A role for the immune system in advanced laryngeal cancer.

abstract：:Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...

journal_title：Scientific reports

authors： Powell TR,Murphy T,Lee SH,Duarte RRR,Lee HA,Smeeth D,Price J,Breen G,Thuret S

更新日期：2017-11-08 00:00:00

abstract：:Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS and to assess the predisposing factors and predictors of severity. A retrospective case-control cohort was stu...

journal_title：Scientific reports

authors： Alkindi S,Al-Busaidi I,Al-Salami B,Raniga S,Pathare A,Ballas SK

更新日期：2020-02-12 00:00:00

abstract：:Although previous findings identified an association between C-reactive protein (CRP) levels, and impaired cognitive functions in patients with schizophrenia (SZ), little is currently known about the relationship between inflammation, cognition, and sex in SZ. The current study aimed to explore the association between...

journal_title：Scientific reports

authors： Dal Santo F,González-Blanco L,García-Álvarez L,de la Fuente-Tomás L,Velasco Á,Álvarez-Vázquez CM,Martínez-Cao C,Sáiz PA,García-Portilla MP,Bobes J

更新日期：2020-09-29 00:00:00

abstract：:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

journal_title：Scientific reports

authors： Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

更新日期：2020-01-28 00:00:00

abstract：:Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of...

journal_title：Scientific reports

authors： Luo JL,Wang SF,Liu W,Tian CX,Wu JW,Zu XT,Zhou WL,Yuan XD,Xiang X

更新日期：2017-08-14 00:00:00

abstract：:The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversi...

journal_title：Scientific reports

authors： Zhang Y,Liu C,Liu J,Guo R,Yan Z,Liu W,Lau WB,Jiao X,Cao J,Xu K,Jia Y,Ma X,Wang Y

更新日期：2020-01-21 00:00:00

abstract：:Altered death receptor signaling and resistance to subsequent apoptosis is an important clinical resistance mechanism. Here, we investigated the role of death receptor resistance in breast cancer progression. Resistance of the estrogen receptor alpha (ER)-positive, chemosensitive MCF7 breast cancer cell line to tumor ...

journal_title：Scientific reports

authors： Antoon JW,Lai R,Struckhoff AP,Nitschke AM,Elliott S,Martin EC,Rhodes LV,Yoon NS,Salvo VA,Shan B,Beckman BS,Nephew KP,Burow ME

更新日期：2012-01-01 00:00:00

abstract：:Accurate and precise structural ensembles of proteins and macromolecular complexes can be obtained with metainference, a recently proposed Bayesian inference method that integrates experimental information with prior knowledge and deals with all sources of errors in the data as well as with sample heterogeneity. The s...

journal_title：Scientific reports

authors： Bonomi M,Camilloni C,Vendruscolo M

更新日期：2016-08-26 00:00:00

abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...

journal_title：Scientific reports

authors： Xue SS,Zhao M,Ke ZF,Cheng BC,Su H,Cao Q,Cao ZK,Wang J,Ji LN,Mao ZW

更新日期：2016-02-26 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation of diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with the activation of host innate immune respo...

journal_title：Scientific reports

authors： Kim JH,Lee J,Bae SJ,Kim Y,Park BJ,Choi JW,Kwon J,Cha GH,Yoo HJ,Jo EK,Bae YS,Lee YH,Yuk JM

更新日期：2017-07-25 00:00:00

abstract：:The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growth and metastasis prevention. We and others have shown that farnesyl dimethyl c...

journal_title：Scientific reports

authors： Husain K,Coppola D,Yang CS,Malafa MP

更新日期：2021-01-26 00:00:00

abstract：:We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...

journal_title：Scientific reports

authors： Soares AG,Kilpi F,Fraser A,Nelson SM,Sattar N,Welsh PI,Tilling K,Lawlor DA

更新日期：2020-12-04 00:00:00

abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

journal_title：Scientific reports

authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

更新日期：2012-01-01 00:00:00

abstract：:Electron- or X-ray-induced characteristic X-ray analysis has been widely used to determine chemical compositions of materials in vast research fields. In recent years, analysis of characteristic X-rays from muonic atoms, in which a muon is captured, has attracted attention because both a muon beam and a muon-induced c...

journal_title：Scientific reports

authors： Terada K,Sato A,Ninomiya K,Kawashima Y,Shimomura K,Yoshida G,Kawai Y,Osawa T,Tachibana S

更新日期：2017-11-13 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...

journal_title：Scientific reports

authors： Ntasis VF,Panousis NI,Tektonidou MG,Dermitzakis ET,Boumpas DT,Bertsias GK,Nikolaou C

更新日期：2020-10-06 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve hMSCs survival may be of high relevance in tissue engineering. Carnitine palmitoyltransferase 1 C (CPT1C) is a pseudoenz...

journal_title：Scientific reports

authors： Roa-Mansergas X,Fadó R,Atari M,Mir JF,Muley H,Serra D,Casals N

更新日期：2018-05-03 00:00:00

abstract：:Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...

journal_title：Scientific reports

authors： Uchida K,Himori N,Hashimoto K,Shiga Y,Tsuda S,Omodaka K,Nakazawa T

更新日期：2020-01-17 00:00:00

abstract：:Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a compreh...

journal_title：Scientific reports

authors： Wang K,Wu D,Zhang H,Das A,Basu M,Malin J,Cao K,Hannenhalli S

更新日期：2018-07-19 00:00:00

abstract：:Aquaporin 9 (AQP9), as an aquaglyceroporin, is expressed in many immune cells and plays important role in tumor initiation and progression. However, the relationship between AQP9 and tumor-infiltrating cells, and its prognostic value in cancers still require comprehensive understanding. Herein, we aimed to elucidate t...

journal_title：Scientific reports

authors： Liu X,Xu Q,Li Z,Xiong B

更新日期：2020-11-27 00:00:00

abstract：:The Raman spectral features from spinal cord tissue sections of transgenic, ALS model mice and non-transgenic mice were compared using 457 nm excitation line, profiting from the favourable signal intensity obtained in the molecular fingerprint region at this wavelength. Transverse sections from four SOD1G93A mice at 7...

journal_title：Scientific reports

authors： Picardi G,Spalloni A,Generosi A,Paci B,Mercuri NB,Luce M,Longone P,Cricenti A

更新日期：2018-08-30 00:00:00

abstract：:Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable changes in gene expression. Therefore, a genome-wide screening of the hep...

journal_title：Scientific reports

authors： Willems E,Guerrero-Bosagna C,Decuypere E,Janssens S,Buyse J,Buys N,Jensen P,Everaert N

更新日期：2016-02-10 00:00:00

abstract：:Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...

journal_title：Scientific reports

authors： Patrono D,Surra A,Catalano G,Rizza G,Berchialla P,Martini S,Tandoi F,Lupo F,Mirabella S,Stratta C,Salizzoni M,Romagnoli R

更新日期：2019-06-27 00:00:00

abstract：:Hepatitis C virus (HCV) infection of hepatocytes promotes liver fibrosis by activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix in liver tissue. Whether or not host factors released from the HCV-infected hepatocytes play role in HSCs activation is unclear. In this study, HSCs w...

journal_title：Scientific reports

authors： Cheng JC,Tseng CP,Liao MH,Peng CY,Yu JS,Chuang PH,Huang JT,Chen JJW

更新日期：2017-06-30 00:00:00

abstract：:Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes with COL6A3 mRNA...

journal_title：Scientific reports

authors： Dankel SN,Grytten E,Bjune JI,Nielsen HJ,Dietrich A,Blüher M,Sagen JV,Mellgren G

更新日期：2020-11-19 00:00:00

abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...

journal_title：Scientific reports

authors： Baye E,de Courten MP,Walker K,Ranasinha S,Earnest A,Forbes JM,de Courten B

更新日期：2017-06-23 00:00:00

abstract：:High quality wafer-scale free-standing WS2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to l...

journal_title：Scientific reports

authors： Yu Y,Fong PW,Wang S,Surya C

更新日期：2016-11-29 00:00:00

abstract：:The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before the onset of emphysematous destruction in COPD. This report extends those observations to the cellular and molecular level in the centrilobular phenotype of emphysematous destruction in lungs donate...

journal_title：Scientific reports

authors： Suzuki M,Sze MA,Campbell JD,Brothers JF 2nd,Lenburg ME,McDonough JE,Elliott WM,Cooper JD,Spira A,Hogg JC

更新日期：2017-08-25 00:00:00

abstract：:Transit-time flow measurement (TTFM) is frequently used to evaluate intraoperative quality control during coronary artery bypass grafting (CABG) and has the ability to assess graft failure intraoperatively. However, perioperative factors affecting TTFM during CABG remain poorly understood. Patients who underwent CABG ...

journal_title：Scientific reports

authors： Lee SW,Jo JY,Kim WJ,Choi DK,Choi IC

更新日期：2020-07-31 00:00:00

abstract：:Anatase TiO2 has been suggested as a potential sodium anode material, but the low electrical conductivity of TiO2 often limits the rate capability, resulting in poor electrochemical properties. To address this limitation, we propose graphene-wrapped anatase TiO2 nanofibers (rGO@TiO2 NFs) through an effective wrapping ...

journal_title：Scientific reports

authors： Yeo Y,Jung JW,Park K,Kim ID

更新日期：2015-09-10 00:00:00

abstract：:Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...

journal_title：Scientific reports

authors： Gao XH,Zhang YL,Zhang ZY,Guo SS,Chen XB,Guo YZ

更新日期：2020-01-08 00:00:00