Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment.

abstract：:The human ether-à-go-go related gene (hERG) channel is crucial for the cardiac action potential by contributing to the fast delayed-rectifier potassium current. Mutations in the hERG channel result in type 2 long QT syndrome (LQT2). The hERG channel contains a cyclic nucleotide-binding homology domain (CNBHD) and this...

journal_title：Scientific reports

authors： Li Y,Ng HQ,Li Q,Kang C

更新日期：2016-03-30 00:00:00

abstract：:Electronic cigarettes (ECs) are nicotine delivery devices that are proposed as tobacco harm reduction products to smokers. Nicotine delivery from ECs is potentially important in their efficacy as smoking substitutes. Herein, nicotine delivery from using a new-generation EC device (variable-wattage, set at 9 W) was eva...

journal_title：Scientific reports

authors： Farsalinos KE,Spyrou A,Stefopoulos C,Tsimopoulou K,Kourkoveli P,Tsiapras D,Kyrzopoulos S,Poulas K,Voudris V

更新日期：2015-06-17 00:00:00

abstract：:To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the secon...

journal_title：Scientific reports

authors： Tagliabue M,Maffini F,Fumagalli C,Gandini S,Lepanto D,Corso F,Cacciola S,Ranghiero A,Rappa A,Vacirca D,Cossu Rocca M,Alterio D,Guerini Rocco E,Cattaneo A,Chu F,Zorzi S,Curigliano G,Chiocca S,Barberis M,Viale G,Ans

更新日期：2020-10-27 00:00:00

abstract：:Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...

journal_title：Scientific reports

authors： Lai FY,Lympousi K,Been F,Benaglia L,Udrisard R,Delémont O,Esseiva P,Thomaidis NS,Covaci A,van Nuijs ALN

更新日期：2018-09-05 00:00:00

abstract：:Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F muta...

journal_title：Scientific reports

authors： Mercier KA,Al-Jazrawe M,Poon R,Acuff Z,Alman B

更新日期：2018-01-12 00:00:00

abstract：:Primary Sjogren's syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to NHL...

journal_title：Scientific reports

authors： Fragkioudaki S,Nezos A,Souliotis VL,Chatziandreou I,Saetta AA,Drakoulis N,Tzioufas AG,Voulgarelis M,Sfikakis PP,Koutsilieris M,Crow MK,Moutsopoulos HM,Mavragani CP

更新日期：2017-08-04 00:00:00

abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

journal_title：Scientific reports

authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

更新日期：2017-04-03 00:00:00

abstract：:Spatially explicit information on electric power consumption (EPC) is crucial for effective electricity allocation and utilization. Many studies have estimated fine-scale spatial EPC based on remotely sensed nighttime light (NTL). However, the spatial non-stationary relationship between EPC and NTL at prefectural leve...

journal_title：Scientific reports

authors： Chen M,Cai H,Yang X,Jin C

更新日期：2020-10-29 00:00:00

abstract：:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...

journal_title：Scientific reports

authors： Choi H,Liu Y,Yang L,Cho ES

更新日期：2020-04-29 00:00:00

abstract：:In utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. Prior studies have proposed that the mode of feeding shapes the gut microbiota and, subsequently the child's health. However, the effect of the mode of feeding and its influence on the ...

journal_title：Scientific reports

authors： Al-Shehri SS,Sweeney EL,Cowley DM,Liley HG,Ranasinghe PD,Charles BG,Shaw PN,Vagenas D,Duley JA,Knox CL

更新日期：2016-12-06 00:00:00

abstract：:Schizotypy is associated with poor emotion regulation that is thought to contribute to the development of psychotic symptoms and to indicate a predisposition to schizophrenia. Having focused primarily on the relationship between schizotypy and explicit emotion regulation, existing studies have, until now, neglected to...

journal_title：Scientific reports

authors： Hoid D,Pan DN,Wang Y,Li X

更新日期：2020-03-03 00:00:00

abstract：:Deforestation associated with the initial settlement of New Zealand is a dramatic example of how humans can alter landscapes through fire. However, evidence linking early human presence and land-cover change is inferential in most continental sites. We employed a multi-proxy approach to reconstruct anthropogenic land ...

journal_title：Scientific reports

authors： Argiriadis E,Battistel D,McWethy DB,Vecchiato M,Kirchgeorg T,Kehrwald NM,Whitlock C,Wilmshurst JM,Barbante C

更新日期：2018-08-14 00:00:00

abstract：:Improving feed efficiency (FE) is a major goal of pig breeding, reducing production costs and providing sustainability to the pig industry. Reliable predictors for FE could assist pig producers. We carried out untargeted blood metabolite profiling in uncastrated males from Danbred Duroc (n = 59) and Danbred Landrace (...

journal_title：Scientific reports

authors： Carmelo VAO,Banerjee P,da Silva Diniz WJ,Kadarmideen HN

更新日期：2020-01-14 00:00:00

abstract：:Although N-acyl-L-homoserine lactone (AHL) based quorum sensing (QS) phenomenon has been observed in mature anaerobic granules, the biological role of AHL-based QS system in anaerobic granulation process remains unexplored. For the first time, a long-term anaerobic bioreactor was operated for 168 days to investigate t...

journal_title：Scientific reports

authors： Ma H,Ma S,Hu H,Ding L,Ren H

更新日期：2018-10-25 00:00:00

abstract：:p53 mutations are frequently detected in malignant gastric cancers. However, the molecular mechanisms by which loss of p53 function promotes gastric cancer are not clear. We utilized Gan mice (K19-Wnt1/C2mE), which have functional p53 and develop intestinal-type gastric tumors, to investigate the role of p53 in gastri...

journal_title：Scientific reports

authors： Ohtsuka J,Oshima H,Ezawa I,Abe R,Oshima M,Ohki R

更新日期：2018-02-02 00:00:00

abstract：:Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

journal_title：Scientific reports

authors： Lard M,ten Siethoff L,Månsson A,Linke H

更新日期：2013-01-01 00:00:00

abstract：:Auricle defects are important and common occurrences in forensic medicine. The accurate measurement and assessment of auricle defects is key to identifying and evaluating injury, and the currently available methods are known to be labor intensive and inaccurate. In this paper, we introduce an identification and docume...

journal_title：Scientific reports

authors： Zhan G,Han L,Li Z,Liu Z,Fu J,Zhong K

更新日期：2018-02-12 00:00:00

abstract：:Kinetic restriction of a thermodynamically favourable equilibrium is a common theme in materials processing. The interfacial instability in systems where rate of material exchange is far greater than the mass transfer through respective bulk phases is of specific interest when tracking the transient interfacial area, ...

journal_title：Scientific reports

authors： Spooner S,Rahnama A,Warnett JM,Williams MA,Li Z,Sridhar S

更新日期：2017-10-30 00:00:00

abstract：:Given a reaction-diffusion system interacting via a complex network, we propose two different techniques to modify the network topology while preserving its dynamical behaviour. In the region of parameters where the homogeneous solution gets spontaneously destabilized, perturbations grow along the unstable directions ...

journal_title：Scientific reports

authors： Cencetti G,Clusella P,Fanelli D

更新日期：2018-11-01 00:00:00

abstract：:Dyschloremia is common in critically ill patients. However, little is known about the effects of dyschloremia on renal function in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). A total of 483 patients who received CRRT for AKI were selected and divided into three groups...

journal_title：Scientific reports

authors： Kee YK,Jeon HJ,Oh J,Shin DH

更新日期：2020-11-12 00:00:00

abstract：:Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating how stem cells adjust to a demand for specialized cells. A failure of the stem cells to respond to this demand can have serious consequences,...

journal_title：Scientific reports

authors： Malpe MS,McSwain LF,Kudyba K,Ng CL,Nicholson J,Brady M,Qian Y,Choksi V,Hudson AG,Parrott BB,Schulz C

更新日期：2020-03-03 00:00:00

abstract：:A toolbox for the quantum simulation of polarons in ultracold atoms is presented. Motivated by the impressive experimental advances in the area of ultracold atomic mixtures, we theoretically study the problem of ultracold atomic impurities immersed in a Bose-Einstein condensate mixture (BEC). The coupling between impu...

journal_title：Scientific reports

authors： Compagno E,De Chiara G,Angelakis DG,Palma GM

更新日期：2017-05-24 00:00:00

abstract：:The study reported here focuses on inertial internal wave currents on the west Florida midshelf in 50 m depth. In situ observations showed that the seasonal shifts in stratification change both the frequency range of inertial internal waves and their modulation time scales. According to the analysis, the subinertial f...

journal_title：Scientific reports

authors： Maksimova EV

更新日期：2018-10-29 00:00:00

abstract：:In experiments that test plant diversity-productivity relationships, the common practice of weeding unsown species and disallowing species colonization may have the unintended consequence of favoring priority effects that maintain niche complementarity in determining productivity. However, in naturally assembled commu...

journal_title：Scientific reports

authors： Jiang K,Tan Z,He Q,Wang L,Zhao Y,Sun X,Hou W,Long W,Zhang H

更新日期：2020-08-07 00:00:00

abstract：:A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...

journal_title：Scientific reports

authors： Fusco G,De Simone A,Arosio P,Vendruscolo M,Veglia G,Dobson CM

更新日期：2016-06-08 00:00:00

abstract：:Bacteriophage T7 is an intracellular parasite that recognizes its host via its tail and tail fiber proteins, known as receptor-binding proteins (RBPs). The RBPs attach to specific lipopolysaccharide (LPS) features on the host. Various studies have shown expansion of the phage's host range via mutations in the genes en...

journal_title：Scientific reports

authors： Holtzman T,Globus R,Molshanski-Mor S,Ben-Shem A,Yosef I,Qimron U

更新日期：2020-01-15 00:00:00

abstract：:Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...

journal_title：Scientific reports

authors： Jöud M,Möller M,Olsson ML

更新日期：2018-04-16 00:00:00

abstract：:Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to examine 41 gastric tissue samples at different pathological stag...

journal_title：Scientific reports

authors： Kuang M,Cheng J,Zhang C,Feng L,Xu X,Zhang Y,Zu M,Cui J,Yu H,Zhang K,Yang A,Cheng S

更新日期：2017-08-10 00:00:00

abstract：:Crystalline atomic layers on solid surfaces are composed of a single building block, unit cell, that is copied and stacked together to form the entire two-dimensional crystal structure. However, it appears that this is not an unique possibility. We report here on synthesis and characterization of the one-atomic-layer-...

journal_title：Scientific reports

authors： Gruznev DV,Bondarenko LV,Matetskiy AV,Mihalyuk AN,Tupchaya AY,Utas OA,Eremeev SV,Hsing CR,Chou JP,Wei CM,Zotov AV,Saranin AA

更新日期：2016-01-19 00:00:00

abstract：:Th17 and regulatory T cells, involved in the pathogenesis of several autoimmune diseases, are new lineages of CD4+ T helper cells. However, the role of their imbalance in human leukocyte antigen B27-associated acute anterior uveitis has not been elucidated. In our study, the percentages of Th17 and Treg cells, their m...

journal_title：Scientific reports

authors： Zhuang Z,Wang Y,Zhu G,Gu Y,Mao L,Hong M,Li Y,Zheng M

更新日期：2017-01-16 00:00:00