y,Ip WH

更新日期：2015-11-02 00:00:00

abstract：:Perinatally HIV-infected patients face the consequences of both chronic infection effects per se and long-term combination antiretroviral therapy (cART) on immunosenescence. Aims of our study were to evaluate which factors independently contribute to immunosenescence in HIV-infected young adults with a very different ...

journal_title：Scientific reports

authors： Quiros-Roldan E,Properzi M,Paghera S,Raffetti E,Castelli F,Imberti L

更新日期：2020-06-22 00:00:00

abstract：:Applications of ferroelectric materials in modern microelectronics will be greatly encouraged if the thermal incompatibility between inorganic ferroelectrics and semiconductor devices is overcome. Here, solution-processable layers of the most commercial ferroelectric compound--morphotrophic phase boundary lead zircona...

journal_title：Scientific reports

authors： Bretos I,Jiménez R,Tomczyk M,Rodríguez-Castellón E,Vilarinho PM,Calzada ML

更新日期：2016-02-03 00:00:00

abstract：:The objective of this study was to unveil the potential mechanism of focused ultrasound (FUS)-enhanced intranasal (IN) brain drug delivery and assess its feasibility in the delivery of therapeutic molecules. Delivery outcomes of fluorescently-labeled dextrans to mouse brains by IN administration either before or after...

journal_title：Scientific reports

authors： Chen H,Yang GZ,Getachew H,Acosta C,Sierra Sánchez C,Konofagou EE

更新日期：2016-06-27 00:00:00

abstract：:Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including hypothalamic arcuate nucleus (ARC), where proopiomelanocortin (POMC) neurons play key roles in feeding regulation. Several studies have e...

journal_title：Scientific reports

authors： Suyama S,Maekawa F,Maejima Y,Kubota N,Kadowaki T,Yada T

更新日期：2016-08-09 00:00:00

abstract：:The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a role in lipid metabolism and inflammation, we investigated the e...

journal_title：Scientific reports

authors： Bae CR,Hino J,Hosoda H,Arai Y,Son C,Makino H,Tokudome T,Tomita T,Kimura T,Nojiri T,Hosoda K,Miyazato M,Kangawa K

更新日期：2017-08-29 00:00:00

abstract：:Mycobacterium tuberculosis (M.tb), the pathogen responsible for tuberculosis (TB) poses as the major cause of death among infectious diseases. The knowledge about the molecular diversity of M.tb enables the implementation of more effective surveillance and control measures and, nowadays, Whole Genome Sequencing (WGS) ...

journal_title：Scientific reports

authors： Verza M,Scheffer MC,Salvato RS,Schorner MA,Barazzetti FH,Machado HM,Medeiros TF,Rovaris DB,Portugal I,Viveiros M,Perdigão J,Kritski A,Bazzo ML

更新日期：2020-07-30 00:00:00

abstract：:A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...

journal_title：Scientific reports

authors： Mallik AK,Farrell G,Liu D,Kavungal V,Wu Q,Semenova Y

更新日期：2018-01-26 00:00:00

abstract：:In this paper, we study a system with two interacting qubits described by the Heisenberg model with dissipative terms, and analyze decay dynamics and the steady-state of geometric quantum discords. Our results indicate that we can ignore the interaction force in the z-direction and adjust the parameters to change the ...

journal_title：Scientific reports

authors： Liang J,Zhang C

更新日期：2020-07-02 00:00:00

abstract：:The increasing performance of optical lattice clocks has made them attractive for scientific applications in space and thus has pushed the development of their components including the interrogation lasers of the clock transitions towards being suitable for space, which amongst others requires making them more power e...

journal_title：Scientific reports

authors： Świerad D,Häfner S,Vogt S,Venon B,Holleville D,Bize S,Kulosa A,Bode S,Singh Y,Bongs K,Rasel EM,Lodewyck J,Le Targat R,Lisdat C,Sterr U

更新日期：2016-09-26 00:00:00

abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...

journal_title：Scientific reports

authors： Obana A,Gohto Y,Gellermann W,Ermakov IV,Sasano H,Seto T,Bernstein PS

更新日期：2019-06-27 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation of diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with the activation of host innate immune respo...

journal_title：Scientific reports

authors： Kim JH,Lee J,Bae SJ,Kim Y,Park BJ,Choi JW,Kwon J,Cha GH,Yoo HJ,Jo EK,Bae YS,Lee YH,Yuk JM

更新日期：2017-07-25 00:00:00

abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...

journal_title：Scientific reports

authors： Kalkunte S,Huang Z,Lippe E,Kumar S,Robertson LW,Sharma S

更新日期：2017-01-10 00:00:00

abstract：:MicroRNAs are arising as the next generation of diagnostic and therapeutic tools for gene silencing. Studies demonstrated that the miR-29 expression is decreased in Alzheimer's disease (AD) patients displaying high levels of human β-secretase (hBACE1). Recent advances toward an effective therapy for AD intend to emplo...

journal_title：Scientific reports

authors： Pereira PA,Tomás JF,Queiroz JA,Figueiras AR,Sousa F

更新日期：2016-01-28 00:00:00

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00

abstract：:CRISPR/Cas9-derived RNA-guided nucleases (RGNs) are DNA targeting systems, which are rapidly being harnessed for gene regulation and gene editing purposes in model organisms and cell lines. As bona fide gene delivery vehicles, viral vectors may be particularly fit to broaden the applicability of RGNs to other cell typ...

journal_title：Scientific reports

authors： Maggio I,Holkers M,Liu J,Janssen JM,Chen X,Gonçalves MA

更新日期：2014-05-29 00:00:00

abstract：:This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...

journal_title：Scientific reports

authors： Song KS,Lee DW,Kim B,Hur BY,Kim MJ,Kim MJ,Hong CW,Park SC,Park HC,Sohn DK,Kim BC,Han KS,Oh JH

更新日期：2019-07-11 00:00:00

abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...

journal_title：Scientific reports

authors： Kuang Q,Xu X,Li R,Dong Y,Li Y,Huang Z,Li Y,Li M

更新日期：2015-09-09 00:00:00

abstract：:The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that MITF binds the CLEAR-box element in the promot...

journal_title：Scientific reports

authors： Möller K,Sigurbjornsdottir S,Arnthorsson AO,Pogenberg V,Dilshat R,Fock V,Brynjolfsdottir SH,Bindesboll C,Bessadottir M,Ogmundsdottir HM,Simonsen A,Larue L,Wilmanns M,Thorsson V,Steingrimsson E,Ogmundsdottir MH

更新日期：2019-01-31 00:00:00

abstract：:Physical reservoir computing approaches have gained increased attention in recent years due to their potential for low-energy high-performance computing. Despite recent successes, there are bounds to what one can achieve simply by making physical reservoirs larger. Therefore, we argue that a switch from single-reservo...

journal_title：Scientific reports

authors： Freiberger M,Bienstman P,Dambre J

更新日期：2020-09-02 00:00:00

abstract：:The recent surge in research on metal-halide-perovskite solar cells has led to a seven-fold increase of efficiency, from ~3% in early devices to over 22% in research prototypes. Oft-cited reasons for this increase are: (i) a carrier diffusion length reaching hundreds of microns; (ii) a low exciton binding energy; and ...

journal_title：Scientific reports

authors： Grånäs O,Vinichenko D,Kaxiras E

更新日期：2016-11-08 00:00:00

abstract：:Rhythm is an essential element of dancing and music. To investigate the neural mechanisms underlying how rhythm is learned, we recorded electroencephalographic (EEG) data during a rhythm-reproducing task that asked participants to memorize an auditory stimulus and reproduce it via tapping. Based on the behavioral resu...

journal_title：Scientific reports

authors： Edagawa K,Kawasaki M

更新日期：2017-02-22 00:00:00

abstract：:The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...

journal_title：Scientific reports

authors： Chatzidakis M,Botton GA

更新日期：2019-02-14 00:00:00