Predictors of impending acute chest syndrome in patients with sickle cell anaemia.


:Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS and to assess the predisposing factors and predictors of severity. A retrospective case-control cohort was studied by retrieving patient information from electronic medical records after ethical approval. One hundred adolescents and adults with SCA and hospital admissions for ACS were identified through the discharge summaries, along with 20 additional patients presenting with VOC, but without ACS (controls). Among the patients with ACS, fever (>38.5 °C), reduced oxygen saturation (<95) and asplenia significantly differed when compared to those of controls (p < 0.05, chi-squared test). The degree of severity was reflected in the use of non-invasive ventilation (NIV), simple and exchange transfusions, and the presence of bilateral pleural effusions and multi-lobar atelectasis/consolidation, which were significantly higher in the cases with ACS than in the controls. Lower haemoglobin (Hb) and high WBC counts were also significantly different between the two groups (p < 0.05, Student's t test). Using logistic regression, our study further demonstrated that asplenia, fever, and reduced O2 saturation, along with low Hb and leukocytosis, were important predictors for the development of ACS.


Sci Rep


Scientific reports


Alkindi S,Al-Busaidi I,Al-Salami B,Raniga S,Pathare A,Ballas SK




Has Abstract


2020-02-12 00:00:00












  • Influence of dietary supplementation with Bacillus licheniformis and Saccharomyces cerevisiae as alternatives to monensin on growth performance, antioxidant, immunity, ruminal fermentation and microbial diversity of fattening lambs.

    abstract::Alternatives to antibiotics for improving productivity and maintaining the health of livestock health are urgently needed. The scope of this research was conducted to investigate the effects of two alternatives (Bacillus licheniformis and Saccharomyces cerevisiae) to monensin on growth performance, antioxidant capacit...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jia P,Cui K,Ma T,Wan F,Wang W,Yang D,Wang Y,Guo B,Zhao L,Diao Q

    更新日期:2018-11-12 00:00:00

  • Thioesterase YbgC affects motility by modulating c-di-GMP levels in Shewanella oneidensis.

    abstract::Because of ubiquity of thioesters, thioesterases play a critical role in metabolism, membrane biosynthesis, signal transduction, and gene regulation. In many bacteria, YbgC is such an enzyme, whose coding gene mostly resides in the tol-pal cluster. Although all other proteins encoded in the tol-pal cluster are clearly...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gao T,Meng Q,Gao H

    更新日期:2017-06-21 00:00:00

  • Expression of SRY-related HMG Box Transcription Factors (Sox) 2 and 9 in Craniopharyngioma Subtypes and Surrounding Brain Tissue.

    abstract::Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors usin...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Thimsen V,John N,Buchfelder M,Flitsch J,Fahlbusch R,Stefanits H,Knosp E,Losa M,Buslei R,Hölsken A

    更新日期:2017-11-20 00:00:00

  • Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer.

    abstract::Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Youn JI,Park SM,Park S,Kim G,Lee HJ,Son J,Hong MH,Ghaderpour A,Baik B,Islam J,Choi JW,Lee EY,Kim HR,Seo SU,Paik S,Yoon HI,Jung I,Xin CF,Jin HT,Cho BC,Seong SY,Ha SJ,Kim HR

    更新日期:2020-06-03 00:00:00

  • A random forest learning assisted "divide and conquer" approach for peptide conformation search.

    abstract::Computational determination of peptide conformations is challenging as it is a problem of finding minima in a high-dimensional space. The "divide and conquer" approach is promising for reliably reducing the search space size. A random forest learning model is proposed here to expand the scope of applicability of the "...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen X,Yang B,Lin Z

    更新日期:2018-06-11 00:00:00

  • AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts.

    abstract::Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sanchez-Alvarez M,Del Pozo MA,Bakal C

    更新日期:2017-11-28 00:00:00

  • Annexin B12 Trimer Formation is Governed by a Network of Protein-Protein and Protein-Lipid Interactions.

    abstract::Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tao M,Isas JM,Langen R

    更新日期:2020-03-24 00:00:00

  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.

    abstract::The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle cells is an important criterion in using them as a cell source to ameliorate skeletal muscle impairments. However, differentiation of hESCs into skeletal muscle cells still remains a challenge, often requiring introduction of trans...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hwang Y,Suk S,Shih YR,Seo T,Du B,Xie Y,Li Z,Varghese S

    更新日期:2014-08-01 00:00:00

  • MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer.

    abstract::Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MDR1 siRNA based stra...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yang X,Iyer AK,Singh A,Choy E,Hornicek FJ,Amiji MM,Duan Z

    更新日期:2015-02-17 00:00:00

  • Freshwater lake ecosystem shift caused by social-economic transitions in Yangtze River Basin over the past century.

    abstract::Global lake systems have undergone rapid degradation over the past century. Scientists and managers are struggling to manage the highly degraded lake systems to cope with escalating anthropogenic pressures. Improved knowledge of how lakes and social systems co-evolved up to the present is vital for understanding, mode...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang K,Yang X,Kattel G,Lin Q,Shen J

    更新日期:2018-11-21 00:00:00

  • mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

    abstract::Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria Ca2+ transfer increases during the early phase of ER stress induced by tunicamycin as an adapt...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bravo-Sagua R,López-Crisosto C,Parra V,Rodriguez-Peña M,Rothermel BA,Quest AF,Lavandero S

    更新日期:2016-11-03 00:00:00

  • Th1, Th17, and Treg Responses are Differently Modulated by TNF-α Inhibitors and Methotrexate in Psoriasis Patients.

    abstract::Psoriasis is a chronic, recurrent, immune-mediated, hyperproliferative inflammatory skin disease. The role of the adaptive immune system, particularly of Th1 and Th17 lymphocytes, has been regarded as prominent in the immunopathogenesis of psoriasis, as well as decreased Tregs function. Immunobiological drugs were adm...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Furiati SC,Catarino JS,Silva MV,Silva RF,Estevam RB,Teodoro RB,Pereira SL,Ataide M,Rodrigues V Jr,Rodrigues DBR

    更新日期:2019-05-17 00:00:00

  • Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men.

    abstract::High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kishimoto S,Maruhashi T,Kajikawa M,Matsui S,Hashimoto H,Takaeko Y,Harada T,Yamaji T,Han Y,Kihara Y,Chayama K,Goto C,Yusoff FM,Nakashima A,Higashi Y

    更新日期:2020-07-10 00:00:00

  • Author Correction: Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Whittington CM,O'Meally D,Laird MK,Belov K,Thompson MB,McAllan BM

    更新日期:2020-07-22 00:00:00

  • Tuning mitochondrial structure and function to criticality by fluctuation-driven mechanotransduction.

    abstract::Cells in vascular walls are exposed to blood pressure variability (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology. For example, BPV is elevated in hypertension but reduced under anesthesia. We hypothesized that the extent of mechanical fluctuations applied to vascu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bartolák-Suki E,Suki B

    更新日期:2020-01-15 00:00:00

  • Forest roadsides harbour less competitive habitats for a relict mountain plant (Pulsatilla vernalis) in lowlands.

    abstract::The long-term survival of relict populations depends on the accessibility of appropriate sites (microrefugia). In recent times, due to the mass extinction of rare species that has resulted from the loss of natural habitats, the question is - Are there any human-made sites that can act as refugial habitats? We examined...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zielińska KM,Kiedrzyński M,Grzyl A,Rewicz A

    更新日期:2016-08-18 00:00:00

  • Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts.

    abstract::It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometri...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jelenkovic A,Sund R,Yokoyama Y,Hur YM,Ullemar V,Almqvist C,Magnusson PK,Willemsen G,Bartels M,Beijsterveldt CEV,Bogl LH,Pietiläinen KH,Vuoksimaa E,Ji F,Ning F,Pang Z,Nelson TL,Whitfield KE,Rebato E,Llewellyn CH,Fi

    更新日期:2018-04-19 00:00:00

  • Operational resilience: concepts, design and analysis.

    abstract::Building resilience into today's complex infrastructures is critical to the daily functioning of society and its ability to withstand and recover from natural disasters, epidemics, and cyber-threats. This study proposes quantitative measures that capture and implement the definition of engineering resilience advanced ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ganin AA,Massaro E,Gutfraind A,Steen N,Keisler JM,Kott A,Mangoubi R,Linkov I

    更新日期:2016-01-19 00:00:00

  • Local melting to design strong and plastically deformable bulk metallic glass composites.

    abstract::Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Qin YS,Han XL,Song KK,Tian YH,Peng CX,Wang L,Sun BA,Wang G,Kaban I,Eckert J

    更新日期:2017-02-13 00:00:00

  • Emotional arousal modulates oscillatory correlates of targeted memory reactivation during NREM, but not REM sleep.

    abstract::Rapid eye movement (REM) sleep is considered to preferentially reprocess emotionally arousing memories. We tested this hypothesis by cueing emotional vs. neutral memories during REM and NREM sleep and wakefulness by presenting associated verbal memory cues after learning. Here we show that cueing during NREM sleep sig...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lehmann M,Schreiner T,Seifritz E,Rasch B

    更新日期:2016-12-16 00:00:00

  • Highly-ordered Triptycene Modifier Layer Based on Blade Coating for Ultraflexible Organic Transistors.

    abstract::We present a highly ordered surface modification layer for polymers based on ambient solution-processed triptycene (Trip) derivatives for high-mobility organic thin-film transistors (OTFTs). The nested packing of Trip molecules results in the formation of 2D hexagonal arrays, which stack one-dimensionally on the surfa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kondo M,Kajitani T,Uemura T,Noda Y,Ishiwari F,Shoji Y,Araki T,Yoshimoto S,Fukushima T,Sekitani T

    更新日期:2019-06-24 00:00:00

  • Comparative study of plasmonic antennas fabricated by electron beam and focused ion beam lithography.

    abstract::We present a comparative study of plasmonic antennas fabricated by electron beam lithography and direct focused ion beam milling. We have investigated optical and structural properties and chemical composition of gold disc-shaped plasmonic antennas on a silicon nitride membrane fabricated by both methods to identify t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Horák M,Bukvišová K,Švarc V,Jaskowiec J,Křápek V,Šikola T

    更新日期:2018-06-25 00:00:00

  • Considering tumour volume for motion corrected DWI of colorectal liver metastases increases sensitivity of ADC to detect treatment-induced changes.

    abstract::ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction me...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pathak R,Tian J,Thacker NA,Morris DM,Ragheb H,Saunders C,Saunders M,Jackson A

    更新日期:2019-03-07 00:00:00

  • A flow feature detection method for modeling pressure distribution around a cylinder in non-uniform flows by using a convolutional neural network.

    abstract::In a myriad of engineering situations, we often hope to establish a model which can acquire load conditions around structures through flow features detection. A data-driven method is developed to predict the pressure on a cylinder from velocity distributions in its wake flow. The proposed deep learning neural network ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ye S,Zhang Z,Song X,Wang Y,Chen Y,Huang C

    更新日期:2020-03-10 00:00:00

  • A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

    abstract::Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Raven KE,Girgis ST,Akram A,Blane B,Leek D,Brown N,Peacock SJ

    更新日期:2021-01-08 00:00:00

  • A physiological role of cyclic electron transport around photosystem I in sustaining photosynthesis under fluctuating light in rice.

    abstract::Plants experience a highly variable light environment over the course of the day. To reveal the molecular mechanisms of their photosynthetic response to fluctuating light, we examined the role of two cyclic electron flows around photosystem I (CEF-PSI)--one depending on PROTON GRADIENT REGULATION 5 (PGR5) and one on N...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yamori W,Makino A,Shikanai T

    更新日期:2016-02-02 00:00:00

  • A bacterial acetyltransferase triggers immunity in Arabidopsis thaliana independent of hypersensitive response.

    abstract::Type-III secreted effectors (T3Es) play critical roles during bacterial pathogenesis in plants. Plant recognition of certain T3Es can trigger defence, often accompanied by macroscopic cell death, termed the hypersensitive response (HR). Economically important species of kiwifruit are susceptible to Pseudomonas syringa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jayaraman J,Choi S,Prokchorchik M,Choi DS,Spiandore A,Rikkerink EH,Templeton MD,Segonzac C,Sohn KH

    更新日期:2017-06-15 00:00:00

  • The development of a scoring and ranking strategy for a patient-tailored adverse drug reaction prediction in polypharmacy.

    abstract::Only few applications are currently dealing with personalized adverse drug reactions (ADRs) prediction in case of polypharmacy. The study aimed to develop a patient-tailored ADR web application, considering characteristics from 734 drugs and relevant patient related factors. The application was designed in Python usin...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Valeanu A,Damian C,Marineci CD,Negres S

    更新日期:2020-06-12 00:00:00

  • Upregulation of chemokine CXCL10 enhances chronic pulmonary inflammation in tree shrew collagen-induced arthritis.

    abstract::Chronic pulmonary inflammation (CPI) gives rise to serious lung injuries in rheumatoid arthritis (RA) patients. However, the molecular mechanism underlying the pathogenesis of RA-associated CPI remains little understood. Here we established a novel tree shrew-based collagen-induced arthritis (TsCIA) model to study RA-...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gao B,Lin J,Jiang Z,Yang Z,Yu H,Ding L,Yu M,Cui Q,Dunavin N,Zhang M,Li M

    更新日期:2018-07-03 00:00:00

  • Tuning of mRNA stability through altering 3'-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations.

    abstract::Synthetic biological circuits that can generate outputs with distinct expression dynamics are useful for a variety of biomedical and industrial applications. We present a method to control output dynamics by altering output mRNA decay rates. Using oscillatory expression of the transcription factor p53 as the circuit r...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Koh WS,Porter JR,Batchelor E

    更新日期:2019-04-12 00:00:00